ACR Meeting Abstracts

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Abstracts tagged "biologic response modifiers"

  • Abstract Number: 1823 • ACR Convergence 2023

    Higher Body Mass Index and Older Age, Both of Which Are Linked to Immunothrombosis Are Associated with Improved Survival with Baricitinib Therapy in COVID-19 Pneumonia

    Paula David1, Niv Ben-Shabbat2, Or Hen1, Howard Amital3, Abdulla watad4 and Dennis McGonagle5, 1University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Leeds, United Kingdom, 2Department of Medicine 'B'. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Sheba Medical Center - Tel Hashomer, Ramat Gan, Israel, 4Sheba Medical Center, Ramat Gan, Israel, 5Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Immunothrombosis is a critical pathological feature of fulminant COVID-19 pneumonia in which immunosuppression with common immunomodulatory agents such as corticosteroids, IL-6 receptor blockers, and…
  • Abstract Number: 1858 • ACR Convergence 2023

    How Did a Mandatory Switch Policy Influence the Uptake of Adalimumab Biosimilar and Other TNF Inhibitors?

    Nick Bansback1, Michael law1, Fiona Clemont2, Mina Tadrous3, Sandra Blitz1 and Mark Harrison1, 1University of British Columbia, Vancouver, BC, Canada, 2University of Calgary, Calgary, AB, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: In response to the low uptake of biosimilars, British Columbia (BC) in Canada became the first jurisdiction in North America to require patients with…
  • Abstract Number: 2045 • ACR Convergence 2023

    Treatment Response in a Cohort of Pediatric Patients with Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)

    Ilaria Maccora1, Arjun Sood2, Grant Schulert3, Alexandra Duell3, Preston Land4, Cameron C Sapp2, Jennifer Huggins3, Tiffany Nguyen2, Megan Quilan-Waters3, Sumit Sharma5, Sunil Srivastava2 and Sheila Angeles-Han6, 1PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Firenze, Italy, 2Cincinnati Eye Institute, Cincinnati, OH, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Cincinnati Children's Hospital, Medical Center, Cincinnati, OH, 5Cleveland Clinic, Cleveland, OH, 6Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose: Pediatric uveitis often requires systemic immunomodulatory therapy (IMT) to prevent sight-threatening complications. Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare autoimmune condition caused…
  • Abstract Number: 2054 • ACR Convergence 2023

    Superiority of Adalimumab in Treating Childhood Chronic Idiopathic Uveitis: Evidence from a Multicentre Experience

    Ilaria Maccora1, Catherine Guly2, Lavinia Sanfilippo3, sara Soldovieri4, Cinzia De Libero5, Athimalaipet V Ramanan6 and Gabriele Simonini7, 1PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Firenze, Italy, 2Ophthalmology Unit, Bristol Eye Hospital, Bristol, United Kingdom, 3Meyer Children's Hospital IRCCC, Florence, Italy, 4Rheumatology Unit, ERN ReConnet Center, Meyer Children's Hospital IRCCS, Florence, Italy, 5Ophthalmology Unit, Meyer Children's Hospital IRCCS, Florence, Italy, 6Bristol Royal Hospital for Children & Translational Health Sciences, University of Bristol, Bristol, United Kingdom, 7Rheumatology Unit, ERN ReConnet Center, Meyer Children's Hospital IRCCS, Florence Italy. NeuroFARBA Department, University of Florence, Florence, Italy

    Background/Purpose: Childhood Chronic Idiopathic Uveitis (cCIU) is a severe ocular condition that accounts for the 40% of all uveitis in children. Its timely and proper…
  • Abstract Number: 2133 • ACR Convergence 2023

    Cardiovascular Risk Factors Are Associated with Discontinuation of Advanced Therapies Due to Treatment Failure in Rheumatoid Arthritis: Results from the OBRI

    Samar Aboulenain1, Xiuying Li2, Mohammad Movahedi3, Claire Bombardier1 and Bindee Kuriya1, 1University of Toronto, Toronto, ON, Canada, 2Toronto General Hospital, Toronto, ON, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Cardiovascular (CVD) comorbidity can impact overall RA care. We demonstrated that CVD risk factors were associated with higher disease activity and disability. Here, we…
  • Abstract Number: 0264 • ACR Convergence 2022

