ACR Meeting Abstracts

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Abstracts tagged "Biologic drugs"

  • Abstract Number: 1539 • 2014 ACR/ARHP Annual Meeting

    Relation Between Number of Previous Anti TNF Agents and Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab

    Daniela Opris1, Diana Mazilu2, Violeta Bojinca3, Andreea Borangiu2, Andra Balanescu4, Denisa Predeteanu5 and Ruxandra Ionescu4, 153 Tineretului Blvd, Bl. 65, s, Sfanta Maria Clinical Hospital, UMF Carol Davila, Bucharest, Romania, 2Sfanta Maria Clinical Hospital, UMF Carol Davila, Bucharest, Romania, 3Intr. Carol Knappe Nr. 9A, Sec, Sfanta Maria Clinical Hospital, UMF Carol Davila, Bucharest, Romania, 4Rheumatology, Sfanta Maria Clinical Hospital, UMF Carol Davila, Bucharest, Romania, 5Bld.Mircea Voda Nr 36., Bl M6,, Sfanta Maria Clinical Hospital, UMF Carol Davila, Bucharest, Romania

    Background/Purpose Debate is still ongoing regarding rituximab (RTX) as a first or second line biologic therapy. The objective of present study is to assess correlations between…
  • Abstract Number: 2316 • 2013 ACR/ARHP Annual Meeting

    Anti-Human TNF-Alpha Domain Antibody Construct, CEP-37247/Placulumab, Is As Efficacious As Other Leading TNF-Alpha-Blockade Therapies in a Humanized Mouse Model of Rheumatoid Arthritis

    Matthew M. Seavey1, Linglong Zou2, Adam Clarke3, Anthony G. Doyle3, Roberta Weiss4, Aric Orbach5, Brad McIntyre6 and Merav Bassan7, 1Nonclinical Development, Pharmacology, Teva Pharmaceuticals, Inc., West Chester, PA, 2GB&T, Teva Biopharmaceuticals, Rockville, MD, 3Discovery Biologics, Teva Pharmaceuticals, Inc., Sydney, Australia, 4Clinical Development, Teva Pharmaceuticals, Inc., Frazer, PA, 5Nonclinical Development, Pharmacology, Teva Pharmaceuticals, Inc., Netanya, Israel, 6Formulation, Teva Pharmaceuticals, Inc., West Cheater, PA, 7Teva R&D - Innovative Project Leadership, Teva Pharmaceuticals, Inc., Netanya, Israel

    Background/Purpose: The cytokine tumor necrosis factor (TNF)alpha is a potent pro-inflammatory mediator involved in several autoimmune diseases including rheumatic arthritis and for over a decade…
  • Abstract Number: 1913 • 2013 ACR/ARHP Annual Meeting

    Expectations RA Patients Have For Their Treatment – A Comparison Of Clinical Results For Biologic and Disease-Modifying Anti-Rheumatic Drug Treated Patients Using Multiple Medical Cohorts

    Tsukasa Matsubara1,2, Hiroaki Matsuno2, Tomomaro Izumihara2, Yuichi Takahashi2, Akira Sagawa2, Motohiro Oribe2, Eisuke Shono2, Kensuke Kume2, Masanori Adachi2, Yuichi Nishioka2, Nobumasa Miyake2, Keisuke Hashimoto2, Toshikaki Miyamoto2, Shigeto Kiyokawa2, Tomohiko Yoshida2, Syoichi Kondo2, Yoshiki Shiohira2, Takanori Azuma2, Yukio Sato2, Masaaki Yoshida2, Kenji Mannami2, Akihiko Nakamura2, Yasuhiko Hirabarashi2, Keiko Funahashi3 and James E. Middleton4, 1Department of Orthopedics, Matsubara Mayflower Hospital, Kato, Japan, 2Japanese Clinician's Biologic Research Group, Kobe, Japan, 3Department of Clinical Research, Matsubara Mayflower Hospital, Kato, Japan, 4Research Institute of Joint Diseases, Kobe, Japan

    Background/Purpose: Treat to Target (T2T) primary principal - “The treatment of rheumatoid arthritis must be based on a shared decision between patient and rheumatologist”. Japan…
  • Abstract Number: 1736 • 2013 ACR/ARHP Annual Meeting

