ACR Meeting Abstracts

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Abstracts tagged "biopsies"

  • Abstract Number: 1661 • 2014 ACR/ARHP Annual Meeting

    Are Repeat Renal Biopsies Important in Managing Lupus Nephritis Flares?

    Angela Pakozdi1, Ravindra Rajakariar2, Michael Sheaff3 and Dev Pyne1, 1Rheumatology, Barts Health NHS Trust, London, United Kingdom, 2Renal Medicine, Barts Health NHS Trust, London, United Kingdom, 3Histopathology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose Lupus nephritis (LN) is the major cause of morbidity and mortality in patients with systemic lupus erythematosus. The role of repeat kidney biopsies (RB)…
  • Abstract Number: 1659 • 2014 ACR/ARHP Annual Meeting

    The Clinical Relevance of a Repeat Biopsy in Lupus Nephritis (LN) Flares

    Milagros Ricse1, Javier Narváez2, Gloria Albert1, Paula Estrada1, Sergi Heredia1, Andrea Zacarias1, Helena Borrell1, Eulalia Armengol1, Xavier Fulladosa3, Joan Torras3, Olga Capdevila4, Francesca Mitjavila4 and Joan Miquel Nolla1, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 3Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, 4Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: Renal biopsy is the gold standard for assessing renal activity and hence guiding treatment. Whether a repeat renal biopsy is helpful during flares of…
  • Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting

    A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis

    Stefania Croci1, Alessandro Zerbini1, Luigi Boiardi2, Francesco Muratore2, Alessandra Bisagni3, Giulia Pazzola2, Luca Cimino4, Antonio Moramarco4, Davide Nicoli5, Enrico Farnetti6, Bruno Casali6, Alberto Cavazza3, Maria Parmeggiani7 and Carlo Salvarani2, 1Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 6Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 7Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
  • Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting

    Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients

    Surjeet Singh1, Andrew Hutchings2, Wulf Forrester-Barker3, Bhaskar Dasgupta4, Andreas P. Diamantopoulos5, Peter Lanyon6, Malgorzata Magliano7, Brendan McDonald8, Konrad Wolfe9 and Raashid Luqmani10, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 4Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 5Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 6Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 7Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, 8Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, 9Department of Pathology, Southend University Hospital, Essex, United Kingdom, 10Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
  • Abstract Number: 792 • 2014 ACR/ARHP Annual Meeting

    Is Temporal Artery Biopsy the Gold Standard for the Diagnosis of Giant Cell Arteritis?

    Marina Scolnik1, Aldo Fabian Ojeda2, Valeria Scaglioni3 and Enrique R. Soriano4, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Departamento de Reumatología, Hospital de Clínicas, FCM-UNA, Asuncion, Paraguay, 3Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: The only test that confirms diagnosis of Giant Cell Arteritis (GCA) is a temporal artery biopsy showing vasculitis with mononuclear cell inflammatory infiltrates, often with…
  • Abstract Number: 791 • 2014 ACR/ARHP Annual Meeting

    Comparison of Clinical Manifestations in Different Histological Subsets of Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Francesco Muratore1, Alberto Cavazza2, Giovanna Restuccia3, Pierluigi Macchioni1, Giuseppe Germanò1, Nicolò Pipitone1, Gianluigi Bajocchi4 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Japan

    Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold standard for the diagnosis of giant cell arteritis (GCA). In some cases of…
  • Abstract Number: 790 • 2014 ACR/ARHP Annual Meeting

    Correlations Between Histopathological Findings and Clinical Manifestations in a Large Monocentric Cohort of Patients with Biopsy-Proven Giant Cell Arteritis

    Luigi Boiardi1, Francesco Muratore1, Giovanna Restuccia2, Alberto Cavazza3, Pierluigi Macchioni1, Giuseppe Germanò1, Nicolò Pipitone1 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Temporal artery biopsy (TAB)…
  • Abstract Number: 788 • 2014 ACR/ARHP Annual Meeting

    Fast-Track Diagnostic Procedure for Giant Cell Arteritis

    Alojzija Hočevar1, Ziga Rotar2 and Matija Tomsic3, 1Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 3Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia

    Background/Purpose Giant cell arteritis (GCA) represents the most common primary vasculitis among adults aged 50 years or above. Recently, the national annual incidence rate in…
  • Abstract Number: 785 • 2014 ACR/ARHP Annual Meeting

    Incidence, Prevalence and Survival of Biopsy-Proven Giant Cell Arteritis in Northern Italy

