Abstracts tagged "Bone density"

Abstract Number: 227 • 2014 ACR/ARHP Annual Meeting
Increasing Fat-Mass May Reverse Bone Loss As Detected By DXA Scan
William Hedges¹ and Marwan Bukhari^2,3, ¹Foundation Programme, Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom, ²Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ³Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
Background/Purpose: Low body mass index (BMI) is a known risk factor for loss of bone mineral density (BMD). It is a part of the FRAX…
Abstract Number: 2831 • 2014 ACR/ARHP Annual Meeting
Development of New Radiographic Vertebral Fractures in Patients with Ankylosing Spondylitis during 4 Years of TNF-α Blocking Therapy: Results from the Glas Cohort
Fiona Maas¹, Anneke Spoorenberg^1,2, Elisabeth Brouwer³, Reinhard Bos², Rizwana N. Chaudhry¹, Freke Wink², Hendrika Bootsma⁴, Eveline van der Veer⁵ and Suzanne Arends^2,4, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Previous studies have shown that the risk of vertebral fractures is increased in patients with ankylosing spondylitis (AS). Prospective longitudinal data about radiographic vertebral…
Abstract Number: 225 • 2014 ACR/ARHP Annual Meeting
Association Between Lean Mass and Hip Bone Mineral Density
Charlotte Beaudart¹, Jean-Yves Reginster², Justine Slomian³, Fanny Buckinx⁴ and Olivier Bruyere⁵, ¹Avenue De L'Hopital 3, University of Liège, Liège, Belgium, ²Bone Cartilage Unit, University of Liège, Liège, Belgium, ³Support Unit in Epidemiology and Biostatistics, University of Liège, Liège, Belgium, ⁴Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium, ⁵Public Health/Epidemiology, University of Liège, Liège, Belgium
Background/Purpose: Fat mass and lean mass (LM) represent 95% of body weight. However, the role of each component on bone mineral density (BMD) is not…
Abstract Number: 2558 • 2014 ACR/ARHP Annual Meeting
Etanercept Increases Bone Mineral Density in Ankylosing Spondylitis, but Does Not Prevent Vertebral Fractures
M.a.C. van der Weijden^1,2, J.C. van Denderen², W.F. Lems¹, M.T. Nurmohamed^1,2, B.a.C Dijkmans^1,2 and I.E. van der Horst-Bruinsma¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose Ankylosing spondylitis (AS) is characterized by chronic inflammation often leading to ankylosis of the spine, but also by a decrease of bone mineral density…
Abstract Number: 208 • 2014 ACR/ARHP Annual Meeting
Correlates of Knee Bone Marrow Lesions in Younger Adults
Benny Samuel Eathakkattu Antony¹, Graeme Jones², Alison Venn³, Lyn March⁴, Flavia Cicutinni⁵, Andrew Halliday⁶, Leigh Blizzard⁷, Marita Cross⁸, Terry Dwyer⁹ and Changhai Ding², ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁶Radiology, Royal Hobart Hospital, Australia, Hobart, Australia, ⁷Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁸University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁹Director, Murdoch Children's Research Institute, Melbourne, Australia
Background/Purpose: Bone marrow lesions (BMLs) of the knee joint are a key player in osteoarthritis of the knee. However, little is known of their determinants,…
Abstract Number: 2287 • 2014 ACR/ARHP Annual Meeting
Cartilage Thickness and Bone Health in Children with Juvenile Idiopathic Arthritis
Marinka Twilt¹, Dan Pradsgaard², Anne Helene Spannow², Arne Horlyck³, Carsten Heuck² and Troels Herlin⁴, ¹Paediatrics, Aarhus University Hospital, Aarhus, Denmark, ²paediatrics, Aarhus University Hospital, Aarhus, Denmark, ³radiology, Aarhus University Hospital, Aarhus, Denmark, ⁴Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose Although treatment options have increased and morbidity has decreased in the last decade Juvenile Idiopathic Arthritis (JIA) may still result in disability. Increasingly ultrasonography…
Abstract Number: 62 • 2014 ACR/ARHP Annual Meeting
Severe Spine Osteoarthritis in Older Men Is Associated with the Risk of Incident Fragility Fracture
Roland Chapurlat¹, Charline Estublier² and Pawel Szulc³, ¹Pavillon F Rheumatology, Hopital Edouard Herriot, Lyon, France, ²Rheumatology, Hôpital Edouard Herriot, Pavillon F, Lyon, France, ³Epidemiology of Osteoporosis, INSERM UMR 1033, Lyon, France
Background/Purpose: Data on the association of osteoarthritis (OA) with bone fragility are limited. In particular, data on the fracture risk in older men with spine…
Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting
Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study
T Damm¹, C Libanati², J Peña¹, G Campbell¹, R Barkmann¹, DA Hanley³, S Goemaere⁴, MA Bolognese⁵, C Recknor⁶, C Mautalen⁷, YC Yang² and CC Glüer¹, ¹Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ²Amgen Inc., Thousand Oaks, CA, ³University of Calgary, Calgary, AB, Canada, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Bethesda Health Research Center, Bethesda, MD, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Centro de Osteopatias Medicas, Buenos Aires, Argentina
Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
Abstract Number: 2149 • 2014 ACR/ARHP Annual Meeting
Relationship Between the Magnitude of Bone Formation in the Anterior Vertebral Corners, As Assessed through 18F-Fluoride Uptake, and Lumbar Spine Bone Mineral Density in Patients with Ankylosing Spondylitis
Seung-Geun Lee¹, Eun-Kyoung Park¹, Geun-Tae Kim², Sang-Yeob Lee³ and Joung-Wokk Lee⁴, ¹Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, ⁴Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea
