Abstracts tagged "Cardiovascular disease"

Abstract Number: 1071 • 2018 ACR/ARHP Annual Meeting
Protective Role of the Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Rs2495477 Polymorphism in Patients with Rheumatoid Arthritis
Sara Remuzgo-Martínez¹, Fernanda Genre¹, Verónica Pulito-Cueto¹, Alfonso Corrales¹, Javier Llorca², Verónica Mijares¹, Leticia Lera-Gómez¹, Virginia Portilla¹, Iván Ferraz-Amaro³, Santos Castañeda⁴, Oreste Gualillo⁵, Javier Martín⁶, Ricardo Blanco¹, Raquel Lopez-Mejías¹ and Miguel Angel González-Gay⁷, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, Santander, Spain, ³Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ⁶Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, PTS Granada, Granada, Spain, Granada, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain
Background/Purpose: RA is associated with the development of cardiovascular (CV) disease and subclinical atherosclerosis, which leads to an increased risk of CV mortality in RA…
Abstract Number: 1650 • 2018 ACR/ARHP Annual Meeting
Subclinical Atheromatosis and Estimation of Cardiovascular Risk in Patients with Axial Spondyloarthritis
Tomas Cazenave¹, Maria Celeste Orozco², Gustavo Citera³, Emilce E Schneeberger¹ and Marcos G. Rosemffet², ¹Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina
Background/Purpose: There is evidence that shows an increased cardiovascular risk in patients with Axial Spondyloarthritis (axSpA). Ultrasonography (US) is a simple imaging tool used to…
Abstract Number: 2354 • 2018 ACR/ARHP Annual Meeting
Perspectives of Patients with Inflammatory Arthritis Regarding Cardiovascular Risk: A Qualitative Study
Iris Navarro-Millán^1,2, Sarah Young³, Sally Shurbaji⁴, Chastity McDavid⁴, Anna Cornelius-Schecter², Bernadette Johnson⁴, Andrea Cherrington⁴, Liana Fraenkel⁵, Jeffrey R. Curtis⁴ and Monika M. Safford², ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Binghamton University, Binghamton, NY, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Yale University, New Haven, CT
Background/Purpose: Cardiovascular disease (CVD) is the most common cause of death among patients with inflammatory arthritis (IA) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA)…
Abstract Number: 471 • 2018 ACR/ARHP Annual Meeting
Early Signs of Diastolic Impairment in Children with Incident Systemic Lupus Erythematosus
Joyce C. Chang^1,2, Brian R. White³, Matthew D. Elias³, Rui Xiao⁴, Andrea M. Knight^5,6,7, Pamela F. Weiss^8,9,10 and Laura M. Mercer-Rosa^3,7, ¹Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁵Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ⁶Division of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁸Center for Clinical Epidemiology and Biostastistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁹Division of Rheumatology, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ¹⁰Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: The timing and etiology of diastolic impairment in pediatric-onset systemic lupus erythematosus (pSLE) are poorly understood, and the role of screening echocardiography remains unclear.…
Abstract Number: 682 • 2018 ACR/ARHP Annual Meeting
Nonsteroidal Anti-Inflammatory Drug Use and Hypertension in Ankylosing Spondylitis
Jean Liew¹, John D. Reveille², Michael Ward³, MinJae Lee⁴, Matthew Brown⁵, Mohammad H. Rahbar⁶, Michael Weisman⁷ and Lianne S. Gensler⁸, ¹Internal Medicine; Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ³National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁴Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁵Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁶Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, USA, Los Angeles, CA, ⁸University of California San Francisco, San Francisco, CA
Background/Purpose: Cardiovascular morbidity and mortality are increased in Ankylosing Spondylitis (AS). Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first line pharmacological therapy in AS; however, their…
Abstract Number: 1100 • 2018 ACR/ARHP Annual Meeting
The Frequencies and Molecular Profiles of CD16+ Monocyte Subsets in Patients with Systemic Lupus Erythematosus, Primary Antiphospholipid Syndrome, and Antiphospholipid Syndrome with Lupus, Identify Specific Clinical Features of These Diseases
Chary Lopez-Pedrera¹, Maria Ángeles Aguirre Zamorano¹, Nuria Barbarroja², Patricia Ruiz-Limon³, Maria Carmen Abalos-Aguilera⁴, Yolanda Jiménez-Gómez², Ivan Arias de la Rosa⁴, Pedro Segui⁵, Rafaela Ortega-Castro², Eduardo Collantes Estevez¹, Alejandro Escudero-Contreras⁴, Lucas Le Lann⁶, Christophe Jamin⁶, Concepcion Marañón⁷, Marta Alarcón-Riquelme⁸, Jacques-Olivier Pers⁶ and Carlos Perez-Sanchez², ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ⁷GENYO, Centre for Genomics and Oncological Research Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain, ⁸Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain
Background/Purpose: This study, developed within the IMI-JU project PRECISESADS framework, aimed to determine the enrichment on CD14+ and CD16+ monocyte subpopulations in SLE, APS and…
Abstract Number: 1729 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Valvular Heart Disease in Patients with Systemic Sclerosis: Results from a Population-Based Cohort (1980-2016)
Reto Kurmann¹, Avneek Singh Sandhu², Cynthia S. Crowson³, Rekha Mankad¹, Thomas Osborn², Kenneth J. Warrington⁴ and Ashima Makol², ¹Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Systemic Sclerosis (SSc) is a complex, heterogenous autoimmune disease characterized by microvascular injury and widespread fibrosis of the skin and internal organs, particularly lungs…
Abstract Number: 2498 • 2018 ACR/ARHP Annual Meeting