    Mariagrazia Catanoso1, Pierluigi Macchioni1, Luigi Boiardi1, Francesco Muratore1, Giovanna Restuccia2, Alberto Cavazza3, Ferdinando Luberto4 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Statistical Service, Azienda Usl Reggio Emilia, Reggio Emilia, Italy

    Background/Purpose: To investigate the incidence, prevalence and mortality of biopsy proven giant cell arteritis (GCA) over a 27-year period in a defined area of northern…
  • Abstract Number: 371 • 2013 ACR/ARHP Annual Meeting

    Inflammatory Cell Infiltrates In The Heart Of Patients With Coronary Artery Disease With and Without Inflammatory Rheumatic Disease: A Biopsy Study

    Jacqueline Kirsti Andersen1, Ingvild Oma2, Ingjerd Lien Kveldstad2, Knut Mikkelsen3, Terje Veel4, Sven M. Almdahl5, Matthew H. Liang6, Øystein T. Førre7, Morten Fagerland8 and Ivana Hollan9, 1Gjøvik University College, Gjøvik, Norway, 2Innlandet Hospital Trust, Lillehammer, Norway, 3Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 4Feiringklinikken, Feiring, Norway, 5Cardiothoracic surgery, University Hospital of North Norway, Tromsø, Norway, 6Harvard Medical School, Boston, MA, 7Oslo University Hospital, Oslo, Norway, 8Department of Biostatistics, Oslo University Hospital, Oslo, Norway, 9Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway

    Background/Purpose:  Systemic rheumatic diseases (SRDs) are associated with increased cardiovascular (CV) morbidity due to accelerated atherosclerosis. However, SRDs are associated also with cardiac vasculitis that…
  • Abstract Number: 218 • 2013 ACR/ARHP Annual Meeting

    The Role Of Salivary GLAND Ultrasound In Sjogren Syndrome: A Single Center Experience

    Giuseppe Germanò1, Niccolò Possemato2, Olga Addimanda1, Pierluigi Macchioni1 and Carlo Salvarani3, 1Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, 3Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: There is increasingly scientific evidence of salivary gland ultrasonography accuracy and usefulness in diagnosing Sjogren Syndrome. [1-2] Methods: 82 patients with suspected Sjogren Syndrome…
  • Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting

    Microarray Analysis Of  Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology

    Arjen B. Blom1, Peter L. van Lent2, Martijn H. van den Bosch1, Hans Cats3, Frank H.J. van den Hoogen4, Peter M. van der Kraan5 and Wim B. van den Berg6, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 5Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 6Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
  • Abstract Number: 1666 • 2013 ACR/ARHP Annual Meeting

    Negative Temporal Artery Biopsies: Pathologic Findings Of Patients With Biopsy-Negative Giant Cell Arteritis Compared To Those Of Patients Without Arteritis

    Francesco Muratore1, Alberto Lo Gullo1, Alberto Cavazza2, Giuseppe Germanò1, Luigi Boiardi1 and Carlo Salvarani3, 1Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold  standard for the diagnosis of giant cell arteritis (GCA). A negative TAB does…
  • Abstract Number: 896 • 2013 ACR/ARHP Annual Meeting

    Increased Rho Kinase (ROCK) Activity In Temporal Artery Biopsies From Patients With Giant Cell Arteritis (GCA)

    Lindsay Lally1, Navneet Narula2, Alessandra B. Pernis3, Wei-Ti Huang4, Uzunma Udeh1 and Robert F. Spiera1, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Pathology, Weill Cornell Medical College, New York, NY, 3Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, 4Biostatistics, Hospital for Special Surgery, New York, NY

    Background/Purpose: ROCKs are implicated in the pathogenesis of many vascular diseases.  ROCK activation is associated with Th17 differentiation and production of Th17-associated cytokines, IL-17 and…
  • Abstract Number: 602 • 2013 ACR/ARHP Annual Meeting

    Repeat Biopsy In Lupus Nephritis: A Single-Center Experience

    Josefina Marin1, Marina Scolnik2, Eliana Lancioni3, Gustavo Greloni4, Cristian Quiroz5, Johana Zacariaz3, Carla Saucedo6, Luis J. Catoggio2 and Enrique R. Soriano2, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 3Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 6Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Renal involvement in systemic lupus erythematosus (SLE) is an important cause of morbidity and even mortality. Lupus nephritis has diverse morphologic manifestations with varying clinical…
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