ACR Meeting Abstracts

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Abstracts tagged "biopsies"

  • Abstract Number: 1963 • 2015 ACR/ARHP Annual Meeting

    Specialty of Provider Referring for Temporal Artery Biopsy Affects the Likelihood of Giant Cell Arteritis (GCA) Diagnosis

    Lindsay Lally1 and Robert F. Spiera2, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Rheumatology, HSS, New York, NY

    Background/Purpose: Presenting signs/symptoms of GCA can be nonspecific and patients can initially present to a spectrum of clinical specialties.  While temporal artery biopsy (TAB) is…
  • Abstract Number: 2160 • 2015 ACR/ARHP Annual Meeting

    The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis: A Diagnostic Accuracy and Cost-Effectiveness Study

    Raashid Luqmani1, Ellen Lee2, Surjeet Singh3, Michael Gillett2, Wolfgang A. Schmidt4, Mike Bradburn2, Bhaskar Dasgupta5,6, Andreas P Diamantopoulos7, Wulf Forrester-Barker8, William Hamilton9, Shauna Masters10, Brendan McDonald11, Eugene McNally8, Colin T. Pease12, Jennifer Piper8, John Salmon13, Allan Wailoo2, Konrad Wolfe14, Andrew Hutchings15 and TABUL Study group, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, 31Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 4Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 5Rheumatology, Southend University Hospital, Essex, United Kingdom, 6Southend University Hospital, Essex, United Kingdom, 7Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 9Primary Care, University of Exeter, Exeter, United Kingdom, 10Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, 11Department of Neuropathology and Ocular Pathology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 12Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 13Ophthalmology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 14Department of Pathology, Southend University Hospital, Essex, United Kingdom, 15Health Services Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

    Background/Purpose: Giant cell arteritis (GCA) is a relatively common form of primary systemic vasculitis which if untreated can lead to permanent sight loss. It is…
  • Abstract Number: 2361 • 2015 ACR/ARHP Annual Meeting

    Abatacept in the Treatment of Adult Dermatomyositis and Polymyositis: a Randomized, Treatment Delayed-Start Trial  

    Ingrid E. Lundberg1, Anna Tjärnlund2, Quan Tang3, Cecilia Wick2, Maryam Dastmalchi4, Herman F Mann5, Jana Tomasová Studýnková5, Radka Chura6, Nicola J. Gullick7, Rosaria Salerno7, Eva Lindroos3,8, Patrick Gordon6 and Jiri Vencovsky5, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 4Department of Medicine, Solna, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 5Institute of Rheumatology, Prague, Czech Republic, 6Department of Rheumatology, King`s College Hospital NHS Foundation Trust, London, United Kingdom, 7Rheumatology, Department of Rheumatology, King`s College Hospital NHS Foundation Trust, London, United Kingdom, 8Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden

    Background/Purpose: The aim of the study was to assess the effects of abatacept, a T cell blocking agent, on disease activity and on muscle biopsy…
  • Abstract Number: 2911 • 2015 ACR/ARHP Annual Meeting

    Tubulointerstitial Involvement in Lupus Nephritis

    Angela Pakozdi1, Ravindra Rajakariar2, Michael Sheaff3 and Dev Pyne1, 1Rheumatology, Barts Health NHS Trust, London, United Kingdom, 2Renal Medicine, Barts Health NHS Trust, London, United Kingdom, 3Histopathology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose: Tubulointerstitial disease is frequent in lupus nephritis (LN) with immune deposits being present in up to one third of patients.[1,2] Lesions including interstitial infiltration,…
  • Abstract Number: 2912 • 2015 ACR/ARHP Annual Meeting

    Concomitant Kidney Disease in Patients with Lupus Nephritis

    Paul Hoover1, Jose A. Gomez Puerta2, Alexander Fine1, Helmut Rennke3 and Karen H. Costenbader4, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Grupo de Inmunología e Inmunogenética, GICIG, Universidad de Antioquia, Medellín, Colombia, Medellín, Colombia, 3Pathology, Brigham and Women's Hospital, Boston, MA, 4Rheumatology, Immunology & Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: The most common and clinically and histologically best-characterized SLE kidney disease is lupus nephritis (LN).  However, other forms of kidney disease can and do…
  • Abstract Number: 2917 • 2015 ACR/ARHP Annual Meeting

    Combined Proliferative and Membranous Lupus Nephritis: Is the Prognosis Really Poor?

