Abstracts tagged "biomarkers and rheumatoid arthritis (RA)"

Abstract Number: 89 • 2015 ACR/ARHP Annual Meeting
A Longitudinal Genome-Wide Association Study of Anti-Tumor Necrosis Factor Response Among Japanese Patients with Rheumatoid Arthritis
Kyoko Honne¹, Ingileif Hallgrimsdottir², Chunsen Wu³, Ronnie Sebro⁴, Nicholas Jewell², Takeo Sakurai⁵, Masahiro Iwamoto⁶, Seiji Minota⁶ and Damini Jawaheer⁷, ¹Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ²UC Berkeley, Berkeley, CA, ³University of Southern Denmark, Odense, Denmark, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Inoue Hospital, Takasaki, Japan, ⁶Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ⁷Children's Hospital Oakland Research Institute, Oakland, CA
Background/Purpose: Studies of patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have been conducted mostly in Caucasian populations.…
Abstract Number: 491 • 2015 ACR/ARHP Annual Meeting
A Paradigm Shift in the Disease Assessment of Rheumatoid Arthritis : From Blood to Urine Testing
Wan-Uk Kim¹, Yune-Jung Park², Seung-Ah Yoo³, Bong Ki Hong³, Gi myo Kim⁴, Susanna Choi⁵, Saseong Lee³ and Chul-Soo Cho⁶, ¹Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea, ³Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea, ⁴Institute of bone and joint diseases, Catholic university, seoul, South Korea, ⁵Institute of Bone and Joint diseases, The Catholic University of Korea, seoul, South Korea, ⁶Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: To optimize treatment for rheumatoid arthritis (RA), it is ideal to monitor disease activity on a daily basis such as glucose measurement since RA…
Abstract Number: 607 • 2015 ACR/ARHP Annual Meeting
Serum Progranulin (PRGN) Level Is Not a Biomarker for Responsiveness to Tumor Necrosis Factor (TNF)-Antagonist Therapy in Rheumatoid Arthritis (RA) Patients
Rosy Rajbhandary¹, Rebekah Neal², Jennifer Johnson³, Qingyun Tian⁴, Jinlong Jian⁵, Chuanju Liu⁶ and William Stohl², ¹Medicine/Rheumatology, LAC+ USC Medical Center, Los Angeles, CA, ²Div of Rheumatology, USC, Los Angeles, CA, ³Medicine, Keck School of Medicine of USC, Los Angeles,, CA, ⁴Nyu,Hid,301 E 17th St, New York University Medical Center, New York, NY, ⁵301 E. 17th St., Rm 1600, New York, NY, ⁶NYU Hospital for joint Diseases, New York, NY
Background/Purpose: PRGN is a growth factor that binds TNF receptors without triggering TNF-like activity, thereby serving as a naturally-occurring antagonist of TNF -mediated inflammatory signaling.…
Abstract Number: 618 • 2015 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Score in Methotrexate Incomplete Responders Predicts Clinical Responses to Non-Biological Versus Biological Therapy in Early RA
Karen Hambardzumyan¹, Rebecca J. Bolce², Saedis Saevarsdottir³, Kristina Forslind^4,5, Johan A Karlsson⁶ and Ronald F. van Vollenhoven¹, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ²Crescendo Bioscience Inc., South San Francisco, CA, ³Department of Medicine, Rheumatology Unit, The Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, ⁵Departments of Rheumatology, Helsingborgs Hospital and University of Lund, Helsingborg and Lund, Sweden, ⁶Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: The Swedish Farmacotherapy (SWEFOT) trial and other trials in rheumatoid arthritis (RA) demonstrated that in MTX incomplete responder patients (MTX-IR) the addition of anti-TNF…
Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
Abstract Number: 1571 • 2015 ACR/ARHP Annual Meeting
How Substantive Is Heart Rate Variability As a Predictor of Anti-TNF Treatment Outcome for Inflammatory Arthritis?
