Abstracts tagged "Calcium pyrophosphate dihydrate (CPPD)"

Abstract Number: 347 • 2019 ACR/ARP Annual Meeting
Patterns and Clinico-Radiological Correlates of Symptomatic Atlantoaxial Joint Involvement in Patients with Calcium Pyrophosphate Deposition Disease
Joana Silva-Dinis¹, Catarina Tenazinha ², Nikita Khmelinskii ², Vítor Teixeira ², Pedro Ávila-Ribeiro ¹, João Eurico Fonseca ¹ and José-Carlos Romeu ², ¹Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Centro Académico de Medicina de Lisboa; Lisbon, Portugal., Lisbon, Portugal, ²Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Lisbon, Portugal., Lisbon, Portugal
Background/Purpose: Atlantoaxial joint involvement in calcium pyrophosphate deposition disease (CPPD) may present as crowned dens syndrome (CDS), a clinico-radiological tetrad defined as the presence of…
Abstract Number: 364 • 2019 ACR/ARP Annual Meeting
Calcium Pyrophosphate Crystal Arthritis During Hospitalizations: A Prospective, Crystal-Proven Case Series
Laura Ranieri¹, Francisca Sivera ² and Mariano Andrés ³, ¹Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ²Hospital General Universitario de Elda, Elda, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Despite more than fifty years after its initial description, key questions for calcium pyrophosphate (CPP) crystal disease, such as clinical spectrum, diagnosis or management…
Abstract Number: 901 • 2019 ACR/ARP Annual Meeting
Sensitivity of Dual-Energy CT, Ultrasound, and X-Ray for Pseudogout: A Pilot Study
Sara K. Tedeschi¹, Daniel Solomon ², Kathleen Vanni ³, Dong Suh ³ and Stacy Smith ⁴, ¹Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ²Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital, Boston
Background/Purpose: Advanced imaging modalities such as ultrasound (US) and dual-energy CT (DECT) can help diagnose crystalline arthritis. DECT is a highly sensitive and specific modality…
Abstract Number: 1238 • 2019 ACR/ARP Annual Meeting
Monosodium Urate and Calcium Pyrophosphatecrystal-induced Interleukin 1 Production Depends on Glucose Uptake Through Glut1 Transporter
Félix Renaudin ¹, Laure Campillo-Gimenez ², Florence Castelli ³, François Fenaille ³, Aurélie Prignon ⁴, Christele Combes ⁵, Martine Cohen-Solal ¹, Frédéric Lioté ⁶ and Hang Korng Ea¹, ¹Université Paris, INSERM UMR1132 BIOSCAR, Paris, France, ²Université Paris, INSERM UMR1132 BIOSCAR, San Diego, ³CEA Paris-Saclay, Laboratoire d’Etudes du Métabolisme des Médicaments, Saclay, France, ⁴UMS28 Phénotypage du petit animal, Laboratoire d'Imagerie Moléculaire Positonique (LIMP), Sorbonne Univerity, Paris, France, ⁵CIRIMAT, Université de Toulouse, INPT,UPS,CNRS,ENSIACET, Toulouse, France, ⁶Rheumatology Department, Lariboisiere Hospital, AP-HP, Paris, France, Paris, France
Background/Purpose: Monosodium urate (MSU) andmonoclinic calcium pyrophosphate dihydrated(mCPPD)crystals are responsible for relapsing acute arthritis which is driven by interleukin 1β (IL-1β).IL-1βproductionrelies onNLRP3 inflammasome activationleading to…
Abstract Number: 1205 • 2018 ACR/ARHP Annual Meeting
Musculoskeletal Ultrasound and Conventional Radiography Evaluation of the Hip in Patients with Calcium Pyrophosphate Deposition Disease
Andrea Di Matteo¹, Emilio Filippucci¹, Edoardo Cipolletta¹, Alice Musca², Marina Carotti³, Riccardo Mashadi Miza⁴, Diogo Jesus⁵, Marco Di Carlo¹, Fausto Salaffi¹ and Walter Grassi¹, ¹Polytechnic University of Marche, Rheumatology Clinic, Jesi, Italy, ²Internal Medicine and Rheumatology Department, Bucharest, Romania, ³Polytechnic University of Marche, Radiology Unit, Ancona, Italy, ⁴Dipartimento Diagnostica per Immagini, Ospedale di Cittadella, ULSS 6 Euganea, Cittadella (PD), Italy, ⁵Rheumatology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal
