ACR Meeting Abstracts

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Abstracts tagged "Biologics"

  • Abstract Number: 324 • 2013 ACR/ARHP Annual Meeting

    Long-Term Safety Of Ustekinumab: 5 Years Of Follow-Up From The Psoriasis Clinical Development Program Including Patients With Psoriatic Arthritis

    Kim Papp1, Christopher E.M Griffiths2, Kenneth B. Gordon3, Mark Lebwohl4, Philippe O. Szapary5, Yasmine Wasfi5, Daphne Chan5, Yaung-Kaung Shen5, Vincent Ho6, Pierre-Dominique Ghislain7, Bruce Strober8 and Kristian Reich9, 1Probity Research, Waterloo, ON, Canada, 2Dermatology Centre, University of Manchester, Manchester, United Kingdom, 3Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Mount Sinai Medical Center, New York, NY, 5Janssen Research & Development, LLC., Spring House, PA, 6University of British Columbia, Vancouver, BC, Canada, 77. Cliniques Universitaires Saint-Luc, Université Catholique de Louvain,, Brussels, Belgium, 8University of Connecticut, Farmington, CT, 9SCIderm Research Institute and Dermatologikum Hamburg, Hamburg, Germany

    Background/Purpose: Ustekinumab(UST) is approved for moderate-to-severe psoriasis (PsO), and is currently in Phase 3 development for psoriatic arthritis (PsA). We report the long-term safety experience…
  • Abstract Number: 2283 • 2013 ACR/ARHP Annual Meeting

    The Evolving Use Of Biologic Monotherapy In Rheumatoid Arthritis and Its Impact On Patient Outcomes

    Laurent Chanroux, Katrina Johnson and Joan Casellas, Therapy Watch, The Research Partnership, London, United Kingdom

    Background/Purpose: The aim of our study is to understand whether the use of biologic monotherapy among rheumatoid arthritis (RA) patients is increasing and whether this…
  • Abstract Number: 1482 • 2013 ACR/ARHP Annual Meeting

    Survival Of Biological Treatment In Chronic Inflammatory Arthritis: A Preliminary Analysis Of 13 Years Of Follow Up In Clinical Practice

    Gabriela Ávila1, Sara Marsal1, Arnald Alonso1, Carolina Diaz2, Estefanía Quesada-Masachs2, María López-Lasanta1 and Isabel Acosta3, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain, 3Vall d'Hebron Hospital Research Institute, Barcelona, Spain

    Background/Purpose: The wide use of biological therapies (BTs) has largely modified the therapeutic approach in Chronic Inflammatory Arthritis (CIA). These relatively new drugs have different…
  • Abstract Number: 717 • 2013 ACR/ARHP Annual Meeting

    Patients With Rheumatoid Arthritis Have Impaired Candida Albicans Specific Th17 Responses But Preserved Oral Candida Albicans Protective Immunity

    Shrinivas Bishu1, E. Wern Su2, Erich Wikerson3, Donald M. Jones4, Kelly A. Reckley5, Sarah L. Gaffen3 and Marc C. Levesque6, 1Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, 2Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 3Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 5Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 6Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) patients are susceptible to infections, even after controlling for the effects of medications.  Recent data suggest an important role for the…
  • Abstract Number: 292 • 2013 ACR/ARHP Annual Meeting

    Body Surface Area-Based Dosing Approach Produced Comparable Golimumab Exposure Across Different Age Ranges After Subcutaneous Administration Of Golimumab In Pediatric Patients With Juvenile Idiopathic Arthritis

    Jocelyn H. Leu1, Alan M. Mendelsohn2, Joyce Ford1, Hugh M. Davis1 and Zhenhua Xu1, 1Janssen Research & Development, LLC., Spring House, PA, 2Immunology, Janssen Research & Development, LLC., Spring House, PA

    Background/Purpose:   To evaluate the pharmacokinetics (PK) of body surface area (BSA)-adjusted dosing of SC golimumab 30 mg/m2 every 4 weeks (q4w) + methotrexate (MTX)…
  • Abstract Number: 2269 • 2013 ACR/ARHP Annual Meeting

    Patient Reported Pain: A Predictor Of Outcomes In Rheumatoid Arthritis From The Consortium Of Rheumatology Researchers Of North America Registry

