Abstracts tagged "biopsies"

Abstract Number: 1360 • 2019 ACR/ARP Annual Meeting
Ultrasound Guided Synovial Biopsies Safely Aid in the Assessment of Inflammatory Arthritis
Khin Lim¹, Ami Ben-artzi ¹, Lindsy Forbess ¹, Swamy Venuturupalli ², John Jalas ³ and Mariko Ishimori ¹, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars Sinai Medical Center, Los Angeles, CA, ³Saint John Health Center, Los Angeles, CA
Background/Purpose: Synovial biopsies have an important role in the diagnostic evaluation of patients with undifferentiated inflammatory arthritis (UIA) whose clinical examination and blood and synovial…
Abstract Number: 2556 • 2019 ACR/ARP Annual Meeting
Histologic Findings from Paired Renal Biopsies and Clinical Outcomes: Results from a Single Site in the Phase III Study of Abatacept in Patients with Proliferative LN
Ana Malvar¹, Valeria Alberton ², Cecilia Recalde ², Sheng Gao ³ and Michael Maldonado ³, ¹Hospital Fernandez; Organización Maedica de Investigación, Buenos Aires, Argentina, ²Hospital Fernandez, Buenos Aires, Argentina, ³Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Current therapeutic management of active Class III or IV proliferative LN relies on the use of maintenance therapy following induction. The optimal method for…
Abstract Number: 1078 • 2018 ACR/ARHP Annual Meeting
Standardization of Synovial Biopsies Procedures across Centers: A Consensus Initiative Using a Delphi Survey
Aurélie Najm^1,2, Benoît Le Goff MD PhD^3,4, Carl Orr⁵, Rogier Thurlings⁶, Juan D. Cañete⁷, Frances Humby⁸, Stefano Alivernini⁹, Søren Andreas Just¹⁰, Vasco C. Romão¹¹, Veit Krenn¹², Ulf Müller-Ladner¹³, Olga Addimanda¹⁴, Antonio Manzo¹⁵, Sander W. Tas¹⁶, Patrick Durez¹⁷, Laurent Meric de Bellefon¹⁷, Maria Stoenoiu¹⁸, Vibeke Strand¹⁹, Mihir D Wechalekar²⁰, João E. Fonseca²¹, Bernard R. Lauwerys²² and Douglas J. Veale²³, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Department of Rheumatology, Nantes University Hospital, Nantes, France, ³Rheumatology, Nantes University Hospital, Nantes, France, ⁴UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁸Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁹Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ¹⁰Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, ¹¹Rheumatology Department, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ¹²Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany, ¹³Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany, ¹⁴Medicine & Rheumatology Unit, Rizzoli Orthopaedic Institute, Bologna, ., Italy, ¹⁵Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, ¹⁶Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ¹⁷Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ¹⁸Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Bruxelles, Belgium, ¹⁹Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ²⁰Royal Adelaide Hospital, Adelaide, Australia, ²¹Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ²²Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Synovial biopsies are increasingly performed in both clinical setting and translational research. Synovial tissue analysis role in prediction of response to treatment is to…
Abstract Number: 1468 • 2018 ACR/ARHP Annual Meeting
Minor Salivary Gland Biopsy: Its Importance in Rheumatoid Arthritis and Secondary Sjögren’s Syndrom
Maria Florencia Rodriguez¹, Cristian Troitiño², Emmanuel Guerra³, Fernando Melo⁴, Anastasia Secco⁵, Natalia Tamborenea³, María Victoria Martire⁶ and Marta Mamani⁴, ¹Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ²Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ³Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ⁶Instituto Médico Platense, La Plata, Argentina
Background/Purpose: Secondary Sjögren's Syndrome (sSS) is a common extraarticular manifestation in patients with Rheumatoid Arthritis (RA). According to the 2002 European American criteria (EA 2002)…
Abstract Number: 1779 • 2018 ACR/ARHP Annual Meeting
Is the Number of IgG4+ Plasma Cells Observed By Immunostaining Important Beyond Its Diagnostic Utility in IgG4-Related Disease?
