ACR Meeting Abstracts

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Abstracts tagged "C-reactive protein (CRP)"

  • Abstract Number: 1581 • ACR Convergence 2024

    Neutrophil-to- lymphocyte Ratio: A Possible Biomarker for Clinical Response After Autologous Hematopoietic Stem Cell Transplantation

    shiri keret1, Lisa Kaly2, Georg Schett3, Christina Bergmann4, Joerg Henes5, Gleb Slobodin2 and Doron Rimar2, 1Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, 2Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Haifa, Israel, 3Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 4Department Internal Medicine III, Friedrich-Alexander-University (FAU) Erlangen-Nurnber, Frankfurt, Germany, 5University Hospital Tuebingen, Tuebingen, Germany

    Background/Purpose: Baseline high Neutrophil- to- lymphocyte ratio (NLR) (higher than 2.95) is associated with severe progressive skin and lung disease and with reduced 5-year survival…
  • Abstract Number: 2396 • ACR Convergence 2024

    PROMISing Outcomes: Understanding the Concordance Between Provider-assessment and Patient-reported Disease Activity in SLE

    Anna Korogodina1, Erin Sundel1, Yaroslav Markov2, Vasileios Kyttaris3, Julianne O'Connell1 and Suzanne Krishfield1, 1Beth Israel Deaconess Medical Center, Boston, MA, 2Yale School of Medicine, New Haven, 3BIDMC, Boston, MA

    Background/Purpose: SLE-related outcomes are traditionally assessed by clinician-derived measures. However, these assessments often do not fully capture how patients experience their disease. We assessed the alignment…
  • Abstract Number: 2509 • ACR Convergence 2024

    Bone Marrow Failure in VEXAS Is Associated with the Degree of UBA1b Deficiency

    Benjamin Turturice1, Alice Fike1, Bhavisha Patel2, Emma Groarke2, Karyssa Stonick1, Shanni Liu1, Wendy Goodspeed1, Kaitlin Quinn1, Neal Young2 and Peter Grayson3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: VEXAS is a multisystem autoinflammatory disorder due to somatic mutations in UBA1. The disease is characterized by ineffective hematopoiesis with increased risk of transfusion…
  • Abstract Number: 0051 • ACR Convergence 2024

    Impact of Tight Junction Proteins on Inflammatory Processes and Microbial Imbalance in Rheumatoid Arthritis

    Arkaitz Mucientes1, jose Manuel Lisbona-Montañez2, Patricia Ruiz-Limón3, Sara Manrique-Arija4, Aimara García-Studer4, Fernando Ortiz-Márquez4, Natalia Mena Vázquez5 and Antonio Fernández-Nebro6, 1IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, 2University of Malaga, Malaga, Andalucia, Spain, 3IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, 4Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 5IBIMA, Málaga, Andalucia, Spain, 6Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain

    Background/Purpose: The etiology of Rheumatoid Arthritis (RA) is not fully understood. Recent studies point to intestinal permeability as an important factor in the establishment and…
  • Abstract Number: 0270 • ACR Convergence 2024

    Longitudinal Patterns of C-Reactive Protein Values in Calcium Pyrophosphate Deposition (CPPD) Disease

    Muneet Gill, Hongshu Guan, Jamie Collins and Sara Tedeschi, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Calcium pyrophosphate deposition (CPPD) disease is a crystalline arthritis affecting older adults. Systemic inflammation occurs during flares of acute calcium pyrophosphate (CPP) crystal arthritis…
  • Abstract Number: 0758 • ACR Convergence 2024

    Difficult to Treat Takayasu Arteritis: Comparative Efficacy of Colchicine and Tofacitinib

    Ravi Kumar1, Prabhu Vasanth2, Ramya Janardhana3, Arvind Ganapati4, Abhishek Patil5, Avinash Jain6, Benzeeta Pinto7, Ramesh Jois8, Shivraj Padiyar9, John Mathew9, Vineeta Shobha3, George Joseph2 and Ruchika goel9, 1Christian Medical college , Vellore , India, Bangalore, India, 2Christian Medical college , Vellore , India, Vellore, Tamil Nadu, India, 3St. John’s Medical College, Bengaluru , India, Bangalore, India, 4Kasturba Medical College, Rheumatology Division, Manipal , India, Vellore, Tamil Nadu, India, 5Manipal Hospital, Rheumatology, Bengaluru, India, Bengaluru, India, 6SMS Medical College and Hospital, Jaipur ,India, JAIPUR, India, 7St. John’s Medical College, Bengaluru , India, Bengaluru, India, 8Manipal Hospital ,Rheumatology, Millers Road, Bengaluru, India, Bengaluru, India, 9Christian Medical college , Vellore , India, Vellore, India

