Abstracts tagged "Bone density"

Abstract Number: 0027 • ACR Convergence 2024
Cation Channel TRPC1 Regulates Mesenchymal Stem Cell Differentiation and Bone Formation
Jyoti Yadav¹, Shivmurat Yadav², Jeremy Houser¹, Marta Onopuik³, Leonidas Tsiokas³ and Mary Beth Humphrey¹, ¹University of Oklahoma College of Medicine, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³University of Oklahoma College of Medicine, Oklahoma City
Background/Purpose: Transient receptor potential canonical 1 (TRPC1), a non-selective cation channel, is characterized by its high permeability to calcium ions (Ca2+), a vital second messenger…
Abstract Number: 2136 • ACR Convergence 2024
Distal Radius Correlation with Femur and Lumbar Spine T-scores: A Comprehensive Analysis
Monder Lafi¹, Hamzah Amin², Muhammed Aqib Khan³ and Marwan Bukhari⁴, ¹LANCASTER UNIVERSITY, Liverpool, United Kingdom, ²Lancaster University, Lancaster, United Kingdom, ³Lancaster Medical School, Lancaster, United Kingdom, ⁴University Hospitals of Morecambe bay NHS foundation trust, Lancaster, United Kingdom
Background/Purpose: Osteoporosis, defined by the WHO as a BMD reduction of 2.5 standard deviations below that of a young healthy adult, is a major public…
Abstract Number: 0030 • ACR Convergence 2024
The Impact of Treadmill Exercise on Various Stages of Osteoarthritis Progression in a Murine Osteoarthritis Model
Mengcun Chen¹, Mingshu Cui², Yangmei Yang³ and Bin Wang¹, ¹Thomas Jefferson University, Philadelphia, PA, ²Thomas Jefferson University, Philadelpha, ³Thomas Jefferson University, Philadephia
Background/Purpose: Evidence supports the benefits of exercise on joint health and its protective effects against osteoarthritis (OA) progression [Allen J, A&R, 2010]. However, most animal…
Abstract Number: 2141 • ACR Convergence 2024
Glucocorticoid Therapy-Associated Bone Fractures Are Associated with Osteoporosis Underscreening in Patients with Rheumatoid Arthritis
Marlene Marte Furment¹ and Andras Perl², ¹SUNY Upstate Medical University, Syracuse, NY, ²SUNY, Syracuse, NY
Background/Purpose: The majority of bone loss happens within 6 months of glucocorticoid treatment. Per the 2022 American College of Rheumatology (ACR) Glucocorticoid-Induced Osteoporosis Guidelines it…
Abstract Number: 0415 • ACR Convergence 2024
Prevalence and Risk Factors of Low Bone Mineral Density in Children with Juvenile Idiopathic Arthritis
narendra bagri, Sushain Kalsotra, vandana jain, Manisha Jana, Maroof Ahmed Khan, Yashdeep Gupta and Sumit Kumar Das, All India Institute of Medical Sciences, New Delhi, Delhi, India
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatological disease in children less than 16 years of age. Various factors have been suggested…
Abstract Number: 2142 • ACR Convergence 2024
Comparison of Bone Mineral Density at the Distal Radius, Hip, and Lumbar Spine in Female Patients Undergoing Surgery for Proximal Femur or Distal Radius Fractures: Implications for Osteoporosis Diagnosis
KEN NAKASEKO, Department of Orthopaedic Surgery and Rheumatology, Kuwana City Medical Center, Kuwana Mie, Japan
Background/Purpose: Osteoporosis is often diagnosed based on bone mineral density (BMD) measurements at the hip or lumbar spine. However, our previous study reported that 38%…
Abstract Number: 1029 • ACR Convergence 2024
An Analysis of Osteoporosis Screening in Males vs. Females Across Lehigh Valley Health Network
Benjamin Wolff¹, Ryan Bigelsen², Kathryn Zaffiri², Susan Kim³ and Philip Dunn⁴, ¹Lehigh Valley Health Network, Macungie, PA, ²Lehigh Valley Health Network, Allentown, PA, ³Lehigh Valley Hospital Network, Allentown, PA, ⁴Lehigh Valley Health Network, Emmaus, PA
Background/Purpose: Osteoporosis is a widely recognized disease of the bone where bone mineral density is decreased leading to increased risk for fracture. Bone mineral density…