Eduardo Martín Nares¹, Jacobo Guerrero Castillo², Arturo Angeles Angeles² and Gabriela Hernandez-Molina¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The histopathological findings in IgG4-related disease (IgG4-RD) includes the presence of dense lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis and the presence of marked IgG4+…
Abstract Number: 2736 • 2018 ACR/ARHP Annual Meeting
Value of Histology for Diagnosis and Classification in ANCA Associated Vasculitis
Julia Kronfeldner¹, Johanna Eifert¹, Stefanie Quickert¹, Peter Oelzner¹, Martin Busch¹, Claus Kroegel², Gunter Wolf¹, Benjamin Seeliger³ and Thomas Neumann^4,5, ¹Department of Internal Medicine III, Jena University Hospital, Jena, Germany, ²Department of Internal Medicine I, Jena University Hospital, Jena, Germany, ³Department of Respiratory Medicine, Medical School Hannover, Hannover, Germany, ⁴Internal Medicine III, Jena University Hospital, Jena, Germany, ⁵Department of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Diagnosis of ANCA-associated vasculitis (AAV) and the classification of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) is based…
Abstract Number: 2761 • 2018 ACR/ARHP Annual Meeting
High-Dose Prednisone Use up to 42 Days Prior to Temporal Artery Biopsy (TAB) Did Not Reduce Yield of Positive Biopsy in the Veterans Health Administration (VHA) Database Cohort
Sarah H. Chung¹, Meredith B. Morcos¹ and Bernard Ng^1,2, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA
Background/Purpose: Temporal artery biopsy (TAB) currently remains the gold-standard confirmatory test for the diagnosis of giant cell arteritis (GCA); positive TAB justifies long-term steroid use…
Abstract Number: 2762 • 2018 ACR/ARHP Annual Meeting
A Longer or Bilateral Temporal Artery Biopsy (TAB) Is More Likely to Yield a Positive Result for Giant Cell Arteritis (GCA) in the Veterans Health Administration (VHA) Database Cohort
Sarah H. Chung¹, Meredith B. Morcos¹ and Bernard Ng^1,2, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA
Background/Purpose: TAB is currently considered the gold standard for the diagnosis of GCA. However, it is suspected that the sensitivity of TAB is limited by…
Abstract Number: 2769 • 2018 ACR/ARHP Annual Meeting
A Single Center Experience of Temporal Artery Biopsies Performed in 30 African American Patients
Ammar Haikal¹, Garth Fraga², Jason Springer¹ and Mehrdad Maz³, ¹Department of Internal Medicine, The University of Kansas Medical Center, Division of Allergy, Clinical Immunology & Rheumatology, Kansas City, KS, ²The University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, ³Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large and medium-sized arteries mostly reported in Caucasians (CCs) over 50 y.o. There is limited…
Abstract Number: 2776 • 2018 ACR/ARHP Annual Meeting
Interleukin-6 Expression in Inflamed and Non-Inflamed Temporal Arteries from Patients with Giant Cell Arteritis
Nicolò Pipitone¹, Francesco Muratore², Ione Tamagnini³, Alberto Cavazza⁴, Luca Cimino⁵, Luigi Boiardi², Giovanna Restuccia⁶, Martina Bonacini⁷, Stefania Croci⁷ and Carlo Salvarani⁸, ¹Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ²Unit of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy, ³Pathology Unit, Department of Oncology, Arsicpedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁵Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unitn, Arcispedale S Maria Nuova, IRCCS, 42100, Italy, ⁷Unit of Clinical Immunology, Allergy and Advanced Biotechnologies, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy, ⁸Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy
Background/Purpose: To evaluate if interleukin-6 (IL-6) expression in the temporal artery biopsy (TAB) specimens may differentiate patients with giant cell arteritis (GCA) from those without.…
Abstract Number: 2782 • 2018 ACR/ARHP Annual Meeting
Is It Necessary to Hold Anticoagulation Prior to Temporal Artery Biopsy?
