Abstracts tagged "Biologic agents"

Abstract Number: 1542 • 2017 ACR/ARHP Annual Meeting
Inequity in Biologic DMARD Prescription for Spa across the Globe: Results from the Multi-Centre, Cross-Sectional, ASAS Comospa Study
Elena Nikiphorou¹, Désirée van der Heijde², Sam Norton³, Robert B.M. Landewé⁴, Anna Moltó⁵, Maxime Dougados⁶, Filip van Den Bosch⁷ and Sofia Ramiro⁸, ¹LUMC, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Academic Rheumatology, King´s College London, London, United Kingdom, ⁴Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁵Paris Descartes University, Paris, France, ⁶Paris-Descartes University,, Paris, France, ⁷Rheumatology, Ghent University Hospital, Gent, Belgium, ⁸Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands
Background/Purpose: The value of biologic DMARDs (bDMARDs) in SpA is well recognized but global access to these treatments can be limited due to high cost…
Abstract Number: 2444 • 2017 ACR/ARHP Annual Meeting
Effectiveness and Safety of CT-P13 in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis and Plaque Psoriasis: Observational Study in Republic of Korea
Dong-Wook Kim¹, Tae-Hwan Kim², Seong Ryul Kwon³, Eun Young Lee⁴, Chang-Nam Son⁵, Yun Sung Kim⁶, Soung Hun Kim⁷, Yong-Beom Park⁸, Jin-Wuk Hur⁹, Hye-Soon Lee¹⁰, Sang Joon Lee¹¹ and Jee Hye Suh¹², ¹Inje University Busan Paik Hospital, Busan, Korea, Republic of (South), ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ³Inha University Hospital, Incheon, Korea, Republic of (South), ⁴Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Keimyung University Dongsan Medial Center, Daegu, Korea, Republic of (South), ⁶Chosun University Hospital, Gwangju, Korea, Republic of (South), ⁷Gwangmyeong Saeum Hospital, Gyeonggi-do, Korea, Republic of (South), ⁸Yonsei University Severance Hospital, Seoul, Korea, Republic of (South), ⁹Eulji University Seoul Hospital, Seoul, Korea, Republic of (South), ¹⁰Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), ¹¹CELLTRION, Inc., Incheon, Korea, Republic of (South), ¹²CELLTRION.Inc, Incheon, Korea, Republic of (South)
Background/Purpose: CT-P13 is approved as a biosimilar of innovator infliximab for marketing in 81 countries. After approval, observational study has been conducted in Republic of…
Abstract Number: 521 • 2017 ACR/ARHP Annual Meeting
Update on the Clinical Phase 1 and Phase 2 Trials Investigating the Fully Human Immunocytokine Dekavil (F8IL10) in Patients with Rheumatoid Arthritis
Mauro Galeazzi¹, Gian Domenico Sebastiani², Jürgen Wollenhaupt³, Jean Dudler⁴, Christof Specker⁵, Reinhard Voll⁶, Pascal Zufferey⁷, Piercarlo Sarzi Puttini⁸, Ombretta Viapiana⁹ and Franziska Bootz¹⁰, ¹Rheumatology, University Hospital of Siena, Siena, Italy, ²Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, ³Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ⁴Rheumatology, Cantonal Hospital Fribourg, Fribourg, Switzerland, ⁵Rheumatology, St. Josef Krankenhaus, Universitätsklinikum Essen, Esssen, Germany, ⁶Clinic for Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Freiburg, Germany, ⁷Department of Rheumatology, University Hospital Lausanne, Lausanne, Switzerland, ⁸Rheumatology, Luigi Sacco Hospital, Milan, Italy, ⁹University Hospital Verona, Verona, Italy, ¹⁰Clinical Department, Philochem AG (Philogen Group), Otelfingen, Switzerland
Background/Purpose: The antibody-based targeted pharmacodelivery of cytokines by means of immunocytokines has the potential to enhance therapeutic activity at the site of disease while sparing…
Abstract Number: 1430 • 2017 ACR/ARHP Annual Meeting
Switching from Synthetic to Biologic Dmards – Is There an Insufficient Use of Methotrexate?