    A Randomized, Controlled, Multicenter, 2‑Arm, Parallel‑Group, Double-Blind Study To Demonstrate The Equivalence Of CT-P10 To Innovator Rituximab With Respect To Pharmacokinetic Profile In Patients With Rheumatoid Arthritis

    Dae-Hyun Yoo1, Won Park2, Slawomir Jeka3, Fidencio Cons Molina4, Pawel Hrycaj5, Piotr Wiland6, Wolfgang Spieler7, Jan Brzezicki8, Eun Young Lee9, Francisco G. Medina-Rodriguez10, Pavel Shesternya11, Sebastiao Radominski12, Marina Stanislav13, Volodymyr Kovalenko14, Dong Hyuk Sheen15, Mie Jin Lim16, Jung-Yoon Choe17, Sung Young Lee18, Seung-Cheol Shim19 and Chang-Hee Suh20, 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 3Clinic of Rheumatology and Connective Tissue Diseases University Hospital No 2 in Bydgoszcz Collegium Medicum UMK in Torun, Bydgoszcz, Poland, 4Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Mexico, 5Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland, 6Department of Rheumatology, Medical University of Wroclaw, Wroclaw, Poland, 7Osteologie und Rheumatologie, ZeFOR GmbH Zentrum für Forschung, Zerbst, Germany, 8Wojewodzki Szpital Zespolony Oddzial Reumatologiczny, Elblag, Poland, 9Internal medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 10Centro de Investigación Farmacológica y Biotecnológica, Mexico City, Mexico, 11Rheumatology Department, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 12CETI Centro de Estudos em Terapias Inovadoras Ltda, Curitiba, Brazil, 13Central Russian National Institute of Rheumatology, Russian Academy of Medical Science, Moscow, Russia, 14Section of Non-coronarogenic Myocardial Diseases and Clinical Rheumatology, National Scientific Center, Kiev, Ukraine, 15Rheumatology, Eulji University Hospital, DaeJeon, South Korea, 16Division of Rheumatology, Department of Internal Medicine,, Inha University Hospital, Incheon, South Korea, 17Rheumatology, Daegu Catholic University Medical Center, Daegu, South Korea, 18Clinical Planning and Medical Affairs Department, CELLTRION, Inc., Incheon, South Korea, 19Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea, 20Department of Rheumatology, Ajou University Hospital, Suwon, South Korea

    Background/Purpose: CT-P10 was developed as a biosimilar candidate to innovator rituximab (RTX), an anti-CD20 monoclonal antibody. This trial is a phase I study to demonstrate…
  • Abstract Number: 1697 • 2013 ACR/ARHP Annual Meeting

    Are Patients With Rheumatoid Arthritis Still At An Increased Risk Of Tuberculosis and What Is The Role Of Biological Treatment?

    Elizabeth V. Arkema1, Jerker Jonsson2, Eva Baecklund3, Maud Rutting4, Judith Bruchfeld5, Nils Feltelius4 and Johan Askling1,6, 1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Swedish Institute for Communicable Disease Control, Solna, Sweden, 3Department of Medical Sciences, Rheumatology, Uppsala University Hospital, Uppsala, Sweden, 4Swedish Medical Products Agency, Uppsala, Sweden, 5Department of Medicine, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden, 6Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose:   Anti-TNF therapy is a risk factor for clinical tuberculosis (TB), which has led to pre-treatment screening and increased vigilance. The extent to which…
  • Abstract Number: 1460 • 2013 ACR/ARHP Annual Meeting

    10 Years Of Treat-To-Target Therapy In Rheumatoid Arthritis Patients (the BeSt study): Clinical and Radiological Outcomes

    I.M. Markusse1, G. Akdemir1, M. van den Broek1, L. Dirven1, R.J. Goekoop2, K.H. Han3, M. van Oosterhout4, P.J.S.M. Kerstens5, W.F. Lems6, T.W.J. Huizinga1 and C.F. Allaart1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Haga Hospital, The Hague, Netherlands, 3Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 4Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 5Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 6Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Long term studies with treat-to-target therapy are essential to guide treatment strategies. We report on a study that compared clinical and radiological outcomes of…
  • Abstract Number: 1461 • 2013 ACR/ARHP Annual Meeting

