Abstracts tagged "Cardiovascular disease"

Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting
Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?
Kimberly P. Liang¹, Douglas P. Landsittel², Suresh R. Mulukutla³, Steven E. Reis⁴, Marc C. Levesque⁵, Donald M. Jones⁶, Rachel Gartland⁷, Ali Shoushtari⁸, Flordeliza S. Villanueva³, Hunter C. Champion⁸ and Larry W. Moreland⁵, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ³Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
Abstract Number: 265 • 2013 ACR/ARHP Annual Meeting
All-Cause Mortality and Incident Cardiovascular Disease In Knee Osteoarthritis: The Framingham Study
Devyani Misra¹, David T. Felson², Ida K. Haugen³, Martin Englund⁴ and Tuhina Neogi¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: Studies examining the relation of osteoarthritis (OA) to mortality or cardiovascular disease (CVD) have reported conflicting results, raising the question of whether OA itself…
Abstract Number: 2448 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Disease Is Associated With Worse Functional Outcomes In Ankylosing Spondylitis
Lianne S. Gensler¹, Michael M. Ward², MinJae Lee³, Mohammad Rahbar⁴, Matthew A. Brown⁵, John D. Reveille⁶ and Michael H. Weisman⁷, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴The University of Texas Health Science Center at Houston, Houston, TX, ⁵Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA
Background/Purpose: Cardiovascular disease is an important comorbidity in inflammatory arthritis. There is evidence that AS patients have a significant burden of cardiovascular comorbidity. This appears…
Abstract Number: 1470 • 2013 ACR/ARHP Annual Meeting
Anti-Tumour Necrosis Factor Alpha Therapy Reduces Platelet Reactivity and Is Associated With Improved Insulin Sensitivity In Patients With Inflammatory Arthritis
Paul A. MacMullan^1,2, Anne M. Madigan¹, Laura J. Durcan³, Karl Egan², Paola M. Bagaglia¹, Dermot Kenny⁴ and Geraldine M. McCarthy¹, ¹Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ²Cardiovascular Biology Laboratory, RCSI, Dublin, Ireland, ³Rheumatology, Mater Misercordiae University Hospital, Dublin 7, Ireland, ⁴Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland
Background/Purpose: Patients with inflammatory arthritis (IA) die prematurely from cardiovascular disease (CVD). The increased CVD risk is not fully explained by traditional risk factors, but…
Abstract Number: 694 • 2013 ACR/ARHP Annual Meeting
Peripheral Bone Marrow-Derived Endothelial Progenitor Cells and N-Terminal Probrain Natriuretic Peptide in Scleroderma Mexican Patients With and Without Diastolic Dysfunction: A Preliminary Report
Jesús Sepúlveda^1,2, Olga Vera-Lastra³, Maria Pilar Cruz-Dominguez⁴, Laura Montiel-Cervantes⁵, Joaquín Gómez-León⁶, Luis Robles-Espinoza⁷, Ramón Lozano-Morales⁷, Sergio Mendoza-Alvarez¹, Rubiraida Molina-Aguilar⁵, Gabriela Medina⁸, Jorge Vela-Ojeda⁹ and Luis J. Jara¹⁰, ¹Internal Medicine, Instituto Mexicano del Seguro Social, Mexico City, Mexico, ²Unidad de Estudios de Posgrado, Universidad Nacional Autónoma de México, Mexico City, Mexico, ³Internal Medicine, MD, Mexico City, Mexico, ⁴Division of Research, Hospital de Especialidades Centro Medico Nacional La Raza., Mexico, DF, Mexico, ⁵Hematology Laboratory, Instituto Mexicano del Seguro Social, Mexico City, Mexico, ⁶Cardiology Department, Instituto Mexicano del Seguro Social, Mexico City, Mexico, ⁷Central Laboratory, Instituto Mexicano del Seguro Social, Mexico City, Mexico, ⁸CMN La Raza IMSS, Seris/Zachila s/n La Raza, Mexico City, Mexico, ⁹Instituto Mexicano del Seguro Social, Mexico City, Mexico, ¹⁰Research and Education, Hospital de Especialidades Centro Medico La Raza, México City, Mexico
