ACR Meeting Abstracts

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Abstracts tagged "biomarkers and BTK"

  • Abstract Number: 1903 • 2019 ACR/ARP Annual Meeting

    BTK Overexpression Is Associated with the Risk of Lymphoma in Primary Sjögren’s Syndrome: Data from Whole Blood Transcriptome of 346 Patients Followed-up Prospectively for 10 Years

    Pierre-Marie Duret1, Tao Ye 2, Wan-Fai Ng 3, Alain Saraux 4, Valérie Devauchelle Pensec 5, Raphaele Seror 6, Veronique Le-Guern 7, Claire Larroche 8, Aleth Perdriger 9, Jean Sibilia 10, Jessica Tarn 11, Gaetane Nocturne 12, Xavier Mariette 13 and Jacques-Eric Gottenberg 14, 1Hôpitaux civils de Colmar, COLMAR CEDEX, France, 2GenomEAST platform / Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Institut de Génétique et de Biologie Moléculaire, IGBMC, Strasbourg, France, 3Musculoskeletal Research Group Institute of Cellular Medicine Faculty of Medical Sciences Newcastle University, Newcastle, United Kingdom, 4CHU de la Cavale-Blanche Brest, Brest, France, 5University Hospital of Brest, Brest, France, 6Hopitaux universitaires Paris Sud, Kremlin-Bicetre, France, 7Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France,, Paris, France, 8Internal Medicine, Paris, France, Paris, France, 9Rheumatology department, Rennes University Hospital, France, Rennes, France, 10CHU Strasbourg, Strasbourg, France, 11Institute of Cellular Medicine Newcastle University, Newcastle, United Kingdom, 12Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, 13Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, 14Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: To identify a molecular signature associated with lymphomagenesis in primary Sjögren’s Syndrome (pSS).Methods: Whole peripheral blood samples were collected from 346 well-phenotyped pSS patients…
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