Abstracts tagged "biopsies"

Abstract Number: 785 • 2014 ACR/ARHP Annual Meeting
Incidence, Prevalence and Survival of Biopsy-Proven Giant Cell Arteritis in Northern Italy
Mariagrazia Catanoso¹, Pierluigi Macchioni¹, Luigi Boiardi¹, Francesco Muratore¹, Giovanna Restuccia², Alberto Cavazza³, Ferdinando Luberto⁴ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Statistical Service, Azienda Usl Reggio Emilia, Reggio Emilia, Italy
Background/Purpose: To investigate the incidence, prevalence and mortality of biopsy proven giant cell arteritis (GCA) over a 27-year period in a defined area of northern…
Abstract Number: 91 • 2014 ACR/ARHP Annual Meeting
Quantitative Proteomics Using Dimethyl Isotope Labeling for Comparison of Fresh Frozen Versus Formalin-Fixed, Paraffin-Embedded Tissue for Lupus Nephritis
Abhimanyu Amarnani¹, Joseph Capri², Puneet Souda³, David Elashoff⁴, Ivan Lopez⁵, Julian Whitelegge³ and Ram Singh¹, ¹Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Pasarow Mass Spectrometry Laboratory, University of California, Los Angeles, Los Angeles, CA, ³The Pasarow Mass Spectrometry Laboratory, University of California, Los Angeles, Los Angeles, CA, ⁴Medicine/Statistics Core, University of California, Los Angeles, Los Angeles, CA, ⁵Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA
Background/Purpose Lupus nephritis (LN) progresses from mild focal inflammation, to diffuse proliferative nephritis, to fibrosis and end-stage renal disease. Though the understanding of LN has…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
Abstract Number: 2787 • 2014 ACR/ARHP Annual Meeting
Identification of Urinary Biomarkers for Lupus Nephritis
Carolina Landolt-Marticorena¹, Stephenie Prokopec², Heather Reich³, James Scholey⁴, Carmen Avila-Casado⁵, Paul R. Fortin⁶, Paul Boutros² and Joan Wither⁷, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Nephrology, University Health Network, Toronto, ON, Canada, ⁴Department of Medicine, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Pathology, University Health Network, Toronto, ON, Canada, ⁶Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada, ⁷Immunology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) is a major determinant of morbidity and mortality in Systemic Lupus Erythematosus (SLE). Variability in clinical course, underlying renal injury, and…
Abstract Number: 2538 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Guided Core Needle Biopsy of the Major Salivary Glands Is a Safe and Useful Diagnostic Tool in the Evaluation of Suspected or Established Sjögren’s Syndrome
Anand Narayan¹, Thomas Grader-Beck², Julius Birnbaum³, Jean Kim⁴, Qing Kay Li⁵, Deborah Belchis⁵, Joel Fradin¹ and Alan N. Baer⁶, ¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Ultrasound-guided core needle biopsy (CNB) has greater inherent risks than fine-needle aspiration for the diagnosis of major salivary gland neoplasms, but provides tissue for…
Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting
High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis
Khalil I. Bourji¹, Alain Meyer^2,3, Emmanuel Chatelus², Erika Pigatto¹, François Singh³, Bernard Geny³, Leonardo Punzi¹, Jacques-Eric Gottenberg², Franco Cozzi¹ and Jean Sibilia², ¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ³Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, France
Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
Abstract Number: 1656 • 2014 ACR/ARHP Annual Meeting
Rate of Histological Transformation to Higher Grade Nephritis in Class II Mesangial Proliferative Lupus Glomerulonephritis
Andrea Zacarias¹, Javier Narváez², Gloria Albert¹, Milagros Ricse¹, Paula Estrada¹, Melany Pestaña³, Chema Mora³, Jesus Rodriguez Moreno¹, Xavier Fulladosa⁴, Manel Rubio Rivas³ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Class II mesangial proliferative lupus nephritis has generally been considered a mild form of the condition, with a good response to glucocorticoid treatment. However,…
Abstract Number: 1655 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis: Clinicopathological Correlation in 126 Biopsies
Milagros Ricse¹, Javier Narváez², Gloria Albert¹, Paula Estrada¹, Helena Borrell¹, Eugenia de Lama³, Xavier Fulladosa⁴, Manel Rubio Rivas⁵, Olga Capdevila⁵, Francesca Mitjavila⁵, Xavier Juanola⁶ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Radiology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁵Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Rheumatology, University Hospital Bellvitge, Barcelona, Spain
Background/Purpose: To analyze the correlation between clinical and laboratory data and type of histological injury in a cohort of patients with lupus nephritis (LN). Methods:…
Abstract Number: 1661 • 2014 ACR/ARHP Annual Meeting
Are Repeat Renal Biopsies Important in Managing Lupus Nephritis Flares?