The Association of Vitamin D with the Lipid Profile in Rheumatoid Arthritis: An Interplay Among Genetic Polymorphisms, DHCR7 Levels and Seasonality
Javier Rodríguez-Carrio^1,2,3, Mercedes Alperi-López⁴, Manuel Naves-Díaz^2,3, Adriana Dusso^2,3, Patricia López¹, Francisco Javier Ballina-García⁵, Jorge B. Cannata-Andía^2,3 and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain, ³Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain, ⁴Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁵Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: Vitamin D deficiency is a common hallmark of rheumatic diseases, and some controversy exists about its effect on rheumatoid arthritis (RA), in particular about…
Abstract Number: 472 • 2018 ACR/ARHP Annual Meeting
Libman Sacks Endocarditis in Pediatric Systemic Lupus Erythematosus: Clinical Features and Complications
Marla Guzman, Meiqian Ma, B. Anne Eberhard and Joyce Hui-Yuen, Pediatric Rheumatology, Cohen Children's Medical Center, New Hyde Park, NY
Background/Purpose: Libman-Sacks endocarditis (LSE) is a rare manifestation of pediatric-onset systemic lupus erythematosus (pSLE). It is difficult to differentiate LSE from infective endocarditis (IE) in immunosuppressed…
Abstract Number: 706 • 2018 ACR/ARHP Annual Meeting
Increased Incidence and Prevalance of Resistant Hypertension in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study
Jocelyn S. Gandelman¹, Omair A. Khan², Megan Shuey³, Jacquelyn E. Neal², Alyson Dickson⁴, April Barnado⁵, Li Wang², William Dupont², C. Michael Stein⁴ and Cecilia P. Chung⁴, ¹Vanderbilt University School of Medicine, Nashville, TN, ²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Department of Pharmacology, Vanderbilt University, Nashville, TN, ⁴Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, ⁵Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Resistant hypertension (RHTN) is associated with increased risk of cardiovascular events in the general population. Patients with systemic lupus erythematous (SLE) have increased cardiovascular…
Abstract Number: 1128 • 2018 ACR/ARHP Annual Meeting
Impact of Urate-Lowering Therapy on the Risk of Cardiovascular Events and All-Cause Mortality Among Individuals with Gout
In Ah Choi¹, Hoyeon Jang² and Gil-Won Kang², ¹Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of (South), ²Department of Health Informatics and Management, College of Medicine, Chungbuk National University, Cheongju, Korea, Republic of (South)
Background/Purpose: Gout results from an increased body pool of urate that occurs with hyperuricemia. Although urate-lowering therapy (ULT) is beneficial to prevent gout attack, current…
Abstract Number: 1744 • 2018 ACR/ARHP Annual Meeting
Prognostic Value of Right Heart Involvement in Systemic Sclerosis:Not Only Pulmonary Arterial Hypertension
Luna Gargani¹, Cosimo Bruni², Antonella Moreo³, Laura Belloli³, Silvia Bellando-Randone², Oscar Massimiliano Epis³, Francesco Ferrara⁴, Olga Vriz⁵, Eduardo Bossone⁶, Petar M. Seferovic⁷, Daniel E. Furst⁸ and Marco Matucci-Cerinic⁹, ¹Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy, ²Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ³Niguarda Ca’ Granda Hospital, Milan, Italy, ⁴"Cava de' Tirreni and Amalfi Coast", University Hospital, Salerno, Italy, ⁵King Faisal Hospital, Riyadh, Saudi Arabia, ⁶Cardarelli Hospital, Naples, Italy, ⁷Department of Cardiology, , Clinical Center of Serbia and Belgrade University School of Medicine, Belgrade, Serbia, ⁸University of California Los Angeles, Los Angeles, CA, ⁹Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose: In SSc, cardiac dysfunction is associated with poor prognosis. Right ventricular involvement is frequently secondary to PAH. Echocardiography is the routine imaging tool to…
Abstract Number: 2631 • 2018 ACR/ARHP Annual Meeting
Hydroxychloroquine Blood Levels Are Significantly Associated with Cardiovascular Risk Factors
Michelle Petri¹, Daniel Goldman¹ and Laurence S Magder², ¹Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ²Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: In studies of SLE patients, the benefits of hydroxychloroquine (HCQ) extend beyond control of disease activity. In particular, HCQ use has decreased multiple cardiovascular…
Abstract Number: 494 • 2018 ACR/ARHP Annual Meeting
Arterial Wall Inflammation Declines after 6 Months of Anti-Inflammatory Therapy with Methotrexate and/or Adalimumab in Rheumatoid Arthritis Patients
Annelies Blanken¹, Rabia Agca¹, Alexandre Voskuyl², Ronald Boellaard³, Conny van der Laken² and Michael Nurmohamed^2,4, ¹Amsterdam Rheumatology and immunology Center, Location Reade, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, ³Radiology and Nuclear Medicine, Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, Amsterdam Rheumatology and immunology Center, Location Reade, Amsterdam, Netherlands
Background/Purpose: Patients with rheumatoid arthritis (RA) have an elevated cardiovascular (CV) disease risk, mostly explained by both an increased prevalence of traditional CV risk factors…
Abstract Number: 722 • 2018 ACR/ARHP Annual Meeting
Increased Blood Pressure Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus: Association with Inflammation, Comorbidities and Increased Mortality
Tyler Reese¹, Alyson Dickson¹, Jacquelyn E. Neal², Jocelyn S. Gandelman³, Omair A. Khan², April Barnado⁴, William Dupont², C. Michael Stein¹ and Cecilia P. Chung¹, ¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University School of Medicine, Nashville, TN, ⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. As outcomes related to disease control have improved, this mortality…

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