ACR Meeting Abstracts

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Abstracts tagged "Biologicals"

  • Abstract Number: 1597 • ACR Convergence 2025

    Effectiveness and Safety of Rituximab Biosimilars in Small Vessel Vasculitis: a Systematic Literature Review

    Caitlyn Kanters1, Joo Young Lee2, Christian Pagnoux3, Lillian Barra4, Jean-Paul Makhzoum5 and Arielle Mendel6, 1McGill University, Montreal, Canada, 2Research institute of the McGill University Health Center, Montreal, QC, Canada, 3Mount Sinai Hospital, University Health Network, Toronto, and Canadian Vasculitis Research Network (CanVasc), Toronto, ON, Canada, 4Western University, London, ON, Canada, 5University of Montreal, Montreal, 6McGill University Health Centre, Montreal, Canada

    Background/Purpose: To evaluate the safety and effectiveness of rituximab biosimilars in the treatment of small vessel vasculitis.Methods: The Medline, CINAHL, Cochrane, Embase and Web of…
  • Abstract Number: 1459 • ACR Convergence 2025

    Fungal Infections, Including Candida, in Patients With Active Psoriatic Arthritis (PsA) Treated With Secukinumab: A Pooled Analysis of 9 Phase 3 Trials

    Shikha Singla1, Linda Grinnell-Merrick2, Weibin Bao3, Artem Zharkov4 and Abhijeet Danve5, 1Medical College of Wisconsin, Milwaukee, WI, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, Hanover, NJ, 4Novartis Pharma AG, Basel, Switzerland, 5Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT

    Background/Purpose: PsA is a chronic inflammatory disease characterized by joint pain, swelling and stiffness, and is often accompanied by cutaneous changes linked to psoriasis. Patients…
  • Abstract Number: 1353 • ACR Convergence 2025

    Phase 3 Study of the Efficacy, Safety and Immunogenicity of the Proposed Tocilizumab Biosimilar RGB-19, Intravenously Administered to Participants With Active Rheumatoid Arthritis: 52-Week Data

    Gerd Burmester1, Hiroaki Matsuno2, Ernest Choy3, Masato Okada4, Roshan Dias5, Károly Horvát-Karajz5, Gordana Dancer5, Yusuke Karibe6, Suguru Masuda6, Joachim Kiefer5 and Paul Emery7, 1Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Matsuno Clinic for Rheumatic Disease, Toyama, and Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 3Division of Infection and Immunity, CREATE Centre, Cardiff University, Cardiff, United Kingdom, 4Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 5Gedeon Richter Plc, Budapest, Hungary, 6Mochida Pharmaceutical Co., Ltd, Tokyo, Japan, 7University of Leeds, Leeds, England, United Kingdom

    Background/Purpose: RGB-19 is a proposed biosimilar to tocilizumab, a monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor. Results of a…
  • Abstract Number: 1116 • ACR Convergence 2025

    Second-line Therapy for Immune-checkpoint Inhibitor-induced Pneumonitis

    Sarah Sun1, Cathryn Lee2 and Pankti Reid3, 1University of Chicago, Chicago, IL, 2University of Chicago, Chicago, 3University of Chicago Medical Center, Chicago, IL

    Background/Purpose: Immune checkpoint inhibitors (ICIs) used for cancer therapy can have varied toxicities among which pneumonitis (ICI-pneumonitis) is a rare (< 5%) but often fatal…
  • Abstract Number: 0659 • ACR Convergence 2025

    Human papillomavirus infection and systemic lupus erythematosus under biologic therapy: a retrospective analysis in a multicenter cohort