    Reasons for Early Discontinuation of Targeted Synthetic (ts) or Biologic (b) DMARDs; Chart Review of 20,343 Drug Episodes Given to Patients with Rheumatoid Arthritis

    Kent Kwas Huston1, Christopher Adams2, Simon Helfgott3, Jasvinder singh4, Nehad Soloman5, Dan Persons6, Scott Milligan6 and Colin Edgerton2, 1Kansas City Physician Partners Center for Rheumatic Disease, Kansas City, MO, 2Articularis Healthcare, Sullivans Island, SC, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4University of Alabama at Birmingham, Birmingham, AL, 5Arizona Arthritis & Rheumatology Associates, P.C., Peoria, AZ, 6Trio Health, Louisville, CO

    Background/Purpose: The development, exacerbation, or unimprovement of clinical conditions during DMARD treatment may lead patients to abandon treatment before the necessary time has elapsed for…
  • Abstract Number: 1436 • ACR Convergence 2022

    Predictors at Diagnosis for Start of Biologic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis

    Mohaned Hameed1, Sofia Exarchou1, Anna Eberhard1, Ankita Sharma1, Ulf Bergström1, Jon Einarsson2 and Carl Turesson3, 1Lund University, Malmö, Sweden, 2Skåne University Hospital, Lund, Sweden, 3Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden

    Background/Purpose: With increasing use of biologic disease modifying anti-rheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) for the management of rheumatoid arthritis (RA), outcomes have…
  • Abstract Number: 1606 • ACR Convergence 2022

    An Expanded Anti-citrullinated Protein Antibody Profile Derived Using Unsupervised Machine Learning Predicts Treatment Responses to Biologic Therapies in Rheumatoid Arthritis

    nozima Aripova1, George Reed2, Bryant England1, William Robinson3, Dimitrios Pappas4, Joel Kremer5, Geoffrey Thiele1 and Ted Mikuls6, 1University of Nebraska Medical Center, Omaha, NE, 2The Corrona Research Foundation and University of Massachusetts, Albany, NY, 3Stanford University School of Medicine, Palo Alto, CA, 4CorEvitas, LLC, Waltham, MA, 5The Corrona Research Foundation, Delray Beach, FL, 6Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) treatments have advanced with the availability of biologic therapies. Despite these advances, 30-40% of patients receiving a biologic do not adequately…
  • Abstract Number: 1679 • ACR Convergence 2022

    The Childhood Arthritis and Rheumatology Research Alliance Start Time Optimization of Biologic Therapy in Polyarticular JIA (STOP-JIA) Study: Three-Year Outcomes

    Yukiko Kimura1, Sarah Ringold2, George Tomlinson3, Laura Schanberg4, Anne Dennos5, MaryEllen Riordan6, Vincent Del Gaizo7, Katherine Murphy8, Pamela Weiss9, Brian Feldman10, Mei Sing Ong11 and Marc Natter12, 1Hackensack Meridian Health, New York, NY, 2Janssen, Seattle, WA, 3University of Toronto, Toronto, ON, Canada, 4Duke University Medical Center, Durham, NC, 5Duke University, Durham, NC, 6Hackensack Meridian Health, Hackensack, NJ, 7CARRA, Inc, Washington, DC, 8CARRA, Inc, New Orleans, LA, 9Children's Hospital of Philadelphia, Glen Mills, PA, 10Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 11Harvard Pilgrim Institute, Boston, MA, 12Boston Children's Hospital, Boston, MA

    Background/Purpose: The CARRA STOP-JIA study compared the effectiveness of the CARRA Consensus Treatment Plans (CTPs) in achieving clinically inactive disease (CID) in untreated polyarticular JIA…
  • Abstract Number: 1732 • ACR Convergence 2021

    Effects of B Cell Activating Factors/B Lymphocyte Stimulator Inhibitors Added to Standard of Care on Infection in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Ruoning Ni1, Jiayi Zheng2 and Ruru Guo3, 1Saint Agnes Healthcare, Baltimore, MD, 2Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (People's Republic), 3Renji Hospital, Shanghai, China (People's Republic)

