Abstracts tagged "Biologic drugs"

Abstract Number: 1144 • 2014 ACR/ARHP Annual Meeting
Economic Implications for Policies Regarding Triple Therapy Use in Patients with Rheumatoid Arthritis
Nick Bansback¹, Diane V. Lacaille², Daphne Guh³, Kamran Shojania⁴ and Aslam H. Anis³, ¹School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ²Rheumatology, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, ³St. Paul's Hospital, Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Recent randomized controlled trials in rheumatoid arthritis (RA) patients have determined that a strategy of first adding the two Disease Modifying Anti-Rheumatic Drugs (DMARDs)…
Abstract Number: 2202 • 2014 ACR/ARHP Annual Meeting
Pilot Study of Tocilizumab in Patients with Erdheim-Chester Disease
Giulio Cavalli¹, Alvise Berti¹, Barbara Gulgielmi¹, Marco Gelpi², Riccardo Biavasco², Corrado Campochiaro¹, Alessandro Tomelleri², Marina Ferrarini³, Maria Grazia Sabbadini² and Lorenzo Dagna², ¹Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, ²Vita-Salute San Raffaele University, Milan, Italy, ³Department of Oncology, San Raffaele Scientific Institute, MIlan, Italy
Background/Purpose Erdheim-Chester disease (ECD) is a rare, systemic disorder of unknown etiology, characterized by tissue infiltration with CD68+, CD1a- foamy histiocytes. ECD is a chronic,…
Abstract Number: 1001 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Inhibit Wnt Signaling Pathway By Secreting Dockcop-1
Satoshi Yamasaki and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: There is evidence of osteoclast activation in the inflamed joints of patients with rheumatoid arthritis (RA). Studies that focus on osteoblasts are not sufficient…
Abstract Number: 2133 • 2014 ACR/ARHP Annual Meeting
Efficacy of Tocilizumab Therapy in Patients with Rheumatoid Arthritis Based on FDG-PET/CT
Koichi Okamura¹, Yukio Yonemoto¹, Chisa Okura² and Kenji Takagishi¹, ¹Orthopaedic Surgery, Gunma University, Maebashi, Japan, ²Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan
Background/Purpose: A humanized anti-interleukin-6 receptor (anti-IL-6R) antibody, tocilizumab (TCZ), is one of the biologics and the C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR)…
Abstract Number: 944 • 2014 ACR/ARHP Annual Meeting
Predict the Chance of Remission for Your RA Patient in Real Life
Till Uhlig¹, Vibeke Norvang², Elisabeth Lie¹, Erik Rødevand³, Knut Mikkelsen⁴, Åse S. Lexberg⁵, Synøve Kalstad⁶ and Tore K. Kvien¹, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway, ⁴Revmatismesykehuset, Lillehammer, Norway, ⁵Dept. of Rheumatology, Vestre Viken Hospital, Drammen, Norway, ⁶Rheumatology, University Hospital of Northern Norway, Tromsø, Norway
Background/Purpose: Clinical remission (REM) is the treatment target in rheumatoid arthritis (RA), and there are several composite REM criteria available. Knowledge on how disease duration affects REM…
Abstract Number: 2123 • 2014 ACR/ARHP Annual Meeting
Significant State-Level Variation in Source of Biologic Drug Coverage Among Beneficiaries with Rheumatoid Arthritis
Chris Tonner¹, Gabriela Schmajuk² and Jinoos Yazdany², ¹3333 California Street, Box 09, University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA
Background/Purpose: Biologic drugs can be obtained both through Medicare's Part B medical benefit (physician administered drugs) or Part D pharmacy benefit (self-administered drugs). Coverage for…
Abstract Number: 483 • 2014 ACR/ARHP Annual Meeting
Risk of HBV Reactivation in Rheumatoid Arthritis Patients Undergoing Treatment with Newer Biological Dmards, Tocilizumab and Abatacept: A Single-Center Real Life Experience
Francesca De Nard¹, Vittorio Grosso², Monica Todoerti³, Carlomaurizio Montecucco⁴ and Roberto Caporali⁵, ¹Division of Rheumatology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ²Division of Rheumatology, University of Pavia, Foundation IRCCS Policlinico S. Matteo, Pavia, Italy, ³Rheumatology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ⁴Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ⁵Division of Rheumatology, Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy
Background/Purpose HBV infection represents a major issue in patients with rheumatoid arthritis (RA) undergoing biological disease-modifying anti-rheumatic drugs (bDMARDs) (1). While the risk of hepatitis…
Abstract Number: 2040 • 2014 ACR/ARHP Annual Meeting
Opportunistic Infections in Patients Treated with Biologic Drug Therapy