    Background/Purpose: Biologic DMARDs (bDMARDs) are mainstay in management of patients with difficult to treat Takayasu Arteritis (D2TTAK). The cost of long-term biologics is prohibitory in…
  • Abstract Number: 0947 • ACR Convergence 2024

    REX-7117 Is a Highly Potent and Selective Oral STAT3 Inhibitor That Demonstrated Potential Efficacy and Safety Differentiation versus JAK/TYK2 Targeting in Preclinical Models of Inflammatory Arthritis

    Alexandra Gardino1, Neil Bifulco1, Jeremy Hunt2, Rishi Vaswani1, Donglim Park2, Patrick Metz2, Ksenya Cohen-Katsenelson2, Jeong-Ho Kim2, Xia Tian2, Aryan Alavi2, Ajay Nirula2, Daniel Treiber2, Brian Hodous1, Seong Kim3 and Paul Smith2, 1Recludix Pharma, Cambridge, MA, 2Recludix Pharma, San Diego, CA, 3Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA

    Background/Purpose: Inhibition of JAK family signaling has translated into clinically meaningful efficacy in rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases. However, small molecule JAK/TYK2…
  • Abstract Number: 1355 • ACR Convergence 2024

    Genetically-determined Variation in C-reactive Protein Impacts Disease Activity Assessment in Rheumatoid Arthritis

    Thomas Riley1, Austin Wheeler2, grant Cannon3, Sauer brian4, Gary Kunkel5, Katherine Wysham6, Bryant England2, Kristin Wipfler7, Kaleb Michaud2, Beth Wallace8, Rachel Elam9, Paul Monach10, Andreas Reimold11, Gail Kerr12, Isaac Smith13, John Richards14, Iris Lee15, Michael March16, Scott Damrauer17, Anurag Verma17, Michael George17, Ted Mikuls2 and Joshua Baker17, 1Hopsital of the University of Pennsylvania, Philadelphia, PA, 2University of Nebraska Medical Center, Omaha, NE, 3University of Utah and Salt Lake City VA, Salt Lake City, UT, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 6VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 7FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, 8Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 9Augusta University, Evans, GA, 10VA Boston Healthcare System, Boston, MA, 11Dallas VA Medical Center, Dallas, TX, 12Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 13Duke University Hospital, Durham, NC, 14Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 15Washington University in St Louis, Saint Louis, MO, 16Children's Hospital of Philadelphia, Philadelphia, 17University of Pennsylvania, Philadelphia, PA

    Background/Purpose: C-reactive protein (CRP) is often used as a biomarker for disease activity in patients with rheumatoid arthritis (RA). We evaluated whether rs1205, a common…
  • Abstract Number: 1475 • ACR Convergence 2024

    Baseline Characteristics and Efficacy in Patients with Radiographic AxSpA (r-axSpA) Stratified by CRP Level: An Analysis from the Ixekizumab Phase III Trial

    Raj Sengupta1, Pedro M Machado2, Philippe Goupille3, Victoria Navarro Compán4, Huji Xu5, mohamed sheesh6, Khai Jing Ng7, Marcus Ngantcha8, Hagen Russ9, Gabriel Doridot6 and Xenofon Baraliakos10, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Department of Neuromuscular Diseases and Centre for Rheumatology, University College London, London, United Kingdom, 3UPR CNRS 4301 CBM, NMNS, University of Tours; Department of Rheumatology, University hospital, Tours, Tours, France, 4La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, 5Changzheng Hospital, Naval Medical University, Shanghai, China, Shanghai, China (People's Republic), 6Eli Lilly, Indianopolis, IN, 7Eli Lilly and Company, Madrid, Spain, 8Eli Lilly and Company, Indianapolis, IN, 9Eli Lilly, Indianopolis, 10Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany

    Background/Purpose: Elevated baseline (BL) C-reactive protein (CRP) level can serve as a predictor for treatment response to TNF inhibitors in patients (pts) with r-axSpA. The…
  • Abstract Number: 0484 • ACR Convergence 2023