    Ivette Casafont-Solé1, Judit Font-Urgelles1, Iñigo Rúa-Figueroa2, Andrea Hernández-martín3, Tarek Salman Montes4, Marta De la Rubia Navarro5, Maria Piqueras García6, Sandra Garrote Corral7, EVA GLORIA TOMERO MURIEL8, Elena De la Mata Pinilla9, Belén Álvarez Rodríguez10, Julia Martínez Barrio11, José Gomez-Puerta12, Paola Vidal-Montal13, Eleonora Penzo14, Consuelo Ramos Giraldez15, Francisco Javier Novoa16, Vicenç Torrente-Segarra17, Jorge Juan Fragío Gil18, Leyre Riancho19 and Irene Altabás-González20, 1Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 2Hospital de Gran Canaria Doctor Negrin, Las Palmas GC, Spain, 3Hospital Universitario de Gran Canaria Dr Negrín, Las palmas, Spain, 4Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, 5Hospital de La Fe, Valencia, 6Servicio Murciano de Salud, Murcia, Spain, 7Hospital Ramón y Cajal, Madrid, 8Hospital Universitario de la Princesa, Madrid, Spain, 9Hospital 12 de Octubre, Madrid, 10Hospital de Áraba, áraba, Spain, 11Department of Rheumatology, Hospital Gregorio Marañón, Madrid, Spain, Madrid, Madrid, Spain, 12Rheumatology Department, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 13Rheumatology. Hospital Universitari de Bellvitge, Barcelona, Catalonia, Spain, 14Hospital Vall d'Hebrón, Barcelona, Spain, 15Hospital Universitario Virgen de Valme, Servicio de Reumatología, Seville, Spain, 16Hospital Insular de Gran Canaria, Las palmas, 17Hospital Comarcal Alt Penedés Garraf, Vilafranca del Penedès, Spain, 18Hospital General Universitario, Valencia, Spain, 19Hospital de Sierrallana, Torrelavega, 20Complejo Hospitalario de Vigo, Vigo, Spain

    Background/Purpose: Human papillomavirus (HPV) is responsible for 99.7% of cervical neoplasms and is the fourth most common cancer among women worldwide. Patients with systemic lupus…
  • Abstract Number: 0814 • ACR Convergence 2025

    Pain Patterns in a Multicenter Randomized Trial of Early RA – Link Between Initially Sustained Joint Inflammation and Subsequent Non-inflammatory Pain Outcomes

    Annie Brink1, Johan Karlsson Wallman2, Jon T Einarsson1, Meliha Kapetanovic1, Elisabeth Mogard1, Elisabet Lindqvist1, Carmen Roseman1, Kristina Lend3, Merete Hetland4, Mikkel Ostergaard5, Kim Horslev-Petersen6, Dan Nordstrom7, Tuulikki Sokka-isler8, Bjorn Gudbjornsson9, Gerður María Gröndal9, Marte Heiberg10, Espen Haavardsholm10, Michael Nurmohamed11, Anna Rudin12, Ronald van Vollenhoven13, Till Uhlig10, Jon Lampa14 and Tor Olofsson2, 1Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Rheumatology, Lund, Sweden, 2Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Rheumatology, Lund, Skane Lan, Sweden, 3Department of Rheumatology and Amsterdam Rheumatology Center, Amsterdam University Medical Centers, Amsterdam; Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 4Copenhagen Center for Arthritis Research (COPECARE) and DANBIO, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 5Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark, 6Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark, 7Division of Rheumatology, Helsinki University Hospital, Helsinki, Finland, 8Department of Medicine and University of Eastern Finland, Jyväskylä Central Hospital, Juväskylä, Finland, 9Landspitali University Hospital; Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 10Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 11Amsterdam Rheumatology and Immunology Center, Reade; Department of Rheumatology and Amsterdam Rheumatology Center, Amsterdam University Medical Centers, Amsterdam, Netherlands, 12Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden, 13Department of Rheumatology, Amsterdam University Medical Centre, Amsterdam, Netherlands, 14Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Emerging data indicate an uncoupling between pain and inflammation during the RA disease course, and comorbid fibromyalgia – thought to stem from central pain…
  • Abstract Number: 0487 • ACR Convergence 2025

    Efficacy of sarilumab in patients with rheumatoid arthritis of different disease activity at treatment initiation: a post-hoc analysis of a Phase 3 trial of sarilumab in Japan

