ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 2145 • ACR Convergence 2022

    Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the KEEPsAKE 1 and KEEPsAKE 2 Trials

    Lars Erik1, Kim Papp2, Douglas White3, Cecilia Asnal4, Wenjing Lu5, Ahmed Soliman5, Byron Padilla6, Michael Chen5 and Andrew Ostor7, 1Bispebjerg-Frederiksberg Hospital, Vedbæk, Denmark, 2K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada, 3Rheumatology Department, Waikato Hospital, and Waikato Clinical School, University of Auckland, Hamilton, New Zealand, 4Hospital Alemán, Buenos Aires, Argentina, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Waukegan, IL, 7Cabrini Hospital, Monash University & Emeritus Research, Melbourne, Australia

    Background/Purpose: PsA is a chronic, systemic inflammatory disease with a variety of clinical manifestations including arthritis, enthesitis, and dactylitis and is associated with skin and…
  • Abstract Number: 0290 • ACR Convergence 2022

    Evaluation of Treatment Discontinuation Due to Adverse Events, and the Effect of Cardiovascular Risk Factors or Type of JAK-inhibitors: An International Collaboration of Registries of Rheumatoid Arthritis Patients (the ‘JAK-pot‘ Study)

    Kim Lauper1, Romain Aymon2, Denis Mongin2, Sytske Anne Bergstra3, Denis Choquette4, Catalin Codreanu5, Ori Elkayam6, Kimme Hyrich7, Florenzo Iannone8, Nevsun Inanc9, Lianne Kearsley-Fleet10, Tore K. kvien11, Eirik Kristianslund12, Burkhard Leeb13, Galina Lukina14, Dan Nordstrom15, Karel Pavelka16, Manuel Pombo-Suarez17, Ziga Rotar18, Maria José Santos19, Delphine Courvoisier20 and Axel Finckh21, 1Geneva University Hospitals, Genéve, Switzerland, 2Geneva University Hospitals, Geneva, Switzerland, 3LUMC, Leiden, Netherlands, 4Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 5Center for Rheumatic Diseases, Bucharest, Romania, 6Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7The University of Manchester, Manchester, United Kingdom, 8School of Medicine University of Bari, Bari, Italy, 9Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 10Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, 11Diakonhjemmet Hospital, Oslo, Norway, 12Diakonhjemmet Hospital, Division of Rheumatology and Research, Oslo, Norway, 13Bioreg, Stockerau, Austria, 14Federal state budgetary scientific institution �Research Institute of rheumatology named after V. A. Nasonova�, Moscow, Russia, 15Helsinki University Hospital, Helsinki, Finland, 16Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 17Hospital Clinico Universitario, Santiago de Compostela, Spain, 18University Medical Centre Ljubljana, Ljubljana, Slovenia, 19Hospital Garcia de Orta, Almada, Charneca da Caparica, Portugal, 20University Hospitals of Geneva, Geneva, Switzerland, 21Geneva University Hospital, Geneve - Vesenaz, Switzerland

    Background/Purpose: The "ORAL Surveillance" study1 suggests an increased risk of serious adverse events (AEs) with tofacitinib, a JAK-inhibitor (JAKi), compared to TNF-inhibitors (TNFi). Currently, there…
  • Abstract Number: 0367 • ACR Convergence 2022

    Comparative Risk of COVID-19 Among Patients with Systemic Lupus Erythematosus According to Immunosuppressant Use

    April Jorge1, Baijun Zhou1, yuqing zhang2 and Hyon Choi3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Quincy, MA, 3MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Patients with SLE are at increased risk of COVID-19 and its severe outcomes, in part due to the use of immunosuppressants. We sought to…
  • Abstract Number: 0512 • ACR Convergence 2022

    Development of CARRA Biologic Consensus Treatment Plans for Management of Refractory Moderate Juvenile Dermatomyositis

    Matthew Sherman1, Hanna Kim2 and Stacey Tarvin3, 1Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH); Children’s National Hospital, Washington, DC, 2Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, 3Riley Hospital for Children at Indiana University Health, Indianapolis, IN

    Background/Purpose: There is a paucity of prospective clinical trials evaluating treatments for juvenile dermatomyositis (JDM). Consensus treatment plans (CTPs) are designed to facilitate comparative effectiveness…
  • Abstract Number: 0785 • ACR Convergence 2022

    Humoral Immune Responses Following Four SARS-CoV-2 Vaccine Doses or COVID-19 Infection in Patients with Immune-Mediated Inflammatory Diseases on Immunosuppressive Therapy: A Prospective Cohort Study