    Corticosteroid Use In Rheumatoid Arthritis Patients On Infliximab: Treatment Implications Based On A REAL-WORLD Canadian Population

    Boulos Haraoui1, Algis V Jovaisas2, William G. Bensen3, Rafat Y. Faraawi4, John T. Kelsall5, Sanjay Dixit6, Emmanouil Rampakakis7, John S. Sampalis7, Francois Nantel8, Susan M. Otawa9, Allen J. Lehman9 and May Shawi10, 1Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, 3Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 4Rheumatologist, KW Musculoskeletal Research Inc., Kitchener, ON, Canada, 5Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, 6McMaster University, Hamilton, ON, Canada, 7JSS Medical Research, Montreal, QC, Canada, 8Janssen Inc., Toronto, ON, Canada, 9Medical Affairs, Janssen Inc., Toronto, ON, Canada, 10Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: The Canadian Rheumatology Association1 recommends that addition of corticosteroids (CS) should be considered only for the shortest period possible in rheumatoid arthritis (RA) patients…
  • Abstract Number: 1469 • 2013 ACR/ARHP Annual Meeting

    Therapeutic Strategy In Patients With Rheumatoid Arthritis and Insufficient Response To a 1st Anti-TNF: Results of the Multicenter Randomized Controlled “ROC” Trial

    Jacques-Eric Gottenberg1, Olivier Brocq2, Aleth Perdriger3, Slim Lassoued4, Jean-Marie Berthelot5, Daniel Wendling6, Liana E. euller-Ziegler7, Martin Soubrier8, Christophe Richez9, Bruno Fautrel10, Arnaud L. Constantin11, Xavier Mariette12, Jacques Morel13, Melanie Gilson14, Grégoire Cormier15, Jean Hugues Salmon16, Stephanie Rist17, Frédéric Liote18, Hubert Marotte19, Christine Bonnet20, Christian Marcelli21, Jeremie Sellam22, Olivier Meyer23, Elisabeth Solau-Gervais24, Sandrine Guis25, Jean-Marc Ziza26, Charles Zarnitsky27, Isabelle Valckenaere28, Olivier Vittecoq29, Alain Saraux30, Yves-Marie Pers31, Martine Gayraud32, Gilles Bolla33, Pascal Claudepierre34, Marc Ardizzone35, Emmanuelle Dernis36, Maxime A. Breban37, Olivier Fain38, Jean-Charles Balblanc39, Ouafaa Aberkane1, Marion Vazel1, Christelle Back1, Elodie Perrodeau40, Philippe Ravaud41 and Jean Sibilia42, 1Strasbourg University Hospital, Strasbourg, France, 2Hospital of Princesse Grâce de Monaco, Monaco, France, 3Rheumatology, Hôpital Sud, Rennes, France, 4Cahors Hospital, Cahors, France, 5Rheumatology Unit, Nantes University Hospital, Nantes, France, 6Rheumatology, University Hospital, Besancon, France, 7Service de Rhumatologie, L Archet Hospital (University), Nice CEDEX 3, France, 8Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, 9Pellegrin Hospital, Bordeaux, France, 10Rheumatology, UPMC - Paris 6 University, Paris, France, 11Rheumatology, Purpan University Hospital, Toulouse, France, 12Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, 13Montpellier University Hospital, Montpellier, France, 14CH Grenoble Hopital Sud, Grenoble, France, 15CHD Les Oudairies, LA ROCHE SUR YON, France, 16Reims Hospital, Reims, France, 17Rheumatology, Orleans Hospital, Orleans, France, 18Hôpital Lariboisière, Paris, France, 19INSERM U1059 and University Hospital, Hôpital Nord, Saint-Etienne, France, 20department of Rheumatology, CHU Dupuytren Limoges, Limoges, France, 21Rheumatology Department, Caen University Hospital, CAEN, France, 22Rheumatology, Hopital Saint-Antoine, Pierre et Marie Curie University Paris 6, AP-HP, 75012, France, 23Rheumatology, Hopital Bichat, Paris, France, 24Poitiers University Hospital, Poitiers, France, 25Rheumatology1, CRMBM UMR CNRS 7339, Aix Marseille Univ; AP-HM, Marseille, France, 26Rheumatology, Croix Saint Simon Hospital, Paris, France, 27Rheumatology, CH du Havre, Le Havre, France, 28Nancy University Hospital, Nancy, France, 29RouenUniversity Hospital, Rouen, France, 30Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, 31Department of Immuno-Rhumatology, CHU Lapeyronie, Montpellier, France, 32Institut Montsouris, Paris, France, 33Cannes Hospital, Cannes, France, 34Rheumatology, Henri Mondor Teaching Hospital, AP-HP, Créteil, France, 35Mulhouse Hospital, Mulhouse, France, 36Le Mans Hospital, Le Mans, France, 37Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, 38Internal Medicine, Jean Verdier Hospital, Bondy, France, 39Rheumatology, Centre Hospitalier Général de Belfort, Belfort, France, 40Epidemiology, Hotel Dieu, Paris, France, 41Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 42Rheumatology, CHU Hautepierre, Strasbourg, France

