ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Cartilage Repair"

  • Abstract Number: 1485 • ACR Convergence 2020

    LNA043, a Novel Cartilage Regenerative Treatment for Osteoarthritis: Results from a First-In-Human Trial in Patients with Knee Osteoarthritis

    Celeste Scotti1, Joseph Gimbel2, Didier Laurent1, Aviv Madar3, Thomas Peters1, Yunyu Zhang3, Florine Polus1, Michael Beste3, Igor Vostiar1, Subhajit Choudhury4, Nicole Gerwin1, Jörg Goldhahn5, Matthias Schieker1 and Ronenn Roubenoff1, 1Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Arizona Research Center, Phoenix, 3Novartis Institutes for BioMedical Research, Cambridge, 4Biostatistics & Pharmacometrics, Novartis Healthcare Pvt. Ltd., Hyderabad, India, 5Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland

    Background/Purpose:LNA043 is a modified human angiopoietin-like 3 (ANGPTL3) protein identified in a phenotypic screen for inducers of chondrogenesis and cartilage repair. The primary objective of…
  • Abstract Number: 1486 • ACR Convergence 2020

    Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study

    Felix Eckstein1, Marc Hochberg2, Hans Guehring3, Flavie Moreau4, Victor Ona4, Asger Bihlet5, Inger Byrjalsen5, Jeppe Andersen5, Benjamin Daelken3, Oliver Guenther3, Christoph Ladel3, Martin Michaelis3 and Philip G Conaghan6, 1Paracelsus Medical University, Salzburg, Austria, 2University of Maryland School of Medicine, Baltimore, MD, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5Nordic Bioscience, Herlev, Denmark, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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