Abstracts tagged "cartilage and osteoarthritis"

Abstract Number: 1991 • 2019 ACR/ARP Annual Meeting
Inhibition of CD44 Intracellular Domain Production Suppresses Bovine Articular Chondrocyte De-differentiation Induced by Excessive Mechanical Stress Loading
Yasumori Sobue¹, Nobunori Takahashi ², Naoki Ishiguro ² and Toshihisa Kojima ², ¹Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. Excessive mechanical stress loading is a risk factor for OA, but the molecular mechanism…
Abstract Number: 1356 • 2018 ACR/ARHP Annual Meeting
Increasing Oral Doses of GLPG1972 Administered Daily for 29 Days Show a Strong Target Engagement in Patients with Knee and/or Hip OA
Henri Deckx¹, Simon Hatch², Martine Robberechts¹, Sonia Dupont³, Julie Desrivot³, Hugh Coleman⁴, Staffan Larsson⁵, André Struglics⁵, Ellen van der Aar¹ and Ann Fieuw¹, ¹Galapagos NV, Mechelen, Belgium, ²Galapagos NV, Boston, MA, ³Galapagos SASU, Romainville, France, ⁴CRU, Covance, Daytona Beach, FL, ⁵Clinical Sciences, Lund University, Lund, Sweden
Background/Purpose: Osteoarthritis (OA) is characterized by structural changes of the joint, of which degradation of articular cartilage is one of the major signs1. The main…
Abstract Number: 1992 • 2018 ACR/ARHP Annual Meeting
The Effect of 4E-BP1 on Osteoarthritis-Related Gene Expression in TGF-β1-Stimulated Chondrocytes
Mi Hyun Lee, Ju-Ryoung Kim, Hyun Sook Hwang and Hyun Ah Kim, Hallym University Sacred Heart Hospital, Kyunggi-do, Korea, Republic of (South)
Background/Purpose: Initiation of protein synthesis is regulated by a repressor of cap-dependent translation, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which prevents eukaryotic initiation factor…
Abstract Number: 1995 • 2018 ACR/ARHP Annual Meeting
Heparan Sulfates from Human Osteoarthritic Cartilage Display Increased Sulfation Pattern, Decrease the Protein Binding Capacity to FGF-2 and Increase the Binding to VEGF and Induce Changes of Human Mesenchymal Stem Cell Behavior
Sarah Shamdani¹, Florent Eymard^2,3, sandrine Chantepie³, Camille Flageollet¹, Nadia Henni-Chebra¹, Yoan Jouan¹, Eric Hay⁴, Martine Cohen-Solal^5,6,7,8, Dulce Papy-Garcia³, Xavier Chevalier^9,10 and Patricia Albanese¹, ¹Val de Marne, Cell Growth, Tissue Repair and Regeneration Laboratory (CRRET), UPEC EA 4397/ERL CNRS 9215, F-94000, Créteil, France, Créteil, France, ²Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France, ³Val de Marne, Cell Growth, Tissue Repair and Regeneration Laboratory (CRRET), UPEC EA 4397/ERL CNRS 9215, F-94000, Créteil, France, Creteil, France, ⁴Rheumatology Department, Lariboisiere Hospital, Inserm UMR-1132, BIOSCAR, Paris, France, ⁵Paris Diderot University, Paris, France, ⁶Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France, ⁷Department of rheumatology and of bone and joint imaging, hospital Lariboisiere, Paris, France, Hôpital Lariboisière, Paris, France, ⁸INSERM UMR1132, Paris Diderot University, Paris, France, ⁹94, Cell Growth, Tissue Repair and Regeneration Laboratory (CRRET), UPEC EA 4397/ERL CNRS 9215, F-94000, Créteil, France, Creteil, France, ¹⁰Rheumatology, Hopital Henri Mondor, APHP, Creteil, France
Background/Purpose: The major Glycosaminoglycan (GAGs) component of the cartilage ECM are Chondroitin Sulfates (CS) and Keratan sulfates (KS). Heparan Sulfates (HS) are also present in…
Abstract Number: 57 • 2017 ACR/ARHP Annual Meeting
Accelerated Development of Aging-Associated and Instability-Induced Osteoarthritis in 12/15-Lipoxygenase Deficient Mice
Lauris Habouri¹, Yassine Ouhaddi¹, Gadid Guedi¹, Jean-Pierre Pelletier², Johanne Martel-Pelletier², mohamed benderdour¹ and Hassan Fahmi², ¹Medicine, CRCHUM, Montreal, QC, Canada, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: 12/15-Lipoxygenase (12/15-LOX) catalyzes the generation of various anti-inflammatory lipid mediators, and has been implicated in several inflammatory and degenerative diseases. However, there is currently…
Abstract Number: 2207 • 2017 ACR/ARHP Annual Meeting
Urine CTX-II, CTX-I, Osteocalcin, and Radiographic Severity of Multiple OA Knee Joints: Does CTX-II Originate from Bone or Cartilage?
