Abstracts tagged "biologic drugs and rheumatoid arthritis (RA)"

Abstract Number: 532 • 2019 ACR/ARP Annual Meeting
A Phase 2 Study of E6011, an Anti-Fractalkine Monoclonal Antibody, ㏌ Patients with Rheumatoid Arthritis Inadequately Responding to Biologics
Yoshiya Tanaka¹, Tsutomu Takeuchi ², Hisashi Yamanaka ³, Toshihiro Nanki ⁴, Hisanori Umehara ⁵, Nobuyuki Yasuda ⁶, Fumitoshi Tago ⁷, Yasumi Kitahara ⁸, Makoto Kawakubo ⁷, Hayato Hisaki ⁸, Seiichiro Hojo ⁸, Tetsu Kawano ⁶ and Toshio Imai ⁶, ¹University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ²Keio University School of Medicine, Tokyo, Japan, ³Sanno Medical Center, Minato-ku, Tokyo, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, ⁵Nagahama City Hospital / Division of Rheumatology and Immunology, Nagahama, Japan, ⁶KAN Research Institute, Inc., Kobe, Japan, ⁷Eisai Co., Ltd., Tokyo, Japan, ⁸Eisai Co., Ltd., Bunkyo-ku, Japan
Background/Purpose: Fractalkine (CX3CL1, designated as FKN hereafter) is the sole member of the CX3C-chemokine which leads to dual actions, chemotaxis and cell adhesion for leukocytes…
Abstract Number: L08 • 2018 ACR/ARHP Annual Meeting
High Baseline Serum IL-6 Identifies a Subgroup of Rheumatoid Arthritis Patients with Rapid Joint Damage and Clinical Progression and Predicts Increased Sarilumab Treatment Response
Anita Boyapati¹, Jérôme Msihid², Sergio Schwartzman³, Ernest Choy⁴, Mark C. Genovese⁵, Gerd R. Burmester⁶, Gordon Lam⁷, Toshio Kimura¹, Jonathan Sadeh⁸ and Neil M.H. Graham¹, ¹Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ²Sanofi Chilly-Mazarin, Chilly-Mazarin, NJ, France, ³Hospital for Special Surgery, New York, NY, ⁴CREATE Center, Cardiff University School of Medicine, Cardiff, Great Britain, ⁵Division of Immunology & Rheumatology, Stanford University, Stanford, CA, ⁶Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany, ⁷Atrium Health, Charlotte, NC, ⁸Sanofi, Bridgewater, NJ
Background/Purpose: Clinical application of biomarkers to predict response to therapy is the next frontier in RA. Despite the key role of IL-6 in RA, the…
Abstract Number: 625 • 2018 ACR/ARHP Annual Meeting
Tapering of Biological Antirheumatic Drugs in Rheumatoid Arthritis Patients Is Achievable and Cost Effective in Daily Clinical Practice: DATA from the Brussels UCL RA Cohort
Stéphanie Dierckx¹, Bernard R. Lauwerys², Tatiana Sokolova¹, Laurent Meric de Bellefon¹, Maria Stoenoiu¹, Adrien Nzeusseu Toukap³, Frédéric A. Houssiau², Aleksandra Avramovska¹ and Patrick Durez¹, ¹Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²Pôle de pathologies rhumatismales systémiques et inflammatoires, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium
Background/Purpose: Several studies have demonstrated that Rheumatoid Arthritis (RA) patients achieving low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs).…
Abstract Number: 1016 • 2017 ACR/ARHP Annual Meeting
The Genetic Biomarkers to Predicting Response of TNF Inhibitors Treatment in Rheumatoid Arthritis
So-Young Bang¹, Youngho Park², Kwangwoo Kim³, Young Bin Joo⁴, Soo-Kyung Cho⁵, Chan-Bum Choi¹, Yoon-Kyoung Sung², Tae-Hwan Kim², Jae-Bum Jun¹, Dae-Hyun Yoo¹, Hye-Soon Lee⁶ and Sang-Cheol Bae⁷, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ³4Department of Biology, Kyung Hee University, Seoul, Korea, Republic of (South), ⁴Internal Medicine, Department of Rheumatology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), ⁵Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ⁶Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), ⁷Department of Rhematology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)
Background/Purpose: Although pharmacogenetic studies of TNF inhibitors (TNFi) response presented the estimates of high heritability, only few loci with suggestive weak association as biomarkers for…
Abstract Number: 2630 • 2016 ACR/ARHP Annual Meeting
EBV Load Quantification in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis Treated By Abatacept and Tocilizumab
