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Abstracts tagged "cardiovascular disease and systemic lupus erythematosus (SLE)"

  • Abstract Number: 707 • 2018 ACR/ARHP Annual Meeting

    Subclinical Parameters of Arterial Stiffness and Arteriosclerosis Correlate with QRISK3 in Systemic Lupus Erythematosus

    Monica Vazquez-Del Mercado1,2, Felipe Perez-Vazquez3, Eduardo Gomez-Bañuelos1, Efrain Chavarria-Avila3, Arcelia Llamas-Garcia4, Karla I. Arrona-Rios4, Gustavo I Diaz-Rubio3, Sergio Duran-Barragan4, Rosa E Navarro-Hernandez3, Bethel Jordan-Estrada3, Natalia Prado-Bachega5, Miguel A. A. Gonzalez-Beltran3, Carlos G Ramos-Becerra6, Fernando Grover-Paez6, David Cardona-Muller7 and Ernesto German Cardona-Muñoz7, 1Servicio de Reumatología, 004086 PNPC CONACyT, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 2Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Mexico, 3Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, 4Servicio en Reumatología, 004086 PNPC CONACyT, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 5Anesthesiology, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 6Centro Universitario de Ciencias de la Salud, INTEC, Universidad de Guadalajara, Guadalajara, Mexico, 7Departamento de Fisiología, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Jalisco, Mexico

    Background/Purpose: It is well known that cardiovascular diseases (CVD) are a major contributor of death in systemic lupus erythematosus (SLE) as well in other rheumatic…
  • Abstract Number: 713 • 2018 ACR/ARHP Annual Meeting

    Soluble ST2 and CXCL-10 May Serve As Biomarkers of Diastolic Dysfunction in SLE and Correlate with Disease Activity and Damage

    Udi Chorin1, Aviram Hochstadt1, David Levartovsky2, Irena Litinsky3, Ofir Elalouf4, Ari Polachek5, Ilana Kaufman6, Uri Arad7, Valerie Aloush7, Sara Borok Lev-Ran8, Irena Wigler7, Jonathan Wollman7, Dan Caspi2, Yael Lahat2, Or Carmi2, Shlomo Berliner9, Ori Elkayam7, Yan Topilsky1 and Daphna Paran2, 1Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 2Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 4Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv Univrsity, Tel Aviv, Israel, 6Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 7Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, 8Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel AViv, Israel, 9Internal Medicine E, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Background/Purpose: Subclinical myocardial dysfunction has been reported to occur earlyin SLE. The pathogenesis and prognosis of this finding is not clear. The study aims to…
  • Abstract Number: 741 • 2018 ACR/ARHP Annual Meeting

    Cardiovascular Risk Re-Classification Using Carotid Ultrasound in Systemic Lupus Erythematosus Patients Is Related to the Damage Produced By the Disease

    Juan Carlos Quevedo1, Iñigo Rúa-Figueroa2, Hiurma Sanchez-Perez3, Beatriz-Segura Tejera4, De Vera-González AM5, Alejandra Gonzalez-Delgado6 and Iván Ferraz-Amaro7, 1Rheumatology, Hospital Doctor Negrin, Las Palmas GC, Spain, 2Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, 3Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, 4Rheumatology Division, Hospital Insular de Gran Canaria, Las Palmas, Spain, 5Division of Central Laboratory. Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 6Division of Central Laboratory. Hospital Universitario de Canarias., Tenerife, Spain, 7Division of Rheumatology.Hospital Universitario de Canarias, Tenerife, Spain

    Background/Purpose: Systemic lupus erythematosus (SLE) is associated with an increased in the prevalence of atherosclerosis. Composite scores of cardiovascular risk factors in patients with SLE…
  • Abstract Number: 1703 • 2018 ACR/ARHP Annual Meeting

    Fragmented Qrs in Patients with Systemic Lupus Erythematosus: Relation to the Disease Activity: A Cross-Sectional Study

    Masahiro Hosonuma, Nobuyuki Yajima, Ryo Yanai and Ryo Takahashi, Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: Cardiovascular disease is an important contributor to mortality in Systemic Lupus Erythematosus (SLE). It has been reported that disease activity at diagnosis was associated…
  • Abstract Number: 709 • 2017 ACR/ARHP Annual Meeting

    Characteristics of Cardiac Diseases in Systemic Lupus Erythematosus and Risk Factors of Different Echocardiographic Features

    Nevin Hammam1,2, Mona H EL zohri3 and Alaa A A Mohamed1, 1Rheumatology, Rehabilitation and Physical medicine, Assiut University, Faculty of Medicine, Assiut, Egypt, 2Department of Physical therapy, University of Alberta, Edmonton, AB, Canada, 3Internal medicine department, Assiut University, Faculty of Medicine, Assiut, Egypt

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by involvement of different organs in the body. The cardiovascular (CVD) involvement in SLE is…
  • Abstract Number: 1178 • 2016 ACR/ARHP Annual Meeting

    Is Subclinical Atherosclerosis Prevalent in a French Patient Cohort with Systemic Lupus Erythematosus?