    Dimitrios A. Pappas1, Chitra K. Karki2, Chin Lee3, George W. Reed4, Ping He5 and Sarah Al Sawah3, 1Columbia University, New York, NY, 2Corrona, LLC., Southborough, MA, 3Eli Lilly and Company, Indianapolis, IN, 4CORRONA, Inc., Southborough, MA, 5UMASS Medical School, Worcester, MA

    Background/Purpose:  Pain is a hallmark of rheumatoid arthritis (RA). The extent to which patient reported pain in RA is related to patterns of biologic treatment…
  • Abstract Number: 1483 • 2013 ACR/ARHP Annual Meeting

    Physician and Patient Characteristics Associated With The Decision To Treat Rheumatoid Arthritis Patients With Biologic Monotherapy In Usual Care Settings

    Mariely Nieves-Plaza1, Heather Eng2, Ilinca D. Metes3, Ashwini Shewede4, Stephen R. Wisniewski2, Ani John4 and Marc C. Levesque5, 1Clinical And Translational Science Institute, Univeristy of Pittsburgh, Pittsburgh, PA, 2Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, 3Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Genentech Inc., South San Francisco, CA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA

    Background/Purpose: Approximately 30% of rheumatoid arthritis (RA) patients treated with a biologic, receive the biologic as monotherapy i.e. without concomitant oral disease modifying anti-rheumatic drugs…
  • Abstract Number: 522 • 2013 ACR/ARHP Annual Meeting

    Abatacept Reduces Disease Activity In Early Primary Sjögren’s Syndrome:One Year Results From a Phase II Open-Label Study

    PM Meiners1, A Vissink2, Fkl Spijkervet3, EA Haacke4, WH Abdulahad5, E Brouwer5, MG Huitema5, N Sillevis Smitt-Kamminga6, FGM Kroese7, S Arends5 and H Bootsma5, 1Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, 4Pathology, University Medical Center Groningen, Groningen, Netherlands, 5Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 6Opthalmology, University Medical Center Groningen, Groningen, Netherlands, 7Rheumatology and clinical immunology, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Traditional DMARDs have limited effects in primary Sjögren's (pSS) patients. B cell depletion therapy with rituximab showed efficacy, but had some side-effects. T and…
  • Abstract Number: 193 • 2013 ACR/ARHP Annual Meeting

    Physician Variability In Rheumatoid Patients Not Receiving Biologics Or Non-Biologic Dmards: Implications For Quality Reporting

    Dimitrios A. Pappas1, Lang Chen2, Leslie R. Harrold3, George W. Reed4, Joel M. Kremer5, Jeffrey D. Greenberg6 and Jeffrey R. Curtis7, 1Department of Medicine, Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, 2Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3University of Massachusetts Medical School, Worcester, MA, 4Corrona, LLC., Southborough, MA, 5Center for Rheumatology, Albany Medical College, Albany, NY, 6Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, 7University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL

    Background/Purpose: Current quality of care guidelines recommend that all patients with Rheumatoid Arthritis (RA) be treated with biologic and/or non-biologic (nb) DMARDs. However, some RA…
  • Abstract Number: 2225 • 2013 ACR/ARHP Annual Meeting

    COVA322: A Novel, Bispecific Tumor-Necrosis-Factor-Alpha / Interleukin-17A (TNF/IL-17A) Inhibitor With Excellent Pharmacokinetic Properties In Mice and Cynomolgus Monkeys

    Mathias Locher, Dragan Grabulovski, Isabella Attinger-Toller, Susann Koenig-Friedrich, Ulrike von der Bey and Julian Bertschinger, Covagen AG, Schlieren, Switzerland

    Background/Purpose: The generation of bispecific antibody molecules with excellent biophysical and pharmacokinetic properties has been a challenging task in the past. We present here COVA322,…
  • Abstract Number: 1473 • 2013 ACR/ARHP Annual Meeting

    Anti-Tumor Necrosis Factor α Therapy (Etanercept) Plus Methotrexate Lowers Serum Amyloid A Levels To a Greater Extent Than Triple Oral Disease Modifying Anti-Rheumatic Drug Therapy In Early Rheumatoid Arthritis Subjects

