Abstracts tagged "biomarkers and proteomics"

Abstract Number: 1868 • 2019 ACR/ARP Annual Meeting
Clinical Correlations of Autoantibodies Against Heat Shock Cognate 71 kDa Protein in Patients with Juvenile Dermatomyositis
Rie Karasawa¹, James N. Jarvis ², Toshiko Sato ¹, Megumi Tanaka ¹, Mark Hicar ², Kazuo Yudoh ¹, Terrance O’Hanlon ³, Payam Noroozi-Farhadi ³ and Lisa G. Rider ⁴, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, ³NIEHS, NIH, Bethesda, MD, ⁴Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD
Background/Purpose: Juvenile dermatomyositis (JDM) is an inflammatory myopathy characterized by prominent vascular and perivascular inflammation in affected skeletal muscles. The mechanisms of vessel injury in…
Abstract Number: 765 • 2017 ACR/ARHP Annual Meeting
Proteomic Analysis of Scleroderma Associated Joint Disease
Chan Kim¹, Julio Mantero², Robert A. Lafyatis³ and Robert W. Simms⁴, ¹Rheumatology and Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ²Arthritis Center, Boston University School of Medicine, Boston, MA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: The pathophysiology of joint disease in scleroderma, a heterogeneous multisystem disease mostly characterized by fibrosis, is unknown. We performed proteomic analysis of serum in…
Abstract Number: 1253 • 2015 ACR/ARHP Annual Meeting
Identification and Validation of Novel Putative Salivary Proteomic Biomarkers in Sjögren’s Syndrome and Different Disease Subsets
Chiara Baldini¹, Daniela Martini¹, Nadia Ucciferri², Silvia Rocchiccioli², Letizia Mattii³, Antonietta Raffaella Maria Sabbatini³, Francesca Sernissi¹, Francesco Ferro¹, Nicoletta Luciano¹, Leonardo Lorenzini¹, Marta Mosca⁴, Stefano Bombardieri¹ and Antonella Cecchettini³, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Institute of Clinical Physiology, Pisa, Italy, Pisa, Italy, ³Department of Clinical and Experimental Medicine, University of Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Pisa, Italy
Background/Purpose: Salivary proteomics has recently appeared as a promising tool for the identification of novel diagnostic biomarkers for primary Sjögren’s syndrome (SS). However, to date…
Abstract Number: 2977 • 2014 ACR/ARHP Annual Meeting
Distinct Serum Protein Signature and Novel Biomarkers of primary Sjogren’s Syndrome Revealed by comprehensive High-Throughput Proteomic Analysis
Ayumi Nishikawa¹, Katsuya Suzuki², Yoshiaki Kassai³, Yuumi Gotou⁴, Takahiro Miyazaki³, Maiko Takiguchi⁵, Masaru Takeshita¹, Atsuko Murota², Rimpei Morita⁶, Akihiko Yoshimura⁶ and Tsutomu Takeuchi², ¹Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁵Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Japan, ⁶Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: The EULAR SS Disease Activity Index (ESSDAI) is currently used as an objective evaluation method of clinical disease activity in clinical research into primary…
Abstract Number: 2645 • 2013 ACR/ARHP Annual Meeting
Pathological Roles Of The Anti-Oxidative Enzyme Peroxiredoxin 2 In Patients With Kawasaki Disease
Rie Karasawa¹, Toshiko Sato¹, Mayumi Tamaki¹, Mikiya Fujieda², Kazuhide Ohta³ and Kazuo Yudoh¹, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Department of Pediatrics, Kochi Medical School, Nankoku, Japan, ³Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan
Background/Purpose: Anti-endothelial cell antibodies (AECA) are autoantibodies that are detected frequently in vasculitis caused by, for example, Kawasaki disease (KD). However, AECA target molecules have…
Abstract Number: 1905 • 2013 ACR/ARHP Annual Meeting
Protein Profiles Of Peripheral Blood Mononuclear Cells As a Biomarker For Behcet’s Disease
Manae Kurokawa¹, Takuya Yoshioka², Toshiyuki Sato¹, Kouhei Nagai¹, Nobuko Iizuka¹, Mitsumi Arito¹, Yukiko Takakuwa², Hiromasa Nakano², Seido Ooka², Naoya Suematsu¹, Kazuki Okamoto¹, HIroshi Nakamura³, Noboru Suzuki⁴, Shoichi Ozaki⁵ and Tomohiro Kato¹, ¹Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ²Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³Department of Rheumatology, Nippon Medical School, Bunkyo-ku, Japan, ⁴Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: To investigate the pathophysiology of Behcet’s disease (BD) and find biomarker candidates for the disease, we analyzed protein profiles of peripheral blood mononuclear cells…