Mahjabeen Haq¹, Danielle Schwartz¹, Monica Weinberg¹, Jillian Cepeda¹, Erin Taub², Asha Patniak³ and Qingping Yao⁴, ¹Department of Medicine-Rheumatology, Allergy, and Immunology Division, Stony Brook University Hospital, stony brook, NY, ²Department of Medicine, Stony Brook University Hospital, stony brook, NY, ³Stony Brook University Hospital, Stony Brook, NY, ⁴Rheumatology, Allergy and Immunology, Stony Brook University Hospital, Stony Brook, NY
Background/Purpose: Giant cell arteritis (GCA) and Temporal arteritis (TA) is characterized by chronic granulomatous inflammation in medium and large-sized vessels. It affects 20 in 100,000…
Abstract Number: 463 • 2018 ACR/ARHP Annual Meeting
Percentage of Glomerular Crescents Predicts Renal Outcomes in Childhood-Onset Lupus Nephritis
Pooja Patel¹, Marietta M. De Guzman¹, Joseph Maliakkal², Michelle Rheault³, David Selewski⁴, Katherine Twombley⁵, Jason Misurac⁶, Cheryl Tran⁷, Alexandru Constantinescu⁸, Ali Mirza Onder⁹, Meredith Seamon¹⁰, Vaishali Singh¹¹, Cynthia Pan¹¹, Joseph Flynn¹², Abiodun Omoloja¹³, William Smoyer¹⁴, Guillermo Hidalgo¹⁵ and Scott E. Wenderfer¹⁶, ¹Pediatrics-Rheumatology, Baylor College of Medicine, Houston, TX, ²Pediatrics-Renal, Saint Louis University, St. Louis, MO, ³Pediatrics-Renal, University of Minnesota, Minneapolis, MN, ⁴Pediatrics-Renal, University of Michigan, Ann Arbor, MI, ⁵Pediatrics-Renal, Medical University of South Carolina, Charleston, SC, ⁶Pediatrics-Renal, University of Iowa, Iowa City, IA, ⁷Pediatrics-Renal, Mayo Clinic, Rochester, MN, ⁸Pediatrics-Renal, Joe DiMaggio Children’s Hospital, Hollywood, FL, ⁹Pediatrics-Renal, University of Tennessee, Memphis, TN, ¹⁰Pediatrics-Renal, The University of Utah, Salt Lake, UT, ¹¹Pediatrics-Renal, Medical College of Wisconsin, Wauwatosa, WI, ¹²Pediatrics-Renal, Seattle Children's Hospital, Seattle, WA, ¹³Pediatrics-Renal, Wright State University, Dayton, OH, ¹⁴Pediatrics-Renal, Nationwide Children’s Hospital, Columbus, OH, ¹⁵Pediatrics-Renal, East Carolina University, Greenville, NC, ¹⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX
Background/Purpose: Outcomes for childhood-onset crescentic lupus nephritis are unclear. The revised classification system for lupus nephritis by the Renal Pathology Society clearly distinguishes between cellular,…
Abstract Number: 724 • 2018 ACR/ARHP Annual Meeting
Are Traditional Biomarkers of Lupus Associated with Renal Pathology in Lupus Nephritis?
Kelly Liang¹, Kimberly P. Liang², Yaming Li³, Alex Hurd³, Douglas Landsittel⁴ and Sheldon Bastacky⁵, ¹Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Biostatistics, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Traditional biomarkers for systemic lupus erythematosus (SLE) and lupus nephritis (LN) include serum creatinine (Cr), complement levels (C3/C4), double-stranded DNA antibody (dsDNA), erythrocyte sedimentation…
Abstract Number: 775 • 2018 ACR/ARHP Annual Meeting
Endomyocardial Biopsies in the Diagnosis of Myocardial Involvement in Systemic Lupus Erythematosus
Laura Geraldino-Pardilla¹, Teja Kapoor², Thania Perez³ and Anca Askanase³, ¹Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Myocardial dysfunction is reported in over half of systemic lupus erythematosus (SLE) patients, yet the underlying pathogenesis remains poorly understood. Endomyocardial biopsies (EMBs) are…
Abstract Number: 820 • 2018 ACR/ARHP Annual Meeting
Incidence And Seasonal Variation Of Biopsy-Proven Giant Cell Arteritis – Revisited: A 20-Year Population-Based Study From Sweden
Pavlos Stamatis¹, Carl Turesson², Jan-Åke Nilsson² and Aladdin Mohammad³, ¹Clinical Sciences, Rheumatology Lund, Lund University, Lund, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden
Background/Purpose: To investigate the incidence rate and seasonal variation of biopsy-proven giant cell arteritis (GCA) in a well-defined population in southern Sweden. Methods: The study…

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