Background/Purpose: Conventional radiography (CR) and, more recently, US play a key role in the diagnosis of CPPD. To date, only a very few studies have…
Abstract Number: 1268 • 2018 ACR/ARHP Annual Meeting
Assessment of the Persistence of Crystals Under Polarised Light Microscopy in Stored Synovial Fluid Samples
Sonia Pastor¹, Rocio Caño², Silvia Gomez-Sabater² and Mariano Andrés^1,3, ¹Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ²Seccion de Reumatologia, Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Lacking an immediate access to a polarized light microscope is sometimes used to justify the clinical diagnosis of crystal-related arthritis. Some studies have assessed…
Abstract Number: 1283 • 2018 ACR/ARHP Annual Meeting
Calcium Pyrophosphate Crystal Deposition in a Cohort of 48 Patients with Gitelman Syndrome
Emilie Chotard¹, Anne Blanchard², Gilles Gailly¹, Rosa Vargas-Poussou³ and Hang-Korng Ea^4,5, ¹AP-HP, Hôpital Lariboisière, service de rhumatologie, centre Viggo Petersen, PARIS, France, ²AP-HP, Hôpital Européen Georges Pompidou, Service de néphrologie, PARIS, France, ³AP-HP, Hôpital Européen Georges Pompidou, Service de génétique, PARIS, France, ⁴AP-HP, Hôpital Lariboisière, service de rhumatologie, centre Viggo Petersen, Paris, France, ⁵INSERM UMR1132, Bioscar, University Paris Diderot, PARIS, France
Background/Purpose: Gitelman syndrome (GS) is a rare recessively inherited tubulopathy, caused by inactive mutations in SLC12A3 gene encoding the thiazide-sensitive-sodium-chloride transporter. It is characterized by…
Abstract Number: 2204 • 2018 ACR/ARHP Annual Meeting
Clinical Utility of a Multi-Energy Spectral CT in Crystal Arthritis
Lisa K. Stamp¹, Nigel Anderson², Fabio Becce³, Maya Rajeswari², Matthew Polson⁴, Olivier Guyen³, Anais Viry³, Chloe Choi², Tracy Kirkbride⁵ and Aamir Raja², ¹University of Otago, Christchurch, New Zealand, ²University of Otago, Christchurch, Christchurch, New Zealand, ³Lausanne University Hospital, Lausanne, Switzerland, ⁴University of Canterbury, Christchurch, New Zealand, ⁵Ara Institute of Canterbury, Christchurch, New Zealand
Background/Purpose: The gold standard for the diagnosis of crystal-related arthritis requires aspiration and visualization of crystals from synovial fluid or tophus material. However, crystal identification…
Abstract Number: 1126 • 2017 ACR/ARHP Annual Meeting
High Osteoprotegerin:RANKL Ratios in Synovial Fluid Correlate with the Presence of Calcium Pyrophosphate Crystals
Ian Chang¹, Daisy Obiora², Ann Rosenthal³ and Charlene J. Williams⁴, ¹Medicine/Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ²Urology, Cooper Hospital, Camden, NJ, ³Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ⁴Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ
Background/Purpose: Calcium pyrophosphate deposition disease (CPDD) is a common cause of both acute and chronic arthritis in the elderly. It is estimated that twenty percent…
Abstract Number: 1132 • 2017 ACR/ARHP Annual Meeting
Compensated Polarized Microscopy for Crystal Identification Shows High Reliability Among Multiple Observers
José Antonio Bernal¹, Mariano Andrés^2,3, Salvador López-Salguero⁴, Vega Jovaní⁵, Paloma Vela^3,6 and Eliseo Pascual⁷, ¹Reumatología, Hospital Universitario del Vinalopó, Elche, Spain, ²Reumatología, Hospital General Universitario Alicante, Alicante, Spain, ³Universidad Miguel Hernández, Elche, Spain, ⁴Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Reumatología, Hospital general universitario de Alicante, Alicante, Spain, ⁶Reumatología, Hospital General Universitario de Alicante. Alicante. Spain, Alicante, Spain, ⁷Emeritus Professor, Universidad Miguel Hernández, Elche, Spain
