ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 0827 • ACR Convergence 2024

    Oral Corticosteroid-Sparing Effects of Mepolizumab in Eosinophilic Granulomatosis with Polyangiitis (EGPA): Results up to 7.4 Years from the Long-Term Access Programme

    Paneez Khoury1, Jared Silver2, Gerhard Wolff3, Robert Price4, Rejina Verghis5, Emmeline Igboekwe2 and Michael E Wechsler6, 1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 2US Medical Affairs-Respiratory, GSK, Durham, 3Clinical Development-Respiratory, GSK, Collegeville, 4Biostatistics, GSK, Stevenage, United Kingdom, 5Biostatistics, Development Respiratory, GSK, Brentford, United Kingdom, 6Department of Medicine, National Jewish Health, Denver, CO

    Background/Purpose: EGPA is a severe, rare, relapsing/remitting inflammatory disease, in which chronic or high oral corticosteroid (OCS) doses lead to adverse effects, adding to disease…
  • Abstract Number: 1120 • ACR Convergence 2024

    Long-Term Echocardiographic Findings in Idiopathic Recurrent Pericarditis Patients Treated with Anakinra

    Zeynep Toker Dincer1, Damla Raimoglu2, Erkin Yilmaz3, Ayten Dag1, Sejla Karup4, Melike Melikoglu1 and Serdal Ugurlu5, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey, 4Cerrahpasa Faculty of Medicine, Istanbul, Turkey, 5Istanbul University-Cerrahpasa, Istanbul, Turkey

    Background/Purpose: Idiopathic recurrent pericarditis (IRP) is characterized by recurrent pericarditis attacks, and autoinflammatory pattern has been highlighted due to similarities in both clinical features and…
  • Abstract Number: 1455 • ACR Convergence 2024

    Incidence and Predictors of Secondary Failure to Biologic Therapy in Patients with Psoriatic Arthritis

    Fadi Kharouf1, Shangyi Gao2, Ali Alhadri2, Daniel Pereira3, Richard Cook4, Vinod Chandran5 and Dafna Gladman6, 1University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 2Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada, 4University of Waterloo, Waterloo, Canada, 5University of Toronto, Toronto, ON, Canada, 6University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Secondary failure to biologic therapy is challenging and contributes to the complexity of managing psoriatic arthritis (PsA). In this study, we aimed to define…
  • Abstract Number: 1548 • ACR Convergence 2024

    Anifrolumab in Systemic Lupus Erythematosus. Spanish National Registry in a Real-world Setting