Lisa Baganz¹, Adrian Richter¹, Yvette Meißner², Matthias Schneider³, Anke Liebhaber⁴, Ilka Schwarze⁵, Anja Strangfeld⁶ and Angela Zink⁷, ¹German Rheumatism Research Center, Berlin, Germany, ²Programme Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, ³Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ⁴Rheumatologist, Halle, Germany, Halle, Germany, ⁵Rheumatologist, Leipzig, Germany, Leipzig, Germany, ⁶Epidemiology, German Rheumatism Research Center, Berlin, Germany, ⁷German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany
Background/Purpose: A recent US-study suggests considerable underuse of MTX and too early switches to biologic (b)DMARDs1 before using a high MTX dose or changing the…
Abstract Number: 1543 • 2017 ACR/ARHP Annual Meeting
Real-World Effectiveness of TNF Inhibition in Spondyloarthritis. Data from a Large Nationwide Prospective Cohort – the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis
Gareth T. Jones¹, Andrew Keat², Ejaz Pathan³ and Gary J. Macfarlane¹, ¹Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, ²Rheumatology., Northwick Park Hospital, London, United Kingdom, ³Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
Background/Purpose: TNF inhibition has revolutionised the treatment of axial spondyloarthritis (AxSpA). Much of what we know about the use of these drugs comes from randomised…
Abstract Number: 2447 • 2017 ACR/ARHP Annual Meeting
Effectiveness and Tolerability of Benepali in Rheumatoid Arthritis Patients Switched from Enbrel
Sarah Dyball¹, Victoria Hoskins², Sharon Christy-Kilner² and Sahena Haque³, ¹Rheumatology, University Hospitals of South Manchester NHS Foundation Trust, Manchester, United Kingdom, ²University Hospitals of South Manchester NHS Foundation Trust, Manchester, United Kingdom, ³Rheumatology department, University Hospitals of South Manchester NHS Foundation Trust, Manchester, United Kingdom
Background/Purpose: Benepali, the etanercept biosimilar, is licenced in the UK for rheumatoid arthritis (RA) and costs less than Enbrel. This study aimed to evaluate the…
Abstract Number: 523 • 2017 ACR/ARHP Annual Meeting
Prevalence of Occult Hepatitis B Carrier Status and Its Associated Risk Factors in Patients with Rheumatic Diseases Undergoing Biological Therapies
Chi Chiu Mok¹, Ling Yin Ho², Kar Li Chan¹, Sau Mei Tse¹ and Chi Hung To³, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, ³Medicine, Pok Oi Hospital, Hong Kong, Hong Kong
Background/Purpose: To study the prevalence of occult hepatitis B carrier status and its associated factors in patients with rheumatic diseases undergoing biological therapies Methods: Consecutive…
Abstract Number: 1439 • 2017 ACR/ARHP Annual Meeting
Factors Influencing the Prescription of Tocilizumab Alone or in Combination with Dmards in Rheumatoid Arthritis Patients in a Real Life Setting. Pooled Analysis of 2 Observational Studies
Alain Saraux¹, René-Marc Flipo², Bernard Combe³, Jacques Tebib⁴, Christelle Baffie⁵, Isabelle Idier⁶ and Alain Cantagrel⁷, ¹Rheumatology Department, Rheumatology Department, CHU de la Cavale Blanche, Brest, France, Brest Cedex, France, ²Rheumatology, Department of Rheumatology, CHU Teaching Hospital Lille, France., Lille, France, ³Rheumatology, Lapeyronie Hospital, Montpellier I university, Montpellier, France, ⁴Rheumatology, University Hospital, Hospices civils de Lyon, Lyon, France, ⁵Statistics, Altizem on behalf of Roche, Boulogne Billancourt, France, ⁶Medical department, Chugai Pharma France, Paris La Defense, France, ⁷Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France
Background/Purpose: Tocilizumab (TCZ) as monotherapy (Mono) is nowadays a standard treatment in rheumatoid arthritis (RA) for patients in whom methotrexate (MTX) gives an inadequate response1.…
Abstract Number: 1550 • 2017 ACR/ARHP Annual Meeting
One-Year Clinical Outcomes in 1623 Patients with Inflammatory Arthritis Who Switched from Originator to Biosimilar Etanercept – an Observational Study from the Danish Danbio Registry
Bente Glintborg¹, Emina Omerovic¹, Kamilla Danebod¹, Dorte Vendelbo Jensen¹, Henrik Nordin¹, Anne Gitte Loft¹, Stavros Chrysidis¹, Johnny Lillelund Raun¹, Oliver Hendricks¹, Hanne Lindegaard¹, Jakob Espesen¹, Susanne Jakobsen¹, Inger Marie J. Hansen¹, Jolanta Grydehøj¹, Emil Dalgaard¹, Dorte Dalsgaard Pedersen¹, Natalia Manilo², Lis Smedegaard Andersen³, Salome Kristensen¹, Asta Linauskas¹, Niels Steen Krogh⁴ and Merete Lund Hetland⁵, ¹The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, ²Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark, ³Department of Rheumatology, The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, ⁴The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ⁵The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark
Background/Purpose: According to Danish national guidelines issued in April 2016, a non-medical switch from originator (ETA, Enbrel) to biosimilar Etanercept (SB4, Benepali) (50 mg s.c.)…
Abstract Number: 2464 • 2017 ACR/ARHP Annual Meeting
Similar Effectiveness of Both Formulations of Tocilizumab (TCZ) in Patients with Rheumatoid Arthritis (RA) Switching from Intravenous (IV) to Subcutaneous (SC) at 6 Months in Real Life
Jean Darloy¹, René-Marc Flipo¹, Nicolas Segaud², Jean-Paul Eschard³, Vincent Goeb⁴, Jean-Hugues Salmon³, Eric Houvenagel⁵, Clément Chopin³, Samuel Gally⁶, David Pau⁷, Isabelle Idier⁸ and Guy Baudens⁹, ¹Rheumatology, Rheumatology Department CHU Teaching Hospital Lille, Lille, France, ²Internal medicine, Internal Medicine Departement Armentières Hospital, Armentières, France, ³Rheumatology, Rheumatology Department CHU Teaching Hospital Reims, Reims, France, ⁴Rheumatologie, Rheumatology Department CHU Teaching Hospital Amiens, Amiens, France, ⁵Rheumatology, Groupe Hospitalier de l'Institut Catholique de Lille, Lomme, France, ⁶Clinical Operations, Roche SAS, Boulogne Billancourt, France, ⁷Statistics, Roche SAS, Boulogne Billancourt, France, ⁸Medical department, Chugai Pharma France, Paris La Defense, France, ⁹Rheumatology, Rheumatology Department CHR Valenciennes, Valenciennes, France
Background/Purpose: It has been proven, in a pivotal RCT, that SC TCZ was non-inferior to IV TCZ [1]. However, the effectiveness of the SC TCZ…
Abstract Number: 88 • 2017 Pediatric Rheumatology Symposium
Clinical Features and Frequency of Biologic use in Patients with Juvenile Dermatomyositis-associated Calcinosis
Amir Orandi¹, Vikas Dharnidharka², Noor Al-Hammadi³ and Kevin Baszis¹, ¹Pediatric Rheumatology, Washington University in St. Louis School of Medicine, Saint Louis, MO, ²Pediatric Nephrology, Washington University in St. Louis School of Medicine, Saint Louis, MO, ³Division of Biostatistics, Washington University in St. Louis School of Medicine, St Louis, MO
Background/Purpose: Calcinosis develops in an estimated 40% of patients with Juvenile Dermatomyositis (JDM). Conflicting studies have not definitively identified actionable risk factors or demonstrated that…
Abstract Number: 10 • 2016 ACR/ARHP Annual Meeting
The Utility of Screening for Infectious Diseases in Recipients of Anti-TNF-α Therapy
Kristal Choi¹, Lester Mertz², Russell Heigh³, James Yiannias⁴ and Janis Blair⁵, ¹Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ, ²Rheumatology, Mayo Clinic Arizona, Scottsdale, AZ, ³Gastroenterology, Mayo Clinic Arizona, Scottsdale, AZ, ⁴Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, ⁵Infectious Diseases, Mayo Clinic Arizona, Scottsdale, AZ
The Utility of Screening for Infectious Diseases in Recipients of Anti-TNF-α Therapy Choi, Kristal, Mertz, Lester, Heigh, Russell, Yiannias, James, Blair, Janis Background/Purpose: Tumor…
Abstract Number: 1358 • 2016 ACR/ARHP Annual Meeting
Response of Hidradenitis Suppurativa to Biologic Therapy
Shaunak Mulani¹, Sean McNish², Sarah Harris¹ and Victoria K. Shanmugam², ¹The George Washington University, Washington, DC, ²Division of Rheumatology, The George Washington University, Washington, DC
Response of Hidradenitis Suppurativa to Biologic Therapy Background/Purpose: Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory disease of apocrine sweat glands, characterized by recurrent abscessing…
Abstract Number: 2001 • 2016 ACR/ARHP Annual Meeting
Perioperative Use of Synthetic Disease-Modifying Anti-Rheumatic Drugs or Tumor Necrosis Factor α Inhibitors Does Not Associate with Increased Rates of Post-Operative Infections
Hsin-Hsuan Juo^1,2, Anders Peck^3,4, Nancy Gove⁵ and Bernard Ng^1,2, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ³Medicine / Rheumatology, University of Washington, Seattle, WA, ⁴The Seattle Arthritis Clinic, Seattle, WA, ⁵Biostatistics, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: The aim of the study is to assess whether the risk of post-operative infectious complications in rheumatoid arthritis (RA) patients undergoing surgical procedures is…
Abstract Number: 2628 • 2016 ACR/ARHP Annual Meeting
Retention of Use and Safety of Subcutaneous Abatacept in Rheumatoid Arthritis: A Patient Record Assessment in a Compassionate Use Programme in South Africa, a Tuberculosis Endemic Country
I Louw¹, M Ally², DC Janse van Rensburg², E Van Duuren³, D Nel³, H Miller-Janson⁴, M de Necker⁴, JC de Beer⁴ and H Duvenhage⁵, ¹Panorama Medical Centre, Cape Town, South Africa, ²University of Pretoria, Pretoria, South Africa, ³Jacaranda Hospital, Pretoria, South Africa, ⁴HEXOR (PTY) Ltd, Pretoria, South Africa, ⁵Bristol-Myers Squibb, Johannesburg, South Africa
Background/Purpose: South Africa is a tuberculosis (TB) endemic country having one of the highest TB infection rates in the world with close to 1000 cases…

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