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Abstracts tagged "biomarkers and immune activation"

  • Abstract Number: 1916 • ACR/ARHP Annual Meeting 2018

    Neutrophil-to-Lymphocyte Ratio Prospectively Predicts the Development of Rheumatic Immune-Related Adverse Events from PD-1 Inhibitor Therapy

    Christopher McMaster1,2, David Liew3,4, Pallavi Shamdasani5, Jessica Leung3,4, Albert Frauman6,7, Jonathan Cebon7,8 and Russell Buchanan4,9, 1Department of Clinical Pharmacology and Therapeutics, Austin Health, Heidelberg, Australia, 2Health and Biomedical Informatics Centre, University of Melbourne, Parkville, Australia, 3Medicine, University of Melbourne, Parkville VIC, Australia, 4Rheumatology, Austin Health, Heidelberg VIC, Australia, 5Department of Rheumatology, Austin Health, Heidelberg, Australia, 6Department of Clinical Pharmacology and Therapeutics, Austin Health, Melbourne, Australia, 7Medicine, University of Melbourne, Melbourne, Australia, 8Olivia Newton-John Cancer Wellness & Research Centre, Melbourne, Australia, 9Medicine, University of Melbourne, Parkville, Australia

    Background/Purpose: Rheumatic immune-related adverse events (irAEs) from PD-1 inhibitor immune checkpoint immunotherapy can not only lead to cessation of immunotherapy, but also can be disabling…

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