    Carmen Secada Gómez1, Vanesa Calvo-Rio2, Miriam Retuerto Guerrero3, Judit Font4, Ivette Casafont-Sole5, Adrián Mayo-Juanatey6, Juan José Alegre Sancho6, Dalifer Freites Nuñez7, Cristina Hormigos8, Noemí Garrido-Puñal9, GUILLERMO GONZALEZ ARRIBAS10, Andrea García-Valle11, Juan Roberto Miguelez Sanchez12, Marta Ibáñez Martínez13, Fernando Lozano Morillo14, Ángel García Manzanares15, Sebastián Sandoval-Moreno16, Josefina Cortés-Hernández17, Desiree Palma18, Leticia Lojo Oliveira19, EVELIN CERVANTES PEREZ20, PAZ COLLADO21, Cristina Arciniega Larios22, Luis Sala Icardo23, Eztizen Labrador-Sánchez24, Cilia Peralta Ginés25, Nahia Plaza-Aulestia26, Miguel Medina Malone27, José Rosas-Gómez de Salazar28, Montserrat Corteguera29, Laura Cebrián19, Fred Anton Pages30, JOSE RAMON LAMUA RIAZUELO31, maria Dolores Fábregas canales32, María José Alados Hernández33, Marta Garijo Bufort34, Anna Pamies Corts35, Luis Sarabia De Ardanaz36, Rodrigo Aguirre-del-Pino37, José Ángel Cabezas Lefler38, Álvaro Seijas-Lopez37, Carmen Carrasco-Cubero39, Ana López-Cerón Cofiño40, Vera Ortiz-Santamaria41, Santos Castañeda42, María Laiño Piñeiro43, Carmen Ordás Calvo44, Celia Arconada Lopez45, Carmen Bejerano46 and Ricardo Blanco-Alonso47, ANA URRUTICOECHEA48, Blanca Garcia-Magallon49, Ana Valeria Acosta Alfaro50, Samuel Leal Rodriguez51, Marina Salido Olivares52 and Patricia Lavilla53 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Valdecilla Hospital, Santander, Cantabria, Spain, 3Complejo Asistencial Universitario de León, Leon, Spain, 4Hospital Germans Trias i Pujol, Barcelona, Spain, 5Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 6Hospital Universitario Doctor Peset, Valencia, Spain, 7Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, 8Hospital Clínico San Carlos, Madrid, Madrid, Spain, 9Hospital Universitario Virgen del Rocío, Sevilla, Spain, 10Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 11Hospital General Río Carrión, Palencia, Spain, 12Hospital Universitario de Móstoles, Madrid, Spain, 13Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 14Hospital Central de La Defensa Gómez Ulla, Madrid, Spain, 15Hospital Universitario de Torrevieja, Alicante, Spain, 16Hospital Universitario Vall d´Hebrón, Barcelona, Spain, 17Hospital Universitario Vall d´Hebrón Hospitals, Barcelona, ES, Barcelona, Spain, 18Hospital Rafael Méndez, Lorca, Murcia, Spain, 19Hospital Universitario Infanta Leonor, Madrid, Spain, 20Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, Spain, 21Hospital Universitario Severo Ochoa, MADRID, Spain, 22Hospital de Mérida, Badajoz, Spain, 23Hospital Universitario de Torrejón, Madrid, Spain, 24Hospital General de La Rioja, Logroño, Spain, 25Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 26Hospital Galdakao, Vizcaya, Spain, 27Hospital Calahorra, La Rioja, Spain, 28Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, 29ComplejoAsistencial de Ávila, Ávila, Spain, 30Complejo Asistencial De Segovia, Segovia, Spain, 31Hospital Universitario del Henares, Madrid, Spain, 32Hospital de Barbastro, Huesca, Spain, 33Hospital Universitario Puerta del Mar, Cádiz, Spain, 34Hospital de Sagunto, Valencia, Spain, 35Hospital Verge de la Cinta, Tortosa, TARRAGONA, Spain, 36Complejo Hospitalario de Jaén, Jaén, Spain, 37Hospital Universitario Lucus Augusti, Lugo, Spain, 38Complejo Asistencial de Zamora, Zamora, Spain, 39Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 40Hospital Santa Bárbara, Soria, Spain, 41Hospital General de Granollers, Barcelona, Spain, 42Hospital Universitario de la Princesa, Madrid, Spain, 43Hospital Universitario de Navarra, Pamplona, Spain, 44Hospital Universitario de Cabueñes, Gijón, Spain, 45Hospital Universitario Infanta Elena, Valdemoro, Madrid, Spain, 46Hospital Universitario Marques de Valdecilla, Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 47Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 48Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, Spain, 49Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, 50Hospital Universitario Infanta Sofía, Madrid, Spain, 51HUP La Fe, Valencia, Spain, 52Hospital Infanta Cristina, Parla, Spain, 53Hospital General de Villalba, Collado Villalba, Spain

    Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1), thus blocking the biological activity of…
  • Abstract Number: 1997 • ACR Convergence 2024

    Features of interleukin-1 and interleukin-6 Inhibitor (IL-1i/IL-6i) Related Severe Delayed Adverse Reactions in Subjects with or Without Reaction-risk Associated HLA-DRB1*15

    Vivian E Saper1, Kazutoyo Osoegawa1, Ruud Verstegen2, Marcelo A Fernandez Vina1 and Lu Tian1, and Drug Hypersensitivity Consortium, 1Stanford University, Stanford, CA, 2The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: A very serious drug-related adverse event is reported with inhibitors of IL-1 and IL-6 (IL-1i/IL6i). This reaction scores as drug reaction with eosinophilia and…
  • Abstract Number: 2270 • ACR Convergence 2024

    Low Yield of Routine Serological Screening for Hepatitis B in Patients with Rheumatoid Arthritis Starting Rituximab Therapy in a Non-Endemic Country

    Pauline Bovens1, Maike Wientjes1, Nathan den Broeder2, David Ten Cate3, Aatke Van der maas4 and Alfons den Broeder1, 1Sint Maartenskliniek, Ubbergen, Netherlands, 2Sint Maartenskliniek, Ubbergen, Gelderland, Netherlands, 3Sint Maartenskliniek, Rotterdam, Netherlands, 4St Maartenskliniek, Ubbergen, Netherlands

    Background/Purpose: Rituximab (RTX) is an effective and safe treatment for patients with RA, but is associated with an increased risk for reactivation of hepatitis B virus…
  • Abstract Number: 2479 • ACR Convergence 2024

    Mepolizumab Treatment Decreased Oral Corticosteroid Use and Improved Clinical Response, Control Status, and Remission in Patients with Eosinophilic Granulomatosis with Polyangiitis: Results up to 24 Months from a Large Network of US Allergy Practices

