Abstracts tagged "Cardiovascular disease"

Abstract Number: 2272 • 2012 ACR/ARHP Annual Meeting
Gene Expression Signatures in Monocytes From Primary Antiphospholipd Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome Identify Specific Pathways Involved in the Pathogenesis of Atherosclerosis and Cardiovascular Disease
Chary Lopez-Pedrera¹, Sebastiano Messineo², Carlos Perez-Sanchez¹, Patricia Ruiz-Limon¹, Mª Angeles Aguirre³, Rosario M. Carretero-Prieto⁴, Antonio Rodriguez-Ariza¹, Nuria Barbarroja⁴, Francisco Velasco¹, Munther A. Khamashta⁵, Eduardo Collantes-Estevez¹ and Mª Jose Cuadrado⁶, ¹IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ²Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Italy., Catanzaro, Italy, ³Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by immune-mediated inflammation in multiple organ systems. SLE, primary Antiphospholipid syndrome (APS) and secondary APS (SAPS) share several…
Abstract Number: 1386 • 2012 ACR/ARHP Annual Meeting
Genetic Variation and Coronary Atherosclerosis in Patients with Systemic Lupus Erythematosus
Cecilia P. Chung¹, Joseph F. Solus², Annette Oeser³, Chun Li⁴, Paolo Raggi⁵, Jeffrey R. Smith³ and C. Michael Stein⁶, ¹Medicine, Vanderbilt University School of Medcine, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵University of Alberta, Edmonton, AB, Canada, ⁶Internal Medicine and Pharmacology, Vanderbilt University, Nashville, TN
Background/Purpose: Premature coronary artery disease is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, this is not explained…
Abstract Number: 699 • 2012 ACR/ARHP Annual Meeting
Endothelial Dysfunction and Vascular Stiffness in Early Diffuse Systemic Sclerosis
Robyn T. Domsic¹, Dana Ivanco², Hunter C. Champion³, Ali Shoushtari³ and Thomas A. Medsger Jr.⁴, ¹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Department of Medicine/Div. of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine/Rheumatology, Univ of Pittsburgh, Pittsburgh, PA
Background/Purpose: Vascular dysfunction is a hallmark of systemic sclerosis (SSc). Current theories postulate endothelial injury and dysfunction as an early event in SSc pathogenesis. Prior…
Abstract Number: 2253 • 2012 ACR/ARHP Annual Meeting
Metabolic Syndrome Is Not Only a Risk Factor for Cardiovascular Events in Systemic Lupus Erythematosus but Also Associated with Cumulative Organ Damage: A Cross-Sectional Analysis of 311 Patients
Semra Ertan-Demir¹, Bahar Artim-Esen², Yasemin Sahinkaya², Özlem Pehlivan², Nilüfer Alpay-Kanitez², Ahmet Omma², Burak Erer², Sevil Kamali², Ahmet Gul², Orhan Aral², Lale Ocal² and Murat Inanc², ¹Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased rates of cardiovascular (CV) events that are one of the major causes of mortality. In addition…
Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Aliza Lipson², Nikolaos Alexopoulos³, Gregory R. Hartlage³, Annette M. Oeser⁴, Aihua Bian⁴, Tebeb Gebretsadik⁵, Ayumi Shintani⁴, Paolo Raggi⁶ and C. Michael Stein⁷, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Rheumatology, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA, ⁴Vanderbilt Medical Center, Nashville, TN, ⁵Biostatistics, Vanderbilt University, Nashville, TN, ⁶University of Alberta, Edmonton, AB, Canada, ⁷School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
Abstract Number: 662 • 2012 ACR/ARHP Annual Meeting
Increased C1q, C4 and C3 Deposition On Platelets in Patients with Systemic Lupus Erythematosus – A Possible Link to Venous Thrombosis?
Christian Lood¹, Sam Eriksson¹, Birgitta Gullstrand², Andreas Jönsen¹, Gunnar Sturfelt³, Lennart Truedsson² and Anders A. Bengtsson⁴, ¹Department of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden, ²Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, ³Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing vascular diseases (VD) such as myocardial infarction, stroke and venous thrombosis, which…
Abstract Number: 2216 • 2012 ACR/ARHP Annual Meeting
Cardiovascular Risk Assessment in Spondyloarthritis Using the Score Chart and Reclassification by Presence of Plaques On Ultrasonography
Jl Rosales-Alexander¹, Juan Salvatierra¹, César Magro Checa¹, Jesús Cantero Hinojosa² and Enrique Raya Álvarez¹, ¹Rheumatology, University Hospital San Cecilio, Granada, Spain, ²Internal Medicine, University Hospital San Cecilio, Granada, Spain
Background/Purpose: Increased cardiovascular (CV) risk have been described in patients with rheumatic diseases including spondyloarthritis (SpA). Besides traditional CV risk factors, disease specific factors have…
Abstract Number: 1262 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients with Higher Disease Severity and Subclinical Carotid Plaque Experience More Cardiovascular Events Despite a Favorable Conventional Cadiovascular Risk Profiles
Yeon-Ah Lee¹, Somi Kim¹, Sang-Hoon Lee², Ran Song², Hyung In Yang² and Seung-Jae Hong¹, ¹Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ²Rheumatology, Hospital at GANGDONG, Kyung Hee University, Seoul, South Korea
Background/Purpose: It has been shown that patients with rheumatoid arthritis (RA) experience cardiovascular (CV) events more often than expected. Increased risks of CV diseases in…
Abstract Number: 667 • 2012 ACR/ARHP Annual Meeting
Interferon-Alpha Impairs the Survival and Function of Circulating Angiogenic Cells in Vitro: A Model of Failed Endothelial Repair in SLE
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus have an increased risk of cardiovascular disease (CVD). No specific targeted therapies for CVD in lupus exist and there…

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