Abstracts tagged "Bisphosphonates"

Abstract Number: 384 • 2015 ACR/ARHP Annual Meeting
Dental Treatments, Tooth Extraction, and Osteonecrosis at Jaw in Japanese Patients with Rheumatoid Arthritis; Results from the IORRA Cohort Study
Takefumi Furuya, Shigeki Momohara, Atsuo Taniguchi and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Oral health is an important issue for the patients with rheumatoid arthritis (RA) because many RA patients were treated with bisphosphonates and bisphosphate use…
Abstract Number: 898 • 2015 ACR/ARHP Annual Meeting
A Randomized Double-Blind Study of Denosumab Compared with Zoledronic Acid in Postmenopausal Women with Osteoporosis Previously Treated with Oral Bisphosphonate
PD Miller¹, N Pannacciulli², JP Brown³, E Czerwinski⁴, BS Nedergaard⁵, MA Bolognese⁶, J Malouf⁷, HG Bone⁸, JY Reginster⁹, A Singer¹⁰, C Wang², RB Wagman² and SR Cummings¹¹, ¹Colorado Center for Bone Research, Lakewood, CO, ²Amgen Inc., Thousand Oaks, CA, ³Laval University and CHU de Québec (CHUL) Research Centre, Québec City, QC, Canada, ⁴Krakow Medical Center, Krakow, Poland, ⁵Center for Clinical and Basic Research, Aalborg, Denmark, ⁶The Bethesda Health Research Center, Bethesda, MD, ⁷Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁸Michigan Bone and Mineral Clinic, Detroit, MI, ⁹University of Liège, Liège, Belgium, ¹⁰Georgetown University Medical Center, Washington, DC, ¹¹San Francisco Coordinating Center, CPMC Research Institute, San Francisco, CA
Background/Purpose: Oral bisphosphonates are the most common osteoporosis treatment, but inconvenient dosing regimens and side effects lead to low adherence. Less frequently dosed bisphosphonates, eg,…
Abstract Number: 1561 • 2015 ACR/ARHP Annual Meeting
The Effect of TNF Blockers on Bone Mineral Density in Rheumatoid Arthritis Patients Receiving Bisphosphonate
Doo-Ho Lim¹, Seokchan Hong², Soo Min Ahn², Byeongzu Ghang³, Wook Jang Seo⁴, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁴Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: Osteoporosis is more frequently observed in patients with rheumatoid arthritis (RA) than in general population. Bisphosphonate (BP), which suppresses bone resorption by inhibiting osteoclast…
Abstract Number: 317 • 2015 ACR/ARHP Annual Meeting
Relation of Incident Bisphosphonate Use to Trajectory of Joint-Space Width
Tuhina Neogi¹, Na Lu², Jingbo Niu¹, Jeffrey Duryea³ and Yuqing Zhang¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Radiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Trials regarding bisphosphonate (Bisph) effects in knee osteoarthritis (OA) have been conflicting, and are unable to provide insights into long-term effects. While Bisph may…
Abstract Number: 350 • 2015 ACR/ARHP Annual Meeting
Atypical Femur Fracture in Rheumatoid Arthritis Patients Treated with Bisphosphonates: A Nested Case-Control Study
JungHee Koh¹, Ji Hyeon Ju², Min Kyung Chung³, Ji Hun Kim³, Seung Min Jung⁴, Ji Yeon Lee², Jennifer Lee³, Seung-Ki Kwok⁵ and Sung-Hwan Park³, ¹Seochogu, Banpodaero, 222, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, school of medicine, The catholic university of Korea, Seoul, South Korea, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Patients with rheumatoid arthritis (RA) are diagnosed with osteoporosis earlier than and those without RA, and are therefore exposed to Bisphosphonates (BPs) for longer.…
Abstract Number: 355 • 2015 ACR/ARHP Annual Meeting
The Clinical and Genetic Spectrum of Low Alkaline Phosphatase in Adults
Leyre Riancho-Zarrabeitia¹, Maria T. García-Unzueta², Jair A. Tenorio³, Juan Gómez-Gerique⁴, Víctor L Ruiz Pérez³, Karen E. Heath³, Pablo Lapunzina³ and José A. Riancho⁵, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Institute of Medical and Molecular Genetics. Hospital U. La Paz. IdiPAZ. Autonomous University of Madrid. CIBERER., Madrid, Spain, ⁴Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. University of Cantabria, Santander, Spain
Background/Purpose: Different from infantile forms, adult forms of hypophosphatasia have less severe manifestations and may go unrecognized. Low serum levels of alkaline phosphatase (ALP), the…
Abstract Number: 368 • 2015 ACR/ARHP Annual Meeting
The Effects of Monitoring on a Quality Indicator for Glucocorticoid–Induced Osteoporosis and Trends of the Drug Variation in a Japanese Hospital
Masei Suda¹, Masato Okada¹, Yasuhiro Suyama², Mitsumasa Kishimoto¹ and Tokutaro Tsuda¹, ¹Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Rheumatology, JR Tokyo General Hospital, Tokyo, Japan
Background/Purpose: Glucocorticoid-induced osteoporosis (GIOP) is one of the most clinically significant side effects of glucocorticoid use, and the prevention of GIOP has become more important…
Abstract Number: 2261 • 2014 ACR/ARHP Annual Meeting
A Meta-Anlaysis of Bisphosphonate and Parathyroid Hormone (PTH) Use in Osteoporosis
