Abstracts tagged "cartilage and chondrocytes"

Abstract Number: 890 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor Signaling Activates FoxO1 and FoxO3 and Promotes Cartilage Autophagy
Benjamin Friedman¹, Carmen Corciulo ², Cristina Castro-Rivera ² and Bruce Cronstein ², ¹Department of Medicine, Division of Rheumatology NYUSoM, NYC, ²NYU Langone, New York
Background/Purpose: Osteoarthritis (OA) is a debilitating and costly condition caused by loss of articular cartilage secondary to chondrocyte dysfunction. Autophagy is a homeostatic pathway that…
Abstract Number: 1135 • 2015 ACR/ARHP Annual Meeting
Krüppel-like Factors (Klfs), Novel Transcriptional Regulators of Articular Chondrocytes That Are Abnormally Expressed in Osteoarthritic Cartilage
Takeshi Teramura¹, Joe Hasei², Hiroshi Asahara^1,3,4 and Martin K. Lotz⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Molecular and Exerpimental Medicine, The Scripps Research Institute, La Jolla, CA, ³Tokyo Medical and Dental University, Tokyo, Japan, ⁴National Research Institute for Child Health and Development, Tokyo, Japan, ⁵Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Krüppel-like factors (Klfs) are known to play key roles in cell cycle regulation, definition of cell fate and regulation of terminal differentiation. There is…
Abstract Number: 768 • 2013 ACR/ARHP Annual Meeting
Inhibition Of X-Box Binding Protein 1 (XBP1) Is Chondroprotective By Promoting Autophagy and Inhibiting Catabolic Responses
Ru L. Bryan¹, Robert Terkeltaub² and Ramon Serrano³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³VA Medical Center, San Diego, CA
Background/Purpose: Chondrocyte stress responses to biomechanical injury and joint inflammation, and associated changes in differentiation and function, provide a foundation upon which cartilage injury and…
Abstract Number: 44 • 2012 ACR/ARHP Annual Meeting
Inhibition of WNT Signaling Pathway by Sclerostin Maintains Cartilage Homeostasis
Wafa Bouaziz¹, Thomas Funck-Brentano¹, Hilene Lin¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Cartilage homeostasis is regulated by several mechanisms that influence the anabolic and catabolic tissue balance. Among them, the local activation of Wnt signaling pathway…