    Hideto Kameda1, Toshiya Takahashi2, Naoki Soeda2 and Yoshiya Tanaka3, 1Department of Internal Medicine, Toho University, Tokyo, Japan, 2Medical Affairs, Asahi Kasei Pharma Corporation, Tokyo, Japan, 3University of Occupational and Environmental Health, Japan, Kitakyushu, Japan

    Background/Purpose: The efficacy and safety of sarilumab (SAR) and methotrexate (MTX) in patients (pts) in Japan with moderate-to-severely active rheumatoid arthritis (RA) and inadequate response…
  • Abstract Number: 0200 • ACR Convergence 2025

    Severe infections and malignancies in patients with cranial and extracranial giant cell arteritis treated with tocilizumab. National multicenter study of 471 patients of clinical practice

    Adrian Martin-Gutierrez1, Javier Loricera2, Vicente Aldasoro Cáceres3, Olga Maiz4, Eugenio de Miguel5, Eva Galíndez Agirregoikoa6, Ivan Ferraz Amaro7, Santos Castañeda8 and Ricardo Blanco9, 1Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain., Renedo de Piélagos, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, Santander, Spain, 3Hospital Universitario de Navarra, Pamplona, Spain, 4Hospital Universitario de Donosti, Donostia, Spain, 5Hospital Universitario La Paz, Madrid, Spain, 6BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 7Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 8Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 9Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain

    Background/Purpose: Infections and malignancies are two of the most feared side effects of biologic therapies. Giant cell arteritis (GCA) is a vasculitis which affects older…
  • Abstract Number: 2688 • ACR Convergence 2025

    Single cell RNA-seq immune profiling of blood samples from a psoriatic disease clinical trial reveals a CD4 T cell population associated with response to IL-23 blockade

    Kathryne Marks1, Anina Sun2, Ifeoluwakiisi Adejoorin1, Lourdes Perez Chada3, Anna Perillo4, Leanne Barrett2, Michael Garshick5, James Krueger6, Joseph Merola7, Marcelo DiCarli2, Deepak Rao1 and Brittany Weber8, 1Brigham and Women's Hospital, Boston, MA, 2Brigham And Women's Hospital, Boston, 3Harvard Medical School, Wayland, MA, 4The Rockefeller University, New York, NY, USA, New York, NY, 5NYU Langone Health, Tenafly, NJ, 6Rockefeller University, New York, NY, 7UT Southwestern Medical Center, Dallas, TX, 8Brigham and Women's Hospital, DEDHAM, MA

    Background/Purpose: The use of IL-23 inhibitors (IL-23i) for psoriatic diseases resulted in significant improvement in disease symptoms for many patients. Whether any blood immune cell…
  • Abstract Number: 1258 • ACR Convergence 2025

    Upadacitinib in the treatment of Rheumatoid Arthritis – Interstitial Lung Disease. National multicenter study of 25 patients in clinical practice.