    Michael E Wechsler1, Anna Kovalszki2, Jared Silver3, Brian Stone4, Lior Seluk5, Lynn Huynh6, Wilson da Costa Junior6, Mingchen Ye6, Jeremiah Hwee7, Mei Sheng Duh6, William McCann4 and Amy G. Edgecomb8, 1Department of Medicine, National Jewish Health, Denver, CO, 2Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 3US Medical Affairs - Respiratory, GSK, Durham, 4Allergy Partners, Asheville, NC, 5Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, 6Analysis Group, Boston, MA, 7Value Evidence and Outcomes, GSK, Mississauga, Canada, 8US Value, Evidence, & Outcomes, Anti-Infectives and Respiratory, GSK, Philadelphia

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a severe rare systemic inflammatory disease characterized by elevated blood eosinophil counts ≥1000 cells/µL and vasculitis of small-…
  • Abstract Number: 0003 • ACR Convergence 2024

    CLN-978, a CD19-directed T Cell Engager (TCE), Leads to Rapid and Deep B Cell Depletion and Has Broad Potential for Development in Autoimmune Diseases

    Máire F. Quigley1, Jennifer S. Michaelson1, Jeffrey Jones1, Farrukh T. Awan2, Geoffrey P. Shouse3, Yue Zhang1, Todd Shearer1, Judy Inumerable1, Irina M. Shapiro1, Patrick A. Baeuerle1 and Stephen Wax1, 1Cullinan Therapeutics, Inc., Cambridge, 2UT Southwestern Medical Center, Dallas, 3City of Hope Comprehensive Cancer Center, Duarte

    Background/Purpose: CD19-directed CAR T cell therapy has been reported to induce profound B cell depletion and deep clinical responses, including drug-free remission, in patients with…
  • Abstract Number: 0393 • ACR Convergence 2024

    Effectiveness of Secukinumab in TMJ Symptoms in Children with JPsA and ERA: A Secondary Data Analysis of JUNIPERA

    Marianne Kerski1, Smriti Mohan1, Cynthia Vizcaya2, Reema Sutariya3, Weibin Bao3 and Matthew Stoll4, 1University of Michigan, Ann Arbor, MI, 2Novartis Pharmaceutical Corporation, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Early recognition and treatment of temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) is of high importance given its impact on…
  • Abstract Number: 0517 • ACR Convergence 2024

    Characterizing Infusion-Related Reactions in Patients with Rheumatoid Arthritis Treated with Biologic DMARDs: Observations from the KOBIO Registry

    Ji-Won Kim1, Ju-Yang Jung2, Chang-Hee Suh3 and Hyoun-Ah Kim1, 1Ajou university school of medicine, Suwon, South Korea, 2Ajou University of medical school, Suwon, South Korea, 3Ajou University Hospital, Suwon, South Korea

    Background/Purpose: The use of biologic disease-modifying antirheumatic drugs (bDMARDs) has revolutionized the management of rheumatoid arthritis (RA), despite their efficacy being occasionally limited by infusion-related…
  • Abstract Number: 0591 • ACR Convergence 2024

    Bimekizumab Maintained Efficacy Responses in Patients with Active Psoriatic Arthritis: Up to 2-Year Results from Two Phase 3 Studies

    Jessica A Walsh1, Joseph F. Merola2, Christopher T Ritchlin3, Yoshiya Tanaka4, Ennio Giulio Favalli5, Dennis McGonagle6, Diamant Thaçi7, Barbara Ink8, Rajan Bajracharya8, Jason Coarse9 and William Tillett10, 1Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 2UT Southwestern Medical Center, Dallas, TX, 3Allergy, Immunology & Rheumatology Division, University of Rochester Medical School, Rochester, NY, 4Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 5ASST Gaetano Pini-CTO, Milan, Lombardia, Italy, 6National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals, Leeds, UK, Leeds, England, United Kingdom, 7Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Schleswig-Holstein, Germany, 8UCB Pharma, Slough, United Kingdom, 9UCB Pharma, Morrisville, NC, 10Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom

    Background/Purpose: PsA is a chronic disease, and patients (pts) can experience loss of response with sustained therapy; therefore, assessing long-term maintenance of response in pts…
  • Abstract Number: 0849 • ACR Convergence 2024

    Effectiveness of Tocilizumab in Aortitis and Aneurysms Associated with Giant Cell Arteritis. Multicenter Open-label Study