    Background/Purpose: The efficacy of B cell activator factor/B lymphocyte stimulator inhibitors (BAFFi/BLySi) for systemic lupus erythematosus (SLE) has been proven in clinical trials. However, it…
  • Abstract Number: 0818 • ACR Convergence 2021

    Biologics Initiation in Moderate vs Severe Rheumatoid Arthritis Patients: Prospective Observational Study from a Canadian Registry

    Nancy Guo1, Xiuying Li2, Mohammad Movahedi3, Angela Cesta4 and Claire Bombardier5, 1Kingston General Hospital, Kingston, ON, Canada, 2OBRI at University Health Network, Toronto, ON, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 4Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada, 5University of Toronto - Toronto, Toronto, ON, Canada

    Background/Purpose: Prior studies have shown that in the real-world setting, rheumatoid arthritis (RA) patients have lower disease activity than those studied in clinical trials. However,…
  • Abstract Number: 1217 • ACR Convergence 2021

    Discontinuation Rate of Tofacitinib Is Similar When Compared to TNF Inhibitors in Rheumatoid Arthritis Patients: Pooled Data from Two Rheumatoid Arthritis Registries in Canada

    Mohammad Movahedi1, Denis Choquette2, Louis Coupal2, Angela Cesta3, Xiuying Li3, Edward Keystone4 and Claire Bombardier5, 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Institut de Rhumatologie de Montréal, Montréal, QC, Canada, 3Toronto General Hospital Research Institute, UHN, Toronto, ON, Canada, 4Keystone Consulting Enterprises Inc., Toronto, ON, Canada, 5University of Toronto - Toronto, Toronto, ON, Canada

    Background/Purpose: Tofacitinib (TOFA) is an oral, small molecule drug used for rheumatoid arthritis (RA) treatment as the first or an alternative option to biologic disease-…
  • Abstract Number: 1219 • ACR Convergence 2021

    Machine Learning Based Prediction Model for Responses of bDMARDs in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Background/Purpose: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient…
  • Abstract Number: 0333 • ACR Convergence 2020

    Comparative Effectiveness of Secukinumab, Adalimumab and Other Tumor Necrosis Factor Inhibitors Used with or Without Methotrexate in the Treatment of Psoriatic Arthritis

    Denis Choquette1, Loïc Choquette Sauvageau2, Louis Bessette3, Isabelle Ferdinand2, Boulos Haraoui4, Frédéric Massicotte2, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard2, Diane Sauvageau2, Édith Villeneuve2 and Louis Coupal2, 1Institut de Rhumatologie de Montréal, Montreal, Canada, 2Institut de Rhumatologie de Montréal, Montréal, QC, Canada, 3Laval University, Quebec, Canada, 4Rheumatology Institute of Montréal, Montreal, Canada

    Background/Purpose: The treatment of psoriatic arthritis has evolved with the addition of agents targeting a different cytokine, Il-17 introduced in 2016. It has proven to…
  • Abstract Number: 0592 • ACR Convergence 2020

    A Rheumatology-Driven Protocol and Treatment Algorithm of SARS-CoV-2 Cytokine Release Syndrome and Its Associated Outcomes

    Sandy Lee1, Neha Chiruvolu2, Muntarin Karim3, Patil Injean4, Loomee Doo5, Donna Jose6, Deepa Panikkath1, Micah Yu5, Anna Lafian5, Wendy De La Pena7, Albert Chow8, Karina Torralba9, Vaneet Sandhu10, Mehrnaz Hojjati5, Marven Cabling5 and Christina Downey1, 1Loma Linda University Medical Center, Redlands, CA, 2UC Riverside School of Medicine, Riverside, CA, 3Loma Linda University Health System, Loma Linda, CA, 4LOMA LINDA UNIVERSITY MEDICAL CENTER - RHEUMATOLOGY, Redlands, CA, 5Loma Linda University Medical Center, LOMA LINDA, CA, 6Loma Linda University Medical Center, Ontario, CA, 7PRCSG, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 8Loma Linda University, San Bernardino, CA, 9Loma Linda University School of Medicine, Redlands, CA, 10Loma Linda University, Loma Linda, CA

    Background/Purpose: The newly identified SARS-CoV-2 has brought Cytokine Release Syndrome (CRS) to a level of prominence not often seen in adult medicine. Mortality rates of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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