Abstracts tagged "biopsies"

Abstract Number: 2538 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Guided Core Needle Biopsy of the Major Salivary Glands Is a Safe and Useful Diagnostic Tool in the Evaluation of Suspected or Established Sjögren’s Syndrome
Anand Narayan¹, Thomas Grader-Beck², Julius Birnbaum³, Jean Kim⁴, Qing Kay Li⁵, Deborah Belchis⁵, Joel Fradin¹ and Alan N. Baer⁶, ¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Ultrasound-guided core needle biopsy (CNB) has greater inherent risks than fine-needle aspiration for the diagnosis of major salivary gland neoplasms, but provides tissue for…
Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting
High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis
Khalil I. Bourji¹, Alain Meyer^2,3, Emmanuel Chatelus², Erika Pigatto¹, François Singh³, Bernard Geny³, Leonardo Punzi¹, Jacques-Eric Gottenberg², Franco Cozzi¹ and Jean Sibilia², ¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ³Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, France
Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
Abstract Number: 1656 • 2014 ACR/ARHP Annual Meeting
Rate of Histological Transformation to Higher Grade Nephritis in Class II Mesangial Proliferative Lupus Glomerulonephritis
Andrea Zacarias¹, Javier Narváez², Gloria Albert¹, Milagros Ricse¹, Paula Estrada¹, Melany Pestaña³, Chema Mora³, Jesus Rodriguez Moreno¹, Xavier Fulladosa⁴, Manel Rubio Rivas³ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Class II mesangial proliferative lupus nephritis has generally been considered a mild form of the condition, with a good response to glucocorticoid treatment. However,…
Abstract Number: 1655 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis: Clinicopathological Correlation in 126 Biopsies
Milagros Ricse¹, Javier Narváez², Gloria Albert¹, Paula Estrada¹, Helena Borrell¹, Eugenia de Lama³, Xavier Fulladosa⁴, Manel Rubio Rivas⁵, Olga Capdevila⁵, Francesca Mitjavila⁵, Xavier Juanola⁶ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Radiology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁵Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Rheumatology, University Hospital Bellvitge, Barcelona, Spain
Background/Purpose: To analyze the correlation between clinical and laboratory data and type of histological injury in a cohort of patients with lupus nephritis (LN). Methods:…
Abstract Number: 1661 • 2014 ACR/ARHP Annual Meeting
Are Repeat Renal Biopsies Important in Managing Lupus Nephritis Flares?
Angela Pakozdi¹, Ravindra Rajakariar², Michael Sheaff³ and Dev Pyne¹, ¹Rheumatology, Barts Health NHS Trust, London, United Kingdom, ²Renal Medicine, Barts Health NHS Trust, London, United Kingdom, ³Histopathology, Barts Health NHS Trust, London, United Kingdom
Background/Purpose Lupus nephritis (LN) is the major cause of morbidity and mortality in patients with systemic lupus erythematosus. The role of repeat kidney biopsies (RB)…
Abstract Number: 1659 • 2014 ACR/ARHP Annual Meeting
The Clinical Relevance of a Repeat Biopsy in Lupus Nephritis (LN) Flares
Milagros Ricse¹, Javier Narváez², Gloria Albert¹, Paula Estrada¹, Sergi Heredia¹, Andrea Zacarias¹, Helena Borrell¹, Eulalia Armengol¹, Xavier Fulladosa³, Joan Torras³, Olga Capdevila⁴, Francesca Mitjavila⁴ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Renal biopsy is the gold standard for assessing renal activity and hence guiding treatment. Whether a repeat renal biopsy is helpful during flares of…
Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting
A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis
Stefania Croci¹, Alessandro Zerbini¹, Luigi Boiardi², Francesco Muratore², Alessandra Bisagni³, Giulia Pazzola², Luca Cimino⁴, Antonio Moramarco⁴, Davide Nicoli⁵, Enrico Farnetti⁶, Bruno Casali⁶, Alberto Cavazza³, Maria Parmeggiani⁷ and Carlo Salvarani², ¹Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁶Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁷Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting
Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients
Surjeet Singh¹, Andrew Hutchings², Wulf Forrester-Barker³, Bhaskar Dasgupta⁴, Andreas P. Diamantopoulos⁵, Peter Lanyon⁶, Malgorzata Magliano⁷, Brendan McDonald⁸, Konrad Wolfe⁹ and Raashid Luqmani¹⁰, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ³University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ⁴Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁵Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁶Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ⁷Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, ⁸Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, ⁹Department of Pathology, Southend University Hospital, Essex, United Kingdom, ¹⁰Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
Abstract Number: 792 • 2014 ACR/ARHP Annual Meeting
Is Temporal Artery Biopsy the Gold Standard for the Diagnosis of Giant Cell Arteritis?
