Abstracts tagged "Bone density"

Abstract Number: 238 • 2014 ACR/ARHP Annual Meeting
RANKL and OPG Gene Polymorphisms: Association with Vertebral Fractures and Bone Mineral Density in Premenopausal Systemic Lupus Erythematosus
Alessandra C. Bonfa¹, Luciana P.C. Seguro², Valéria Caparbo³, Eloisa Bonfa³ and Rosa M R Pereira³, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose To evaluate single nucleotide polymorphisms (SNPs) of the receptor activator of NF-κB ligand (RANKL), RANK and osteoprotegerin (OPG) genes in premenopausal systemic lupus erythematosus…
Abstract Number: 240 • 2014 ACR/ARHP Annual Meeting
An Observational Study on the Influence of Glucocorticoid Exposure on Bone
Joseph Heath¹, Alexander Oldroyd², Maarten Boers³ and Marwan Bukhari², ¹Faculty of health and medicine, Lancaster University, Lancaster, United Kingdom, ²Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ³Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose It is well known that glucocorticoids are detrimental to bone health and has been postulated that their influence is more than their effect on…
Abstract Number: 235 • 2014 ACR/ARHP Annual Meeting
Lower P1NP Serum Levels: a Predictive Marker of Bone Loss after One-Year Follow-up in premenopausal SLE Patients
Luciana Seguro¹, Caio B. Casella¹, Valéria Caparbo¹, Ricardo M. Oliveira², Alessandra C Bonfa¹, Eloisa Bonfa¹ and Rosa M R Pereira¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²RDO Diagnosticos Medicos, São Paulo, Brazil
Background/Purpose: Systemic Lupus Erythematosus (SLE) is associated with high risk of low bone mass/fractures but this risk is still controversial in premenopausal women. Our aim…
Abstract Number: 229 • 2014 ACR/ARHP Annual Meeting
Correlates of Heel Bone Mass in Young Adults: The Role of Cholesterol over 20 Years from Childhood to Early Adulthood
Benny Samuel Eathakkattu Antony¹, Changhai Ding², Alison Venn³, Terry Dwyer⁴ and Graeme Jones², ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Director, Murdoch Children's Research Institute, Melbourne, Australia
Background/Purpose The association between lipids and bone mass in adult life is controversial and there is limited evidence in childhood. The aim of this study…
Abstract Number: 227 • 2014 ACR/ARHP Annual Meeting
Increasing Fat-Mass May Reverse Bone Loss As Detected By DXA Scan
William Hedges¹ and Marwan Bukhari^2,3, ¹Foundation Programme, Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom, ²Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ³Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
Background/Purpose: Low body mass index (BMI) is a known risk factor for loss of bone mineral density (BMD). It is a part of the FRAX…
Abstract Number: 2831 • 2014 ACR/ARHP Annual Meeting
Development of New Radiographic Vertebral Fractures in Patients with Ankylosing Spondylitis during 4 Years of TNF-α Blocking Therapy: Results from the Glas Cohort
Fiona Maas¹, Anneke Spoorenberg^1,2, Elisabeth Brouwer³, Reinhard Bos², Rizwana N. Chaudhry¹, Freke Wink², Hendrika Bootsma⁴, Eveline van der Veer⁵ and Suzanne Arends^2,4, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Previous studies have shown that the risk of vertebral fractures is increased in patients with ankylosing spondylitis (AS). Prospective longitudinal data about radiographic vertebral…
Abstract Number: 225 • 2014 ACR/ARHP Annual Meeting
Association Between Lean Mass and Hip Bone Mineral Density
Charlotte Beaudart¹, Jean-Yves Reginster², Justine Slomian³, Fanny Buckinx⁴ and Olivier Bruyere⁵, ¹Avenue De L'Hopital 3, University of Liège, Liège, Belgium, ²Bone Cartilage Unit, University of Liège, Liège, Belgium, ³Support Unit in Epidemiology and Biostatistics, University of Liège, Liège, Belgium, ⁴Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium, ⁵Public Health/Epidemiology, University of Liège, Liège, Belgium
Background/Purpose: Fat mass and lean mass (LM) represent 95% of body weight. However, the role of each component on bone mineral density (BMD) is not…
Abstract Number: 2558 • 2014 ACR/ARHP Annual Meeting
Etanercept Increases Bone Mineral Density in Ankylosing Spondylitis, but Does Not Prevent Vertebral Fractures
M.a.C. van der Weijden^1,2, J.C. van Denderen², W.F. Lems¹, M.T. Nurmohamed^1,2, B.a.C Dijkmans^1,2 and I.E. van der Horst-Bruinsma¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose Ankylosing spondylitis (AS) is characterized by chronic inflammation often leading to ankylosis of the spine, but also by a decrease of bone mineral density…
Abstract Number: 208 • 2014 ACR/ARHP Annual Meeting
Correlates of Knee Bone Marrow Lesions in Younger Adults