Background/Purpose: 18F-fluoride uptake represents active osteoblastic bone synthesis. We investigated the relationship between the magnitude of bone formation in anterior vertebral corners, as assessed through…
Abstract Number: 2013 • 2014 ACR/ARHP Annual Meeting
Quality Appraisal of Educational Websites on Osteoporosis and Bone Health
Maria A. Lopez-Olivo¹, Noha Abdel-Wahab^2,3, Abhinav Dodeja⁴, Gregory Pratt⁵ and Maria E. Suarez-Almazor², ¹Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Rheumatology & Rehabilitation Department, Assiut University Hospital, Assiut, Egypt, ⁴The University of Texas Health Science Center, School of Public Health, Houston, TX, ⁵Research Medical Library, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Osteoporosis, like many other chronic diseases, can have better outcomes when informed patients get involved in self-management, resulting in better ourtcomes. Bone health education…
Abstract Number: 1818 • 2014 ACR/ARHP Annual Meeting
Subchondral Bone Mineral Density Improves Prediction of Knee Osteoarthritis Progression Compared with Clinical Factors Alone: Data from the Osteoarthritis Initiative
Michael P. Lavalley¹, Grace H. Lo², Lori Lyn Price³, Jeffrey Driban⁴, Charles Eaton⁵ and Timothy E. McAlindon⁶, ¹Biostatistics, Boston University, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Tufts Medical Center, Boston, MA, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose A prediction rule for knee osteoarthritis (OA) progression would have great clinical utility in identifying at-risk patients for intervention. Rules using clinically available measurements…
Abstract Number: 1795 • 2014 ACR/ARHP Annual Meeting
Denosumab Restores Cortical Bone Loss at the Distal Radius Associated with Aging and Reduces Wrist Fracture Risk: Analyses from the Cross-over Group in the Extension of the Denosumab Pivotal Fracture Trial
JP Bilezikian¹, CL Benhamou², CJF Lin³, JP Brown⁴, NS Daizadeh³, PR Ebeling⁵, A Fahrleitner-Pammer⁶, E Franek⁷, N Gilchrist⁸, PD Miller⁹, JA Simon¹⁰, I Valter¹¹, CAF Zerbini¹² and C Libanati³, ¹College of Physicians and Surgeons, Columbia University, New York, NY, ²CHR d'Orléans, Orléans, France, ³Amgen Inc., Thousand Oaks, CA, ⁴CHU de Québec Research Centre and Laval University, Quebec City, QC, Canada, ⁵Monash University, Clayton, Australia, ⁶Medical University, Graz, Austria, ⁷Medical Research Center, Polish Academy of Sciences, Warsaw, Poland, ⁸The Princess Margaret Hospital, Christchurch, New Zealand, ⁹Colorado Center for Bone Research, Lakewood, CO, ¹⁰George Washington University, Washington, DC, ¹¹Center for Clinical and Basic Research, Tallinn, Estonia, ¹²Centro Paulista de Investigação Clinica, São Paulo, Brazil
Background/Purpose: Cortical bone loss is a major determinant of increased fracture risk. Denosumab (DMAb) has been shown to increase BMD at sites of cortical bone,…
Abstract Number: 1219 • 2013 ACR/ARHP Annual Meeting
Phase 3 Fracture Trial Of Odanacatib For Osteoporosis – Baseline Characteristics and Study Design
Socrates Papapoulos¹, Henry G. Bone², David W. Dempster³, John Eisman⁴, Susan Greenspan⁵, Michael McClung⁶, Toshitaka Nakamura⁷, Joseph Shih⁸, Albert Leung⁹, Arthur Santora¹⁰, N. Verbruggen¹¹ and Antonio Lombardi¹², ¹Leiden University Medical Center, Leiden, Netherlands, ²Michigan Bone and Mineral Clinic, Detroit, MI, ³Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, ⁴The Garvan Institute of Medical Research, Sydney, Australia, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Oregon Osteoporosis Center, Portland, OR, ⁷University of Occupational & Environmental Health, Fukuoaka, Japan, ⁸Robert Wood Johnson Medical School, Piscataway, NJ, ⁹Clinical Research, Merck Sharp and Dohme Corp., Rahway, NJ, ¹⁰Merck Sharp & Dohme Corp., Whitehouse Station, NJ, ¹¹MSD Belgium, Brussels, Belgium, ¹²Merck Sharp and Dohme Corp., Rahway, NJ
Background/Purpose: Odanacatib is a selective and reversible inhibitor of cathepsin K; a collagenase secreted by osteoclasts, and is currently being evaluated for the treatment of…
Abstract Number: 1221 • 2013 ACR/ARHP Annual Meeting
The Effects Of Hyperthyroidism On Bone Mineral Density At Different Sites- An Observational Case-Control Study
Christopher Varley¹, Alexander Oldroyd¹ and Marwan Bukhari², ¹Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ²Department of Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
Background/Purpose: Hyperthyroidism has been described as a risk factor for poor bone health.1, 2 The FRAXTM tool has been used to identify the ten year…
Abstract Number: 1225 • 2013 ACR/ARHP Annual Meeting
FRAX 10-Year Fracture Risk In Women With a Fracture Of The Distal Forearm: Agreement Between Assessments With and Without Bone Mineral Density and Influence Of Measurement Side In Individual Patients
Emilie Egsmose¹, Mette Birkvig², Thora Buhl³ and Ole Rintek Madsen³, ¹Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ²Osteoporosis Clinic, Copenhagen University Hospital Gentofte, Copenhagen, Denmark, ³Copenhagen University Hospital Gentofte, Copenhagen, Denmark
Background/Purpose: The FRAX® tool has been developed by WHO to evaluate fracture (Fx) risk of patients. It is based on individual patient models that integrate…

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