ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 1009 • ACR Convergence 2020

    Missing Data and Multiple Imputation in Rheumatoid Arthritis Registries Using Sequential Random Forest Method

    Ahmed Al-Saber1, Adeeba Al-Herz2, Jiazhu Pan1, Khulood Saleh3, Adel Al-Awadhi4, Waleed Al-Kandari3, Eman Hasan5, Aqeel Ghanem6, Mohammed Hussain5, Yaser Ali7, Ebrahim Nahar7, Ahmad Alenizi8, Sawsan Hayat7, Fatemah Abutiban9, Ali Aldei5, Amjad Alkadi10, Heba Alhajeri7, Husain Behbehani3, Naser Alhadhood3, Khaled Mokaddem5, Ahmed Khadrawy3, Ammad Fazal3, Agaz Zaman7, Ghada Mazloum7, Youssef Bartella5, Sally Hamed5 and Ramia Alsouk8, 1Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom, 2Al-Amiri Hospital, Kuwait City, Kuwait, 3Farwania Hosiptal, Farwania, Kuwait, 4Faculty of Medicine, Kuwait University, Jabria, Kuwait, 5Al-Amiri Hospital, Kuwait, Kuwait, 6Mubarak Al-Kabeer Hospital, Kuwait City, Kuwait, 7Mubarak Al-Kabeer Hospital, Hawally, Kuwait, 8Jahra Hospital, Jahra, Kuwait, 9Rheumatology Unit, Department of Medicine, Jaber Alahmed Alsabah hospital, State of Kuwait, Jahra, Kuwait, 10Sabah Hospital, Kuwait, Kuwait

    Background/Purpose: Missing data in clinical epidemiological researches violate the intention to treat principle, reduce statistical power and can induce bias if they are related to…
  • Abstract Number: 1347 • ACR Convergence 2020

    Predictors of Response in Patients with Non-Radiographic Axial Spondyloarthritis Receiving Certolizumab Pegol in the C-axSpAnd Study

    Walter Maksymowych1, Thomas Kumke2, Simone Auteri3, Bengt Hoepken2, Lars Bauer2 and Martin Rudwaleit4, 1University of Alberta, Edmonton, AB, Canada, 2UCB Pharma, Monheim am Rhein, Germany, 3UCB Pharma, Milan, Italy, 4Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany

    Background/Purpose: Identification of predictive clinical factors of long-term treatment response in non-radiographic axial spondyloarthritis (nr-axSpA) may contribute to improved management of patients with this chronic…
  • Abstract Number: 1477 • ACR Convergence 2020

    Adherence in Patients with Chronic Rheumatic Diseases Treated with Biological and Synthetic Targeted Therapies During COVID-19 Pandemic

    Patricia Castro Pérez1, Alberto Onteniente González1, Angel Aragón Díez1, Angel Gallegos Cid1, Jesús Garcia-Arroba Muñoz1 and Jose Manuel Rodriguez heredia1, 1Hospital de Getafe, Madrid, Spain

    Background/Purpose: Adherence to treatments for chronic rheumatic diseases is influenced by many factors, including the patient's belief in the development of adverse effects such as…
  • Abstract Number: 1845 • ACR Convergence 2020

    Long-Term Clinical Outcomes of Patients with Lupus Nephritis Treated with an Intensified B-Cell Depletion Protocol: A Matched Case-Control Study

    Dario Roccatello1, Savino Sciascia2, Roberta Fenoglio2 and Rossi Daniela2, 1S Giovanni Hospital, Univ of Turin, Turin, Italy, 2University of Torino, Torino, Italy

    Background/Purpose: Targeting B-cells remains an attractive option in Lupus Nephritis (LN) despite the negative results of RCTs.Methods: Sixty patients with active LN were included in…
  • Abstract Number: 0163 • ACR Convergence 2020

    Cost of Non-Persistence in the Treatment with Subcutaneous Tumor Necrosis Factor-Alpha Inhibitors of Inflammatory Arthritis: A Propensity Score Matching Approach

    Johan Dalén1, Karin Luttropp1, Tor Olofsson2, Christopher Black3 and Amy Puenpatom4, 1ICON plc, Stockholm, Sweden, Stockholm, Sweden, 2Department of Clinical Sciences, Lund, Rheumatology, Lund University, Sweden; Department of Rheumatology, Skåne University Hospital, Lund, Sweden, Lund, Sweden, 3Merck & Co., Inc., Kenilworth, NJ, USA, Rahway, NJ, 4Merck & Co., Inc., Kenilworth, NJ, USA, North Wales, PA

