ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 0423 • ACR Convergence 2022

    Direct and Indirect Effect of TNFi on BASMI Components in People with Axial Spondyloarthritis: A Longitudinal Study

    Ana Pinto1, Claire Harris2, Rhys Hayward2, Andrew Keat2 and Pedro Machado2, 1Local Health Unit of Guarda, Barcelos, Portugal, 2Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, United Kingdom

    Background/Purpose: The Bath Ankylosing Spondylitis Metrology Index (BASMI) is an index of spinal mobility for people with axial spondyloarthritis (axSpA). BASMI is one of the…
  • Abstract Number: 0759 • ACR Convergence 2022

    Immunogenicity of COVID-19 Vaccines in Patients with Autoimmune and Inflammatory Rheumatic Diseases (AIIRD) on Immunomodulatory Therapies (IMT): An Updated Cohort Study

    Gordon Lam1, Andrew Laster1, Heather Gladue1, Ahmad Kashif1, Erin Siceloff2, Victoria Lackey1, Cheryl Robertson1, Ashley Toci1, Maggie McCarter3 and Leonard Calabrese4, 1Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 2Arthritis and Osteoporosis Consultants of the Carolinas, Stallings, NC, 3University of South Carolina, Columbia, SC, 4Cleveland Clinic, Cleveland, OH

    Background/Purpose: AIIRD patients may have a blunted immune response to the COVID-19 vaccines, but this is uncertain as these individuals were not included in clinical…
  • Abstract Number: 0850 • ACR Convergence 2022

    Outcomes of Patients with Juvenile Idiopathic Arthritis Following Failure of Initial Tumor Necrosis Factor Inhibitor Medication in the Childhood Arthritis and Rheumatology Research Alliance Registry

    Melissa Mannion1, Shahla Amin2, Stephen Balevic3, Colleen Correll4, Timothy Beukelman1 and , for the CARRA Registry Investigators5, 1University of Alabama at Birmingham, Birmingham, AL, 2Childhood Arthritis and Rheumatology Research Alliance, Washington, DC, 3Duke University, Durham, NC, 4University of Minnesota, Minneapolis, MN, 5CARRA, Washington, DC

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are the most commonly used first biologics to treat juvenile idiopathic arthritis (JIA), but it is unknown what subsequent…
  • Abstract Number: 1015 • ACR Convergence 2022

    Predictors of Nail Response with Guselkumab: A Post Hoc Analysis of the VOYAGE 2 Clinical Trial

    Alexander Egeberg1, William Tillett2, Enikö Sonkoly3, Patricia Gorecki4, Anna Tjärnlund5, Jozefien Buyze6, Sven Wegner7 and Dennis McGonagle8, 1Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, 2Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 3Dermatology and Venereology Division, Karolinska Institutet; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 4Janssen-Cilag Ltd, High Wycombe, United Kingdom, 5Janssen-Cilag AB, Solna, Sweden, 6Janssen Pharmaceutica NV, Beerse, Belgium, 7Janssen-Cilag GmbH, Neuss, Germany, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Understanding factors that impact response to therapy may help improve disease management, clinical outcomes and patient quality of life. Nails are often overlooked in…
  • Abstract Number: 1289 • ACR Convergence 2022

    Evaluating Peri–operative Preferences of Bariatric Surgeons in the Management of Immunosuppressive Therapy During Bariatric Surgery

    Suguni Aushadhi Loku Galappaththy1 and Nicole Fearing2, 1University of Missouri Kansas City, Kansas City, MO, 2HCA Menorah Medical Center, Overland Park, KS

    Background/Purpose: As the number of bariatric procedures increases, surgeons will encounter more patients on long-term immunosuppressive medications that may increase post-operative complications. Currently, there are…
  • Abstract Number: 1438 • ACR Convergence 2022

    The Ratio Between Biological and Glucocorticoid Use in Different Countries Worldwide: Results from the METEOR Registry

    Isabell Nevins1, CF Allaart1, David Vega Morales2, Lai Ling Winchow3, Arvind Chopra4, Ana Maria Rodrigues5, Tom Huizinga1, Maarten Boers6 and Sytske Anne Bergstra7, 1Leiden University Medical Center, Leiden, Netherlands, 2Autonomous University of Nuevo León, Monterrey, Mexico, 3Chris hani baragwanath academic hospital, Johannesburg, South Africa, 4Center for Rheumatic Diseases, Pune, Maharashtra, India, 5Reuma.pt, Sociedade Portuguesa de Reumatologia, Lisbon, Portugal, 6Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 7LUMC, Leiden, Netherlands