Laura Encinas¹, Maria Haye Salinas¹, Veronica Saurit¹, Alejandro J. Alvarellos², Francisco Caeiro¹, Cristina Battagliotti³, Ida Elena Exeni⁴, Carla Gobbi⁵, Bernardo Pons-Estel⁶, Ingrid Strusberg⁷, Sergio Paira⁸, Eduardo Mussano⁹, Maria Apaz¹⁰, Ana Quinteros¹¹, Ana Capuccio¹², Mercedes De La Sota¹³, Maria Larroude¹⁴, Amelia Granel¹⁵, Oscar Rillo¹⁶, Enrique Soriano¹⁷, Gustavo Citera¹⁸, Diana Dubinsky¹⁹, Mari Delgado²⁰, Analia Alvarez²¹, Graciela Gómez²², Gustavo Casado²³, Santiago Aguero²⁴, Monica Sacnum²⁰, Mercedes Garcia²⁰, Sidney Soares de Souza²⁵, Edson Javier Velozo²⁶, C Paruolo²⁰, Monica Patricia Diaz²⁷, Emilia Cavillion²⁸, Juan C. Barreira²⁹, Gimena Gómez³⁰ and E. Scheines³¹, ¹Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, ²Reumatología, Hospital Privado Córdoba, Córdoba, Argentina, ³Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ⁴Sanatorio Parque, Cordoba, Argentina, ⁵Hospital Còrdoba, Còrdoba, Argentina, ⁶Sanatorio Parque, Rosario, Argentina, ⁷Instituto Reumatológico Strusberg, Cordoba, Argentina, ⁸Section of Rheumatology, Hospital Jose Maria Cullen, Santa Fe, Argentina, ⁹Hospital Nacional De Clinicas, Mariquita Sanchez 2304, Buenos Aires, Argentina, ¹⁰Pediatric Rheumatology, Hospital de niños de cordoba, córdoba, Argentina, Argentina, ¹¹Centro Integral de Reumatología, Tucumán, Argentina, ¹²Rheumatology, Hospital cesar Milstein, Buenos Aires, Argentina, ¹³Consultorio, Bahia Blanca, Argentina, ¹⁴Consultorio, Buenos Aires, Argentina, ¹⁵Rheumatology, Hospital San Roque de Gonnet, La Plata, La Plata, Argentina, ¹⁶Rheumatology, Hospital Sirio Libanes, Buenos Aires, Argentina, ¹⁷Hospital Italiano, Buenos Aires, Argentina, ¹⁸Universidad de Buenos Aires, Buenos Aires, Argentina, ¹⁹Rheumatology, Hospital de Clinicas, Jose de San Martin, Capital Federal, Argentina, ²⁰consultorio, Buenos Aires, Argentina, ²¹Cemic, Buenos Aires, Argentina, ²²Diaz Colodrero 2537 8° A, Insituto de Investigaciones Medicas de la UBA, Capital Federal, Argentina, ²³Hospital Militar Central, Buenos Aires, Argentina, ²⁴Pasaje Sanchez Gardel 148, Sanatorio Pasteur, Catamarca, Argentina, ²⁵REUMAR, Buenos Aires, Argentina, ²⁶25 DE MAYO 255 -LIBERTADOR SAN, Sanatorio Adventista Del Plata, Entre Rios, Argentina, ²⁷Espana 327, consultorio, Bariloche, Argentina, ²⁸Consultorio, Cordoba, Argentina, ²⁹Rheumatology, British Hospital, Buenos Aires, Argentina, ³⁰Hospital Argerich, Buenos Aires, Argentina, ³¹Rheumatology, Hospital Manuel Rocca, Ciudad Autonoma de Buenos Aires, Argentina
Background/Purpose Biological drug therapy is frequently used to treat autoimmune diseases.These drugs have an increased risk of infections, among them opportunistic infections.To evaluate the frequency…
Abstract Number: 476 • 2014 ACR/ARHP Annual Meeting
Medium-Term Safety of TNF-Alpha Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials
Lucile Poiroux¹, Yannick Allanore², Andre Kahan³ and Jerome Avouac⁴, ¹Rhumatologie A, Cochin Hospital, Paris, France, ²Rheumatology, Rheumatology A, Paris Descartes University, Cochin Hospital, APHP, Paris, France, Paris, France, ³Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Cochin Hospital, Paris, France
Background/Purpose: TNF-a inhibitors have changed the prognosis of rheumatoid arthritis (RA). The number of molecules and the time of exposure have increased. However, few studies…
Abstract Number: 2036 • 2014 ACR/ARHP Annual Meeting
Biologic Disease-Modifying Antirheumatic Drugs and Risk of High-Grade Cervical Dysplasia and Cervical Cancer in Women with RA
Seoyoung C. Kim¹, Sebastian Schneeweiss², Jun Liu³, Elizabeth W. Karlson⁴, Jeffrey N. Katz⁵, Sarah Feldman² and Daniel H. Solomon⁶, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Division of Pharmaoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Human papillomaviruses (HPV) are causes of high-grade cervical dysplasia and cervical cancer. Persistent HPV infection, the major risk factor for cervical cancer, is associated…
Abstract Number: 473 • 2014 ACR/ARHP Annual Meeting
Complications of Varicella Zona Virus Infections Are More Frequent in Patients Treated with Biologic Drugs When Combined with Steroids