Abstract Number: 2143 • ACR Convergence 2024
Analysis of Effectiveness and Safety of Romosozumab in Patients with Very High Risk of Fracture in a Spanish Population
Marina soledad Moreno Garcia¹, Roxana González Mazario², yedra uson Rodriguez³, Erardo meriño Ibarra⁴, Emilio Giner⁵, Juan Carlos Cobeta García⁶, Marilia Arce Benavente⁷, maria Dolores Fábregas canales⁸, Julia Ullier Bellmunt³, Giuliano Boselli³, pilar martinez Valles⁷, Jorge Juan Fragío Gil⁹, carlos Vazquez Galeano⁷ and Ana Turrion Nieves¹⁰, ¹hospital Miguel Servet . Zaragoza, Zaragoza, Aragon, Spain, ²Hospital General de Valencia, Valencia, Comunidad Valenciana, Spain, ³hospital miguel servet, zaragoza, Aragon, Spain, ⁴Hospital San Jorge Huesca, zaragoza, ⁵Hospital Royo Villanova, Teruel, Spain, ⁶Hospital Ernest Lluch, zaragoza, ⁷hospital miguel servet, Zaragoza, ⁸Hospital de Barbastro, Huesca, Spain, ⁹Hospital General Universitario, Valencia, Comunidad Valenciana, Spain, ¹⁰Rheumatology Department, Hospital Universitario Virgen de la Vega, Salamanca, Spain
Background/Purpose: Excluding clinical trials, there is limited evidence on the effect of 12 months of romosozumab treatment on increasing bone mineral density (BMD) in real-world…
Abstract Number: 1066 • ACR Convergence 2024
Development of a Pharmacy-Led Intervention to Improve Osteoporosis Screening in VA Community-Based Outpatient Clinics
Krista Topalsky¹, Lee Arphai², Mary Ellen Amos², Amanda Mertz², Christopher Blum³, Timothy Godbey², Lori Leonard², Maya Mattar⁴, Elizabeth Cable² and Robert Wenzell², ¹University Hospitals/ Case Western Reserve University, Shaker Heights, OH, ²Cleveland VA Medical Center, Cleveland, OH, ³Cleveland VA Medical Center, Cleveland, ⁴Louis Stokes VA medical Center, Mayfield Heights, OH
Background/Purpose: Osteoporosis is a major public health concern in the United States, leading to significant morbidity, mortality, and increased economic burden. Fractures are projected to…
Abstract Number: 2226 • ACR Convergence 2024
Site-specific Differences in the Association of Non-vertebral Major Osteoporotic Fractures and Rheumatoid Arthritis
John Chen¹, Malini Chandra², Laura Carbone³, John Schousboe⁴, Elisha Garcia² and Joan Lo², ¹Kaiser Permanente Oakland Medical Center, Oakland, CA, ²Kaiser Permanente, Oakland, CA, ³Augusta University, Augusta, GA, ⁴University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) and osteoporosis are both chronic, potentially debilitating conditions that frequently co-occur, affecting millions of people annually. Among those with osteoporosis, RA…
Abstract Number: 1084 • ACR Convergence 2024
Osteoporosis and Osteopenia Diagnosed by Dual-Energy X-Ray Absorptiometry Are Not Increased in Patients with Gout
Karla Miller¹, grant Cannon¹, Kyle Register², Nadia Grant² and Naomi Schlesinger², ¹University of Utah and Salt Lake City VA, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT
Background/Purpose: Controversy exists surrounding the association of gout with osteoporosis diagnosis or incident fragility fractures. Dual-Energy X-Ray Absorptiometry (DXA) scan is the gold standard for…
Abstract Number: 2563 • ACR Convergence 2024
Efficacy and Safety Results of CT-P41 (Proposed Denosumab Biosimilar) Compared to Reference Denosumab in Postmenopausal Women with Osteoporosis: 78-Week Results from Phase 3 Randomized Controlled Trial
Jean-Yves Reginster¹, Stuart L. Silverman², Edward Czerwinski³, Przemyslaw Borowy⁴, Tomasz Budlewski⁵, Joanna Kwiatek⁶, Svitlana Postol⁷, Airi Põder⁸, Jerzy Supronik⁹, SungHyun Kim¹⁰, JeeHye Suh¹⁰, GoEun Yang¹⁰, NooRi Han¹⁰, NaHyun Kim¹⁰ and SeoHee Bae¹⁰, ¹Biochemistry Dept, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, CLARENS, Switzerland, ²OMC clinical research center and Cedars Sinai Medical Center, Beverly Hills, CA, ³Krakow Medical Centre, Kraków, Poland, ⁴Krakowskie Centrum Medyczne, Krakow, Poland, ⁵Department of Rheumatology, Medical University of Lodz, Lodz, Poland, ⁶Centrum Medyczne Poznan - PRATIA, Skorzewo, Poland, ⁷Medical Center of Medbud - Clinic LLC, Kyiv, Ukraine, ⁸Clinical Research Centre Ltd, Tartu, Estonia, ⁹Osteo-Medic s.c., Białystok, Poland, ¹⁰Celltrion, Inc., Incheon, Republic of Korea