    Higher Levels of High-sensitivity CRP Are Associated with Future Risk of Developing Psoriatic Arthritis Among Patients with Psoriasis: A Prospective Cohort Study

    Lihi Eder1, Vinod Chandran2, Cheryl Rosen3, Richard J. Cook4 and Dafna Gladman5, 1Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada, 3Division of Dermatology, Toronto Western Hospital, Toronto, ON, Canada, 4Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Simple and accessible biomarkers that predict the development of psoriatic arthritis (PsA) among psoriasis patients are critically needed to improve early detection of high-risk…
  • Abstract Number: 0518 • ACR Convergence 2023

    Tofacitinib Efficacy and Safety in Patients with Ankylosing Spondylitis by Baseline C-Reactive Protein Levels: A Post Hoc Analysis

    Atul Deodhar1, Xenofon Baraliakos2, Marina Nighat Magrey3, Lianne Gensler4, Amit V. Thorat5, Surya Pemmaraju6, Mary Jane Cadatal7 and Peter Nash8, 1Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Case Western Reserve University, University Hospitals, Cleveland, OH, 4University of California San Francisco, Department of Medicine, Division of Rheumatology, San Francisco, CA, 5Pfizer Australia, Sydney, Australia, 6Pfizer Inc., Chennai, Tamil Nadu, India, 7Pfizer Inc., Manila, Philippines, 8School of Medicine, Griffith University, Brisbane, Australia

    Background/Purpose: Elevated baseline (BL) CRP levels can predict treatment response in patients (pts) with AS. Tofacitinib is a Janus kinase inhibitor for the treatment of…
  • Abstract Number: 0522 • ACR Convergence 2023

    Effect of Secukinumab versus Adalimumab Biosimilar on Radiographic Progression in Patients with Radiographic Axial Spondyloarthritis: Results from Subgroup Analyses by Baseline Syndesmophytes and C-reactive Protein Status

    Xenofon Baraliakos1, Désirée van der Heijde2, Pedro Machado3, Victoria Navarro-Compán4, Lianne Gensler5, Patricia Pertel6, Erhard Quebe-Fehling6, Aimee Readie7, Hanno Richards6 and Denis Poddubnyy8, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom, 4Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, 5University of California San Francisco, Department of Medicine, Division of Rheumatology, San Francisco, CA, 6Novartis Pharma AG, Basel, Switzerland, 7Novartis Pharmaceuticals Corporation, Immunology, East Hanover, NJ, 8Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: SURPASS, a phase 3b randomized controlled study in patients with radiographic axial spondyloarthritis (r-axSpA), found low spinal radiographic progression over 2 years with no…
  • Abstract Number: 1842 • ACR Convergence 2023

    Reduction in the Concomitant Ordering of Erythrocyte Sedimentation Rate and C-Reactive Protein Within the Rheumatology Clinics at an Academic Medical Center

    Ruchi Desai1, Nainesh Shah1, Ray Zhang1, Maria Bacalao2, Haidy Galous3, David Karp1 and Puneet Bajaj1, 1UT Southwestern Medical Center, Dallas, TX, 2UT Southwestern, Dallas, TX, 3UT Southwestern, Southlake, TX

    Background/Purpose: ESR and CRP are two laboratory values usedto assess inflammation. There is data to support that CRPis superior to ESR to detect/monitor inflammation or…
  • Abstract Number: 2100 • ACR Convergence 2023

    Paradoxical Antagonistic Association of Visceral and Subcutaneous Adipose Tissue with Circulating C-Reactive Protein in Rheumatoid Arthritis

    Jon Giles and Joan Bathon, Columbia University, New York, NY

    Background/Purpose: C-reactive protein (CRP) is used as an indicator of disease activity in people with RA.However, adipose tissue also expresses inflammatory cytokines that induce hepatic…
  • Abstract Number: 0885 • ACR Convergence 2022

    Association Between Changes in Inflammatory Pathways Associated with a Reduction in CV Risk: Results from the LiiRA Study

    brittany weber1, Dana Weisenfeld1, Thany Seyok1, Elena Massarotti1, Selena Huang1, Derrick Todd1, Jonathan Coblyn1, michael weinblatt1, Tianrun Cai1, Kumar Dahal1, leanne BArrett1, Daniel Solomon1, Jorge Plutzky1, Marcy Bolster2, marcelo Dicarli1 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased cardiovascular (CV) risk. Coronary flow reserve (CFR) is a quantitative imaging biomarker of CV risk that…
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