Abstracts tagged "cathepsin k inhibitor and osteoarthritis"

Abstract Number: 429 • 2018 ACR/ARHP Annual Meeting
The Potential Clinical Relevance of Imaging Biomarker Data from Short-Term Interventional Trials in Osteoarthritis: A Comparison of the Cathepsin K Inhibitor Miv-711 Phase 2a MRI Knee Joint Data and KL-Matched 5577 Knee Control Data from the Osteoarthritis Initiative
Philip G. Conaghan¹, Michael A Bowes², Sarah R. Kingsbury¹, Alan Brett², Gwenael Guillard², Åsa Jansson³, Cecilia Wadell³, Richard Bethell³ and John Öhd³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Medivir AB, Huddinge, Sweden
Background/Purpose: New imaging biomarkers using supervised machine learning offer opportunities to demonstrate effects of potential DMOADs on joint structure in short, small trials based on…
Abstract Number: 14L • 2017 ACR/ARHP Annual Meeting
Miv-711, a Novel Cathepsin K Inhibitor Demonstrates Evidence of Osteoarthritis Structure Modification: Results from a 6 Month Randomized Double-Blind Placebo-Controlled Phase IIA Trial
Philip G. Conaghan¹, Michael A Bowes², Sarah R. Kingsbury¹, Alan Brett², Gwenael Guillard², Åsa Jansson³, Cecilia Wadell³, Richard Bethell³ and John Öhd³, ¹University of Leeds, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Medivir AB, Huddinge, Sweden

Background/Purpose: The need for drugs that achieve structure modification in OA is imminent but their development has been burdened by the need for large, long…

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