    Hilde Ørbo1, Kristin Hammersbøen Bjørlykke2, Joe Sexton1, Anne Therese Tveter1, Ingrid Jyssum1, Ingrid Egeland Christensen1, David Warren3, Tore K. Kvien1, Adity Chopra4, Grete Birkeland Kro3, Jørgen Jahnsen2, Ludvig A. Munthe3, Espen Haavardsholm1, Gunnveig Grødeland3, Sella Aarrestad Provan1, Kristin Kaasen Jørgensen2, Silje Watterdal Syversen1 and Guro Løvik Goll1, 1Diakonhjemmet Hospital, Oslo, Norway, 2Akershus University Hospital, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway, 4Oslo University Hospital, Oslo, Oslo, Norway

    Background/Purpose: Patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy have impaired humoral immune responses to SARS-CoV-2 vaccination. This study aimed to assess serologic response…
  • Abstract Number: 0917 • ACR Convergence 2022

    Fifty-two-week Results from a Phase 3, Randomized, Double-blind, Active-controlled Clinical Trial to Compare BAT1806/BIIB800, a Proposed Tocilizumab Biosimilar, with a Tocilizumab Reference Product in Subjects with Moderate to Severe RA with an Inadequate Response to Methotrexate

    Xiaomei Leng1, Piotr Leszczynski2, Sławomir Jeka3, Shengyun Liu4, Huaxiang Liu5, Malgorzata Miakisz6, Jieruo Gu7, Lali Kilasonia8, Mykola Stanislavchuk9, Xiaolei Yang10, Yinbo Zhou11, Qingfeng Dong11, Marian Mitroiu12, Janet Addison13 and Xiaofeng Zeng14, 1Peking Union Medical College Hospital, Department of Rheumatology and Clinical Immunology, Beijing, China, 2Poznan University of Medical Sciences, Department of Rheumatology, Rehabilitation and Internal Medicine, Poznan, Poland, 3University Hospital No 2 in Bydgoszcz Collegium Medicum UMK, Clinic and Department of Rheumatology and Connective Tissue Diseases, Bydgoszcz, Poland, 4First Affiliated Hospital of Zhengzhou University, Department of Rheumatology and Immunology, Zhengzhou, China, 5Qilu Hospital of Shandong University, Department of Rheumatology, Jinan, China, 6Twoja Przychodnia Centrum Medyczne, Internal Medicine and Rheumatology, Nowa Sól, Poland, 7The Third Affiliated Hospital of Sun Yat-sen University, Department of Rheumatology, Guangzhou, China, 8Tbilisi Heart and Vascular Clinic Ltd, Rheumatology, Tbilisi, Georgia, 9National Pirogov Memorial Medical University, Internal Medicine, Vinnytsia, Ukraine, 10Bio-Thera Solutions, Ltd., Research and Development, Guangzhou, China, 11Bio-Thera Solutions Ltd, Research and Development, Guangzhou, China, 12Biogen International GmbH, Evidence Generation Biosimilars, Baar, Switzerland, 13Biogen Idec Ltd, Maidenhead, United Kingdom, 14Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China

    Background/Purpose: BAT1806 (also referred to as BIIB800) is a proposed biosimilar to tocilizumab reference product (TCZ). Results of this Phase 3, randomized, double-blind, active-controlled trial…
  • Abstract Number: 1073 • ACR Convergence 2022

    Analysis of Clinical Outcomes in ANCA-associated Vasculitis Treated with Rituximab: Eighty Years a Single Center Experience in Japan

    Soko Kawashima1, Mitsumasa Kishimoto2, Yoshinori Komagata3 and Shinya kaname4, 1Kyorin University, Mitaka Tokyo, Japan, 2Kyorin University School of Medicine, Yokohama, Japan, 3Kyorin University School of Medicine, Tokyo, Japan, 4Kyorin University, Tokyo, Japan

    Background/Purpose: Contrary to many Western countries, MPO-ANCA-associated vasculitis (MPO-AAV) is dominant in Japan. The therapeutic response to rituximab (RTX) may differ. Therefore, we conducted a…
  • Abstract Number: 1424 • ACR Convergence 2022

    Cost-Effectiveness of a Progressive Spacing of Tocilizumab or Abatacept in Patients with Rheumatoid Arthritis in Sustained Remission: A Medico-Economic Analysis of the ToLEDo Trial

    Joanna KEDRA1, Lina El Houari1, Florence Tubach1, Benjamin granger1 and Bruno Fautrel2, 1Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, PEPITES, F75013, Paris, France, Paris, France, 2Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France

    Background/Purpose: Biologic Disease Modifying Anti-Rheumatic Drugs (bDMARDs) progressive tapering is a real opportunity in people living with rheumatoid arthritis (RA) having achieved remission both from…
  • Abstract Number: 1629 • ACR Convergence 2022

