Abstracts tagged "Bone density"

Abstract Number: 2106 • ACR Convergence 2025
Prevalence and Characteristics of Morphometric Vertebral Fractures in the Spanish Population: Data from the OsteoSER Study
Carmen Gomez Vaquero¹, Montserrat Roig Kim², Jordi Fiter Areste³, Marta Domínguez-Álvaro⁴, Luis María Jiménez Liñán⁵, Miguel Bernad⁶, Antonio Álvarez-Cienfuegos⁷, Blanca Correa⁸, Antonio Pascual-Vergara⁹, Alejandra Montero Costa¹⁰, Cristina Momblan Trejo¹¹, Manuel Jiménez Rodríguez¹², María Anadón González¹³, Sara Josefina Barcat Zarate¹⁴, Sara Alvar Pariente¹⁵, Cristina Ruiz Pavón¹⁶, Pedro J. Lacalle Chanivet¹⁷, Balbina Marín de Prada¹⁸, Soledad García Frías¹⁹, Francisco Javier Maestro Saavedra²⁰, Marta Poch i Mora²¹, José Luis Gea González²², Carlota Quiroga Fernández²³, Eduardo Acevedo Martel²⁴ and Enrique González-Dávila²⁵, ¹Hospital Universitari de Bellvitge, ⁰⁸⁹⁰⁷ L'Hospitalet, Spain, ²Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, ³Hospital Universitari Son Espases, Palma de Mallorca, Spain, ⁴Sociedad Española de Reumatología, Madrid, Spain, ⁵Hospital Don Benito-Villanueva, Don Benito, Spain, ⁶Hospital Universitario La Paz, Madrid, Spain, ⁷Hospital Vega Baja, Orihuela, Spain, ⁸Clínica Sanz y Correa, A Coruña, Spain, ⁹Centro de Salud Ronda-Norte y Ronda-Sur, Ronda, Spain, ¹⁰Centro de Salud Fuencarral, Madrid, Spain, ¹¹Centro de Atención Primaria Viladecans Montbaig, Sant Climent de Llobregat, Spain, ¹²Centro de Salud Don Benito Oeste, Don Benito, Spain, ¹³Consultorio de Pedrezuela, Pedrezuela, Spain, ¹⁴Centro de Salud Orihuela ¹-El Rabaloche, Orihuela, Spain, ¹⁵Centro de Salud Malpica, Malpica, Spain, ¹⁶Centro de Salud Ronda-Norte, Ronda, Spain, ¹⁷Centro de Salud de Santa Amalia, Santa Amalia, Spain, ¹⁸Centro de Atención Primaria Ramona Via i Pros, El Prat de Llobregat, Spain, ¹⁹Centro de Salud de Cortes de la Frontera, Cortes de la Frontera, Spain, ²⁰Centro de Salud Elviña Mesoiro, A Coruña, Spain, ²¹Centro de Atención Primaria CAP ¹⁷ de Setembre, El Prat de Llobregat, Spain, ²²Centro de Salud de Benejúzar, Benezujar, Spain, ²³Centro de Salud Os Mallos, A Coruña, Spain, ²⁴Centro de Salud Ronda-Sur Santa Bárbara, Ronda, Spain, ²⁵Departamento de Matemáticas. Universidad de La Laguna, Tenerife, Spain
Background/Purpose: Most vertebral fractures (VFs) are asymptomatic. Vertebral Fracture Assessment (VFA) using DXA is a low-radiation method to detect morphometric vertebral fractures (MVFs). This study…
Abstract Number: 0337 • ACR Convergence 2025
Bridging the Bone Gap: A Quality Improvement Project on Osteoporosis Screening Practices in a Teaching Institution
Aakanksha Pitliya¹, Alexandra Georgiana Boc², Hema Latha Anam², Richard Oletsky², Dipabali Chaudhuri² and Rajesh Thirumaran², ¹Mercy Catholic Medical Center, Darby, PA, Clifton Heights, PA, ²Mercy Catholic Medical Center, Darby, PA
Background/Purpose: Osteoporosis remains underdiagnosed despite clear guidelines. As primary care physicians and trainees are key to preventive care, this quality improvement (QI) project aimed to…
Abstract Number: 1791 • ACR Convergence 2025
Determining the Effect of CD14 Deficiency on Osteoblastogenesis and Subchondral Bone Remodeling In Mice
Kate Sharp¹, Lance Murphy², Vu Nguyen³, Baofeng Hu⁴ and Carla Scanzello⁵, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania, Phildealphia, ⁴University of Pennsylvania, Wynnewood, PA, ⁵University of Pennsylvania, Philadelphia
Background/Purpose: Osteoarthritis (OA) is a debilitating disease affecting ~54% of US adults 75 and older. Toll-like receptor 4 (TLR4), and its co-receptor CD14, have been…
Abstract Number: 0246 • ACR Convergence 2025
Fracture Risk in Intestinal Autoimmune-mediated Diseases Patients: Clinical Insights from REMS
Marco Di Paola¹, Fiorella Anna Lombardi¹, Edmund J MacLaughlin², Maurizio Muratore³, Kathleen Methric⁴, Gianmarco Del Vecchio⁵, Giusy Peluso⁶, Chiara Stomaci⁷, Roberto Franchini¹, Francesco Conversano¹, Paola Pisani¹ and Sergio Casciaro¹, ¹Institute of Clinical Physiology, National Research Council, Lecce, Puglia, Italy, ²Rheumatology Associates of Delmarva and BoneVue Diagnostics, Easton, MD, ³ASL- LE, "Vito Fazzi" Hospital, Lecce, Puglia, Italy, ⁴BoneVue Diagnostics, Catonsville, MD, ⁵Department of Research and Development, Echolight S.p.a., Lecce, Puglia, Italy, ⁶Department of Innovative Engineering, University of Salento, Lecce, Puglia, Italy, ⁷Department of Biological and Envinronmental Sciences and Technologies, University of Salento, Lecce, Puglia, Italy
Background/Purpose: Intestinal Bowel Diseases (IBD), including Crohn’s (ChD), and Ulcerative Colitis (UCD), along with Celiac (ClD), diseases are chronic inflammatory conditions that primarily affect the…
Abstract Number: 2686 • ACR Convergence 2025
Impact of autoimmunity, disease activity and treatment on the time course of bone density, microstructure and biomechanics in inflammatory arthritis.
