Abstracts tagged "Calcium"

Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting
Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production
Supriya Murthy¹, Elisabeth Jaeger¹, Sebastian Jung¹, Kathleen Friedrich², Olga Seifert¹, Christoph Baerwald¹, Matthias Pierer¹ and Manuela Rossol¹, ¹Department of Internal Medicine, Rheumatology, University of Leipzig, Leipzig, Germany, ²Department of Internal Medicine, Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…
Abstract Number: 1449 • 2016 ACR/ARHP Annual Meeting
The Efficiency of the Regulation of Ca2+ Entry through Calcium Release-Activated Calcium Channel in the Treatment of Rheumatoid Arthritis
Shuang Liu¹, Hitoshi Hasegawa², Takeshi Kiyoi³, Tatsuya Sawasaki⁴ and Kazutaka Maeyama⁵, ¹Dept. Pharmacology,, Ehime University Graduate School of Medicine, Toon-shi, Japan, ²Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan, ³Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, ⁴Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan, ⁵Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan
Background/Purpose: The regulation of Ca2+ entry by targeting a store-operated calcium release-activated channel (CRAC), known as ORAI, has shown benefits in the treatment of rheumatoid…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2557 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor (TNF) Sensitizes Rheumatoid Synovial Fibroblasts to TRPA1-Mediated Calcium Flux, Anti-Proliferation and Cell Death
Torsten Lowin¹, Rainer Straub² and Georg Pongratz³, ¹Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, ²Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ³Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) are one main contributor of joint destruction since they resist apoptosis and secrete pro-inflammatory cytokines and matrix…
Abstract Number: 379 • 2015 ACR/ARHP Annual Meeting
Validation of a Short Calcium Intake List to Estimate Daily Dietary Calcium Intake of Patients with Osteoporosis
Linda Rasch¹, Marian de van der Schueren², Lilian van Tuyl¹, Irene Bultink¹ and Willem Lems¹, ¹Amsterdam Rheumatology and immunology Center, location VU University Medical Center, Department of Rheumatology, Amsterdam, Netherlands, ²Department of Nutrition and Dietetics, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Calcium supplements are prescribed for prevention of osteoporotic fractures, but excess intake has been associated with cardiovascular events. The most adequate tools for estimating…
Abstract Number: 1148 • 2015 ACR/ARHP Annual Meeting
The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability
Joanna Sherwood¹, Jessica Bertrand¹, Francesco Dell'Accio² and Thomas Pap³, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²EMR, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ³Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: We have recently demonstrated that ELR+ CXC chemokines signaling via the CXCR2 receptor, are produced by healthy chondrocytes and are retained within the cartilage…
Abstract Number: 2085 • 2015 ACR/ARHP Annual Meeting
DC-STAMP Regulates Osteoclastogenesis through the Ca2+ /NFATc1 Axis
Yahui Grace Chiu¹, Dongge Li², Yue-Xin Xu³, Tzong-Ren Sheu⁴, Minsoo Kim⁵ and Christopher T. Ritchlin⁶, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ³Microbiology & Immunology, University of Rochester, Rochester, NY, ⁴Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ⁵Microbiology and Immunology, University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Osteoclasts (OC) are the only cell type known to erode bone. Many bone diseases including osteoporosis and arthritis are caused by excessive OC activity.…
Abstract Number: 2906 • 2014 ACR/ARHP Annual Meeting
Systemic Delivery of Short Hairpin RNA Targeting Calcium Release-Activated Calcium Channel 3 Down-Regulates Severity of Collagen-Induced Arthritis
Shuang Liu¹, Takeshi Kiyoi², Shohei Watanabe³ and Kazutaka Maeyama¹, ¹Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan, ²Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, ³Japan Community Health Care Organization Uwajima Hospital, Ehime, Japan
Background/Purpose: In recent years, one widespread and potentially important Ca2+ channel, store-operated Ca2+-release-activated Ca2+ (CRAC) channel is raised in drug discovery for rheumatoid arthritis (RA).…
Abstract Number: 2794 • 2014 ACR/ARHP Annual Meeting
