Abstracts tagged "calcium signaling"

Abstract Number: 1948 • 2019 ACR/ARP Annual Meeting
The Mechanism of DC-STAMP-Mediated Signaling in Cell-Cell Fusion and Osteoclast Maturation
Ananta Paine¹, Kerstin Tiedemann ², Maria de la luz Garcia-Hernandez ¹, Svetlana Komarova ² and Christopher Ritchlin ¹, ¹Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ²Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; Shriners Hospital for Children-Canada, Montreal, Quebec, Canada, Montréal, QC, Canada
Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DC-STAMP) is…

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Abstracts tagged "calcium signaling"

The Mechanism of DC-STAMP-Mediated Signaling in Cell-Cell Fusion and Osteoclast Maturation