Abstracts tagged "biologic response modifiers"

Abstract Number: 1163 • 2012 ACR/ARHP Annual Meeting
Risk Factors for Radiologic Progression in Polyarticular Juvenile Idiopathic Arthritis Patients Treated with Biologic Agents
Tomohiro Kubota¹, Tsuyoshi Yamatou², Yukiko Nonaka², Harumi Akaike², Tomokazu Nagakura³, Yuichi Yamasaki¹, Tomoko Takezaki², Yasuhito Nerome², Hiroyuki Imanaka² and Syuji Takei⁴, ¹Dept of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ²Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, ³Department of Pediatrics, House of Meguminoseibo, Usuki, Japan, ⁴School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Background/Purpose: Progression of joint damage is sometimes observed in JIA patients during the biologic therapy. However, it is difficult to evaluate the radiographic progression by…
Abstract Number: 1174 • 2012 ACR/ARHP Annual Meeting
Severe Adverse Events Associated with Use of Biologic Therapy in Juvenile Idiopathic Arthritis: A Single-Center Study
Ricardo A. G. Russo¹ and Marìa M. Katsicas², ¹Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ²Immunology & Rheumatology., Hospital de Pediatrìa Garrahan, Buenos Aires, Argentina
Background/Purpose: biologic agents have revolutionized the treatment of Juvenile Idiopathic Arthritis (JIA) and other conditions due to their high efficacy and safety. However, with the…
Abstract Number: 2172 • 2012 ACR/ARHP Annual Meeting
An Update of Management of Coccidioidomycosis in Patients On Biologic Response Modifiers and Disease-Modifying Antirheumatic Drugs
Susan Knowles¹, Dominick Sudano¹, Sara Taroumian², Neil M. Ampel³, John Galgiani⁴, Jeffrey R. Lisse¹ and Susan E. Hoover⁵, ¹Department of Rheumatology, University of Arizona, Tucson, AZ, ²Department of Rheumatology, University of California, Los Angeles, Los Angeles, CA, ³Infectious Disease, University of Arizona, Tucson, AZ, ⁴Valley Fever Center for Excellence, Tucson, AZ, ⁵Infectious Diseases, University of Arizona, Tucson, AZ
Background/Purpose: Coccidioidomycosis (valley fever) is an endemic fungal infection in the Southwestern United States which typically causes a self-limited pulmonary illness. Patients with rheumatic disease…
Abstract Number: 1142 • 2012 ACR/ARHP Annual Meeting
Efficacy of Biologic Agents in Juvenile Idiopathic Arthritis: A Systematic Review Using Indirect Comparisons
Janneke Anink¹, Marieke H. Otten¹, Sandra Spronk² and Lisette W.A. Van Suijlekom-Smit¹, ¹Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, ²Department of Epidemiology and Radiology, Erasmus MC, Rotterdam, Netherlands
Background/Purpose: During the last decade the availability of biologic agents for the treatment of juvenile idiopathic arthritis (JIA) increased substantially. Because direct head-to-head trials comparing…
Abstract Number: 2155 • 2012 ACR/ARHP Annual Meeting
The Annualized Progression of Radiologic Damage in Placebo Arms of Rheumatoid Arthritis Trials Is Much Lower Than the Mean Annual Progression Since Disease Onset
Jean-Marie Berthelot and Celine Cozic, Rheumatology Unit, Nantes University Hospital, Nantes, France
Background/Purpose : A previous meta-analysis by Graudal and Jürgens (Arthritis Rheum. 2010;62:2852–63) challenged the belief that biologics better protect rheumatoid arthritis (RA) from joint destruction…
Abstract Number: 1145 • 2012 ACR/ARHP Annual Meeting
Use of Non-Etanercept Biologics in Children with Juvenile Idiopathic Arthritis: Results From the Biologics for Children with Rheumatic Diseases Study
Lianne Kearsley-Fleet¹, Eileen Baildam², Michael Beresford³, Rebecca Davies⁴, Helen E. Foster⁵, Katy Mowbray¹, Taunton R. Southwood⁶, Wendy Thomson¹ and Kimme L. Hyrich⁷, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, ³University of Liverpool, Institute of Translational Medicine (Child Health), Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁵Institute Cellular Medicine, Musculoskeletal Research Group, Newcastle upon Tyne, United Kingdom, ⁶Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, ⁷Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom
Background/Purpose: The management of juvenile idiopathic arthritis (JIA) has been revolutionised by the introduction of biologic therapy, although the majority remain unlicensed for children. Until…
