Abstracts tagged "cancer treatments and myositis"

Abstract Number: 2288 • 2018 ACR/ARHP Annual Meeting
Preexisting Anti-Acetylcholine Receptor Autoantibodies and B Cell Lymphopenia Are Associated with the Development of Myositis in Thymoma Patients Treated with Avelumab, an Immune Checkpoint Inhibitor Targeting Programmed Death-Ligand 1
Andrew Mammen¹, Arun Rajan², Katherine Pak¹, Tanya Lehky³, Livia Casciola-Rosen⁴, Renee Donahue², Lauren Lepone², Anastasia Zekeridou⁵, Sean Pittock⁵, Raffit Hassan², Jeffrey Schlom² and James Gulley², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NCI, NIH, Bethesda, MD, ³NINDS, NIH, Bethesda, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Neurology, Mayo Clinic, Rochester, MN
Background/Purpose: Immune checkpoint inhibitors (ICIs) enhance the immune response against tumors but may also trigger immune-related adverse events (IRAEs). Myositis following receipt of ICIs is…