Background/Purpose: The gold standard for crystal-related arthritis diagnosis remains synovial fluid analysis by a microscope fitted with compensated polarized filters as it has been shown…
Abstract Number: 1135 • 2017 ACR/ARHP Annual Meeting
the Incidence of Knee Chondrocalcinosis and Its Risk Factors in Community-Based Cohort
Jae-Bum Jun¹, Nam H. Cho², Yoonah Song³, Seunghun Lee⁴ and Yoon-Kyoung Sung¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Korea, Republic of (South), ³Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ⁴Department of Radiology, Hanyang University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Chondrocalcinosis (CC) results from deposition of calcium pyrophosphate dihydrate (CPPD) in articular cartilage. It is a relatively common radiographic finding of the joints, especially…
Abstract Number: 2053 • 2017 ACR/ARHP Annual Meeting
Computed Tomography Dependent Diagnosis of Crowned Dens Syndrome; A Cervical Manifestation of Patients with Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Ammar Haikal¹, Brian Everist², Pim Jetanalin³ and Mehrdad Maz³, ¹Department Internal Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ²Department of Radiology (MSK), Department of Radiology (MSK), University of Kansas Medical Center, Kansas City, KS, ³Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Crowned Dens Syndrome (CDS), a variation of Calcium Pyrophosphate Deposition Disease (CPPD), is a radiologic-clinical entity defined by the association of radiological calcifications around…
Abstract Number: 2082 • 2017 ACR/ARHP Annual Meeting
Clinical Presentation, Management, and Prognosis of Pseudogout in Prosthetic Joint Implant Patients: A Retrospective Study
Merit P. George¹, Floranne C. Ernste², Aaron J. Tande³, Douglas R. Osmon³, Tad M. Mabry⁴ and Elie F. Berbari³, ¹Mayo Clinic School of Medicine, Rochester, MN, ²Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ³Division of Infectious Diseases, Mayo Clinic Rochester, Rochester, MN, ⁴Division of Orthopedic Surgery, Mayo Clinic Rochester, Rochester, MN
Background/Purpose: The prevalence of total knee arthroplasty (TKA) and total hip arthroplasty (THA) has risen considerably in the U.S. There has been a relative lack…
Abstract Number: 222 • 2016 ACR/ARHP Annual Meeting
Role of Synovial Biopsy in Diagnosis of Crystal Arthropathies
Viju Moses¹, Jaya Asirvatham², Jonathan McHugh² and Robert Ike¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Pathology, University of Michigan, Ann Arbor, MI
Title: Role of Synovial Biopsy in Diagnosis of Crystal Arthropathies Background/Purpose: Diagnosis of crystal arthropathies (CAs) can be challenging. Advances in arthroscopy and ultrasound guided…
Abstract Number: 2270 • 2016 ACR/ARHP Annual Meeting
Inflammasome/IL-1β Activation Induced By Calcium Pyrophosphate Dihydrate Crystals Is Mainly Driven By a P2X7 Receptor-Independent Potassium Efflux
Laure Campillo-Gimenez¹, Félix Renaudin², Pierre Bobé³, Marjolaine Gosset⁴, Christèle Combes⁵, Martine Cohen-Solal^2,6, Frederic Lioté^2,6 and Hang-Korng Ea^2,6, ¹Hôpital Lariboisière, Centre Viggo Petersen, INSERM UMR1132, Paris Diderot University, Paris, France, ²INSERM UMR1132, Paris Diderot University, Paris, France, ³INSERM UMRS757, Paris Sud University, Orsay, France, ⁴EA2496, Paris Descartes University, Montrouge, France, ⁵ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁶AP-HP, Lariboisière Hospital, Rheumatology Department, Paris, France
Background/Purpose: Calcium pyrophosphate crystals including monoclinic and triclinic dihydrate phases (m- and t-CPPD) are found in 40% of end-stage osteoarthritis (OA) patients. Frequently asymptomatic, it…

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