Jacques Morel¹, Florence Tubach^2,3, Yannick Allanore⁴, Daniel Wendling⁵, Celine Cozic⁶, Emmanuelle Dernis Labous⁷, Eric Legangneux⁸, Thao Pham⁹, Sophie Odoit¹⁰, Isabelle Roitg¹¹, Isabelle Koné-Paut¹², Pierre Quartier¹³, Jean Sibilia¹⁴ and Severine Guillaume Czitrom¹⁵, ¹Rheumatology, Hopital Lapeyronie, Montpellier, France, ²Département d'Epidémiologie Biostatistique et Recherche Clinique, APHP, Hôpital Bichat, Paris, France, ³INSERM, Universite Paris Diderot, Paris, France, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Service de Rhumatologie, CHU J Minjoz, Besancon, France, ⁶Rheumatology, CHD la Roche sur Yon, La Roche Sur Yon, France, ⁷Rhumatologie, Ch Du Mans, Le Mans, France, ⁸Rheumatology, Centre Hospitalier Public du Cotentin, 50100, France, ⁹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ¹⁰Dermatology, CHU de la Réunion, Saint Denis, France, ¹¹Hopital De Perpignan, Perpignan, France, ¹²Pediatrics Rheumatology, CHU Bicêtre, Le Kremlin Bicêtre, France, ¹³Pediatric Rheumatology, IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France, ¹⁴Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹⁵Ch De Bicetre, Le Kremlin Bicetre Cedex, France
Background/Purpose To assess varicella zona virus (VZV) infection features under biological drugs. Methods A call for observations was sent from april 2013 to april 2014…
Abstract Number: 2042 • 2014 ACR/ARHP Annual Meeting
Tuberculin Conversion in Patients with Autoimmune Arthropathies Receiving Biologic Therapy
Osvaldo Luis Cerda¹, Maria de los Angeles Correa², Amelia Granel³, Ana Inés Marcos³, Claudia L. Giraldo⁴, Oscar L. Rillo⁵ and Gustavo Citera⁶, ¹Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology, Instituto de Rehabilitación Psicofísica de Buenos Aires, Buenos Aires, Argentina, ³Rheumatology, Hospital San Roque de Gonnet, La Plata, La Plata, Argentina, ⁴Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁵Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁶Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose: Patients receiving biologic DMARDs are at increase risk of developing tuberculosis (TB). Tuberculosis skin test (TST) is recommended to screen for TB infection prior…
Abstract Number: 471 • 2014 ACR/ARHP Annual Meeting
Improving of Safety in Treatment with Biologics during First Seven-Years Experiences; Long-Term Results from Observational Cohort Study of Clinical Practice Using Multicenter Registry in Japan
Toshihisa Kojima¹, Nobunori Takahashi¹, Koji Funahashi², Shuji Asai², Yutaka Yoshioka², Kenya Terabe², Nobuyuki Asai^2,3, Toki Takemoto², Naoki Ishiguro¹, Atsushi Kaneko⁴, Yuji Hirano⁵, Yuichiro Yabe⁶ and Yasuhide Kanayama⁷, ¹Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Nagoya University Hospital, Nagoya, Japan, ³Nagoya Univeristy Hospital, Nagoya, Japan, ⁴Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan, ⁵Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan, ⁶Rheumatology, JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan, ⁷Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital, Toyota, Japan
Background/Purpose: Many evidences including clinical trials of biologics lead us earlier and more aggressive treatment strategy for patients with rheumatoid arthritis (RA). It is stated…
Abstract Number: 1909 • 2014 ACR/ARHP Annual Meeting
Incidence of Congestive Heart Failure in Subjects with Rheumatoid Arthritis Receiving Anti-Tumour Necrosis Factor Drugs: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Alper van Sijl¹, Mamas Mamas², Mark Lunt^3,4, . BSRBR Control Centre Consortium³, Kath Watson⁵, Deborah P. Symmons^3,6 and Kimme L. Hyrich⁷, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ²Manchester Heart Centre, Manchester Royal Infirmary, Oxford Road, Manchester, UK; Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁷Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom
Background/Purpose Subjects with rheumatoid arthritis (RA) are at a higher risk of developing cardiovascular (CV) disease compared to the general population, with an increased incidence…
Abstract Number: 301 • 2014 ACR/ARHP Annual Meeting
Pregnancies in Females with Juvenile Idiopathic Arthritis (JIA) Who Were Exposed to Biologics and/or Methotrexate – Results from a Biologic Register
Katrin Stüdemann¹, Martina Niewerth¹, Jens Klotsche¹, Angela Zink², Gerd Horneff³ and Kirsten Minden^1,4, ¹Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ²German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, ³Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ⁴Chidlrens´ hospital, Charité University Medicine, Berlin, Germany
Background/Purpose JIA often continues into adult life and affects about 1 in 1,000 people of childbearing age. Little is known about the impact of JIA…

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