Abstracts tagged "CD8 cells"

Abstract Number: 2849 • 2014 ACR/ARHP Annual Meeting
Involvement of CD8⁺ T Cells in the Pathogenesis of Giant Cell Arteritis and Polymyalgia Rheumatica
Maxime Samson¹, Sylvain Audia¹, Malika Trad², Marion Ciudad², Hervé Devilliers³, Alexandrine Gautheron², Valérie Quipourt⁴, Francois Maurier⁵, Nadine Meaux Ruault⁶, Patrick Manckoundia⁴, Paul Ornetti⁷, Jean-Francis Maillefert⁸, Jean-François Besancenot³, Christophe Ferrand⁹, Philippe Saas⁹, Laurent Martin¹⁰, Nona Janikashvili² and Bernard Bonnotte¹, ¹Dijon University Hospital, INSERM UMR 1098, Besançon ; University of Burgundy, Faculty of Medicine, IFR100 ; Department of Internal Medicine and Clinical Immunology, Dijon, France, ²University of Burgundy, Faculty of Medicine, IFR100, INSERM UMR 1098, Besançon, Dijon, France, ³Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, ⁴Dijon University Hospital, Department of Geriatric Internal Medicine, Dijon, France, ⁵HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁶Besançon University Hospital, Department of Internal Medicine, Besançon, France, ⁷Dijon University Hospital, Department of Rheumatology, Dijon, France, ⁸Rheumatology, University Hospital Dijon, Dijon, France, ⁹Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France, ¹⁰Dijon University Hospital, INSERM UMR 1098, Besançon ; University of Burgundy, Faculty of Medicine, IFR100 ; Department of Pathology, Dijon, France
Background/Purpose Previous studies have demonstrated the implication of CD4+ T cells, especially T helper (Th1) and Th17 cells, in the pathogenesis of giant cell arteritis (GCA)…
Abstract Number: 2726 • 2014 ACR/ARHP Annual Meeting
CD28null T Cells from Polymyositis Patients Are Cytotoxic to Autologous Muscle Cells in Vitro Via Perforin-Dependent Mechanisms
Jayesh Pandya¹, Paulius Venalis¹, Lubna Al-Khalili², Mohammad Shahadat Hossain¹, Ingrid E. Lundberg¹, Vivianne Malmström¹ and Andreas E. R. Fasth¹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Division of Industrial Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden
Background/Purpose: Inflammatory infiltrates of muscles in polymyositis are dominated by CD4+CD28null and CD8+CD28null T cells. In contrast to conventional CD28+ T cells, these cells…
Abstract Number: 1899 • 2014 ACR/ARHP Annual Meeting
Blockade of Interleukin-33 Signaling Prevents Death in a Mouse Model of Familial Hemophagocytic Lymphohistiocytosis
Julia Rood¹, Portia Kreiger², Erietta Stelekati¹, E. John Wherry¹ and Edward M. Behrens³, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Pathology, Alfred I. duPont Hospital for Children, Wilmington, DE, ³Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose Cytokine storm syndromes, such as macrophage activation syndrome and familial hemophagocytic lymphohistiocytosis (FHL), represent important causes of mortality in pediatric rheumatology. Studies of a…
Abstract Number: 633 • 2014 ACR/ARHP Annual Meeting
Immunological and Clinical Relationships of Synovial IL-17+ T Cells in Psoriatic Arthritis
Bruce Kirkham¹, Bina Menon² and Leonie S. Taams³, ¹Rheumatology, Guy's & St Thomas NHS Foundation Trust, London, United Kingdom, ²Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, ³Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom
Background/Purpose We recently reported elevated numbers of synovial fluid IL-17+CD4- T cells (mainly CD8+ (Tc17) cells) in Psoriatic Arthritis (PsA), correlating with clinical, serological and…

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