Deletion of the Inhibitory Receptor Motif, ITIM, on DC-STAMP Alters Osteoclast Differentiation and Function
Yahui Grace Chiu¹, Edward M. Schwarz², Dongge Li¹, Yuexin Xu³, Minsoo Kim³ and Christopher T. Ritchlin⁴, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Microbiology and Immunology, University of Rochester, Rochester, NY, ⁴Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein), a 7-pass transmembrane protein essential for cell-to-cell fusion during osteoclast (OC) differentiation, is expressed on the cell surface of…
Abstract Number: 2683 • 2014 ACR/ARHP Annual Meeting
The Discovery of Novel Splicing Variants of Neurogranin and Their Role in the Pathogenesis of Systemic Lupus Erythematosus
Xiaofang Luo¹, Xuelan He¹, Chaonan Wu¹, Juan Ni¹, Ling li Dong² and Shouxin Li², ¹Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Background/Purpose Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with a diverse array of clinical manifestations that is characterized by the production of antibodies…
Abstract Number: 1996 • 2014 ACR/ARHP Annual Meeting
Improvement in Basic Bone Health Knowledge Among VA Primary Care Practitioners during a Focused Musculoskeletal Mini-Residency
Mathilde Pioro¹, Nancy Fisher¹, Marissa Grotzke², Grant W. Cannon³ and Michael Battistone⁴, ¹Rheumatology, Cleveland Veterans Affairs Medical Center, Cleveland, OH, ²Salt Lake CIty Veterans Affairs Medical Center, Salt Lake CIty, UT, ³Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴University of Utah Health Sciences Center, Salt Lake City, UT
Background/Purpose: Osteopenia and osteoporosis are common yet underrecognized in the veteran population. Methods: We tested basic bone health related knowledge among Veterans Affairs (VA) primary…
Abstract Number: 1680 • 2014 ACR/ARHP Annual Meeting
an Indirect Comparisons Analysis of Medications Used for Treatment of Raynaud’s Phenomenon
Sampath Manickam¹, Elie Donath², Sandeep Dayanand³ and Jonathan Greer⁴, ¹University of Miami Palm Beach Internal Medicine, West Palm Beach, FL, ²Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, FL, ³University of Miami Palm Beach Internal medicine, West palm beach, FL, ⁴Arthritis & Rheumatology Associates, Boynton Beach, FL
An Indirect Comparisons Analysis of Medications used for treatment of Raynaud’s phenomenonBackground/Purpose: There are several pharmacological treatments used for treatment of Raynaud’s phenomenon: calcium channel…
Abstract Number: 1035 • 2014 ACR/ARHP Annual Meeting
TNF-á Modulates the Expression of Circadian Clock Genes Via Calcium Signaling in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Nao Shibanuma², Teppei Hashimoto^3,4, Yoshiko Kawasaki⁴, Naonori Hashimoto¹, Ayako Nakai¹, Kenta Kaneshiro¹, Koji Tateishi⁵, Natsuko Nakagawa⁵ and Akira Hashiramoto^1,4,6, ¹Faculty of Health Sciences, Kobe University School of Medicine, Kobe, Japan, ²Department of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ³Department of General Internal Medicine, Kobe University School of Medicine, Kobe, Japan, ⁴Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁶Clinical Immunology, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 136 • 2013 ACR/ARHP Annual Meeting
The Detection Of Primary Hyperparathyroidism In Patients Diagnosed With Fibromyalgia
Michael Tsoukas¹, Peter A. Ste-Marie², Yoram Shir², Mary-Ann Fitzcharles³ and Elliot Mitmaker⁴, ¹Endocrinology, McGill University Health Centre, Montreal, QC, Canada, ²Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology & Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ⁴General and Endocrine Surgery, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Some illnesses, such as hypothyroidism or small fiber neuropathy, may present similarly to fibromyalgia (FM), or may in turn lead to an augmented polysymptomatic…
Abstract Number: 1822 • 2013 ACR/ARHP Annual Meeting
Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ² –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice
Chang-Hoon Lee¹, Myeung Su Lee¹, Won Seok Lee², Wan-Hee Yoo³, Ju-Young Kim⁴, Jae-Min Oh⁴ and Yong-Geun Jeong⁵, ¹Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁴Department of Anatomy, School of Medicine, Wonkwang University, Iksan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, South Korea
Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…

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