Abstracts tagged "biomarkers and nephritis"

Abstract Number: 2850 • 2016 ACR/ARHP Annual Meeting
Changes in Urinary Biomarker Levels Can Predict Treatment Responses in Lupus Nephritis
Joan Wither¹, Stephenie Prokopec², Babak Noamani¹, Dennisse Bonilla¹, Zahi Touma³, Carmen Avila-Casado⁴, Heather Reich⁵, James Scholey⁵, Paul R. Fortin⁶, Paul Boutros² and Carolina Landolt-Marticorena¹, ¹Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Pathology, University Health Network, Toronto, ON, Canada, ⁵Nephrology, University Health Network, Toronto, ON, Canada, ⁶Université Laval, CHU de Québec, Québec, QC, Canada
Background/Purpose: The relapsing and remitting nature of lupus nephritis (LN) poses a challenge to clinicians who must balance the risk of long term kidney damage…
Abstract Number: 2863 • 2016 ACR/ARHP Annual Meeting
High Frequency of Terminally Differentiated CD8+ T Cells Characterize Systemic Lupus Erythematosus Patients with Renal Involvement
Nataly Manjarrez-Orduño¹, Laurence Menard¹, Julie Carman¹, Suzanne Suchard¹, Francesca Casano¹, Deborah Lee¹, Sium Habte¹, Sherif Daouti², Selena Kansal³, Dana Banas³, Can Jiang³, Dawn Stetsko³, Mark Cunningham³, Vivek Jayaswal⁴, Somnath Bandyopadhyay³, Sarah Hu³, Richard A. Furie⁵ and Steven G. Nadler⁶, ¹Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Princeton, NY, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Biocon Bristol-Myers Squibb Research Center, Bangalore, India, ⁵Division of Rheumatology, Northwell Health, Great Neck, NY, ⁶Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: SLE is a highly heterogeneous disease. The identification of disease subtypes with different pathological mechanisms is crucial to identify subjects with different disease progression…
Abstract Number: 1070 • 2015 ACR/ARHP Annual Meeting
CD 14(C-159T) Polymorphism and Soluble CD14 Are Associated with Increased Disease Activity and Nephritis in SLE
Sarit sekhar Pattanaik¹, Aditya kumar Panda², Rashmi ranjan Sahoo¹, Rina Tripathy³ and Bidyut kumar Das¹, ¹Medicine, SCB Medical College, Cuttack, India, ²Centre for Life science, Central University of Jharkand, Ranchi, India, ³Biochemistry, SCB Medical College, Cuttack, India
Background/Purpose: Cluster of differentiation 14 (CD14) plays an important role in innate immune system as a co-receptor in TLRs (2, 4, 7 and 9) signaling.…