    Background/Purpose: TNF inhibitors often represent the 1st biologic prescribed to patients with rheumatoid arthritis (RA). Approximately one third of patients fail to respond. However, therapeutic…
  • Abstract Number: 1344 • 2013 ACR/ARHP Annual Meeting

    Optimal Rheumatoid Arthritis Patient Selection For Biological Treatment From Pharmacoeconomic Perspectives Based On The Institute Of Rheumatology, Rheumatoid Arthritis (IORRA) Cohort

    Eiichi Tanaka1, Eisuke Inoue2, Yoko Shimizu3, Akiko Kobayashi2, Naoki Sugimoto2, Daisuke Hoshi2, Kumi Shidara2, Eri Sato3, Yohei Seto2, Ayako Nakajima4, Shigeki Momohara2, Atsuo Taniguchi2 and Hisashi Yamanaka3, 1Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, 3Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: With the recent introduction of biological DMARDs, the economic burden of rheumatoid arthritis (RA) treatment has increased. Previous studies evaluated the cost-effectiveness of biologics,…
  • Abstract Number: 1334 • 2013 ACR/ARHP Annual Meeting

    Predicted Versus Observed Radiographic Progression In a Rheumatoid Arthritis Randomized Trial

    Adrian Levitsky1, Kristina Forslind2,3 and Ronald F. van Vollenhoven4, 1Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 2Department of Clinical Sciences, Section of Rheumatology, Skåne University Hospital, Lund, Sweden, 3Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden, 4Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Radiographic progression is a key outcome in early RA. We previously developed a radiographic progression prediction method based on the patient’s report of symptom…
  • Abstract Number: 997 • 2013 ACR/ARHP Annual Meeting

    Does Biologic Treatment For Rheumatoid Arthritis Offset Health Care Costs In Patients With Rheumatoid Arthritis? An Instrumental Variable Approach Using Administrative Data

    Nick Bansback1, Eric Fu2, Daphne Guh2, Huiying Sun2, Wei Zhang2, Diane Lacaille3,4 and Aslam H. Anis1, 1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, 2St. Paul's Hospital, Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada, 3Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, 4Medicine, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Expenditure on biologic therapies for rheumatoid arthritis (RA) accounts for the highest pharmaceutical spending in many western healthcare systems. Given their clinical benefit with…
  • Abstract Number: 998 • 2013 ACR/ARHP Annual Meeting

    Adequacy Of Drug Coverage and Cost-Sharing For Medicare Beneficiaries With Rheumatoid Arthritis

    Jinoos Yazdany1, R. Adams Dudley2, Randi Chen3 and Chien-Wen Tseng4, 1Medicine, University of California, San Francisco, San Francisco, CA, 2Medicine, University of California San Francisco Philip R. Lee Institute for Health Policy Studies, San Francisco, CA, 3Pacific Health Research and Education Institute, Honolulu, HI, 4Dept of Family Medicine and Community Health, University of Hawaii and Pacific Health Research and Education Institute, Honolulu, HI

    Background/Purpose :  Biologic and non-biologic disease-modifying anti-rheumatic drugs (DMARDs) significantly reduce pain, disability and mortality in rheumatoid arthritis (RA).  We evaluated how well RA drugs…
  • Abstract Number: 495 • 2013 ACR/ARHP Annual Meeting

    The Impact Of Inadequate Response To Prior Biologic Agents On Abatacept Drug Retention In Rheumatoid Arthritis Patients. A Pan-European Analysis Of RA Registries