Zsolt Kulcsar¹, Lena Saleh², Shravani Gangidi³ and Poonam Khadka⁴, ¹Rheumatology/Leadership Preventive Medicine Residency, Dartmouth Hitchcock Medical Center, lebanon, NH, ²The Dartmouth Institute For Healthcare Policy and Clinical Practice, Lebanon, NH, ³The Dartmouth Institute For Healthcare Policy and Clinical Practice, lebanon, NH, ⁴Endocrinology, Dartmouth Hitchcock Medical Center, lebanon, NH
Background/Purpose: Bisphosphonates are currently the drug of choice for treatment of osteoporosis. While anabolic agents like parathyroid hormone (PTH) have shown greater improvements in bone…
Abstract Number: 2263 • 2014 ACR/ARHP Annual Meeting
Continued Zoledronic Acid Use in a Large Healthcare System
Robert A. Overman¹, Julie C. Lauffenburger², Margaret L. Gourlay³ and Chad L. Deal⁴, ¹Eshelman School of Pharmacy - Division of Pharmaceutical Policy and Outcomes, University of North Carolina, Chapel Hill, NC, ²Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, ³Family Medicine, University of North Carolina, Chapel Hill, NC, ⁴Dept of Rheum & Imm Dis /A 50, Cleveland Clinic, Cleveland, OH
Background/Purpose: Oral bisphosphonates adherence has been reported as less than 50% at one year. With patients frequently having refill gaps greater than 30 days. Zoledronic…
Abstract Number: 2265 • 2014 ACR/ARHP Annual Meeting
Comparative Effects of Raloxifene and Bisphosphonate on Bone Mineral Density and Osteoporotic Fracture Outcomes in Rheumatoid Arthritis Patients
Kowoon Joo¹, Won Park², Seong-Ryul Kwon³, Mie-Jin Lim³ and Kyong-Hee Jung³, ¹Inha University Hospital, Incheon, South Korea, ²Medicine/Rheumatology, Inha University Hospital, Incheon, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea
Background/Purpose: Rheumatoid arthritis (RA) accelerates bone loss, increasing the risk of osteoporosis and osteoporotic fractures. We evaluated the effect of raloxifene and bisphosphonate on bone…
Abstract Number: 1162 • 2014 ACR/ARHP Annual Meeting
Patterns of Use of Long-Term (> 5 Years) Oral Bisphophonate Prescription Among Primary Care Providers and Rheumatologists for the Treatment of Osteopenia and Osteoporosis in a Veteran Population
Mathilde Pioro¹, Stephanie Ogorzaly² and Maya Mattar³, ¹Rheumatology, Cleveland Veterans Affairs Medical Center, Cleveland, OH, ²Pharmacy Service, Veterans' Affairs Medical Center, Cleveland Veterans' Affairs Medical Center, Cleveland, OH, ³Medicine/Rheumatology, University Hospitals Case Medical Center, Cleveland, OH
Background/Purpose: Osteoporosis is a widely prevalent but underrecognized condition. Oral bisphosphonates are considered first-line treatment of osteoporosis in men and women however long term use…
Abstract Number: 854 • 2014 ACR/ARHP Annual Meeting
Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy (SpA): A 48-Week Randomized Controlled Trial
Chi Chiu Mok¹, Angela Li², Kar Li Chan¹ and Ling Yin Ho¹, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Radiology, Tuen Mun Hospital, Hong Kong, Hong Kong
Background/Purpose To compare the efficacy of golimumab(GLM) and pamidronate(PAM) in the treatment of SpA.Methods Inclusion criteria: (1) patients ≥18 years of age; (2) fulfills the…
Abstract Number: 831 • 2014 ACR/ARHP Annual Meeting
Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD)
Edward Roddy, Sara Muller, Zoe Paskins, Samantha Hider, Milisa Blagojevic-Bucknall and Christian Mallen, Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom
Background/Purpose: Acute pseudogout is the most dramatic clinical manifestation of calcium pyrophosphate crystal deposition (CPPD). CPPD is most commonly sporadic and age-related but can rarely…
Abstract Number: 48 • 2014 ACR/ARHP Annual Meeting
Osteoporotic Women at High Risk for Fractures Despite Two Years of Oral Bisphosphonate Therapy: Analysis Using the Canadian Multicentre Osteoporosis Study
Jonathan D. Adachi¹, David Goltzman², Ankita Modi³, Jackson Tang⁴, Chun-Po S. Fan⁴ and Jessica Weaver³, ¹Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ²McGill University, Montreal, QC, Canada, ³Global Health Outcomes, Merck & Co., Inc., Whitehouse Station, NJ, ⁴Asclepius Analytics, New York, NY
Background/Purpose Individuals with osteoporosis (OP) have an increased susceptibility to fractures. Prevention and treatment of postmenopausal OP is critical to decreasing the risk of non-traumatic…
Abstract Number: 1236 • 2013 ACR/ARHP Annual Meeting
Outcomes and Costs Of Sacral Insufficiency Fractures
Shahryar Hadavi¹, Sanam Kia¹, Christian Dejaco², Bhaskar Dasgupta² and Frances Borg³, ¹Rheumatology Department, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ²Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ³Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom
Background/Purpose: Sacral insufficiency fracture (SIF) is a poorly recognised cause of lower back pain in the elderly with significant potential morbidity. Diagnosis is often slow…

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