    Ilinca D. Metes1, Douglas W. Chew1, Aarat M. Patel1, G.K. Balasubramani2, S. Louis Bridges Jr.3, Jeffrey R. Curtis4, Stephen R. Wisniewski2, Larry W. Moreland5 and Marc C. Levesque6, 1Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, 3Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Amyloidosis is often due to an underlying inflammatory disorder, such as rheumatoid arthritis (RA), with organ deposition of serum amyloid A (SAA).  Oral disease…
  • Abstract Number: 502 • 2013 ACR/ARHP Annual Meeting

    Early Introduction Of Biologic Treatment Is An Important Predictor Of Sustained Favorable Outcome Including Clinical Remission In Early Arthritis But Not Of Sustained Favorable Outcome On Structure and Function Only: Results From The Espoir Cohort

    Cécile Gaujoux-Viala1, Laure Gossec2, Maxime Dougados3, Francis Guillemin4 and Bruno Fautrel5, 1EA 2415, Montpellier I University, Nîmes University Hospital, Rheumatology Department, Nîmes, France, 2Rheumatology, Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France, 3Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, 4CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, 5Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France

    Background/Purpose: The relevant elements to evaluate health states in RA should include remission, good functional ability and structural stability [1]. The concept of favorable outcome…
  • Abstract Number: 194 • 2013 ACR/ARHP Annual Meeting

    Team Managed Care From a Patient’s Perspective: A Study Of Biological Patients At a Canadian Centre

    Dawn Heap1, Margaret Saldanha1, Melissa Deamude1, Cynthia Mech2, Helena Ross1, Kathy Kislinsky1, Lauri Vanstone3, Arthur N. Lau4 and William G. Bensen5, 1Dr. William G. Bensen, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, 2Dr. William G. Bensen, Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, 3Dr. William Bensen Rheumatology Biologic Clinic, Rheumatology Health Team, Hamilton, ON, Canada, 4Rheumatology and Clinical Epidemiology, Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 5Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada

    Background/Purpose: In Canada, there is a widening care gap in Inflammatory Arthritis due to the increased aging population, higher disease prevalence, dwindling numbers of practicing…
  • Abstract Number: 2031 • 2013 ACR/ARHP Annual Meeting

    GRAID – Interim Analysis Of The Retrospective German Register In Autoimmune Diseases

    Thomas Dörner1, Enno Schmidt2, Christoph Fiehn3, Frank Behrens4, Rebecca Fischer-Betz5, Martin Fleck6, Julia Holle7, Joerg C. Henes8, Annett M. Jacobi9, Christian Kneitz10, Esther Wittenborn11, Fabian Proft12, Hendrik Schulze-Koops13 and Christof Iking-Konert14, 1CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, 2Department of Dermatology, University of Lübeck, Lübeck, Germany, 3ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany, 4CIRI/Div. Rheumatology, J.W. Goethe-University, Frankfurt/Main, Germany, 5Department of Rheumatology, University of Düsseldorf, Düsseldorf, Germany, 6Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany, 7Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany, 8Department of Internal Medicine II, Rheumatology Division, University Hospital Tuebingen, Tuebingen, Germany, 9Rheumatology Internal Medicine D, University Hospital Münster, Münster, Germany, 10Internal Medicine II, Hospital Südstadt, Rostock, Germany, 11Roche Pharma AG, Grenzach-Wyhlen, Germany, 12Rheumaeinheit, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany, 13Division of Rheumatology, University of Munich, Munich, Germany, 14Department of Rheumatology, University Hospital Hamburg Eppendorf, Hamburg, Germany

    Background/Purpose: Autoimmune diseases are characterized by high morbidity and lead frequently to physical disability and loss of income. They are the third most important disease…
  • Abstract Number: 1446 • 2013 ACR/ARHP Annual Meeting

    The Efficacy Of Etanercept In Combination With Methotrexate In Moderate To Severe Rheumatoid Arthritis Is Not Dependent On The Dosage Of Methotrexate

    T.W.J. Huizinga1, Fiona Brock2, Urs Kerkmann3 and Gaia Gallo3, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Quanticate, Hitchin, Hertfordshire, United Kingdom, 3Pfizer Europe, Rome, Italy

    Background/Purpose:  Anti-TNF therapy in combination with a synthetic DMARD such as methotrexate (MTX) has been extensively shown to be superior to MTX and anti-TNF therapy…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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