Andrew Holman¹ and Edmund Ng², ¹Inmedix, Normandy Park, WA, ²Statistical Thinking, Seattle, WA
Background/Purpose: As rheumatologists search for new targets to improve immunosuppressive outcomes, the autonomic nervous system (ANS) as a co-factor in autoimmune disease expression has gained…
Abstract Number: 1680 • 2015 ACR/ARHP Annual Meeting
Selective JAK1 Inhibition with Filgotinib (GLPG0634) Decreases Plasma Markers of Inflammation and Joint Damage in Patients with Rheumatoid Arthritis
René Galien¹, Annegret Van der Aa², Roland Blanque¹, Sophie Darquenne¹, Pille Harrison² and Chantal Tasset², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium
Background/Purpose: Among the 4 Janus kinase (JAK) family members, JAK1 often has a dominant role in the intracellular signaling for cytokines involved in auto-immune and…
Abstract Number: 2781 • 2015 ACR/ARHP Annual Meeting
Absence of Effects of Filgotinib on Erythrocytes, CD8+ and NK Cells in Rheumatoid Arthritis Patients Brings Further Evidence for the JAK1 Selectivity of Filgotinib
René Galien^1,2, Reginald Brys³, Annegret Van der Aa³, Pille Harrison³ and Chantal Tasset³, ¹Galapagos SASU, Romainville, France, ²102 Avenue Gaston Roussel, Galapagos SASU, Romainville, France, ³Galapagos NV, Mechelen, Belgium
Background/Purpose: The distinct role of JAK family members (JAK1, JAK2, JAK3 and TYK2) in signaling for cytokines and growth factors has established these kinases as…
Abstract Number: 2086 • 2014 ACR/ARHP Annual Meeting
Replication of PTPRC As Genetic Biomarker of Response to TNF Inhibitors in Patients with Rheumatoid Arthritis
Antonio Gonzalez¹, Aida Ferreiro-Iglesias², Juan Gomez-Reino³ and on Behalf of Their Collaborators⁴, ¹Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²Insitituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ³Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ⁴multiple, multiple, Spain
Background/Purpose The use of biomarkers to predict response to the different drugs available for treating rheumatoid arthritis (RA) is a very desirable goal. However, success…
Abstract Number: 2020 • 2014 ACR/ARHP Annual Meeting
Circulating Carotenoids and Subsequent Risk of Rheumatoid Arthritis
Yang Hu¹, Karen H. Costenbader², Elizabeth W. Karlson² and Bing Lu², ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Antioxidant components in food may be biologically relevant to the prevention of rheumatoid arthritis (RA). Evidence from prospective cohort studies regarding the relationship between…
Abstract Number: 409 • 2014 ACR/ARHP Annual Meeting
Soluble CD163 Is a Marker of Disease Activity in Early Rheumatoid Arthritis and Reflects TNFα Levels
Stinne Greisen¹, Holger Jon Møller², Kristian Steengaard-Petersen³, Merete Lund Hetland⁴, Kim Hoerslev-Petersen⁵, Peter Junker⁶, Mikkel Ostergaard⁷, Malene Hvid¹ and Bent Deleuran¹, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴DANBIO, Center for Rheumatology and Spine Diseases, Glostrup University Hospital, Glostrup, Denmark, Glostrup, Denmark, ⁵Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁶Odense University Hospital, Odense, Denmark, ⁷Copenhagen University Hospital at Glostrup, Copenhagen, Denmark
Background/Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and eventually destruction, where TNFa is a central mediator of both processes.…
Abstract Number: 404 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Disease Activity and Levels of HMGB1 in Patients with Rheumatoid Arthritis
David S. Pisetsky^1,2, Diane Spencer³, Stephen R. Wisniewski⁴, Jason Lyons⁴, Melissa Saul⁵, Mandy J. McGeachy⁶, Yong Gil Hwang⁷, Heather Eng⁴ and Larry W. Moreland⁶, ¹Medical Research Service, Durham VAMC, Durham, NC, ²Duke University Medical Center, Durham, NC, ³Medicine, Duke University Medical Center, Durham, NC, ⁴Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁵Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁶Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose HMGB1 (High Mobility Group Box 1), a non-histone nuclear protein, is a prototypic alarmin that displays immunological activity following release during cell death or…
