Abstracts tagged "Cartilage Mechano biology"

Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Meike Sambale¹, starlee lively², Osvaldo Espin-Garcia², Pratibha Potla², Chiara Pastrello³, Alexandra Schaefer¹, Jessica Bertrand⁴, Mohit Kapoor⁵, Thomas Pap¹ and Joanna Sherwood¹, ¹University Hospital Münster, Münster, Germany, ²University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
Abstract Number: 0025 • ACR Convergence 2022
Wnt Pathway/Innate Immunity Equilibrium in OA Articular Cells
Eloi Franco-Trepat¹, Ana Alonso Pérez¹, María Guillán-Fresco², Miriam López Fagúndez¹, Andrés Pazos-Pérez³, Antia Crespo Golmar⁴, María Piñeiro-Ramil⁵, Ana Lois Iglesias⁶, Alberto Jorge-Mora¹ and Rodolfo Gomez¹, ¹MSP Group - Institute IDIS - CHUS - SERGAS, Santiago de Compostela, Spain, ²MSP Group - Institute IDIS - CHUS - SERGAS, Catoira, Spain, ³MSP Group - Institute IDIS - CHUS - SERGAS, Pontevedra, Spain, ⁴MSP Group - Institute IDIS - CHUS - SERGAS, León, Spain, ⁵MSP Group - Institute IDIS - CHUAC - SERGA, A Coruña, Spain, ⁶MSP Group - Institute IDIS - CHUAC - SERGAS, A Coruña, Spain
Background/Purpose: The progressive degradation of osteoarthritis (OA) cartilage has been associated with articular innate immune responses (IIR) mediated by the Toll-like receptor 4 (TLR4). Additionally,…
Abstract Number: 1475 • ACR Convergence 2021
Long Term Compressive Loading Modulates the Extracellular Matrix Response to Growth Factors in Bovine Cartilage Explants
Frederik Gillesberg¹, Amalie Engstrøm¹, Morten Karsdal², Anne-Christine Bay-Jensen³ and Christian S Thudium³, ¹University of Copenhagen, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Mechanical loading of cartilage is an essential part of the function and maintenance of the joint. Despite the apparent importance of continuous mechanical loading,…

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