Abstract Number: 2093 • 2012 ACR/ARHP Annual Meeting
Rates of Opportunistic Infections Among Rheumatoid Arthritis Patients Switching Biologic Therapy
John Baddley¹, Shuo Yang², Klye Brizendine³, Scott DuVall⁴, Kevin L. Winthrop⁵, Mary J. Burton⁶, Nivedita M. Patkar⁷, Elizabeth S. Delzell⁸, Monika M. Safford⁹, Jasvinder A. Singh¹⁰, Iris E. Navarro¹¹, Grant W. Cannon¹², Ted R. Mikuls¹³, Lang Chen¹¹, Kenneth G. Saag¹⁴, Kimberly Alexander¹⁵, Pavel Napalkov¹⁵, Aaron Kamauu¹⁶ and Jeffrey R. Curtis¹⁷, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Infectious Disease, Birmingham, AL, ⁴VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ⁵Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ⁶VA Hospital, Jackson, MS, ⁷Immunology/Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁸Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁹Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Department of Medicine, University of Alabama, Tuscaloosa, AL, ¹¹Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹²Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, ¹³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁴Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ¹⁵Epidemiology, Genentech, Inc., South San Francisco, CA, ¹⁶Anolinx, Bountiful, UT, ¹⁷Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL
Background/Purpose: The incidence of opportunistic infections (OIs) in patients on biologics is low, but may approach several cases per 100 person-years (PY). Data on risks…
Abstract Number: 1146 • 2012 ACR/ARHP Annual Meeting
Choice of Systemic JIA Treatment Among Childhood Arthritis and Rheumatology Research Alliance (CARRA) Rheumatologists
Jennifer E. Weiss¹, Esi M. Morgan DeWitt², Timothy Beukelman³, Laura E. Schanberg⁴, Rayfel Schneider⁵ and Yukiko Kimura⁶, ¹Pediatric Rheumatology, Hackensack University Medical Center, Hackensack, NJ, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Pediatrics, Duke University Medical Center, Durham, NC, ⁵Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati, OH, Canada, ⁶Pediatric Rheumatology, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ
Background/Purpose: Despite recent advances in identifying effective treatments for systemic Juvenile Idiopathic Arthritis (sJIA), many pediatric rheumatologists continue to use corticosteroids and methotrexate. The Childhood…
Abstract Number: 2055 • 2012 ACR/ARHP Annual Meeting
TEAM-Managed Care of Biological Patients At A Canadian Centre
Melissa Deamude¹, Dawn Heap², Melanie Kanellos², Debbie Kislinsky³, Kathy Kislinsky¹, Cynthia Mech⁴, Helena Ross¹, Peggy Saldanha³, Lauri Vanstone⁵, Kathleen Brown⁶ and William G. Bensen⁷, ¹Dr. William G. Bensen, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, ²Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, ³Dr. William Bensen Rheumatology Clinic, Hamilton, ON, Canada, ⁴Dr. William G. Bensen, Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, ⁵Dr. William Bensen Rheumatology Biologic Clinic, Rheumatology Health Team, Hamilton, ON, Canada, ⁶Dr. William Bensen Rheumatology Clinic, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, ⁷Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada
Background/Purpose: Managing complex arthritic patients with biologics is exacting and time consuming. As a result in January 2008 we established a separate biologic clinic with…
Abstract Number: 1004 • 2012 ACR/ARHP Annual Meeting
A Unique Single Nucleotide Polymorphism in the 3’ UTR of the MED29 Gene On Chromosome 19 Is Associated with the Clinical Outcome of Different Biologic Response Modifiers
Susanne Drynda¹, David Leesch², Marietta Gloetzner² and Joern Kekow², ¹Clinic of Rheumatology, Univ of Magdeburg, Clinic of Rheumatology, Vogelsang-Gommern, Germany, ²Clinic of Rheumatology, Univ of Magdeburg, Vogelsang-Gommern, Germany
Background/Purpose: Due to the wide range of highly specific and effective biologic response modifiers that are available today for the treatment of RA it has…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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