    Background/Purpose: Few studies have explored cost consequences of non-persistence in the treatment with Subcutaneous Tumor Necrosis Factor-Alpha Inhibitors (SC-TNFi) in Inflammatory Arthritis (IA; rheumatoid arthritis…
  • Abstract Number: 0238 • ACR Convergence 2020

    Gestational Desire and Certolizumab Pegol in Patients with Chronic Inflammatory Rheumatic Disease. Preliminary Results of the GESTAMAD Cohort

    Laura Gonzalez Hombrado1, Marina Salido Olivares2, Maria Carmen Ortega de la O3, Pilar Navarro Alonso4, Patricia Castro Perez5, Ana Castilla6, Alvaro Garcia Martos7, Celia Arconada3, Angel Aragon Diez8, Carolina Marin huertas3 and Eva Maria Andres Esteban9, 1Hospital Universitario del Tajo, MADRID, Spain, 2Hospital de Parla, Madrid, Spain, 3Hospital infanta Elena, Madrid, Spain, 4Hospital de Fuenlabrada, Madrid, Madrid, Spain, 5Hospital Universitario de Getafe, Madrid, Spain, 6Hospital Universitario La Paz, Madrid, Spain, 7Hospital Universitario del Tajo, Madrid, 8Hospital Universitario de Gerafe, Madrid, Spain, 9Rey Juan Carlos University, Madrid, Spain

    Background/Purpose: INTRODUCTION The use of biological therapies during pregnancy has been contraindicated since the beginning of the use of these drugs. In recent years several…
  • Abstract Number: 0366 • ACR Convergence 2020

    Symptoms of Peripheral Arthritis Are Significantly Improved in Patients with Ankylosing Spondylitis Treated with Secukinumab

    Philip Mease1, Atul Deodhar2, Renato Calheiros3, Xiangyi Meng4, Todd Fox5 and Xenofon Baraliakos6, 1Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Novartis Pharmaceuticals Corporation, Hoboken, NJ, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5Novartis Pharma AG, Aesch, Switzerland, 6Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton associated with pain, stiffness, and disability.1 Up to 66% of patients (pts)…
  • Abstract Number: 0584 • ACR Convergence 2020

    Total Cost of Care for Patients with Rheumatoid Arthritis

    Kjel Johnson1, Rebecca Karos2, Elisea Avalos-Reyes3, Fabio Casadio4, Michele Hamburger5 and Chiara Leprai4, 1CVS Health, Lincoln, RI, 2CVS Health, Wellesley, MA, 3CVS Health, Irving, TX, 4CVS Health, New York, NY, 5Frances Hamburger Institute, Hauppauge, NY

    Background/Purpose: The range of medical costs associated with rheumatoid arthritis (RA) is, in part, related to the various treatment options. Treatment for RA focuses on…
  • Abstract Number: 0806 • ACR Convergence 2020

    Identification and Adjustment for Factors Associated with Clinical Response in Rheumatoid Arthritis Clinical Trials to Improve Comparisons of Treatment Efficacy

    Anthony Cordisco1 and Joshua Baker1, 1Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Numerous clinical trials have been published in rheumatoid arthritis (RA), but comparing efficacies of disease-modifying anti-rheumatic drugs (DMARDs) is complicated by a lack of…
  • Abstract Number: 0881 • ACR Convergence 2020

    Reduction of Anterior Uveitis Flares in Patients with Axial Spondyloarthritis During Certolizumab Pegol Treatment: 96-Week Results from the C-VIEW Study

    Irene van der Horst-Bruinsma1, Rianne van Bentum1, Frank Verbraak2, Thomas Rath3, James Rosenbaum4, Bengt Hoepken5, Oscar Irvin-Sellers6, Thomas Kumke5, Lars Bauer5 and Martin Rudwaleit7, 1Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, 2Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, 3St Franziskus-Hospital, Münster, Germany, 4Oregon Health & Science University, Portland, OR, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Slough, United Kingdom, 7Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany

    Background/Purpose: Acute anterior uveitis (AAU) is the most common extra-articular manifestation in axial spondyloarthritis (axSpA), affecting up to 40% of patients and causing significant burden.1…
  • Abstract Number: 1038 • ACR Convergence 2020

