ACR Meeting Abstracts

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Abstracts tagged "biomarkers and diagnosis"

  • Abstract Number: 695 • 2017 ACR/ARHP Annual Meeting

    Development of a Multimarker Model for the Detection of Systemic Lupus Erythematosus Based on New and Traditional Autoantibodies

    Petra Budde1, Hans-Dieter Zucht1, Johannes Schulte-Pelkum1, Daniel Wirtz1, Torsten Witte2, Matthias Schneider3 and Peter Schulz-Knappe1, 1Protagen AG, Dortmund, Germany, 2Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, 3Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

    Background/Purpose:  Given the heterogeneity of clinical presentations, the diagnosis of Systemic Lupus Erythematosus (SLE) can be challenging, in particular in those patients presenting with early…
  • Abstract Number: 263 • 2015 ACR/ARHP Annual Meeting

    Use of Serum Ferritin and Heme Oxygenase 1 for the Diagnosis of Adult-Onset Still’s Disease: A Preliminary Report of Multicenter Study

    Yohei Kirino1, Yasushi Kawaguchi2, Yoshifumi Tada3, Seiji Minota4, Toshiyuki Ota5, Kohei Nagasawa6, Hiroshi Tsukamoto7, Syuji Takei8,9, Takahiko Horiuchi10, Hiroki Takahashi11, Hisae Ichida2, Masahiro Iwamoto4, Atsuhisa Ueda1, Akihide Ohta12, Yoshiaki Ishigatsubo1,13 and Hypercytokinemia Study Group, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 3Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, 4Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 5Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, 6Rheumatic Disease Center, Sawara Hospital, Fukuoka, Japan, 7First Dept of Internal Med, Kyushu University, Fukuoka, Japan, 8School of Health Sciences, Faculty of Medicine,, Kagoshima University, Kagoshima City, Japan, 9School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, 10Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 11epartment of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, 12Department of Adult and Gerontological Nursing, Saga University School of Medicine, Saga, Japan, 13Yokosuka Rheumatic Diseases Center, Yokosuka City Hospital, Yokosuka, Japan

    Background/Purpose: Yamaguchi's criteria for classification of adult-onset Still's disease (AOSD) has been widely applied in clinic despite it was established decades ago.  However, hyperferritinemia, which…
  • Abstract Number: 740 • 2015 ACR/ARHP Annual Meeting

    The Prevalence of Anti-DFS70 Antibodies in an International Inception Cohort of Systemic Lupus Erythematosus

    May Choi1, John G. Hanly2, Murray Urowitz3,4, Juanita Romero-Diaz5, Caroline Gordon6, Sang-Cheol Bae7, Sasha Bernatsky8, Daniel J Wallace9, Joan T. Merrill10, David A. Isenberg11, Anisur Rahman12, Ellen M. Ginzler13, Paul R. Fortin14, Dafna Gladman15, Jorge Sanchez-Guerrero16, Michelle Petri17, Ian N. Bruce18, Mary Anne Dooley19, Rosalind Ramsey-Goldman20, Cynthia Aranow21, Graciela S. Alarcon22, Kristján Steinsson23, Ola Nived24, Gunnar K. Sturfelt25, Susan Manzi26, Munther Khamashta27, Ronald F. van Vollenhoven28, Asad Zoma29, Guillermo Ruiz-Irastorza30, S. Sam Lim31, Thomas Stoll32, Murat Inanc33, Kenneth C. Kalunian34, Diane L. Kamen35, Peter Maddison36, Christine A. Peschken37, Søren Jacobsen38, Anca Askanase39, Jill P. Buyon40, W. Winn Chatham41, Manuel Ramos-Casals42, Yvan St. Pierre43, Ann E. Clarke44 and Marvin J. Fritzler1, 1Medicine, University of Calgary, Calgary, AB, Canada, 2Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, 3Rheumatology, TWH, Toronto, ON, Canada, 4Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 6Rheumatology (East Wing), Medical School, Birmingham, United Kingdom, 7Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 8Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, 9Cedars-Sinai Medical Center, West Hollywood, CA, 10Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 11Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 12Centre for Rheumatology Research, U College of London, London, United Kingdom, 13Medicine/Box 42, SUNY-Downstate, Brooklyn, NY, 14Rheumatology, University of Laval, Quebec, QC, Canada, 15Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 16Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 17Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, 18Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 19UNC Kidney Centre, Chapel Hill, NC, 20Northwestern University Feinberg School of Medicine, Chicago, IL, 21Feinstein Institute for Medical Research, Mahasset, NY, 22Medicine, University of Alabama at Birmingham, Birmingham, AL, 23Rheumatology, Univ. Hospital, Reykjavik, Iceland, 24Rheumatology, Inst of Clinical sciences, Lund, Sweden, 25Department of Rheumatology, Univ Hospital Lund, Lund, Sweden, 26Rheumatology, Allegheny Health Network, Pittsburgh, PA, 27Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 28Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 29Rheumatology, Hairmyres Hospital, East Kilbride, United Kingdom, 30Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, 31Emory University School of Medicine, Atlanta, GA, 32Abteilung Rheumatologie/Rehab, Kantonsspital Schaffhausen, Schaffhausen, Switzerland, 33Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 34Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, 35Medicine, Medical University of South Carolina, Charleston, SC, 36School of Sport, Health and Exercise Sciences, Bangor University, George Building, Bangor, Gwynedd, LL57 2PZ, UK., Bangor, United Kingdom, 37Rheumatology, Univ of Manitoba, Winnipeg, MB, Canada, 38Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 39Columbia University College of Physicians & Surgeons, New York, NY, 40Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 41Medicine/Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 42Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, 43Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 44Immunology/Epidemiology, Montreal General Hospital, Montreal, QC, Canada

    Background/Purpose: Autoantibodies to the nuclear autoantigen dense fine speckles 70 (DFS70) are associated with a new paradigm whereby when they are found in isolation (monospecific…
  • Abstract Number: 2460 • 2014 ACR/ARHP Annual Meeting

    Phospho-STAT1/3 and Gene Expression Measurement in Circulating CD4+ T Cells As Diagnostic Tools in Early Autoantibody-Negative Rheumatoid Arthritis

    Amy E. Anderson1, Arthur G Pratt1, Mamdouh Sedhom2, Nisha Nair3, Jonathan Massey3, Christine Routledge1, Ben Hargreaves1, Philip Brown1, Anne Barton4, John D Isaacs1 and Ranjeny Thomas2, 1Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational Research Institute, The University of Queensland Diamantina Institute, Queensland, Australia, 3NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, 4NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose Early diagnosis of rheumatoid arthritis (RA) improves outcomes but is challenging, particularly amongst anti-citrullinated peptide auto-antibody (ACPA) negative individuals. Previously we identified an IL-6…
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