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Abstracts tagged "biologic drugs and randomized trials"

  • Abstract Number: 1864 • ACR/ARHP Annual Meeting 2018

    Ixekizumab Significantly Improves Signs, Symptoms, and Spinal Inflammation of Active Ankylosing Spondylitis/Radiographic Axial Spondyloarthritis: 16-Week Results of a Phase 3 Randomized, Active and Placebo-Controlled Trial

    Désirée van der Heijde1, James Cheng-Chung Wei2, Maxime Dougados3, Philip J. Mease4, Atul A. Deodhar5, Walter P. Maksymowych6, Filip van Den Bosch7, Joachim Sieper8, Tetsuya Tomita9, Robert B.M. Landewé10, Lotus Mallbris11, Fangyi Zhao11, David Adams11, Beth Pangallo11 and Hilde Carlier11, 1Leiden University Medical Centre, Leiden, Netherlands, 2Allergy/Immunology/Rheumatology, Chung Shan Med Univ Hospital, Taichung, Taiwan, 3Rheumatology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France, Paris, France, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Oregon Health & Science U, Portland, OR, 6University of Alberta, Edmonton, AB, Canada, 7Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 8Charité University Hospital, Berlin, Germany, 9Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan, 10Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, 11Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: COAST-V (NCT02696785) is the first phase 3 study of ixekizumab (IXE), a high-affinity anti-IL-17A monoclonal antibody, in patients (pts) with active radiographic axial SpA…

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