    Axel Finckh1, Florenzo Iannone2, Juan Gomez Reino3, David Neto4, Elisabeth Lie5, Piet van Riel6, Merete Lund Hetland7, Karel Pavelka8, Carl Turesson9, Xavier Mariette10 and Jacques-Eric Gottenberg11, 1Department of Medical Specialities, University of Geneva, Geneva, Switzerland, 2D.I.M.I.M.P, Rheumatology Unit - University of Bari, Bari, Italy, 3Rheumatology Department, Hospital Clínico de Santiago, Santiago de Compostela, Spain, 4Rheumatology, University of Geneva, Geneva, Switzerland, 5Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 6Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 7Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, 8Department of Clinical and Experimental Rheumatology, Charles University, Prague, Czech Republic, 9Lund University, Malmö, Sweden, 10Paris-Sud University, Paris, France, 11Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France

    Background/Purpose: In rheumatoid arthritis (RA), abatacept (ABA) may be used in biologic naïve patients (pts) or after failure to an anti-TNF or other biologic agents…
  • Abstract Number: 2808 • 2013 ACR/ARHP Annual Meeting

    Favorable Outcome Of Hepatitis E Virus Infection In Patients With Inflammatory Arthritides Treated With Immunosupressants

    Hélène Bauer1, Cécile Luxembourger2, Sophie Fournier3, Alain G. Cantagrel4, Jean Marie Peron3, Anne Marie Roque Afonso5, Pascal Claudepierre6, S. Fabre7, Christophe Hudry8, Guillaume Lefevre9, Antoine Martin10, Laurent Messer11, Béatrice Pallot Prades12, Christian Roux13, Christelle Sordet14, Claire Veissier15, Daniel Wendling16, Jacques-Eric Gottenberg17 and Jean Sibilia18, 1rhumatologie, CHU de Hautepierre, Strasbourg, France, 2rhumatologie, CHU de Toulouse, Toulouse, France, 3Hépato-gastro-entérologie, CHU de Toulouse, Toulouse, France, 4Centre Hospitalier Universitaire de Toulouse, Toulouse, France, 5INSERM U785, CNR hépatites A et E, virologie hôpital Paul Brousse, Villejuif, France, 6Rheumatology, Henri Mondor Teaching Hospital, AP-HP, Créteil, France, 7Unité clinique d'immuno-rhumatologie, CHU MONTPELLIER, Montpellier, France, 8Rheumatology, Hopital Cochin, Paris, France, 9Lille University Hospital, Internal Medicine Department, Lille, France, 10Rhumatologie, Centre Hospitalier De St Brieuc, St Brieuc, France, 11Rhumatologie, Hopitaux Civils de Colmar, Colmar, France, 12Rhumatologie, CHU St Etienne, St Etienne, France, 13Rheuamtology, CHU L' Archet University Nice, Nice, France, 14Rheumatology, Strasbourg University Hospital, Strasbourg, France, 15rhumatologie, CHU de Bordeaux, Bordeaux, France, 16Rheumatology, University Hospital, Besancon, France, 17Strasbourg University Hospital, Strasbourg, France, 18Rheumatology, CHU Hautepierre, Strasbourg, France

    Background/Purpose: In inflammatory rheumatic diseases, the prevalence, clinical presentation and outcome of hepatitis E, an ubiquitous viral infection, remain unknown. We therefore addressed these issues…
  • Abstract Number: 328 • 2013 ACR/ARHP Annual Meeting

    Clinical Characteristics Of Patients Who Switch Biologic Therapy Within The First Two Years: Results From a Large US Registry Population

    Philip J. Mease1, Emily Edson-Heredia2, Katherine C. Saunders3, Catherine L. Shuler2, Baojin Zhu2, Monica Chaudhari4 and Jeffrey D. Greenberg5, 1Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, 2Eli Lilly and Company, Indianapolis, IN, 3Corrona, LLC., Southborough, MA, 4Axio Research LLC, Seattle, WA, 5Departments of Medicine (Rheum Div) and Hospital for Joint Diseases, New York Hospital for Joint Diseases, New York, NY

    Background/Purpose: The use of biologic therapy in psoriatic arthritis (PsA) has altered the disease course and has been shown to reduce disease activity. Data comparing…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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