    Ana Serrano-Combarro1, Belén Atienza-mateo2, Leticia del Olmo Perez3, Sara García-Perez4, Guillermo Gonzalez Mozo de Rosales5, Jose Rosas Gómez de Salazar6, ana Urruticoechea-Arana7, Andrea García-Valle8, Jesús Loarce9, Paula García-Escudero10, Bryan Josué Flores Robles11, Rafael B. Melero-González12, Alicia Garcia13, Maria Martín López14, Patricia López Viejo15, Maria Jose Perez Gaan16, Nuria Vegas Revenga17, Angel Garcia-Aparicio18, M.Pilar Bernabeu Gonzalvez19, Juan Moreno Morales20 and Ricardo Blanco21, 1Division of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, Inmunopathology group, Santander, Santander, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, PALMA DE MALLORCA/BALEARES, Spain, 3HGU Nuestra Señora del Prado, Talavera de la Reina, Talavera de la Reina, Spain, 4Complejo Hospitalario de Vigo, Vigo, Spain, 5Basurto University Hospital, Bilbao, Spain, 6Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 7Rheumatology Division. Hospital Universitario Son Espases, Palma de Mallorca, Spain, 8Rheumatology. Hospital General Río Carrión, Palencia, Castilla y Leon, Spain, 9Ramón y Cajal University Hospital, Madrid, Spain, 10Hospital Universitario Álava, Bilbao, Spain, 11Hospital San Pedro, Logroño, Spain, 12COMPLEXO HOSPITALARIO UNIVERSITARIO DE OURENSE, O Carballino, Spain, 13Rheumatologist, La Laguna, Spain, 14Hospital 12 de Octubre, Madrid, Spain, 15Hospital Severo Ochoa (Leganés), Leganes, Spain, 16Hospital Universitario Virgen de las Nieves, Granada, Spain, 17Galdakao- Usansolo University Hospital, Galdakao, Spain, 18Hospital Universitario de Toledo, Toledo, Spain, 19Rheumatology Department, Dr. Balmis General University Hospital, Alicante, Spain., Alicante, Spain, 20Hospital Universitario Santa Lucia Cartagena, Cartagena, Spain, 21Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). Abatacept and rituximab are usually the recommended drugs. JAK inhibitors (JAKi)…
  • Abstract Number: 2345 • ACR Convergence 2025

    Biological Sex-Related Differences in Radiographic Progression and Relationship with Early Clinical Response: Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo‑Controlled Study in Biologic-Naive Participants with Active Psoriatic Arthritis Treated with Guselkumab

    Dafna D. Gladman1, Lihi Eder2, Carlo Selmi3, Philip J. Mease4, Alexis Ogdie5, Karissa Lozenski6, Mohamed Sharaf7, Emmanouil Rampakakis8, Laura Pina Vegas9 and Laura Coates10, 1Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3Humanitas University, Milan, Italy, 4Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 5University of Pennsylvania, Philadelphia, PA, 6Johnson & Johnson, Horsham, PA, 7Janssen - Johnson & Johnson, Dubai, United Arab Emirates, 8JSS Medical Research, Montréal, QC, Canada, 9Epidemiology in Dermatology and Evaluation of Therapeutics (EpiDermE), University Paris-Est Créteil Val de Marne, Créteil, France; Rheumatology, Hospital Henri Mondor, AP-HP, Créteil, France, Creteil, France, 10Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: Previous research has shown that women with psoriatic arthritis (PsA) often have lower rates of clinical response to medication but less severe radiographic joint…
  • Abstract Number: 2029 • ACR Convergence 2025

    Characteristics of a Historical Cohort of Adult Patients with Juvenile Idiopathic Arthritis

    Francina salabert-Carreras1, Raquel Ugena-García2, Cristina Rocamora-Gisbert3, Cristina Calomarde-Gómez2, Clara Churtichaga Domenech1, Judith Vidal ripoll1, LOURDES MATEO SORIA4, Laia Gifre-Sala1, Maria Aparicio3, Susana Holgado5, Águeda Prior Español1, Anne Riveros frutos3, Ivette Casafont-Solé2, Eva Forcadell Pirretas1, Anna Pujol Manresa1, Judit Font-Urgelles2, Melania Martínez-Morillo1 and Annika Nack3, 1Hospital Germans Trias i Pujol, Barcelona, 2Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 3Hospital Germans Trias i Pujol, Barcelona, Spain, 4HOSPITAL GERMANS TRIAS I PUJOL, BADALONA, Spain, 5Hospital Germans Trias i Pujol, Barcelona, Catalonia, Spain

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. Up to one-third of patients experience disease flares in adulthood, with…
  • Abstract Number: 1592 • ACR Convergence 2025

    Mepolizumab to Benralizumab Switch in Eosinophilic Granulomatosis with Polyangiitis (EGPA)