Koray Tascilar¹, Alp Temiz¹, Filippo Fagni², Arnd Kleyer³, Louis Schuster¹, Stephan Kemenes¹, Sara Bayat¹, David Simon⁴ and Georg Schett⁵, ¹Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, ²Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Bayern, Germany, ³Charite Universitätsmedizin Berlin, Erlangen, Bayern, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, Berlin, Germany, ⁵Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany
Background/Purpose: RA and PsA follow different pathomechanisms and incur disease-specific erosive and osteoproliferative bone changes. We used data from a large cohort of RA and…
Abstract Number: 1727 • ACR Convergence 2025
Distribution of Fracture Risk Status and Osteoporosis Treatment Use Among Postmenopausal Women with Osteoporosis in the United States
Hsu-Chih Chien, Min Kim, Michele McDermott, Mary Oates, Xiaodong Li and Lara Yoon, Amgen Inc, Thousand Oaks, CA
Background/Purpose: Current guidelines recommend treating women with postmenopausal osteoporosis (PMO) based on fracture risk. Anabolic therapy (AT), the RANKL inhibitor denosumab (Dmab), and intravenous zoledronic…
Abstract Number: 0056 • ACR Convergence 2025
Repository Corticotropin Injection Reduces Inflammation and Bone Turnover Markers in the Murine CIA Model
Maripat Corr¹, Grace Hsueh², Aaron place², David Lucas² and NANCY LANE³, ¹ucsd, San Diego, CA, ²ANI Pharmaceuticals, Inc., Baudette, MN, ³University of California at Davis, School of Medicine, Sacramento, CA
Background/Purpose: Melanocortin receptor agonists, such as adrenocorticotropic hormone (ACTH), are anti-inflammatory with pleotropic functions. We aimed to evaluate the effects of a repository corticotropin injection…
Abstract Number: 2596 • ACR Convergence 2025
Predicting Osteoporosis Using Routine Clinical Data: A Machine Learning Approach
Shiza sarfraz and Hassam Ali, East Carolina University Brody School of Medicine, Greenville, NC
Background/Purpose: Dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis but is underutilized due to access, cost, and referral barriers. We aimed to…
Abstract Number: 1691 • ACR Convergence 2025
Standardizing DXA Screening in Childhood-Onset Systemic Lupus Erythematosus at A Single Center: A Quality Improvement Initiative Using a Decision-Tree Algorithm
Andrea Gutierrez¹, Stephanie Armendariz², Muniza Mogri³ and Kristina Ciaglia⁴, ¹UT Southwestern Medical Center, Dallas, TX, ²Texas Scottish Rite Hospital, Dallas, TX, ³UT Southwestern Medical Center / Children’s Health Dallas, Dallas, TX, ⁴UT Southwestern, Children's Medical Center, and Scottish Rite for Children, Dallas, TX
Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) are at increased risk of low bone mineral density, with studies showing a 40% frequency of osteopenia (Lilleby,…
Abstract Number: 0051 • ACR Convergence 2025
Spp1+ Macrophages Are Specifically Enriched in Arthritic Joints and Associated with Abnormal Bone Metabolism in Collagen-Induced Arthritis Mice
Chenjia He, Xuyang Xia, Heng Xu, Geng Yin and Qibing Xie, West China Hospital, Sichuan University, Chengdu, China (People's Republic)
Background/Purpose: Synovial fluid (SF) of RA patients contains unique SPP1+ macrophages that drive pathogenesis by activating fibroblast-like synoviocytes (FLS). Single-cell RNA sequencing (scRNA-seq) data from…
Abstract Number: 2595 • ACR Convergence 2025
Impact of Different Types of Physical Activity on Bone Health in Patients with Inflammatory Rheumatic Diseases: a Cross-Sectional Analysis from a Prospective Cohort Study
Edgar Wiebe¹, Claire-Felicia Liebich², Dörte Huscher³, Lien Meerkatt⁴, Andriko Palmowski⁵, Sandra Hermann¹, Burkhard Muche⁵, Zhivana Boyadzhieva², Gerhard Krönke⁶, Bernd Wolfarth² and FRANK BUTTGEREIT⁷, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, Berlin, Germany, ²Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Berlin, Germany, ³Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Berlin, Germany, ⁴Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany, ⁵Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁶Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, Berlin, Berlin, Germany, ⁷Charité University Medicine Berlin, Berlin, Berlin, Germany
