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Abstracts tagged "Cardiac fibrosis"

  • Abstract Number: 1045 • ACR/ARP Annual Meeting 2019

    Myocardial Involvement in SSc: Key Role of Lin-gp38+ Stromal Cells in the Onset of Fibrosis and Defects of the Conduction System

    Mara Stellato1, Michal Rudnik 2, Florian Renoux 3, Przemyslaw Blyszczuk 4, Elena Osto 5, Matthias Dewenter 6, Petra Seebeck 7, Elena Pachera 2, Oliver Distler 8 and Gabriela Kania 4, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland, 3Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, 4Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Institute of Clinical Chemistry, University Hospital Zurich, Switzerland, Zurich, Zurich, Switzerland, 6Department of Molecular Cardiology and Epigenetics, University Hospital, Heidelberg, Germany, Heidelberg, Germany, 7Zurich integrative Rodent Physiology, University of Zurich, Switzerland, Zurich, Switzerland, 8Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Cardiac fibrosis is a known complication of SSc, associated with increased mortality. During fibrogenesis, fibroblasts differentiate into myofibroblasts and secrete excessive extracellular matrix proteins.…

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