    Adrien Cottu1, Irene Mattioli2, Xavier Puéchal3, Loic Guillevin4, Mathieu Groh5, Camille Taillé6, Maxime Samson7, Pascal Cathébras8, Halil Yildiz9, Grégory Pugnet10, Stéphane Jouneau11, Marie-Charlotte Besse12, François Lifermann13, Jean-Philippe Martellosio14, Laurent Guilleminault15, Colas Tcherakian16, Yann Nguyen17, Claire Demoreuil18, Philippe Guilpain19, Giacomo Emmi20 and Benjamin Terrier21, 1Internal medicine departement, Cochin Hospital, Paris, France, 2Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 3Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( 75014 ), Ile-de-France, France, 4Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, Paris, France, 5Hôpital Foch, Suresnes, France, 6Bichat hospital, APHP, Paris, France, 7CHU Dijon Bourgogne, Dijon, France, 8Internal medicine department, CHU St-Etienne, Saint-Etienne, France, 9Internal medicine department, Saint-Luc, Saint-Luc, France, 10CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France, 11Respiratory Medicine, Université de Rennes 1, CHU Pontchaillou, Rennes, France, 12Tours University Hospital, 37000 tours, Ile-de-France, France, 13Internal Medicine, CH de Dax, Dax, France, 14Internal medicine department, CHU Poitiers, Poitiers, France, 15CHU Toulouse, Toulouse University, Toulouse, France, 16Pneumology department, Foch, Suresnes, France, 17Department of Internal Medicine, Beaujon Hospital, AP-HP Nord, Université Paris Cité, Clichy, France, Clichy, France, 18Internal medicine department, Brest CHU, Brest, France, 19Internal medicine department, CHU Montpellier, Montpellier, France, 20Department of Medical, Surgery and Health Sciences, University of Trieste, Italy and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy, Trieste, Italy, 21Cochin Hospital, Paris, France

    Background/Purpose: Glucocorticoid (GC)-dependent asthma and ENT exacerbations may persist in more than half of patients with eosinophilic granulomatosis with polyangiitis (EGPA). Mepolizumab and benralizumab, monoclonal…
  • Abstract Number: 1458 • ACR Convergence 2025

    Clinical Efficacy of Bimekizumab Treatment up to 2 Years Across Patients with Psoriatic Arthritis and Varying Baseline Joint Involvement: Results from a Post Hoc Analysis of Two Pooled Phase 3 Studies

    Philip J. Mease1, Laure Gossec2, Hideto Kameda3, David Nicholls4, Proton Rahman5, Barbara Ink6, Rajan Bajracharya6, Patrick Healy7 and Laura Coates8, 1Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, 2Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 3Department of Internal Medicine, Toho University, Tokyo, Japan, 4Clinical Trials Unit, University of the Sunshine Coast, Queensland, Australia, 5Division of Rheumatology, Craig L. Dobbin Genetics Research Centre, Discipline of Medicine, Memorial University of Newfoundland, St. John's, Canada, 6UCB, Slough, England, United Kingdom, 7UCB, Morrisville, NC, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom

    Background/Purpose: Patients (pts) in PsA clinical trials often have greater joint involvement than in the clinical setting due to trial inclusion criteria,1 thus it is…
  • Abstract Number: 1350 • ACR Convergence 2025

    Initial Biologic Therapy Improves Sexual Function in Female Patients with Rheumatoid Arthritis: A 6 Month Follow-Up Study

    Daniel Zavada1, Barbora Vala2, Adela Navratilova2, Veronika Losterova2, Lenka Moravcova2, Jiri Vencovsky3, Ladislav Šenolt4, Karel Pavelka5 and Michal Tomcik5, 1Institute of Rheumatology, Prague; Charles University, Third Faculty of Medicine, Hlavné mesto Praha, Czech Republic, 2Institute of Rheumatology, Praha, Czech Republic, 3Institute of Rheumatology, Praha 8, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) significantly impacts quality of life in multiple domains. This study aimed to evaluate the impact of initial biologic/targeted synthetic disease-modifying anti-rheumatic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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