    Ryota Sakai1, Akiko Shibata1, Kentaro Chino1, Jun Kikuchi2, Tsuneo Kondo1, Ayumi Okuyama1, Hirofumi Takei1 and Koichi Amano1, 1Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, 2Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan

    Background/Purpose: Using light microscopy (LM) or immunofluorescence (IF), combined proliferative and membranous lupus nephritis (LN) is defined as an active proliferative class III/IV lesion and…
  • Abstract Number: 175 • 2015 ACR/ARHP Annual Meeting

    Correlating Semiquantitative Ultrasound Scores with Measured Synovial Thickness

    Ralf G. Thiele1, Darren Tabechian1, Laura C Coates2 and Jennifer H. Anolik1, 1University of Rochester Medical Center, Rochester, NY, 2Medicine, University of Rochester, Rochester, NY

    Background/Purpose: In studies of rheumatoid arthritis using ultrasonography (US), findings of synovial thickening are often reported in semiquantitative scores. For synovial biopsies of small joints,…
  • Abstract Number: 185 • 2015 ACR/ARHP Annual Meeting

    Success Rate and Utility of Ultrasound Guided Synovial Biopsies in Clinical Practice

    Aurélie Najm, Benoît Le Goff and Yves Maugars, Rheumatology, Rheumatology, Nantes, France

    Background/Purpose: Histological and bacteriological analysis of synovial tissue (ST) can be useful in the diagnosis of arthritis of undetermined origin. Ultrasound can assist this biopsy…
  • Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting

    High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis

    Khalil I. Bourji1, Alain Meyer2,3, Emmanuel Chatelus2, Erika Pigatto1, François Singh3, Bernard Geny3, Leonardo Punzi1, Jacques-Eric Gottenberg2, Franco Cozzi1 and Jean Sibilia2, 1Division of Rheumatology, University Hospital of Padova, Padova, Italy, 2Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 3Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, France

    Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
  • Abstract Number: 1656 • 2014 ACR/ARHP Annual Meeting

    Rate of Histological Transformation to Higher Grade  Nephritis in Class II Mesangial Proliferative Lupus Glomerulonephritis

    Andrea Zacarias1, Javier Narváez2, Gloria Albert1, Milagros Ricse1, Paula Estrada1, Melany Pestaña3, Chema Mora3, Jesus Rodriguez Moreno1, Xavier Fulladosa4, Manel Rubio Rivas3 and Joan Miquel Nolla1, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 3Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, 4Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: Class II mesangial proliferative lupus nephritis has generally been considered a mild form of the condition, with a good response to glucocorticoid treatment. However,…
  • Abstract Number: 1655 • 2014 ACR/ARHP Annual Meeting

    Lupus Nephritis: Clinicopathological Correlation in 126 Biopsies

    Milagros Ricse1, Javier Narváez2, Gloria Albert1, Paula Estrada1, Helena Borrell1, Eugenia de Lama3, Xavier Fulladosa4, Manel Rubio Rivas5, Olga Capdevila5, Francesca Mitjavila5, Xavier Juanola6 and Joan Miquel Nolla1, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 3Radiology, Hospital Universitario de Bellvitge, Barcelona, Spain, 4Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, 5Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, 6Rheumatology, University Hospital Bellvitge, Barcelona, Spain

    Background/Purpose: To analyze the correlation between clinical and laboratory data and type of histological injury in a cohort of patients with lupus nephritis (LN). Methods:…
  • Abstract Number: 1661 • 2014 ACR/ARHP Annual Meeting

    Are Repeat Renal Biopsies Important in Managing Lupus Nephritis Flares?

    Angela Pakozdi1, Ravindra Rajakariar2, Michael Sheaff3 and Dev Pyne1, 1Rheumatology, Barts Health NHS Trust, London, United Kingdom, 2Renal Medicine, Barts Health NHS Trust, London, United Kingdom, 3Histopathology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose Lupus nephritis (LN) is the major cause of morbidity and mortality in patients with systemic lupus erythematosus. The role of repeat kidney biopsies (RB)…
  • Abstract Number: 1659 • 2014 ACR/ARHP Annual Meeting

    The Clinical Relevance of a Repeat Biopsy in Lupus Nephritis (LN) Flares

    Milagros Ricse1, Javier Narváez2, Gloria Albert1, Paula Estrada1, Sergi Heredia1, Andrea Zacarias1, Helena Borrell1, Eulalia Armengol1, Xavier Fulladosa3, Joan Torras3, Olga Capdevila4, Francesca Mitjavila4 and Joan Miquel Nolla1, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 3Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, 4Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: Renal biopsy is the gold standard for assessing renal activity and hence guiding treatment. Whether a repeat renal biopsy is helpful during flares of…
  • Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting

    A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis

    Stefania Croci1, Alessandro Zerbini1, Luigi Boiardi2, Francesco Muratore2, Alessandra Bisagni3, Giulia Pazzola2, Luca Cimino4, Antonio Moramarco4, Davide Nicoli5, Enrico Farnetti6, Bruno Casali6, Alberto Cavazza3, Maria Parmeggiani7 and Carlo Salvarani2, 1Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 5Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 6Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 7Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy

    Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
  • Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting

    Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients

    Surjeet Singh1, Andrew Hutchings2, Wulf Forrester-Barker3, Bhaskar Dasgupta4, Andreas P. Diamantopoulos5, Peter Lanyon6, Malgorzata Magliano7, Brendan McDonald8, Konrad Wolfe9 and Raashid Luqmani10, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 4Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 5Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 6Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 7Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, 8Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, 9Department of Pathology, Southend University Hospital, Essex, United Kingdom, 10Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom

    Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
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