Benny Samuel Eathakkattu Antony¹, Graeme Jones², Alison Venn³, Lyn March⁴, Flavia Cicutinni⁵, Andrew Halliday⁶, Leigh Blizzard⁷, Marita Cross⁸, Terry Dwyer⁹ and Changhai Ding², ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁶Radiology, Royal Hobart Hospital, Australia, Hobart, Australia, ⁷Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁸University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁹Director, Murdoch Children's Research Institute, Melbourne, Australia
Background/Purpose: Bone marrow lesions (BMLs) of the knee joint are a key player in osteoarthritis of the knee. However, little is known of their determinants,…
Abstract Number: 2287 • 2014 ACR/ARHP Annual Meeting
Cartilage Thickness and Bone Health in Children with Juvenile Idiopathic Arthritis
Marinka Twilt¹, Dan Pradsgaard², Anne Helene Spannow², Arne Horlyck³, Carsten Heuck² and Troels Herlin⁴, ¹Paediatrics, Aarhus University Hospital, Aarhus, Denmark, ²paediatrics, Aarhus University Hospital, Aarhus, Denmark, ³radiology, Aarhus University Hospital, Aarhus, Denmark, ⁴Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose Although treatment options have increased and morbidity has decreased in the last decade Juvenile Idiopathic Arthritis (JIA) may still result in disability. Increasingly ultrasonography…
Abstract Number: 62 • 2014 ACR/ARHP Annual Meeting
Severe Spine Osteoarthritis in Older Men Is Associated with the Risk of Incident Fragility Fracture
Roland Chapurlat¹, Charline Estublier² and Pawel Szulc³, ¹Pavillon F Rheumatology, Hopital Edouard Herriot, Lyon, France, ²Rheumatology, Hôpital Edouard Herriot, Pavillon F, Lyon, France, ³Epidemiology of Osteoporosis, INSERM UMR 1033, Lyon, France
Background/Purpose: Data on the association of osteoarthritis (OA) with bone fragility are limited. In particular, data on the fracture risk in older men with spine…
Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting
Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study
T Damm¹, C Libanati², J Peña¹, G Campbell¹, R Barkmann¹, DA Hanley³, S Goemaere⁴, MA Bolognese⁵, C Recknor⁶, C Mautalen⁷, YC Yang² and CC Glüer¹, ¹Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ²Amgen Inc., Thousand Oaks, CA, ³University of Calgary, Calgary, AB, Canada, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Bethesda Health Research Center, Bethesda, MD, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Centro de Osteopatias Medicas, Buenos Aires, Argentina
Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
Abstract Number: 1237 • 2013 ACR/ARHP Annual Meeting
Denosumab Leads To Significantly Greater Increases In Bone Mineral Density Than Ibandronate and Risedronate In Postmenopausal Women At High Risk For Fracture Who Were Previously Treated With An Oral Bisphosphonate
Jacques P. Brown¹, Michael A. Bolognese², Pei-Ran Ho³, Jesse Hall³, Christian Roux⁴, Henry G. Bone⁵, Sydney Bonnick⁶, Joop van den Bergh⁷, Irene Ferreira⁸, Prayashi Ghelani⁹, Paula Dakin³, Rachel B. Wagman³ and Chris Recknor¹⁰, ¹CHU de Québec Research Centre and Laval University, Quebec City, QC, Canada, ²Bethesda Health Research Center, Bethesda, MD, ³Amgen Inc., Thousand Oaks, CA, ⁴Paris Descartes University, Paris, France, ⁵Michigan Bone and Mineral Clinic, Detroit, MI, ⁶Clinical Research Center of North Texas, Denton, TX, ⁷VieCuri Medical Centre and Maastricht University, Venlo, Netherlands, ⁸Amgen Inc., Cambridge, United Kingdom, ⁹Ovatech Solutions, London, United Kingdom, ¹⁰United Osteoporosis Centers, Gainesville, GA
Denosumab Leads to Significantly Greater Increases in Bone Mineral Density Than Ibandronate and Risedronate in Postmenopausal Women at High Risk for Fracture Who Were Previously…
Abstract Number: 1239 • 2013 ACR/ARHP Annual Meeting
The Effects Of Hyperparathyroidism On Body Mass Index and Bone Mineral Density- An Observational Case-Control Study
Chris Varley¹, Alexander Oldroyd² and Marwan Bukhari³, ¹Lancaster Medical School, Lancaster University, Llandudno, United Kingdom, ²Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ³Department of Rheumatology, Royal Lancaster Infirmary, Lancaster, United Kingdom
Background/Purpose: Hyperparathyroidism is associated with reduced bone mineral density (BMD) and increased fracture risk. A previous study from this group has shown that bone loss…
Abstract Number: 1222 • 2013 ACR/ARHP Annual Meeting
Analysis Of Corelation Of Bone Mineral Density Of Spine With Other Sites In Ankylosing Spondylitis As Compared To Rheumatoid Arthritis and Control Populations
Janie Bruce¹ and Vikas Majithia^2,3, ¹Div of Rheumatology, University of Mississippi School of Medicine, Jackson, MS, ²Div of Rheumatology, University of Mississippi Medical Center, Jackson, MS, ³G.V. "Sonny" Montogomery VA Medical Center, Jackson, MS
Background/Purpose: Bone mineral density (BMD) at the 3 central sites usually correlates with each other but the effect of disease states on this correlation is…

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