    STAT1 and JAK2 Are the Most Appropriate Targets of JAK-inhibitor Therapy for Sarcoidosis: An In-silico Meta-nalysis

    Marcia Friedman1, Brian Le2, Dongseok Choi2 and James Rosenbaum2, 1Oregon Health and Science University, Portland, OR, 2Oregon Health & Science University, Portland, OR

    Background/Purpose: Our group was the first to contend that STAT1 mediated genes were expressed in sarcoidosis. Since that time, several other groups have found similar…
  • Abstract Number: 1349 • ACR Convergence 2020

    Guselkumab Provides Domain-Specific and Comprehensive Efficacy as Assessed Using Composite Endpoints in Patients with Active Psoriatic Arthritis

    Laura Coates1, Christopher Ritchlin2, Laure Gossec3, Philip Helliwell4, Proton Rahman5, Elizabeth Hsia6, Alexa Kollmeier7, Xie Xu8, Chetan Karyekar9, May Shawi10, Wim Noël11, Yusang Jiang12, Shihong Sheng12, Prasheen Agarwal12 and Philip Mease13, 1University of Oxford, Oxford, United Kingdom, 2Department of Medicine, University of Rochester Medical Center, Rochester, NY, 3Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Memorial University of Newfoundland, Department of Medicine, St John's, Canada, 6Janssen Research & Development, LLC and University of Pennsylvania Medical Center, Spring House, PA, 7Janssen Research & Development, LLC, La Jolla, CA, 8Janssen Research & Development, LLC, San Marcos, CA, 9Janssen Global Services, LLC, Horsham, PA, 10Janssen Global Services, LLC, Toronto, ON, Canada, 11Janssen Medical Affairs, LLC, Beerse, Belgium, 12Janssen Research & Development, LLC, Spring House, PA, 13Seattle Rheumatology Associates, P.L.L.C., Seattle, WA

    Background/Purpose: Guselkumab (GUS) is a human monoclonal antibody that specifically binds to the p19-subunit of IL-23. GUS has demonstrated efficacy across the various manifestations of…
  • Abstract Number: 1485 • ACR Convergence 2020

    LNA043, a Novel Cartilage Regenerative Treatment for Osteoarthritis: Results from a First-In-Human Trial in Patients with Knee Osteoarthritis

    Celeste Scotti1, Joseph Gimbel2, Didier Laurent1, Aviv Madar3, Thomas Peters1, Yunyu Zhang3, Florine Polus1, Michael Beste3, Igor Vostiar1, Subhajit Choudhury4, Nicole Gerwin1, Jörg Goldhahn5, Matthias Schieker1 and Ronenn Roubenoff1, 1Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Arizona Research Center, Phoenix, 3Novartis Institutes for BioMedical Research, Cambridge, 4Biostatistics & Pharmacometrics, Novartis Healthcare Pvt. Ltd., Hyderabad, India, 5Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland

    Background/Purpose:LNA043 is a modified human angiopoietin-like 3 (ANGPTL3) protein identified in a phenotypic screen for inducers of chondrogenesis and cartilage repair. The primary objective of…
  • Abstract Number: 1924 • ACR Convergence 2020

    Low Immunogenicity in Patients with Giant Cell Arteritis Treated with Tocilizumab: 3-Year Results from the Randomized Controlled Portion and the Open-Label Follow-Up of a Phase 3 Trial

    John H. Stone1, Navita L. Mallalieu2 and Min Bao3, 1Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 2Roche Innovation Center, New York, NY, 3Genentech, South San Francisco, CA

    Background/Purpose: Tocilizumab (TCZ) has low immunogenicity in patients with rheumatoid arthritis (RA).1 The risk for TCZ immunogenicity remains to be determined in patients with giant…
  • Abstract Number: 0189 • ACR Convergence 2020

    Determining the Relationship Between Mycobacterium Avium Subspecies Paratuberculosis Serostatus, Dietary Habits, Medication Regimen, and Joint Pain in Patients with Rheumatoid Arthritis

    Chelsea Guan1, Shazia Majid2, Sweta Chalise2, Saleh Naser2, Robert Sharp2 and Shazia Beg3, 1University of Central Florida, Orlando, FL, 2University of Central Florida, Orlando, 3University of Central Florida College of Medicine, Orlando

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that primarily affects synovial tissues. While the exact etiology is unknown, it is hypothesized that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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