    Adrián Martín-Gutiérrez1, Javier Loricera2, Carmen Secada Gómez3, Iñigo Hernández-Rodríguez4, Susana Romero Yuste5, Eugenio De Miguel6, Eva Galindez-Agirregoikoa7, ivan Ferraz-Amaro8, Julio Sánchez-Martín9, Patricia Moya Albarado10, Cristina Campos Fernández11, Fernando Lopez-Gutierrez12, Santos Castañeda13 and Ricardo Blanco-Alonso14, and the Tocilizumab in Giant Cell Arteritis Spanish Collaborative Group, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 4Complejo Hospitalario Universitario de Vigo, Vigo, Spain, 5Department of Rheumatology, University Hospital Complex of Pontevedra, Pontevedra, Spain, 6Hospital Universitario La Paz, Madrid, Spain, 7BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 8Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 9Hospital Universitario 12 de Octubre, Madrid, Spain, 10Hospital de San Pau, Barcelona, Spain, 11Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 13Hospital Universitario de la Princesa, Madrid, Spain, 14Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Giant Cell Arteritis (GCA) was initially described involving mainly the extracranial branches of the carotid arteries. However, GCA also may involve the aorta (GCA-aortitis)…
  • Abstract Number: 1132 • ACR Convergence 2024

    Guselkumab and Golimumab Combination Induction Therapy in Ulcerative Colitis Results in Early Local Tissue Healing That Is Sustained Through Guselkumab Maintenance Therapy

    Dylan Richards1, Marion Vetter1, Matthew Germinaro1, Bram Verstockt2, Raja Atreya3, Julián Panés4, Bruce E. Sands5, Brian G. Feagan6, Bradford McRae7, Daniel Cua1, Patrick Branigan1 and Tom C. Freeman1, 1Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 2Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium, Leuven, Belgium, 3Department of Medicine I, Gastroenterology, Endocrinology and Pneumology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 4Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, Barcelona, Spain, 5Icahn School of Medicine at Mount Sinai, New York, NY, USA, New York, NY, 6Alimentiv Inc, London, ON, Canada, London, ON, Canada, 7Janssen Research & Development, Cambridge, MA, USA, Cambridge, MA

    Background/Purpose: Combination induction therapy with guselkumab (GUS), an interleukin (IL)-23p19 subunit antagonist, and golimumab (GOL), a tumor necrosis factor (TNFα) antagonist, induced higher rates of…
  • Abstract Number: 1457 • ACR Convergence 2024

    Treat-to-Target Approaches in Early Psoriatic Arthritis: Early Secukinumab versus Standard Care – 12- and 24-Week Results from a Multicenter, Open-Label, Randomized Controlled Trial

    Gonul Hazal Koc1, Marc R. Kok2, Fazira R. Kasiem3, Jolanda Luime3, Ilja Tchetverikov4, Kim Wilhelm - de Jong3, Lindy A. Korswagen5, Jessica Bijsterbosch6, Yvonne P. M. Goekoop-Ruiterman7, Paul Baudoin8, Petra Kok9, Reinhard Bos10, radboud J.e.m. Dolhain11 and Marijn Vis3, 1Erasmus MC, Rotterdam, Zuid-Holland, Netherlands, 2Maasstad Hospital, Rotterdam, Netherlands, 3Erasmus MC, Rotterdam, Netherlands, 4Albert Schweitzer Hospital, Dordrecht, Netherlands, 5Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands, 6Amphia Hospital, North Brabant, Netherlands, 7Haga Hospital, Den Haag, Netherlands, 8Reumazorg Zuid West Nederland, Roosendaal, Netherlands, 9Reinier de Graaf Gasthuis, Delft, Netherlands, 10Medical Center Leeuwarden, Leeuwarden, Netherlands, 11Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: The Strategy Treatments aiming at Minimal Disease Activity in PsA (STAMP) is a one-year randomized controlled trial designed to investigate the efficacy of two…
  • Abstract Number: 1553 • ACR Convergence 2024

    Safety, Pharmacokinetics, Clinical Efficacy and Exploratory Biomarker Results from a Randomized, Double-Blind, Placebo-Controlled Phase 1b Study of Enpatoran in Active Systemic and Cutaneous Lupus Erythematosus (SLE/CLE)

    Torsten Witte1, Ruth Fernandez Ruiz2, Nadezda Abramova3, Dominika Weinelt3, Flavie Moreau4, Lena Klopp-Schulze5, Jamie Shaw6, Deborah Denis7 and Joerg Wenzel8, 1Dept of Immunology and Rheumatology, Hannover, Germany, 2Global Clinical Development, EMD Serono, Billerica, MA, 3Global Patient Safety, the healthcare business of Merck KGaA, Darmstadt, Germany, 4Global Biostatistics, EMD Serono, Billerica, MA, 5Quantitative Pharmacology, the healthcare business of Merck KGaA, Darmstadt, Germany, 6Companion Diagnostics and Biomarker Strategy, EMD Serono, Billerica, MA, 7EMD Serono, Rockland, MA, 8Department of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany

    Background/Purpose: Enpatoran, a highly selective, potent and reversible dual toll-like receptor 7/8 (TLR7/8) inhibitor, targets key innate and adaptive immune processes involved in the pathogenesis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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