Emmanuel Massy¹, Gaétan Texier², Olivier Muis Pistor³, marielle Martin⁴, Isabelle Auger⁵, jean-Pierre Mattei⁶, Sandrine Guis⁷, Thao Pham^8,9,10, Jean Roudier^11,12,13 and Nathalie Balandraud¹⁴, ¹Rheumatology, Hôpital Sainte Marguerite, marseille, France, ²Centre d'épidémiologie et de santé publique des armées (CESPA) Marseille, marseille, France, ³rheumatology, Hôpital Sainte marguerite, marseille, France, ⁴INSERM UMRS 1097, marseille, France, ⁵Université Aix Marseille II, INSERM UMR1097, Marseille, France, ⁶Rheumatology, Hôpital Sainte Marguerite AP-HM, marseille, France, ⁷Rheumatology 1, CRMBM-CEMEREM 7339, Aix-Marseille Université, AP-HM, CNRS, Marseilles, France, ⁸Rheumatology, Service de rhumatoiogie, Marseille, France, ⁹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ¹⁰Rheumatology, APHM, Aix Marseille University, Marseille, France, ¹¹Laboratoire d'Immunogénétique de la polyarthrite rhumatoide, INSERM UMR639, Marseille Cedex 09, France, ¹²Rheumatology 1, Aix Marseille Univ, AP-HM, INSERM, Marseille, France, ¹³Hopital Sainte Marguerite, Marseille, France, ¹⁴Rheumatology 1, AP-HM, INSERM, Marseilles, France
Background/Purpose: For twenty years, the Epstein-Barr Virus (EBV) has been suspected to contribute to Rheumatoid Arthritis (RA). Immunity against EBV is impaired in RA. RA…
Abstract Number: 2242 • 2016 ACR/ARHP Annual Meeting
Comparison of Assessment and Management of RA and Other Rheumatic Diseases By Rheumatologists in Private Practices or an Academic Medical Center
Anna Coleman¹, Herbert Lindsley² and Jo Wick³, ¹Rheumatology, University of Kansas Medical Center, Kansas City, KS, ²Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ³Biostatistics, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Since 80% of rheumatologists practice outside the university setting, training projects for rheumatoid arthritis (RA) may benefit from an improved understanding of RA management…
Abstract Number: 2823 • 2014 ACR/ARHP Annual Meeting
Comparable Efficacy with Sarilumab Plus Methotrexate in Biologic-Experienced and Biologic-Naïve Patients with Moderate-to-Severe Rheumatoid Arthritis from a Phase 3, Randomized, Double-Blind, Placebo-Controlled, International Study
Roy Fleischmann^1,2, Dennis L. Decktor³, Chunpeng Fan⁴, Hubert Van Hoogstraten⁵ and Mark C Genovese⁶, ¹Metroplax Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, ²University of Texas Southwestern Medical Center, Dallas, TX, ³Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁴Biostatistics, Sanofi, Bridgewater, NJ, ⁵Sanofi, Bridgewater, NJ, ⁶Division of Immunology and Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose For patients with prior exposure to tumor necrosis factor-α inhibitor (TNF-I), the likelihood of response to subsequent treatment with a TNF-I declines with the…
Abstract Number: 2528 • 2014 ACR/ARHP Annual Meeting
Efficacy Meta-Analysis of Randomized Controlled Trials (RCTs) of Biologics in Methotrexate-Naive Patients with Early Rheumatoid Arthritis
Yusuf Yazici¹, Chunqiao Luo² and Christopher Swearingen³, ¹New York University Hospital for Joint Diseases, New York, NY, ²University of Arkansas, Biostatistics, Little Rock, AR, ³Pediatrics and Biostatistics, University of Arkansas, Little Rock, AR
Background/Purpose NNT analysis is a useful tool for putting RCT efficacy results into perspective in patient care. For clinical decision making, the NNT is a…
Abstract Number: 2419 • 2014 ACR/ARHP Annual Meeting
Efficacy of Biologic Medications in Active Rheumatoid Arthritis: A Systematic Review
Lynden Roberts^1,2, Kathleen Tymms³, Julien de Jager⁴, Geoffrey Littlejohn⁵, Hedley Griffiths⁶, David Nicholls⁷, Paul Bird⁸, Jennifer Young⁹ and Jane Zochling¹⁰, ¹JCU Clinical School, Townsville, QLD, Australia, ²Monash Medical Centre, Clayton, VIC, Australia, ³Canberra Rheumatology, Canberra, ACT, Australia, ⁴Olser House, Southport, QLD, Australia, ⁵Rheumatology, Monash Medical Centre and Monash University, Clayton, VIC, Australia, ⁶Barwon Rheumatology Service, Geelong, VIC, Australia, ⁷Coast Joint Care, Maroochydore, QLD, Australia, ⁸Combined Rheumatology Practice, Sydney, NSW, Australia, ⁹4-10 Inman Road, Roche Products Pty Limited, Sydney, NSW, Australia, ¹⁰Department of Rheumatology, Menzies Research Institute Tasmania, Hobart, TAS, Australia
Background/Purpose: In the last decade, biologic medications have transformed the management of RA. The effectiveness of these medications has been reported in numerous randomized controlled…
Abstract Number: 1910 • 2014 ACR/ARHP Annual Meeting
Risk of Hypersensitiviy Among Medicare Patients with Rheumatoid Arthritis Who Were Taking Biologics
