Abstracts tagged "biomarkers and immune activation"

Abstract Number: 1916 • 2018 ACR/ARHP Annual Meeting
Neutrophil-to-Lymphocyte Ratio Prospectively Predicts the Development of Rheumatic Immune-Related Adverse Events from PD-1 Inhibitor Therapy
Christopher McMaster^1,2, David Liew^3,4, Pallavi Shamdasani⁵, Jessica Leung^3,4, Albert Frauman^6,7, Jonathan Cebon^7,8 and Russell Buchanan^4,9, ¹Department of Clinical Pharmacology and Therapeutics, Austin Health, Heidelberg, Australia, ²Health and Biomedical Informatics Centre, University of Melbourne, Parkville, Australia, ³Medicine, University of Melbourne, Parkville VIC, Australia, ⁴Rheumatology, Austin Health, Heidelberg VIC, Australia, ⁵Department of Rheumatology, Austin Health, Heidelberg, Australia, ⁶Department of Clinical Pharmacology and Therapeutics, Austin Health, Melbourne, Australia, ⁷Medicine, University of Melbourne, Melbourne, Australia, ⁸Olivia Newton-John Cancer Wellness & Research Centre, Melbourne, Australia, ⁹Medicine, University of Melbourne, Parkville, Australia
Background/Purpose: Rheumatic immune-related adverse events (irAEs) from PD-1 inhibitor immune checkpoint immunotherapy can not only lead to cessation of immunotherapy, but also can be disabling…