    AUR200: An Improved BAFF/APRIL Inhibitor with Increased Potency and Safety for the Treatment of B Cell-Mediated Diseases

    Shawn Morales, Jennifer Cross and Robert Huizinga, Aurinia Pharmaceuticals, Inc., Victoria, BC, Canada

    Background/Purpose: AUR200 targets both B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), which are key mediators in the pathogenesis of B cell-mediated autoimmune…
  • Abstract Number: 2031 • ACR Convergence 2022

    Efficacy and Safety of Telitacicept in Primary Sjögren’s Syndrome: A Randomized, Double-blind, Placebo-controlled, Phase 2 Trial

    Dong Xu1, Shangzhu Zhang1, Cibo Huang2, Chenghui Huang3, Li Qin4, Xiaomei Li5, Meiqing Chen6, Xiumei Liu7, Yi Liu8, Zhijun Li9, Jiankang Hu10, Chunde Bao11, wei Wei12, Jing Tian13, Xinwang Duan14, Jianmin Fang15 and Xiaofeng Zeng16, 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Beijing Hospital, Beijing, China, 3The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 4Huzhou Third Municipal Hospital, Huzhou, China, 5Anhui Provincial Hospital, Hefei, China, 6The First Affiliated Hospital of Xiamen University, Xiamen, China, 7The First Hospital of Shanxi Medical University, Taiyuan, China, 8West China Hospital of Sichuan University, Chengdu, China, 9The First Affiliated Hospital of Bengbu Medical College, Bengbu, China, 10Jiangxi Pingxiang People’s Hospital, Shanghai, China, 11Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, 12Tianjin Medical University General Hospital, Tianjin, China, 13Second Xiangya Hospital of Central South University, Changsha, China, 14The Second Affiliated Hospital of Nanchang University, Nanchang, China, 15Shanghai Tongji Hospital, Shanghai, China, 16Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China

    Background/Purpose: To evaluate the efficacy and safety of telitacicept in adult patients with primary Sjögren’s syndrome (pSS) in a phase II randomized double-blind placebo-controlled trial.Methods:…
  • Abstract Number: 2151 • ACR Convergence 2022

    Izokibep Demonstrates Clinically Relevant Efficacy Benefits on Enthesitis, Dactylitis and Nail Outcomes in Active PsA Patients: A 16-week Randomized, Placebo-controlled Trial

    Kurt de Vlam1, Peter Taylor2, Philip J Mease3, Paul Peloso4, Dieter Wetzel5, Nicolai Brun5, Brian Wiens6, Jan Brandt-Juergens7, Edit Drescher8, Eva Dokoupilova9, Anna Rowinska-Osuch10, Nadia Abdel- Kader Martin11 and Frank Behrens12, 1University Hospitals Leuven, Leuven, Belgium, 2University of Oxford, Oxford, United Kingdom, 3Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 4ACELYRIN, Naples, FL, 5Affibody AB, Solna, Sweden, 6ACELYRIN, Inc., Los Angeles, CA, 7Rheumatologische Schwerpunktpraxis, Berlin, Germany, 8Veszprem Megyei Csolnoky Ferenc Korhaz, Budapest, Hungary, 9Medical Plus, s.r.o. & Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Brno, Prague, Czech Republic, 10ETG Network, Warsaw, Poland, 11Hospital Infanta Luisa Quiron, Rheumatology, Sevilla, Spain, 12Rheumatology University Hospital & Fraunhofer Institute Translational Medicine and Pharmacology, Goethe-University Frankfurt, Frankfurt Am Main, Germany

    Background/Purpose: PsA is a chronic, inflammatory disease with multiple manifestations, with arthritis and skin involvement. Other areas of inflammation include enthesitis, dactylitis and nail involvement.…
  • Abstract Number: 0076 • ACR Convergence 2022

    Real World Rheumatology Practice of Biologic Monotherapy for the Treatment of Patients with Rheumatoid Arthritis: A Four-year Cohort Study Using a National Claims Database

    Ko-Jen Li1, Kuo-Cherh Huang2, Chia-Cheng Lin3 and Chia-Li Chang2, 1National Taiwan University Hospital, Taipei, Taiwan, 2Taipei Medical University, Taipei, Taiwan, 3Chugai Pharma Taiwan Ltd., Taipei, Taiwan

    Background/Purpose: There is a growing concern over the rise of polypharmacy, arguably one of the most pressing prescribing challenges. The option of biologic monotherapy is…
  • Abstract Number: 0291 • ACR Convergence 2022

