ACR Meeting Abstracts

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Abstracts tagged "cell biology"

  • Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting

    Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock

    Maggie Kalev-Zylinska1, James Hearn1, Jing Rong1, Mark Zhu2, Jacob Munro3, Jillian Cornish4, Nicola Dalbeth1 and Raewyn Poulsen2, 1University of Auckland, Auckland, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Orthopaedics, Auckland City Hospital, Auckland, New Zealand, 4Department of Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…
  • Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting

    Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock

    Jing Rong1, Mark Zhu2, Jacob Munro3, Geraldine M. McCarthy4, Jillian Cornish5, Nicola Dalbeth1 and Raewyn Poulsen2, 1University of Auckland, Auckland, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Orthopaedics, Auckland City Hospital, Auckland, New Zealand, 4Mater Misericordiae University Hospital, Dublin, Ireland, 5Department of Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…
  • Abstract Number: 2157 • 2016 ACR/ARHP Annual Meeting

    Share the Fate: Fibroblast-like Synoviocyte Cell-to-Cell Organelle Transfer Is Directed By the Inflammatory Microenvironment

    Ruth Byrne1, Isabel Olmos Calvo2, Thomas Karonitsch3, Felix Kartnig4, Johannes Holinka5, Günter Steiner6, Peter Ertl7, Josef Smolen8 and Hans Peter Kiener9, 1Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2Nanotechnology, Austrian Institute for Technology, Vienna, Austria, 3Internal Medicine III, Vienna Medical University, Vienna, Austria, 4Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 6Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 7Vienna University of Technology, Vienna, Austria, 8Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 9Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Fibroblast-like synoviocytes (FLS) form a complex tissue network via long-distance intercellular connections with wide intercellular matrix spaces. The adaptive synovial tissue response to inflammation…
  • Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting

    Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection

    Jason Ptacek, Ellen L. Berg and Alison O'Mahony, BioSeek, a division of DiscoveRx Corp., South San Francisco, CA

    Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…
  • Abstract Number: 2794 • 2014 ACR/ARHP Annual Meeting

    Deletion of the Inhibitory Receptor Motif, ITIM, on DC-STAMP Alters Osteoclast Differentiation and Function

    Yahui Grace Chiu1, Edward M. Schwarz2, Dongge Li1, Yuexin Xu3, Minsoo Kim3 and Christopher T. Ritchlin4, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Microbiology and Immunology, University of Rochester, Rochester, NY, 4Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein), a 7-pass transmembrane protein essential for cell-to-cell fusion during osteoclast (OC) differentiation, is expressed on the cell surface of…
  • Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting

    Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis

    Raquel Gago-Fuentes1, Patricia Fernández-Puente2,3, Paula Carpintero-Fernández1, Jesus Mateos2,3, Maria Dolores Mayan1 and Francisco Javier Blanco2,3, 1Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 3Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…
  • Abstract Number: 783 • 2014 ACR/ARHP Annual Meeting

    Increased Migration and Proliferation Potential Characterize Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis

    Alexis Regent1,2, Kim-Heang Ly3, Matthieu Groh2, Chabha Khifer4, Sebastien Lofek4, Guilhem Clary5, Philippe Chafey5, Cédric Broussard5, Christian Federici5, Claire Le Jeunne2, Elisabeth Vidal6, Antoine Brezin7, Veronique witko-Sarsat5, Loïc Guillevin2 and Luc Mouthon2, 1Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 3Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges;, Limoges, France, 4Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, 5Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, 6Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges, France, 7Service d’ophtalmologie, hôpital Cochin, AP-HP, Paris, France

    Background/Purpose The pathophysiology of GCA is poorly understood. Questions remain regarding the mechanisms underlying vascular remodeling. Methods Vascular smooth muscle cells (VSMC) were cultured from…
  • Abstract Number: 751 • 2014 ACR/ARHP Annual Meeting

    Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

    Shervin Assassi1, William Swindell2, Minghua Wu1, Filemon K. Tan1, Dinesh Khanna3, Daniel E. Furst4, Donald Tashkin5, Richard Jahan-Tigh6, Maureen D Mayes1, Johann Gudjonsson2 and Jeffrey T. Chang6, 1Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 2Dermatology, University of Michigan, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI, 4University of California at Los Angeles, Los Angeles, CA, 5Medicine, University of California at Los Angeles, Los Angeles, CA, 6University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose:  To examine the heterogeneity of global transcriptome patterns in systemic sclerosis (SSc) skin from a large cohort of patients and controls. Methods: Skin biopsies…
  • Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting

    Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage

    Maria Dolores Mayan1,2,3, Paula Carpintero-Fernández1,2, Raquel Gago-Fuentes1,2, Patricia Fernández-Puente1, Purificacion Filgueira-Fernandez1, Noa Goyanes1, Virgin Valiunas4, Peter Brink4, Gary Goldberg5 and Francisco J. Blanco6,7, 1Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, 2These authors contribute equally to this work, A Coruña, Spain, 3Correspondence to: [email protected] and [email protected], A Coruña, Spain, 4Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, 5Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, 6Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, 7Proteo-Red/ISCIII, Madrid, Spain

    Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…
  • Abstract Number: 1859 • 2013 ACR/ARHP Annual Meeting

    OX40+ T Cells and OX40L+ B Cells Accumulate In The Inflamed Joints and OX40 Signalling Is Skewed Towards Autoreactivity

    Julie Kristine Laustsen1, Tue Rasmussen2, Malene Hvid3 and Bent Deleuran4, 1Department of Medical Biomedicine, Aarhus University, Aarhus N, Denmark, 2Dept of Biomedicine, Aarhus University, Aarhus, Denmark, 3Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies and autoreactive T cells, leading to synovitis and joint destruction. The…
  • Abstract Number: 668 • 2013 ACR/ARHP Annual Meeting

    Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation

    Yongqing Wang1, David R. Giovannucci2 and Bashar Kahaleh3, 1Medicine, University of Toledo, Toledo, OH, 2Neurosciences, University of Toledo, Toledo, OH, 3Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Cold exposure induces vasospasm and incites reperfusion injury in SSc. The mechanisms responsible for enhanced cold sensitivity in SSc are poorly understood. Transient receptor…
  • Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting

    Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease

    Melissa E. Munroe1, Jourdan R. Anderson2, Timothy F. Gross3, Laura L. Stunz4, Gail A. Bishop4 and Judith A. James5, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4The University of Iowa, Iowa City, IA, 5Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…
  • Abstract Number: 1151 • 2012 ACR/ARHP Annual Meeting

    Low-Dose Methotrexate and the Selective Accumulation of Intracellular Aminoimidazolecarboxamide Ribotide

    Ryan S. Funk1, Leon van Haandel1, Mara L Becker2 and J.S. Leeder1, 1Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, 2Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO

    Background/Purpose:   Current evidence suggests that the anti-folate methotrexate (MTX) mediates its anti-inflammatory effects through inhibition of the purine synthesis pathway causing the accumulation of…
  • Abstract Number: 23 • 2012 ACR/ARHP Annual Meeting

    Differential Effects of Bone Morphogenetic Protein 2 and 9 On Chondroprotective Transforming Growth Factor β Signaling

    Arjan P. van Caam1, Esmeralda N. Blaney Davidson1, Elly L. Vitters2, Laurie de Kroon1, Ellen W. van Geffen3, Peter ten Dijke4, Wim B. van den Berg2 and Peter M. van der Kraan2, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by loss of articular cartilage. TGFβ is considered as a protective factor against cartilage loss in young cartilage…
  • • 2012 ACR/ARHP Annual Meeting

    Lee C. Howley Sr. Prize for Arthritis Research Introductory Talk I

    Andrew D. Luster, Massachusetts General Hospital, Charlestown, MA

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