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Abstracts tagged "Biologics and IL-6"

  • Abstract Number: 2710 • 2019 ACR/ARP Annual Meeting

    Sarilumab, a Human Monoclonal Antibody to the Interleukin-6 Receptor, in Polyarticular-course Juvenile Idiopathic Arthritis: A 12-week, Multinational, Open-label, Dose-finding Study

    Fabrizio De Benedetti1, Inmaculada Calvo Penadés 2, Nadina Rubio-Pérez 3, Alexey Maschan 4, Pierre Quartier 5, Zbigniew Żuber 6, Marina Stanislav 7, Raul Barria 8, Daniel Clemente 9, Gabriel Vega-Cornejo 10, Nancy Liu 11, Christine Xu 11, Angeliki Giannelou 12, Bolanle Akinlade 12 and Lydie Baret-Cormel 13, 1Bambino Gesù Children’s Hospital, Rome, Italy, 2Hospital Univ. La Fe, Valencia, Spain, 3University Hospital Dr. José Eleuterio González, Monterrey, Mexico, 4Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia, 5Necker Hospital, Paris, France, 6Andrzej Frycz Modrzewski Krakow University, Kraków, Poland, 7V.A. Nasonova Research Rheumatology Institute, Moscow, Russia, 8Bioreuma, Concepción, Chile, 9Hospital Infantil Universitario Niño Jesús, Madrid, Spain, 10CREA de Guadalajara, Jalisco, Mexico, 11Sanofi, Bridgewater, NJ, 12Regeneron, New York, NY, 13Sanofi, Chilly-Mazarin, France

    Background/Purpose: Sarilumab blocks interleukin-6 (IL-6) from binding to membrane and soluble IL-6 receptor-α. Sarilumab is approved for adults with rheumatoid arthritis (RA) and is being…
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ACR Pediatric Rheumatology Symposium 2020

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