Abstract Number: 367 • 2014 ACR/ARHP Annual Meeting
In Early Rheumatoid Arthritis Patients with Non-Response to Methotrexate Monotherapy the Change in Multi-Biomarker Disease Activity Score Is Differentially Associated with Subsequent Response to Non-Biological Versus Biological Therapy
Karen Hambardzumyan¹, R.J. Bolce², Saedis Saevarsdottir³, Kristina Forslind⁴, Ingemar F. Petersson⁵, Pierre Geborek⁶, Eric H. Sasso², David Chernoff², Scott Cruickshank⁷ and Ronald F. van Vollenhoven⁸, ¹ClinTRID, the Karolinska Institute, Stockholm, Sweden, ²Crescendo Bioscience Inc., South San Francisco, CA, ³Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Lund University, Lund, Sweden, ⁶Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁷Scott Cruickshank and Associates, Inc., Santa Barbara, CA, ⁸Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden
Background/Purpose For patients with early RA (eRA), methotrexate (MTX) is recommended as first-line treatment and in non-responders both the addition of conventional non-biological disease modifying…
Abstract Number: 875 • 2013 ACR/ARHP Annual Meeting
Microrna Expression Profiles Associated With Response To Adalimumab and Methotrexate Versus Methotrexate: A Placebo-Controlled Clinical Trial
Sophine B. Krintel¹, Christian Dehlendorff², Merete Lund Hetland³, Kim Hørslev-Petersen⁴, Klaus K. Andersen², Peter Junker⁵, Jan Pødenphant⁶, Torkell Ellingsen⁷, Palle Ahlqvist⁸, Hanne M. Lindegaard⁹, Asta Linauskas¹⁰, Annette Schlemmer¹¹, Mette Y. Dam¹², Ib Hansen¹³, Hans Chr Horn¹⁴, Anette Jørgensen¹⁵, Johnny Raun¹⁶, Christian G. Ammitzbøll¹², Mikkel Østergaard¹⁷, Kristian Stengaard-Pedersen¹² and Julia S. Johansen¹⁸, ¹Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, ²Danish Cancer Society Research Center, Copenhagen, Denmark, ³DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, ⁴Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, ⁵University of Southern Denmark, Odense, Denmark, ⁶Copenhagen University at Gentofte, Hellerup, Denmark, ⁷Silkeborg Regional Hospital, Silkeborg, Denmark, ⁸University of Southern Denmark, Vejle, Denmark, ⁹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Vendsyssel Hospital, Hjørring, Denmark, ¹¹Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ¹²Arhus University Hospital, Aarhus, Denmark, ¹³Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹⁴Internal Medicine/Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁵Rheumatology, Arhus University Hospital, Aarhus, Denmark, ¹⁶University of Southern Denmark, Graasten, Denmark, ¹⁷Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ¹⁸Department of Internal Medicine and Oncology, Herlev Hospital, Herlev, Denmark
Background/Purpose: The response to anti-TNF therapy varies widely between patients with rheumatoid arthritis (RA). MicroRNAs (miRNAs) are suggested to influence susceptibility to RA and disease…
Abstract Number: 478 • 2013 ACR/ARHP Annual Meeting
Analysis Of The JAK1 Selectivity Of GLPG0634 and Its Main Metabolite In Different Species, Healthy Volunteers and Rheumatoid Arthritis Patients
René Galien¹, Béatrice Vayssière¹, Steve de Vos², Marielle Auberval¹, Nick Vandeghinste², Sonia Dupont¹, Philippe Clément-Lacroix¹, Philippe Delerive¹, Frédéric Vanhoutte², Reginald Brys², Annegret Van der Aa², Luc Van Rompaey² and Gerben van 't Klooster², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium
Background/Purpose: The 4 Janus kinases (JAK1, JAK2, JAK3 and TYK2) are cytoplasmic tyrosine kinases that transduce intracellular signaling for cytokines including interleukins and interferons, and…

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