Angela Pakozdi¹, Ravindra Rajakariar², Michael Sheaff³ and Dev Pyne¹, ¹Rheumatology, Barts Health NHS Trust, London, United Kingdom, ²Renal Medicine, Barts Health NHS Trust, London, United Kingdom, ³Histopathology, Barts Health NHS Trust, London, United Kingdom
Background/Purpose Lupus nephritis (LN) is the major cause of morbidity and mortality in patients with systemic lupus erythematosus. The role of repeat kidney biopsies (RB)…
Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting
Microarray Analysis Of Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology
Arjen B. Blom¹, Peter L. van Lent², Martijn H. van den Bosch¹, Hans Cats³, Frank H.J. van den Hoogen⁴, Peter M. van der Kraan⁵ and Wim B. van den Berg⁶, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
Abstract Number: 1666 • 2013 ACR/ARHP Annual Meeting
Negative Temporal Artery Biopsies: Pathologic Findings Of Patients With Biopsy-Negative Giant Cell Arteritis Compared To Those Of Patients Without Arteritis
Francesco Muratore¹, Alberto Lo Gullo¹, Alberto Cavazza², Giuseppe Germanò¹, Luigi Boiardi¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold standard for the diagnosis of giant cell arteritis (GCA). A negative TAB does…
Abstract Number: 896 • 2013 ACR/ARHP Annual Meeting
Increased Rho Kinase (ROCK) Activity In Temporal Artery Biopsies From Patients With Giant Cell Arteritis (GCA)
Lindsay Lally¹, Navneet Narula², Alessandra B. Pernis³, Wei-Ti Huang⁴, Uzunma Udeh¹ and Robert F. Spiera¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Pathology, Weill Cornell Medical College, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Biostatistics, Hospital for Special Surgery, New York, NY
Background/Purpose: ROCKs are implicated in the pathogenesis of many vascular diseases. ROCK activation is associated with Th17 differentiation and production of Th17-associated cytokines, IL-17 and…
Abstract Number: 602 • 2013 ACR/ARHP Annual Meeting
Repeat Biopsy In Lupus Nephritis: A Single-Center Experience
Josefina Marin¹, Marina Scolnik², Eliana Lancioni³, Gustavo Greloni⁴, Cristian Quiroz⁵, Johana Zacariaz³, Carla Saucedo⁶, Luis J. Catoggio² and Enrique R. Soriano², ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ³Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁶Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Renal involvement in systemic lupus erythematosus (SLE) is an important cause of morbidity and even mortality. Lupus nephritis has diverse morphologic manifestations with varying clinical…
Abstract Number: 603 • 2013 ACR/ARHP Annual Meeting
Factors Associated With a Double Increase In Serum Creatinine In Biopsy Proven Lupus Nephritis From a Single Center In Spain
Raúl Menor Almagro¹, M. H. Cardiel², Javier Rubio Garrido³, J. Luis de la Iglesia¹, José Javier Perez Venegas¹, María Mar Ruiz Tudela¹, José Javier Salaberri¹ and Manuel Paez-Camino¹, ¹Rheumatology, Hospital de Jerez, Jerez de la Frontera, Spain, ²Centro de Investigacion Clinica de Morelia, Morelia, Mexico, ³Pathology, Hospital de Jerez, Jerez de la Frontera, Spain
Background/Purpose: Lupus nephritis is a common and feared complication in systemic lupus erythematosus (SLE). Clinicians have relied on different variables to help to predict those…
Abstract Number: 594 • 2013 ACR/ARHP Annual Meeting
Renal Biopsy Findings In Lupus Patient With Insignificant Proteinuria : Relation To Disease Activity and Clinical Manifestations
Abdel Azeim M. Al-Hefny¹, Samah El-bakry², Sameh A. Mobasher³, Ola H. Nada⁴ and Nouran Abaza⁵, ¹Department of Internal Medicine and Rheumatology, Professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Cairo, Egypt, ²Department of Internal Medicine and Rheumatology, Assistant professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ³Department of Internal Medicine and Rheumatology, Lecturer of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁴Department of Pathology, Faculty of Medicine, Ain Shams University, Lecturer of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁵Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background/Purpose: Lupus nephritis (LN) remains one of the most serious manifestations of systemic lupus erythematosus (SLE) and is associated with significant morbidity and mortality. Early…

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