Asger R. Bihlet¹, Inger Byrjalsen², Anne C. Bay-Jensen³, Jeppe Andersen⁴, Claus Christiansen¹, Bente J. Riis¹ and Morten Asser Karsdal³, ¹Nordic Bioscience, Clinical Development, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark, ⁴Clinical Development, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Excessive cartilage degradation is a known characteristic of osteoarthritis (OA), and several methods of quantification of cartilage degradation exist. Biomarkers such as urinary C-telopeptide…
Abstract Number: 2949 • 2017 ACR/ARHP Annual Meeting
The Relation of Cumulative Load to Prevalent Cartilage Damage in the Knee
Dana Mathews¹, Tuhina Neogi², Joshua Stefanik², Ali Guermazi³, Frank Roemer³, Louise Thoma⁴, Hiral Master⁴, Meredith Christiansen⁴, Cora E. Lewis⁵, Michael C. Nevitt⁶, James Torner⁷ and Daniel White⁸, ¹Physical Therapy, Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁴Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷University of Iowa, Iowa City, IA, ⁸Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Cartilage damage, which is a precursor and feature of knee osteoarthritis (OA), has been linked to both obesity and excessive joint loading. Assessment of…
Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Beatriz Carames¹, Paloma Lopez de Figueroa¹, Madalena Ribeiro¹, Valentina Calamia², Fernando Osorio³, Carlos Lopez-Otin³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
Abstract Number: 1129 • 2015 ACR/ARHP Annual Meeting
Transthyretin Deposition Accelerates the Development of Experimental Osteoarthritis in Mice
Tokio Matsuzaki¹, Oscar Alvarez-Garcia², Yukio Akasaki³, Natalia Reixach⁴, Joel Buxbaum² and Martin K. Lotz⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³Kyushu University, Fukuoka, Japan, ⁴Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁵Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Deposition of amyloid is a common aging-associated phenomenon and a key factor in the pathogenesis of several aging-related diseases. Osteoarthritis (OA) is the most…
Abstract Number: 93 • 2014 ACR/ARHP Annual Meeting
Protein Profiling of Secretome Human Cartilage to Identify Potential EARLY Specific Biomarkers in Osteoarthritis
Lucia Lourido, Valentina Calamia, Patricia Fernandez-Puente, Jesus Mateos, Francisco J. Blanco Garcia, Beatriz Rocha, Carolina Fernández-Costa, Carlos Fernandez-Lopez, Natividad Oreiro and Cristina Ruiz-Romero, Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is characterized by the progressive loss of cartilage structural extracellular matrix (ECM) components. The release of these proteins from the tissue can…
Abstract Number: 70 • 2013 ACR/ARHP Annual Meeting
Chondrocyte Hypertrophy, Measured By The Secretion Of Collagen Type X, Is Associated With Cartilage Degradation and Systemic Inflammation In Osteoarthritis
Yi He¹, Natasja Stæhr Gudman², Niels Ulrik Hansen¹, Jianxia Wang³, Di Su⁴, Qinlong Zheng⁴, Ole Simonsen⁵, Kristian Kjaer Petersen⁶, Moustapha Kassem⁷, Morten Asser Karsdal² and Anne C. Bay-Jensen⁸, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Cartilage biology and biomarkers, Nordic Bioscience China, Beijing, China, ⁴Nordic Bioscience China, Beijing, China, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁷Department of Endocrinology and Metabolism, Odense University Hospital and University of Southern, Odense, Denmark, ⁸Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. The hypertrophy-like changes, such as expression of hypertrophy…