Background/Purpose: Physical exercise helps maintain bone mineral density (BMD), prevent falls, and reduce fracture risk. Strength and weight-bearing exercises are particularly effective. However, individuals with…
Abstract Number: 1352 • ACR Convergence 2025
Prediction of 5-Year Fracture Risk in Rheumatoid and Psoriatic Arthritis Using REMS Technology
Marco Di Paola¹, Edmund J MacLaughlin², Kathleen Methric³, Maurizio Muratore⁴, Gianmarco Del Vecchio⁵, Giusy Peluso⁶, Ernesto Casciaro¹, Fabiola Rosa Contaldo⁷, Fiorella Anna Lombardi¹, Paola Pisani¹, Francesco Conversano¹ and Sergio Casciaro¹, ¹Institute of Clinical Physiology, National Research Council, Lecce, Puglia, Italy, ²Rheumatology Associates of Delmarva and BoneVue Diagnostics, Easton, MD, ³BoneVue Diagnostics, Catonsville, MD, ⁴ASL- LE, "Vito Fazzi" Hospital, Lecce, Puglia, Italy, ⁵Department of Research and Development, Echolight S.p.a., Lecce, Puglia, Italy, ⁶Department of Innovative Engineering, University of Salento, Lecce, Puglia, Italy, ⁷Department of Biological and Environmental Sciences and Technologies, University of Salento, University of Salento, Lecce, Puglia, Italy
Background/Purpose: Autoimmune arthritis, including Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PA), are among the most common forms of inflammatory joint diseases. These conditions affect joints…
Abstract Number: 2592 • ACR Convergence 2025
Romosozumab and Denosumab Combination Therapy in Postmenopausal Osteoporosis
Giovanni Adami¹, Francesco Pollastri², Angelo Fassio², Camilla Benini², Davide Gatti², Ombretta Viapiana² and Maurizio Rossini², ¹University of Verona, Italy, Verona, Italy, ²University of Verona, Verona, Italy
Background/Purpose: Transition from long-term denosumab to PTH-analogs or romosozumab might expose patients to the risk of the so-called rebound phenomenon. Adding romosozumab to denosumab might…
Abstract Number: 0452 • ACR Convergence 2025
Ten-Year Real-World Longitudinal Analysis of Bone Mineral Density in Rheumatoid Arthritis: Impact of RA and Osteoporosis Treatments
Keigo Hayashi¹, Kei Hirose², Natsuki Kubota¹, Yuya Terajima¹, Kazuya Matsumoto¹, Takato Nakadoi¹, Shoichi Nawachi¹, Yoshia Miyawaki³, Eri Katsuyama⁴, Takayuki Katsuyama¹, Haruki Watanabe¹, Mariko Narazaki¹, Yoshinori Matsumoto¹ and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Japan, ³Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan, ⁴Faculty of Health Science, Okayama University Medical School, Graduate School of Health Sciences, Boston, MA
Background/Purpose: Despite advancements in rheumatoid arthritis (RA) and osteoporosis management that have improved patient outcomes, osteoporosis continues to be a significant clinical concern in RA.…
Abstract Number: 2501 • ACR Convergence 2025
Microvascular dysfunction contributes to hand bone deterioration in SSc patients
Rosanna Campitiello¹, Sabrina Paolino², Andrea Casabella³, Giulia Davoli², Elisa Caratto⁴, Emanuele Gotelli¹, Elvis Hysa⁵, Carmen Pizzorni², Vanessa Smith⁶, Alberto Sulli² and Maurizio Cutolo⁷, ¹University of Genoa, Genoa, Liguria, Italy, ²University of Genoa, Genova, Italy, ³IRCCS Ospedale Policlinico San Martino, Genova, Italy, ⁴Univeristy of Genoa, Alessandria, Italy, ⁵University of Genoa, Genoa, Italy, ⁶Ghent University Hospital, Gent, Belgium, ⁷University of Genova, Genova, Italy
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by endothelial dysfunction, self-reactive immune response and progressive systemic fibrosis1. It is well established that…

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