Abstracts tagged "CD4+CTL"

Abstract Number: 1048 • 2019 ACR/ARP Annual Meeting
Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis
Takashi Maehara ¹, Cory Perugino², Naoki Kaneko ¹, Hamid Mattoo ³, Jesper Kers ⁴, Hugues Allard-Chamard ⁵, Vinay Mahajan ⁵, Hang Liu ⁵, Samuel Murphy ⁵, Musie Ghebremichael ⁵, Yesim Tuncay ⁵, Emanuel Della Torre ⁶, Lloyd Liang ², Sydney Montesi ⁷, Zachary Wallace ², David Fox ⁸, Robert Lafyatis ⁹, John Stone ¹⁰, Dinesh Khanna ¹¹ and Shiv Pillai ¹², ¹Kyushu University, Fukuoka, Japan, ²Massachusetts General Hospital, Boston, ³Sanofi, Cambridge, ⁴University of Amsterdam, Amsterdam, Netherlands, ⁵Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁶Hospital San Raffaele, milan, Italy, ⁷Massachusetts General Hospital, Boston, MA, ⁸University of Michigan, Ann Arbor, ⁹University of Pittsburgh, Pittsburgh, PA, ¹⁰Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹¹Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ¹²Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: The CD4+ T cell subset driving the pathogenesis of systemic sclerosis (SSc) remains poorly understood. Many different CD4+ T cell subsets have been implicated,…

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