Abstract Number: 2754 • 2013 ACR/ARHP Annual Meeting
Trajectory Of Cartilage Thickness Change During The Years Prior To Knee Replacement: Data From The Osteoarthritis Initiative
Felix Eckstein¹, Robert M. Boudreau², Zhijie Wang³, Michael J. Hannon³, Wolfgang Wirth¹, Sebastian Cotofana⁴, Ali Guermazi⁵, Frank Roemer⁶, Michael C. Nevitt⁷, Markus John⁸, Christoph Ladel⁹, David J. Hunter¹⁰ and C. Kent Kwoh¹¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Musculoskeletal Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Boston University, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Merck KG, Darmstadt, Germany, ¹⁰Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ¹¹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee replacement (KR) represents a clinically important and cost-effective endpoint of knee osteoarthritis (OA). We have shown previously that, in a year prior to…
Abstract Number: 2672 • 2013 ACR/ARHP Annual Meeting
Associations Between Popliteal Artery Wall Thickness and Knee Structure In Adults Without Clinical Knee Disease: A Prospective Cohort Study
Yuanyuan Wang¹, Diaz Novera¹, Anita Wluka², Jessica Fairley¹, Graham Giles³, Richard O'Sullivan⁴, Andrew Teichtahl⁵ and Flavia Cicuttini², ¹Monash University, Melbourne, Australia, ²Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ³University of Melbourne, Melbourne, Australia, ⁴Epworth Hospital, Melbourne, Australia, ⁵Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: There is evidence for a vascular contribution to the pathogenesis of osteoarthritis. The aim of this study was to examine the association between popliteal…
Abstract Number: 2148 • 2013 ACR/ARHP Annual Meeting
Use Of Low Dose Aspirin Is Associated With Reduced Medial Tibial Cartilage Loss In Symptomatic Osteoarthritis: DATA From A Cohort Study
Anita Wluka¹, Changhai Ding², Yuanyuan Wang³, Graeme Jones⁴, Andrew Teichtahl⁵ and Flavia Cicuttini¹, ¹Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Monash University, Melbourne, Australia, ⁴Menzies Research Institute Tasmania, University of Tasmania, HOBART, Australia, ⁵Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Inflammation and vascular disease have recently been shown to play a role in the pathogenesis of osteoarthritis (OA). Low dose aspirin is commonly used…
Abstract Number: 241 • 2013 ACR/ARHP Annual Meeting
Exploratory Factor Analysis Of a Parsimonious Medial Cartilage Damage Index Reveals One Factor Associated With Radiographic Severity and Symptoms: Data From The Osteoarthritis Initiative
Grace H. Lo¹, Lori Lyn Price^2,3, Ming Zhang⁴, Jeffrey B. Driban⁵, Daniel Harper⁴ and Timothy E. McAlindon⁶, ¹VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Rheumotology, Tufts Medical Center, Boston, MA, ⁵Rheumatology, Tufts Medical Center, Boston, MA, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: The cartilage damage index (CDI) is a parsimonious method of measuring articular cartilage approximating regional cartilage volume based on 18 locations within the knee,…

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