    Tofacitinib Leads to Significant Weight Gain – A Real Life Experience of 429 Patients

    Naga Prabu1, velammal petchaippan2, Gayathri anand3, Aswathi kumar1 and Saranya Ramachandiran3, 1SAKTHI RHEUMATOLOGY CENTRE PVT LTD, Coimbatore, India, 2PSG INSTTUTE OF MEDICAL SCIENCES AND RESEARCH, Coimbatore, India, 3sakthi rheumatology centre pvt l;td, Coimbatore, India

    Background/Purpose: Tofacitinib(Tofa) an oral Janus kinase inhibitor(JAK) has shown good promise in the management of rheumatoid arthritis and psoriatic arthritis. While being increasingly used in…
  • Abstract Number: 0391 • ACR Convergence 2022

    Dynamics of Nail Psoriasis with Guselkumab Treatment and Withdrawal in Association with Skin Response and Patient-reported Outcomes Based on a post Hoc Analysis of Clinical Trial Data

    William Tillett1, Alexander Egeberg2, Enikö Sonkoly3, Patricia Gorecki4, Anna Tjärnlund5, Jozefien Buyze6, Sven Wegner7 and Dennis McGonagle8, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, 3Dermatology and Venereology Division, Karolinska Institutet; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 4Janssen-Cilag Ltd, High Wycombe, United Kingdom, 5Janssen-Cilag AB, Solna, Sweden, 6Janssen Pharmaceutica NV, Beerse, Belgium, 7Janssen-Cilag GmbH, Neuss, Germany, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Nail psoriasis can be difficult to treat, affects ~50% of patients with psoriasis and can involve the nail matrix (pitting, leukonychia) and/or nail bed…
  • Abstract Number: 0542 • ACR Convergence 2022

    ASAS-EULAR Recommendations for the Management of Axial Spondyloarthritis: 2022 Update

    Sofia Ramiro1, Elena Nikiphorou2, Alexandre Sepriano3, Augusta Ortolan4, Casper Webers5, Xenofon Baraliakos6, Robert Landewé7, Filip Van den bosch8, Boryana Boteva9, Ann Bremander10, Philippe Carron11, Adrian Ciurea12, floris van Gaalen1, Pal Geher13, Lianne Gensler14, Josef Hermann15, Manouk de Hooge16, Marketa Husakova17, Uta Kiltz18, Clementina Lopez-Medina19, Pedro Machado20, Helena Marzo-Ortega21, Anna Molto22, Victoria Navarro-Compán23, Michael Nissen24, Fernando Pimentel-Santos25, Denis Poddubnyy26, Fabian Proft26, Martin Rudwaleit27, Mark Telkman9, Sizheng Zhao28, Nelly Ziade29 and Désirée van der Heijde30, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center & King's College London, London, United Kingdom, 3Leiden University Medical Centre, Portela Loures, Portugal, 4University of Padova/Leiden University Medical Center, Padova, Italy, 5Maastricht University Medical Centre, Maastricht, Netherlands, 6Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 7Amsterdam University Medical Center, Meerssen, Netherlands, 8Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 9Patients with Arthritis and Rheumatism (PARE) working group, EULAR, Zürich, Switzerland, 10Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark, 11Ghent University Hospital, Ghent, Belgium, 12University Hospital Zurich, Zürich, Switzerland, 13Semmelweis University, Budapest, Hungary, 14Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA, 15Medical University of Graz, Graz, Austria, 16Ghent University Hospital, Luxembourg, Luxembourg, 17Department of Rheumatology, First Faculty of Medicine, Charles University and Rheumatology Institute, Prague, Prague, Czech Republic, 18Rheumazentrum Ruhrgebiet, Herne, Germany, 19Reina Sofia University Hospital, Rheumatology Department, Jaén, Spain, 20University College London, London, United Kingdom, 21Leeds Teaching Hospitals Trust and University of Leeds, Leeds, United Kingdom, 22Rheumatology Department, Hôpital Cochin,Assistance Publique- Hôpitaux de Paris, Paris, France, 23Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, 24Hopitaux Universitaires de Genève, Geneva, Switzerland, 25NOVA Medical School; Universidade NOVA e Lisboa, Lisboa, Portugal, 26Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 27University of Bielefeld, Klinikum Bielefeld, Bielefeld; Germany Klinikum Bielefeld and Charité Berlin, Germany, and Gent University, Gent, Belgium, 28University of Manchester, Liverpool, United Kingdom, 29Saint-Joseph University, Beirut, Lebanon, 30Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands

    Background/Purpose: Since the last update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis (axSpA) in 2016, substantial new evidence has become available on…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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