Marina Scolnik¹, Aldo Fabian Ojeda², Valeria Scaglioni³ and Enrique R. Soriano⁴, ¹Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Departamento de Reumatología, Hospital de Clínicas, FCM-UNA, Asuncion, Paraguay, ³Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina
Background/Purpose: The only test that confirms diagnosis of Giant Cell Arteritis (GCA) is a temporal artery biopsy showing vasculitis with mononuclear cell inflammatory infiltrates, often with…
Abstract Number: 603 • 2013 ACR/ARHP Annual Meeting
Factors Associated With a Double Increase In Serum Creatinine In Biopsy Proven Lupus Nephritis From a Single Center In Spain
Raúl Menor Almagro¹, M. H. Cardiel², Javier Rubio Garrido³, J. Luis de la Iglesia¹, José Javier Perez Venegas¹, María Mar Ruiz Tudela¹, José Javier Salaberri¹ and Manuel Paez-Camino¹, ¹Rheumatology, Hospital de Jerez, Jerez de la Frontera, Spain, ²Centro de Investigacion Clinica de Morelia, Morelia, Mexico, ³Pathology, Hospital de Jerez, Jerez de la Frontera, Spain
Background/Purpose: Lupus nephritis is a common and feared complication in systemic lupus erythematosus (SLE). Clinicians have relied on different variables to help to predict those…
Abstract Number: 594 • 2013 ACR/ARHP Annual Meeting
Renal Biopsy Findings In Lupus Patient With Insignificant Proteinuria : Relation To Disease Activity and Clinical Manifestations
Abdel Azeim M. Al-Hefny¹, Samah El-bakry², Sameh A. Mobasher³, Ola H. Nada⁴ and Nouran Abaza⁵, ¹Department of Internal Medicine and Rheumatology, Professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Cairo, Egypt, ²Department of Internal Medicine and Rheumatology, Assistant professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ³Department of Internal Medicine and Rheumatology, Lecturer of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁴Department of Pathology, Faculty of Medicine, Ain Shams University, Lecturer of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁵Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background/Purpose: Lupus nephritis (LN) remains one of the most serious manifestations of systemic lupus erythematosus (SLE) and is associated with significant morbidity and mortality. Early…
Abstract Number: 513 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Labial Minor Salivary Gland Biopsy For Primary Sjögren’s Syndrome
Raquel Altoe¹, Valeria Valim², Maria Carmem S. Santos³, Erica V. Serrano¹ and Samira T. Miyamoto⁴, ¹Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ²Clínica Médica - Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ³Farmacologia, Universidade de Vila Velha, Vitória, Brazil, ⁴Educação Integrada em Saúde - Reumatologia, Universidade Federal do Espírito Santo, Vitoria, Brazil
Background/Purpose: The presence of lymphocytic infiltrate with ≥ 1 focus score/4mm2 in minor salivary gland is a useful tool for the diagnosis of Sjögren's syndrome…
Abstract Number: 388 • 2013 ACR/ARHP Annual Meeting
Vitamin D Levels and Inflammation In The Aortic Wall Of Patients With Inflammatory Rheumatic Disease and Coronary Artery Disease
Ingvild Oma¹, Jacqueline Kirsti Andersen², Torstein Lyberg³, Øyvind Molberg⁴, Jon Elling Whist¹, Ingjerd Lien Kvelstad¹, Terje Veel⁵, Morten Fagerland⁶, Sven M. Almdahl⁷, Knut Mikkelsen⁸ and Ivana Hollan⁹, ¹Innlandet Hospital Trust, Lillehammer, Norway, ²Gjøvik University College, Gjøvik, Norway, ³Oslo University Hospital, Oslo, Norway, ⁴Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ⁵Feiringklinikken, Feiring, Norway, ⁶Department of Biostatistics, Oslo University Hospital, Oslo, Norway, ⁷Cardiothoracic surgery, University Hospital of North Norway, Tromsø, Norway, ⁸Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁹Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway
Background/Purpose: Vitamin D is involved in immune reactions, and vitamin D deficiency is associated with autoimmune diseases and with cardiovascular diseases. In Feiring Heart Biopsy…
Abstract Number: 371 • 2013 ACR/ARHP Annual Meeting
Inflammatory Cell Infiltrates In The Heart Of Patients With Coronary Artery Disease With and Without Inflammatory Rheumatic Disease: A Biopsy Study
Jacqueline Kirsti Andersen¹, Ingvild Oma², Ingjerd Lien Kveldstad², Knut Mikkelsen³, Terje Veel⁴, Sven M. Almdahl⁵, Matthew H. Liang⁶, Øystein T. Førre⁷, Morten Fagerland⁸ and Ivana Hollan⁹, ¹Gjøvik University College, Gjøvik, Norway, ²Innlandet Hospital Trust, Lillehammer, Norway, ³Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Feiringklinikken, Feiring, Norway, ⁵Cardiothoracic surgery, University Hospital of North Norway, Tromsø, Norway, ⁶Harvard Medical School, Boston, MA, ⁷Oslo University Hospital, Oslo, Norway, ⁸Department of Biostatistics, Oslo University Hospital, Oslo, Norway, ⁹Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway
Background/Purpose: Systemic rheumatic diseases (SRDs) are associated with increased cardiovascular (CV) morbidity due to accelerated atherosclerosis. However, SRDs are associated also with cardiac vasculitis that…
Abstract Number: 218 • 2013 ACR/ARHP Annual Meeting
The Role Of Salivary GLAND Ultrasound In Sjogren Syndrome: A Single Center Experience
Giuseppe Germanò¹, Niccolò Possemato², Olga Addimanda¹, Pierluigi Macchioni¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: There is increasingly scientific evidence of salivary gland ultrasonography accuracy and usefulness in diagnosing Sjogren Syndrome. [1-2] Methods: 82 patients with suspected Sjogren Syndrome…

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