Background/Purpose: Diastolic dysfunction (DD) in systemic sclerosis (SSc) is a marker of increased risk of death. The N-terminal pro-brain natriuretic peptide (NT-proBNP) is a neurohormone…
Abstract Number: 415 • 2013 ACR/ARHP Annual Meeting
Stability Of Carotid Intima Media Thickness and No Plaque Formation In Inflammatory Arthritis Patients On Biologics Over One Year
Stephanie O. Keeling¹, Asvina Bissonauth², Jeff Odenbach², Quazi Ibrahim³ and Michael Sean McMurtry⁴, ¹Division of Rheumatology, Department of Medicine, University of Alberta, Canada, Edmonton, AB, Canada, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Medicine, EPICORE, Edmonton, AB, Canada, ⁴Cardiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Carotid intima media (cIMT) measurement is a validated surrogate measure of cardiovascular (CV) disease. Our aim was to evaluate baseline and follow-up cIMTs in…
Abstract Number: 266 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Disease In Osteoarthritis: Hip Versus Knee and The Influence Of Multiple Symptomatic Joint Involvement
Anthony V. Perruccio¹, Rita A. Kandel² and Aileen M. Davis³, ¹Toronto Western Hospital, Toronto Western Research Institute, and University of Toronto, Toronto, ON, Canada, ²Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ³Health Care and Outcomes Research, Toronto Western Research Institute; Departments of Rehabilitation Science and Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
Background/Purpose: The strength of association between obesity and osteoarthritis (OA) is reported to vary by joint (e.g. stronger association with knee than hip). As well,…
Abstract Number: 2357 • 2013 ACR/ARHP Annual Meeting
Confounding By Indication Distorts The Relationship Between Steroid Use and Cardiovascular Disease In Rheumatoid Arthritis
Alper M. van Sijl¹, Maarten Boers², Alexandre E. Voskuyl¹ and Mike T. Nurmohamed¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Glucocorticoids (GC) are among the most effective drugs in rheumatoid arthritis (RA), but concerns over long-term side effects have not been resolved. Recent studies…
Abstract Number: 1411 • 2013 ACR/ARHP Annual Meeting
The Peroxisome Proliferator Activated Receptor-gamma pioglitazone Decreases Cardiovascular Risk and Disease Activity In Patients With Rheumatoid arthritis
Wendy Marder¹, Shokoufeh Khalatbari², James D. Myles³, Rita Hench⁴, Susan Lustig⁴, Srilakshmi Yalavarthi⁵, Aishwarya Parameswaran⁴, Robert Brook² and Mariana J. Kaplan⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Medicine, University of Michigan at Ann Arbor, Ann Arbor, MI, ³Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Michigan Rheumatology, Ann Arbor, MI, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Rheumatoid arthritis (RA) is associated with heightened mortality due to atherosclerotic cardiovascular disease (CVD). Inflammatory pathways in RA negatively affect vascular physiology and promote…
Abstract Number: 680 • 2013 ACR/ARHP Annual Meeting
Diastolic Dysfunction Amongst Autoantibody Subgroups Of Patients With Diffuse Scleroderma
Cory Perugino¹, John Stephens², Colin O'Rourke³ and Soumya Chatterjee⁴, ¹Internal Medicine, Cleveland Clinic, Cleveland, OH, ²Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ³Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH
Background/Purpose: Scleroderma or systemic sclerosis (SSc) is an autoimmune disease characterized by microangiopathy, tissue hypoxia, and fibrosis. At least seven different autoantibodies have been identified…
Abstract Number: 382 • 2013 ACR/ARHP Annual Meeting
Effect Of Biologic Disease Modifiers On Cardiovascular Risk Of Patients With Rheumatoid Arthritis – 2 Years Prospective Cohort Study
