Abstracts tagged "bmp and chondrocytes"

Abstract Number: 773 • ACR/ARP Annual Meeting 2019
Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with Juvenile Idiopathic Arthritis, Through the Abrogation of TGFβ Signaling, to Delay Cell Differentiation and Maturation
Megan Simonds ¹, Amanda Schlefman ¹, Suzanne McCahan ¹, Kathleen Sullivan ², Carlos Rose ³ and AnneMarie Brescia³, ¹Nemours Biomedical Research, Wilmington, DE, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Nemours/ Alfred I DuPont Hospital for Children, Wilmington, DE
Background/Purpose: Progression of Juvenile Idiopathic Arthritis (JIA) can lead to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in the pathogenesis…