    Tess Van Meerhaeghe1, Alexis Mathian1, Matthieu Wargny1, Miguel HIe1, Micheline Pha1, Julien Haroche2, Fleur Cohen1, Thi-Huang Du Boutin1 and Zahir Amoura1, 1Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, 2Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France

    Background/Purpose: Systemic lupus erythematosus (SLE) seems associated with an increased risk of cardiovascular disease. These data are mainly based on studies mostly from North America.…
  • Abstract Number: 1800 • 2016 ACR/ARHP Annual Meeting

    Prevalence of ECG Cardiovascular Abnormalities in Lupus Patients: A Novel Approach Using 5 ECG Elements

    Hanan Al Rayes1, Paula Harvey2, Dafna D Gladman3, Arthy Sabapathy1, Murray Urowitz1 and Zahi Touma1, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: Lupus patients are at increased risk for cardiovascular disease (CVD). Chou et al. (Ann Inter Med 2011) found that resting ECG abnormalities, in particular…
  • Abstract Number: 1841 • 2016 ACR/ARHP Annual Meeting

    Dysregulation of the Splicing Machinery Components in Leukocytes from Patients with Systemic Lupus Erythematosus: Influence on Autoimmune and Atherothrombotic Mechanisms

    Chary Lopez-Pedrera1, Sergio Pedraza-Arévalo2, Mercedes del Río-Moreno2, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon3, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Ivan Arias de la Rosa3, Eduardo Collantes-Estévez1, Pedro Segui1, Maria Jose Cuadrado4, Justo P Castaño2, Raul M Luque2 and Carlos Perez-Sanchez1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Department of Cell Biology, Physiology and Immunology. University of Cordoba, Hospital Universitario Reina Sofia (HURS), Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), CIBERobn, and ceiA3, Córdoba, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose:  The aim of this study was to evaluate whether alterations in the splicing-machinery could influence the development and activity of the disease and the…
  • Abstract Number: 2833 • 2016 ACR/ARHP Annual Meeting

    Low Plasma Concentrations of Apolipoprotein M Correlate to Disease Activity and Endothelial Dysfunction in SLE

    Helena Tydén1, Christian Lood2, Andreas Jönsen3, Birgitta Gullstrand4, Bjorn Dahlback5 and Anders A. Bengtsson3, 1Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, 2Department of Clinical Sciences, Section of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 3Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, 4Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden, 5Department of Translational Medicine, Division of Clinical Chemistry, Lund University, Skane University Hospital Malmö, Malmö, Sweden

    Background/Purpose:   Human apoM is a 25kDa apolipoprotein present in 5% of HDL particles in plasma. In mouse models, apoM is antiatherogenic and vasculoprotective and…
  • Abstract Number: 59 • 2015 ACR/ARHP Annual Meeting

    Variation in Heart Failure Hospitalizations Among U.S. Medicaid Recipients with SLE 2000-2010, By Race and Ethnicity

    Medha Barbhaiya1, Candace H. Feldman1, Hongshu Guan1, Jose A. Gomez Puerta2, Michael A. Fischer3 and Karen H. Costenbader1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Grupo de Inmunología e Inmunogenética, GICIG, Universidad de Antioquia, Medellín, Colombia, Medellín, Colombia, 3Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Heart failure (HF) is a leading cause of hospital admissions. In the US, Blacks have higher HF prevalence than other racial/ethnic groups. Cardiovascular disease…
  • Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting

    Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease

    Anselm Mak1,2, Herbert Schwarz3, Nien Yee Kow2, Sen Hee Tay4 and Lieng Hsi Ling2,5, 1National University Health System, Singapore, Singapore, 2Medicine, National University of Singapore, Singapore, Singapore, 3Physiology, National Unversity of Singapore, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5National Unversity Heart Centre Singapore, National Unversity Health System, Singapore, Singapore

    Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…
  • Abstract Number: 1823 • 2015 ACR/ARHP Annual Meeting

    Visceral Adiposity in Premenopausal Lupus Patients: Correlation with Systemic Inflammation

    Luciana Seguro1, Valéria Caparbo2, Eloisa Bonfá1 and Rosa M R Pereira3, 1Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: SLE is associated with high prevalence of metabolic syndrome and obesity, which can be related to the high risk of cardiovascular events in this…
  • Abstract Number: 1854 • 2015 ACR/ARHP Annual Meeting

    Identification and Characterization of microRNAs Related to the Pathogenesis of Cardiovascular Disease in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Role of Specific Autoantibodies

    Chary Lopez-Pedrera1, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon1, Nuria Barbarroja1, Yolanda Jiménez Gómez1, Eduardo Collantes-Estevez1, Mª Jose Cuadrado2, Rocio Gonzalez-Conejero3, Constantino Martinez3 and Carlos Perez-Sanchez1, 1IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, 2Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 3Regional Centre for Blood Donation, University of Murcia, Murcia, Spain

    Background/Purpose: 1) To identify and characterize miRNAs related to the pathogenesis of CVD in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) patients; 2) To…
  • Abstract Number: 2640 • 2014 ACR/ARHP Annual Meeting

    Prevalence and Predictors of ECG Cardiovascular Abnormalities in Lupus Patients

    Zahi Touma1, Paula Harvey2, Dafna D. Gladman3, Dominique Ibanez1, Arthy Sabapathy3 and Murray B. Urowitz3, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Cardiology, Women's College Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose:   Patients with lupus are at increased risk for cardiovascular disease. Previous studies on healthy adults showed that abnormalities detected on resting electrocardiography (ECG)…
  • Abstract Number: 623 • 2013 ACR/ARHP Annual Meeting

    Lupus Patients Have a High Prevalence Of Abnormalities On Resting Electrocardiogram That Are Associated With Increased Risk For Cardiovascular Events

    Zahi Touma1, Paula Harvey2, Dafna D. Gladman3, Arthy Sabapathy4 and Murray B. Urowitz3, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Cardiology, Women's College Hospital, Toronto, ON, Canada, 3Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Patients with lupus are at increased risk for cardiovascular disease (CVD). Abnormalities detected on resting electrocardiography (ECG) that may be associated with an increased…
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