Huifeng Yun¹, Fenglong Xie², Lang Chen³, James Lewis⁴ and Jeffrey R. Curtis⁵, ¹Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ²Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Pennsylvania, Philadelphia, PA, ⁵University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Healthcare providers have been alerted to the potential drug hypersensitivity reactions (HSRs, an adverse drug reaction that are uncommon but may be severe and…
Abstract Number: 1541 • 2014 ACR/ARHP Annual Meeting
Distinct Regulation of T Helper Cell Differentiation By Biologic DMARD Therapy in Rheumatoid Arthritis
Shingo Nakayamada¹, Satoshi Kubo¹, Maiko Yoshikawa¹, Naoki Yunoue¹, Yusuke Miyazaki¹, Kazuyoshi Saito¹ and Yoshiya Tanaka², ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), T helper cells can differentiate into functionally distinct subsets, leading to the persistent inflammation and immune abnormality…
Abstract Number: 1478 • 2013 ACR/ARHP Annual Meeting
The Prevalence Of Biological Monotherapy Among Rheumatoid Arthritis Patients In Denmark: Results From The Danish Nationwide Danbio Registry
Tanja Schjoedt Joergensen¹, Lars-Erik Kristensen², Tove Lorenzen³, Jørgen Jensen⁴, Lida Zanjani⁵, Toke Laursen⁶, Sheraz Butt⁷, Mette Y. Dam⁸, Hanne M. Lindegaard⁹, Jakob Espesen¹⁰, Oliver Hendricks¹¹, Prabhat Kumar¹², Anita Kincses¹³, Line H. Larsen¹⁴, Marlene Andersen¹⁵, Esben K. Næser¹⁶, Dorte V. Jensen¹⁷, Jolanta Grydehøj¹⁸, Barbara Unger¹⁹, Ninna Dufour²⁰, Vibeke N. Sørensen²¹, Sara Vildhøj²², Inger Marie J. Hansen²³, Johnny Raun²⁴ and Merete Lund Hetland²⁵, ¹The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen F, Denmark, ²Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden, ³Department of Rheumatology, Region Hospital Silkeborg, Silkeborg, Denmark, ⁴Department of Rheumatology, Køge, Denmark, ⁵Department of Rheumatology, Glostrup, Denmark, ⁶Department of Rheumatology, Gentofte, Denmark, ⁷Department of Rheumatology, Frederiksberg, Denmark, ⁸Department of Rheumatology, Aarhus, Denmark, ⁹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Rheumatology, Vejle, Denmark, ¹¹Department of Rheumatology, Gråsten, Denmark, ¹²Department of Rheumatology, Esbjerg, Denmark, ¹³Department of Rheumatology, Copenhagen, Denmark, ¹⁴Department of Rheumatology, Aalborg, Denmark, ¹⁵Department of Rheumatology, Aalborg University, Hjørring, Denmark, ¹⁶Department of Rheumatology, Silkeborg, Denmark, ¹⁷Department of Rheumatology, Rønne, Denmark, ¹⁸Department of Rheumatology, Viborg, Denmark, ¹⁹Department of Rheumatology, Horsens, Denmark, ²⁰Department of Rheumatology, Helsingør, Denmark, ²¹Department of Rheumatology, Randers, Denmark, ²²Department of Rheumatology, Holstebro, Denmark, ²³Department of Rheumatology, Svendborg, Denmark, ²⁴Department of Rheumatology, Fredericia, Denmark, ²⁵Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark
Background/Purpose: It is estimated that between 10 and 30% of rheumatoid arthritis (RA) patients are methotrexate (MTX)-intolerant and discontinuation is common in clinical practice. For…
Abstract Number: 1442 • 2013 ACR/ARHP Annual Meeting
Three-Year Drug Survival and Effectiveness Of Abatacept and Tocilizumab In Patients with Rheumatoid Arthritis Treated In Routine Care. Results From The Nationwide Danish Danbio Registry
HCB Leffers^1,2, Mikkel Østergaard³, Bente Glintborg⁴, Niels Steen Krogh⁵, Ulrik Tarp⁶, Tove Lorenzen⁷, Annette Hansen⁸, Lene Dreyer⁹ and Merete L. Hetland³, ¹DANBIO, On behalf of Depts of Rheumatology, North, South, Central, Zealand and Capital Region, Glostrup, Denmark, ²Department of Rheumatology, Frederiksberg Hospital, Frderiksberg, Denmark, ³Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ⁵ZiteLab ApS, Copenhagen, Denmark, ⁶Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁷Department of Rheumatology, Region Hospital Silkeborg, Silkeborg, Denmark, ⁸Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark, ⁹Internal Medicine - Rheumatology Section, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark
Background/Purpose: Treatment with abatacept and tocilizumab has been shown to be efficacious in rheumatoid arthritis (RA) patients refractory to tumor necrosis factor inhibitor (TNFi). However,…

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