    Background/Purpose: Previous studies have demonstrated differing bDMARD prescription rates between countries, which seems to be amongst others related to a country's socioeconomic status. In contrast,…
  • Abstract Number: 1842 • ACR Convergence 2022

    Vaccination in Patients with Autoinflammatory Periodic Syndromes Under Canakinumab – Safety Data Interim Analysis of the RELIANCE Registry

    Jasmin B. Kuemmerle-Deschner1, Joerg Henes2, Birgit Kortus-Goetze3, Tilmann Kallinich4, Prasad T. Oommen5, Juergen Rech6, Tobias Krickau7, Frank Weller-Heinemann8, Gerd Horneff9, Ales Janda10, Ivan Foeldvari11, Catharina Schuetz12, Frank Dressler13, Michael Borte14, Markus Hufnagel15, Florian Meier16, Michael Fiene17, Julia Weber-Arden18 and Norbert Blank19, 1Department of Pediatrics, Division of Pediatric Rheumatology, University Hospital Tübingen, Tübingen, Germany, 2Center for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases (INDIRA), University Hospital Tübingen, Tübingen, Germany, 3Division of Nephrology, University of Marburg, Marburg, Germany, 4Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 5Clinic of Pediatric Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 6University Clinic Erlangen, Erlangen, Germany, 7Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Pediatrics, Erlangen, Germany, 8Klinikum Bremen-Mitte, Prof. Hess Kinderklinik, Bremen, Germany, 9Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 10Department of Pediatrics, University Hospital Ulm, Ulm, Germany, 11Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 12Pediatrics, Medizinische Fakultaet Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Germany, 13Division of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany, 14ImmunoDeficiencyCenter Leipzig (IDCL), Hospital St. Georg gGmbH Leipzig, Germany, Leipzig, Sachsen, Germany, 15Division of Pediatric Infectious Diseases and Rheumatology, Department of Pediatrics and Adolescent Medicine, University Hospital Medical Center Freiburg, Medical Faculty, University of Freiburg, Freiburg, Germany, 16Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany, and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt, Germany, 17Rheumatology Center Greifswald, Greifswald, Germany, 18Novartis Pharma GmbH, Nuernberg, Germany, 19Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Background/Purpose: Treatment of autoinflammatory periodic syndromes with the interleukin-1β inhibitor canakinumab (CAN) has been shown to be safe and effective in clinical trials and in…
  • Abstract Number: 2113 • ACR Convergence 2022

    Improvement in Key PsA Core Domains with Guselkumab Treatment in an Enriched Population of ACR20 Non-Responders at Week 24: Post Hoc Analysis of Two Phase 3 Studies

    Dennis McGonagle1, Derek Haaland2, Philip Helliwell3, A. Marilise Marrache4, May Shawi5, Emmanouil Rampakakis6, Peter Nash7, Fedra Irazoque Palazuelos8 and Arthur Kavanaugh9, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 2The Waterside Clinic, Oro Medonte, ON, Canada, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Janssen Inc., Dollard-des-Ormeaux, QC, Canada, 5Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 6McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 7School of Medicine, Griffith University, Sunshine Coast, Australia, 8Angeles Mocel Hospital; Universidad Autónoma de México, Ciudad de México, Mexico, 9University of California San Diego, La Jolla, CA

    Background/Purpose: Despite available PsA treatments, a portion of PsA patients (pts) does not achieve improvements in PsA signs and symptoms according to ACR response criteria.…
  • Abstract Number: 2209 • ACR Convergence 2022

    Efficacy of Secukinumab in Enthesitis-related Arthritis and Juvenile Psoriatic Arthritis Subtypes of Juvenile Idiopathic Arthritis: Results from a Randomized, Phase 3 Study

    Hermine Brunner1, Elena Chertok2, Joke Dehoorne3, Gerd Horneff4, Tilmann Kallinich5, Ingrid Louw6, Maria Alessio7, Sandrine Compeyrot-Lacassagne8, Bernard Lauwerys9, Neil Martin10, Katherine Marzan11, W Patrick Knibbe12, Ruvie Martin13, Xuan Zhu14, sarah whelan15, Luminita Pricop16, Daniel Lovell17, Alberto Martini18 and Nicola Ruperto19, 1Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Department of Pediatrics, Cincinnati, OH, 2Voronezh State Medical University, Voronezh, Russia, 3University Hospital Gent, Gent, Belgium, 4Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 5Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 6Panaroma Medical Centre, Cape Town, South Africa, 7Policlinico Federico II di Napoli, Napoli, Italy, 8Great Ormond Street Hospital for Children, London, United Kingdom, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Royal Hospital for Children, Glasgow, Scotland, United Kingdom, 11Children's Hospital Los Angeles, Los Angeles, CA, 12St. Luke's Hospital System, Meridian, ID, 13Novartis Pharmaceutical Corporation, East Hanover, NJ, 14Novartis Pharmaceuticals Corporation, Basking Ridge, NJ, 15Novartis Ireland Ltd, Crumlin, Dublin, Ireland, 16Novartis Pharmaceuticals Corporation, East Hanover, NJ, 17Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 18Istituto Giannina Gaslini, Genova, Italy, 19IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy

    Background/Purpose: Juvenile idiopathic arthritis (JIA) categories of enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) represent pediatric counterparts of adult non-radiographic axial spondyloarthritis and psoriatic…
  • Abstract Number: 0139 • ACR Convergence 2022

    A Clinical Study Designed to Support a Demonstration of Interchangeability Between AVT02 and Reference Adalimumab (Humira®)

    Steven Feldman1, Heimo stroissnig2, Richard Kay3, Joanna Sobierska4, Roshan Dias4, Eric Guenzi5, Hendrik Otto2, Halimuniyazi Haliduola2, Abid Sattar6, Ruth Ruffieux4, Matjaz Steijger4 and Fausto Berti4, 1Wake Forest School of Medicine, Winston-Salem, NC, 2Alvotech, Jülich, Germany, 3RK Statistics, Bakewell, United Kingdom, 4Alvotech, Zürich, Switzerland, 5UGA Biopharma, Bonn, Germany, 6Alvotech, London, United Kingdom

    Background/Purpose: To support a demonstration of interchangeability of proposed biosimilar AVT02 and Humira® (reference adalimumab).Methods: Participants with chronic plaque psoriasis were selected for the study…
  • Abstract Number: 0314 • ACR Convergence 2022

    Olokizumab Improved Patient Reported Outcomes in TNF Incomplete Responder (TNF-IR) Rheumatoid Arthritis Patients: Results from the Phase III Randomized Controlled Trial

    Vibeke Strand1, Evgeny Nasonov2, Tatiana Lisitsyna2, Alexander Lila2, Sofia Kuzkina3, Mikhail Samsonov4 and Eugen Feist5, 1Stanford University School of Medicine, Stanford, CA, 2V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia, 3R-Pharm, Moscow, Russia, 4R-Pharm JSC, Moscow, Russia, 5Helios Clinic Vogelsang-Gommern, cooperation partner of the Otto von Guericke University Magdeburg, Magdeburg, Germany

    Background/Purpose: Olokizumab (OKZ) is an interleukin-6-inhibitor for treatment of rheumatoid arthritis (RA). In these analyses we present patient reported outcomes (PROs) reported by TNF-IR patients…
  • Abstract Number: 0424 • ACR Convergence 2022

    The Efficacy and Safety of CT-P13 as First-line and Subsequent-line Therapy in Patients with Ankylosing Spondylitis: Real-life Data from TURKBIO Cohort

    Sadettin Uslu1, Semih Gulle1, Gercek Can2, Soner Senel3, Sedat Capar4, Huseyin ediz dalkilic5, Servet Akar6, Suleyman Serdar Koca7, Abdurrahman Tufan8, Ayten Yazici9, Sema Yilmaz10, Nevsun Inanc11, Merih Birlik1, Dilek Solmaz12, Ayse Cefle9, Berna Goker13, Servet Yolbas14, Niels Steen Krough15, Neslihan Yilmaz16, Sukran Erten17, Cemal Bes18, Ozgul Soysal19, Mehmet Akif Ozturk13, Seminur Haznedaroglu13, Sule Yavuz16, Haner Direskeneli20, Fatoş Onen21 and Ismail Sari22, 1Dokuz Eylul University School of Medicine Division of Rheumatology, Izmir, Turkey, 2Dokuz Eylul University School of Medicine Division of Rheumatology, Istanbul, Turkey, 3Erciyes University School of Medicine Division of Rheumatology, Kayseri, Turkey, 4Dokuz Eylul University Faculty of Science Department of Statistics, Izmir, Turkey, 5Uludag University School of Medicine Division of Rheumatology, Bursa, Turkey, 6Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 7Firat University School of Medicine Division of Rheumatology, Elazıg, Turkey, 8Gazi University Medical Faculty Hospital, Istanbul, Turkey, 9Kocaeli University School of Medicine Division of Rheumatology, Kocaeli, Turkey, 10Selcuk University School of Medicine Division of Rheumatology, Konya, Turkey, 11Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 12Kâtip Celebi University School of Medicine Division of Rheumatology, Izmir, Turkey, 13Gazi University School of Medicine Division of Rheumatology, Ankara, Turkey, 14Inonu University School of Medicine Division of Rheumatology, Malatya, Turkey, 15Zitelab Aps, Kopenhag, Denmark, 16Demiroglu Bilim University School of Medicine Division of Rheumatology, Istanbul, Turkey, 17Yildirim Beyazit University School of Medicine Division of Rheumatology, Ankara, Turkey, 18Basaksehir Cam and Sakura ospital, Division of Rheumatology, Istanbul, Turkey, 19Celal Bayar University, School of Medicine Division of Rheumatology, Manisa, Turkey, 20Marmara University School of Medicine Division of Rheumatology, Istanbul, Turkey, 21Dokuz Eylul University, Faculty of Medicine, Rheumatology, İzmir, Turkey, 22Dokuz Eylul University School of Medicine Division of Rheumatology, İzmir, Turkey