Background/Purpose: CT-P41 is a proposed biosimilar of the reference denosumab (DEN), a fully human monoclonal antibody that binds the cytokine receptor activator of NF-κb ligand…
Abstract Number: 1616 • ACR Convergence 2024
Vitamin D Supplementation in the Prevention of Severe Adverse Effects Caused ByGlucocorticoids: Study from the ARTESER Registry of Giant Cell Arteritis
Gaston Ariel Ghio¹, Marta Domínguez-Álvaro², Ricardo Blanco-Alonso³, Santos Castañeda⁴, Iñigo Hernández-Rodríguez⁵, Elisa Fernández-Fernández:⁶, Maite Silva-Diaz⁷, Joaquin María Belzunegui:⁸, Clara Moriano⁹, Julio Sánchez-Martín¹⁰, Javier Narvaez-García¹¹, Eva Galindez¹², Anne Riveros Frutos¹³, Francisco Ortiz Sanjuán¹⁴, Tarek Carlos Salman Monte:¹⁵, Margarida Vasques Rocha:¹⁶, Carlota L Iñiguez:¹⁷, Alicia García Dorta¹⁸, Clara Molina Almela¹⁹ and María Alcalde Villar:²⁰, and ARTESER Project Collaborative Group, ¹Hospital Universitari Mutua Terrassa, Terrassa, Catalonia, Spain, ²Sociedad Española de Reumatología, Madrid, Spain, ³Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, ⁴Hospital Universitario de la Princesa, Madrid, Spain, ⁵Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ⁶La Paz University Hospital, Alcalá de Henares, Madrid, Spain, ⁷Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, ⁸H de Donostia, Donostia-San Sebasti, Spain, ⁹Hospital León, LEON, Spain, ¹⁰Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Hospital Universitario de Bellvitge, Barcelona, Spain, ¹²Hospital Universitario de Cabueñes, Bilbao, Spain, ¹³Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ¹⁴Hospital Universitario de Cabueñes, Gijón, Asturias, Spain, ¹⁵Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, ¹⁶Hospital Universitario Araba, Vitoria, Spain, ¹⁷Hospital Universitario Lucus Augusti, Galicia, Spain, Galicia, Spain, ¹⁸Rheumatologist, La Laguna, Spain, ¹⁹Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain, ²⁰Hospital Universitario Severo Ochoa Leganés, Madrid, Spain, Madrid, Spain
Background/Purpose: Glucocorticoids (GC) are the gold standard for the treatment of giant cellarteritis (GCA). However, these drugs, when used at high doses and for prolonged…
Abstract Number: 2114 • ACR Convergence 2024
CT and DXA Bone Fragility Evaluation After Bariatric Surgery
Marine FAUNY¹, Marion Halin², Edem Allado², Laurent Brunaud², Claire Nomine Criqui², Eliane Albuisson², Isabelle Chary-Valckenaere³, Damien Loeuille⁴ and Didier Quilliot², ¹CH TOUL, Toul, Lorraine, France, ²Nancy University Hospital, Vandoeuvre, Lorraine, France, ³Nancy University Hospital, Vandœuvre-lès-Nancy, Lorraine, France, ⁴Phd, Nancy Vandoeuvre, Lorraine, France
Background/Purpose: Bariatric surgery could impact bone metabolism and induce significant changes, leading to increased bone resorption and an increased risk of fractures.The primary objective was…
Abstract Number: 2118 • ACR Convergence 2024
Cytotoxic T Lymphocyte Antigen-4 Improves Osteoporosis in Patient with Rheumatoid Arthritis
Yen-An Chang¹ and Ming‑Han Chen², ¹Division of Allergy, Immunology, Rheumatology/Department of Medicint/Taipei Veterans General Hospital, Taipei City, Taiwan (Republic of China), ²Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan
Background/Purpose: Rheumatoid arthritis (RA) is recognized as a risk factor for osteoporosis. Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) acts as an inhibitory regulator post-T cell activation,…

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