Majed M. Khraishi¹ and Rana Aslanov², ¹Nexus Clinical Research, St John's, NF, Canada, ²Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada
Background/Purpose: People with RA have a higher risk for developing cardiovascular diseases than the general population. The pathogenic mechanisms in RA appear to be complex…
Abstract Number: 220 • 2013 ACR/ARHP Annual Meeting
Asymptomatic Myocardial Ischemic Disease In Takayasu’s Arteritis: Detection By Magnetic Resonance Imaging
Cloé Comarmond¹, Philippe Cluzel², Dan Toledano³, Nathalie Costedoat-Chalumeau⁴, Richard Isnard⁵, Fabien Koskas⁶, Patrice Cacoub Sr.⁷ and David Saadoun⁸, ¹Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ²Cadiovascular Imaging and Interventional Radiology, Pitié-Salpétrière, Paris, France, ³Cardiovascular Imaging and Interventional Radiology, Hôpital Pitié-Salpêtrière, Paris, France, ⁴Internal Medicine, Hopital Cochin, Paris, France, ⁵Cardiology, CHU Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651 Paris Cedex 13, Paris, France, Paris, France, ⁶Vascular Surgery, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France, ⁸DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France
Background/Purpose: Takayasu's arteritis (TA) may affected myocardium and caused coronary stenosis. The aim of this study was to assess the prevalence and pattern of myocardial…
Abstract Number: 2343 • 2013 ACR/ARHP Annual Meeting
Assessment Of Subclinical Atherosclerosis (Flow Mediated Dilatation and arterial stiffness) After 24 Weeks Of a Tocilizumab Therapy In 22 Patients With Rheumatoid Arthritis
Martin Soubrier¹, Thomas Frayssac², Bruno Pereira³, Marion Couderc Sr.⁴, Coline Daron², Jean Jacques Dubost⁵, Sandrine Malochet-Guinamand⁴, Anne Tournadre⁴ and Sylvain Mathieu⁴, ¹Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ²CHU CLERMONT-FERRAND, Clermont-ferrand, France, ³Clinical research department, Clermont-Ferrand, France, ⁴Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France
Background/Purpose: Increased incidence of cardiovascular diseases and sub-clinical atherosclerosis have been observed in rheumatoid arthritis (RA). Inflammation and traditional risk factors could be involved in…
Abstract Number: 1387 • 2013 ACR/ARHP Annual Meeting
Reversing Vascular Dysfunction In Rheumatoid Arthritis: Peroxisome Proliferator-Activated Receptor Gamma Agonist Therapy Improves Augmentation Index But Not Endothelial Function
Michelle J. Ormseth¹, Aihua Bian², Annette M. Oeser², Andrew Cunningham², Ayumi Shintani², S. Bobo Tanner³ and C. Michael Stein⁴, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Vanderbilt Medical Center, Nashville, TN, ³Div of Rheumatology & Allergy, Vanderbilt Medical Center, Nashville, TN, ⁴School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Rheumatoid arthritis (RA) is associated with insulin resistance and increased cardiovascular (CV) risk. Impaired vascular function, including arterial stiffness and endothelial dysfunction, is associated…
Abstract Number: 624 • 2013 ACR/ARHP Annual Meeting
Extremely High Coronary Artery Calcium Scores Among Patients With Systemic Lupus Erythematosus
Susan Due Kay¹, Anne Voss², Axel Cosmus Pyndt Diederichsen³ and Mikael Kjær Poulsen⁴, ¹Department of Rheumatology, Odense University hospital, University of Southern Denmark, Odense - 5000, Denmark, ²Dept of Rheumatology, Odense University Hospital, Odense C, Denmark, ³Departmen of Cardiology,, Odense University Hospital, Odens-5000, Denmark, ⁴Department of Cardiology, Odense University Hospital, Odense - 5000, Denmark
Background/Purpose: Investigations of major lupus-cohorts have demonstrated cardiovascular disease to have major impact on morbidity and mortality (Am J Epidemiol 1997;145:408-15). The aim of this…

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