    Background/Purpose: In this study, it was aimed to evaluate the long-term drug survival, efficacy and safety of infliximab biosimilar CT-P13 in Turkish patients diagnosed with…
  • Abstract Number: 0762 • ACR Convergence 2022

    Rituximab-treated Rheumatic Patients: B-cell Levels Predict Sero-conversion After COVID-19 Boost or Re-vaccination in Initial Vaccine Non-responders

    Christian Ammitzboell1, marianne Kragh thomsen2, Jakob Bøgn Andersen1, Jens Magnus Berth Jensen3, marie-Louise From Hermansen1, anders Dahl Johannsen1, Mads Lamm Larsen1, Clara Elbæl Mistegaard1, Susan Mikkelsen3, Fruzsina Szabados3, Signe Risbøl Vils1, Christian Erikstrup3, Ellen-Margrethe Hauge1 and Anne Troldborg1, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark, 3Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Treatment with rituximab (RTX) has presented a challenge during the COVID-19 pandemic, as antibody response after primary vaccination are markedly reduced and often undetectable.The primary…
  • Abstract Number: 0858 • ACR Convergence 2022

    Predicting the Occurrence of Drug-Free Inactive Disease Two Years After Diagnosis of Non-Systemic Juvenile Idiopathic Arthritis

    Melissa Mannion1, Chen Chen2, Olha Halyabar3, Susan Paetkau4, Tingting Qiu5 and Bin Huang6, 1University of Alabama at Birmingham, Birmingham, AL, 2Cincinnati Children's Hospital Medical Center, Taipei, Taiwan, 3Children's Hospital/Boston Medical Center, Boston, MA, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Cinciannati, OH

    Background/Purpose: The goal of treatment for juvenile idiopathic arthritis (JIA) is inactive disease (ID), but the optimal treatment for each patient to maximize ID and…
  • Abstract Number: 1023 • ACR Convergence 2022

    Are We Treating-to-target in Spondyloarthritis (SpA)? A Cross Sectional Analysis from the Asia Pacific League of Associations for Rheumatology (APLAR) SpA Registry

    Isaac Cheng1, Ying Ying Leung2, Ho SO1, Praveena Chiowchanwisawakit3, Stanley Angkodjojo4, Muhammad Saeed5, Kichul Shin6, Han Joo Baek7, Mohit Goyal8, Muhammad Haroon9, Eman Satti10, Nallasivan Subramanian11, Fariz Yahya12, Soosan Soroosh13, ASAL ADNAN RIDHA14, Ho Yin Chung15, James Cheng-Chung WEI16, Kishimoto Mitsumasa17 and Lai-shan Tam1, 1The Chinese University of Hong Kong, Hong Kong, China, 2Rheumatology Department, Singapore General Hospital, Singapore, Singapore, 3Mahidol University, Bangkok, Thailand, 4Sengkang General Hospital / Singhealth, Singapore, Singapore, 5Central Park Medical College, Lahore, Pakistan, 6Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 7Gachon University College of Medicine, Inchon, Republic of Korea, 8CARE Pain & Arthritis Centre, Udaipur, India, 9Doctor, Tralee, Ireland, 10Hamad Medical Corporation, Doha, Qatar, 11Velammal Medical College Hospital, Velammal, India, 12University of Malaya, Kuala Lumpur, Malaysia, 13Army University for Medical School, Tehran, Iran, 14Baghdad Teaching Hospital, Baghdad, Iraq, 15Chiron Medical, Hong Kong, Hong Kong, 16Chung Shan Medical University Hospital, Taichung, Taiwan, 17Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Data on the extent to which internationally agreed treat-to-target (T2T) recommendations were applied in clinical practice in patients with SpA across the Asia-Pacific region…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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