Abstracts tagged "bone remodeling and spondylarthropathy"

Abstract Number: 2819 • 2015 ACR/ARHP Annual Meeting
Rorc Antagonism Inhibits IL-23-Dependent Aberrant Bone Formation in Vivo
Mark Panzenbeck¹, Kathleen Hoyt¹, Donald Souza², Gregg Davis¹, Elizabeth Glynn¹, Thomas Wieckowski¹, Michael Turner¹, Robert Hughes¹, Dustin Smith¹, Christian Harcken¹, Gerald Nabozny³ and Mark Labadia⁴, ¹Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Immunology & Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: RORγt is a nuclear hormone receptor expressed in Th17 cells and distinct subsets of lymphoid cells, including innate lymphoid cells (ILC), and γδ T-cells.…

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Abstracts tagged "bone remodeling and spondylarthropathy"

Rorc Antagonism Inhibits IL-23-Dependent Aberrant Bone Formation in Vivo