ACR Meeting Abstracts

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Abstracts tagged "Biologic agents"

  • Abstract Number: 629 • 2017 ACR/ARHP Annual Meeting

    Is Earlier Golimumab Treatment Initiation in Psa and As Patients Associated with Improved Outcomes?

    Suneil Kapur1, Proton Rahman2, Michelle Teo3, Jodie Reis4, Rajwinder Dhillon5, Pauline Boulos6, Raman Rai7, Regan Arendse8, Julie Vaillancourt9, Emmanouil Rampakakis9, Allen J Lehman10, Francois Nantel11 and Brendan Osborne11, 1University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, 2Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 3Balfour Medical Clinic, Penticton, BC, Canada, 4University of Saskatchewan, Saskatoon, SK, Canada, 5Private Practice, Niagara Falls, ON, Canada, 6Private Practice, Dundas, ON, Canada, 7Private Practice, Hamilton, ON, Canada, 8University of Saskatchewan, Saskatoon, ON, Canada, 9JSS Medical Research, Montreal, QC, Canada, 10Janssen Inc., Toronto, ON, Canada, 11Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Previous studies have suggested that treating patients earlier with biologics could improve disease outcomes. The aim of this analysis was to assess the impact…
  • Abstract Number: 1524 • 2017 ACR/ARHP Annual Meeting

    Real-World Use of Secukinumab Among Biologic-NaïVe and Biologic-Experienced Patients with Ankylosing Spondylitis in the United States

    Kurt R. Oelke1, Rahul Garg2, Yunfeng Li3, Xing Liu4, Huanxue Zhou4 and Yujin Park3, 1Rheumatic Disease Center, Glendale, WI, 2PRO Unlimited, Inc, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4KMK Consulting, Inc, Morristown, NJ

    Background/Purpose: Secukinumab is a fully human anti–interleukin-17A monoclonal antibody approved for the treatment of patients with moderate to severe ankylosing spondylitis (AS). A limited number…
  • Abstract Number: 2029 • 2017 ACR/ARHP Annual Meeting

    Improved Provider Awareness and Delivery of Zoster Vaccination in Patients with Rheumatoid Arthritis Contemplating Biologic Therapy: Need to Target Eligible Patients Prescribed for Vaccination Post-Clinic

    Gina Prakash1, Kenneth O'Rourke2 and Stephen Mullis3, 1Department of Internal medicine, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston Salem, NC, 2Department of Internal Medicine, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Internal Medicine, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston Salem, NC

    Background/Purpose: Vaccination against herpes zoster (shingles) can reduce the frequency of infection, the severity of shingles should it occur, and the frequency of post-herpetic neuralgia.…
  • Abstract Number: 210 • 2017 ACR/ARHP Annual Meeting

    Pharmacovigilance Surveillance of Autoimmune Diseases Induced By Biological Agents: A Review of 12013 Cases (aeBIOGEAS-SEMI Registry)

    Soledad Retamozo1,2,3, Manuel Ramos-Casals4,5, Marta Pérez de Lis6, Alejandra Flores-Chavez7,8,9, Sofia Arteaga10,11, Celeste Galcerán-Chaves12, Belchin Kostov13, Roberto Pérez-Alvarez6 and Pilar Brito-Zerón2,14, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 5Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, 6Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 7Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 8Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, 9Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, 10Residente de Reumatologia II año, Universidad de Antioquia, Medellin, Colombia, Medellin, Colombia, 11d) Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 12Neuroscience Clinical Institute, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, 13Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, 14Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain

    Background/Purpose: The increasing use of biological agents has been linked with the paradoxical development of autoimmune processes. The scenario has dramatically change in recent years…
  • Abstract Number: 635 • 2017 ACR/ARHP Annual Meeting

    Short-Term Efficacy and Safety of New Biological Agents Targeting the IL-6, IL-12/23 and IL-17 Pathways for Active Psoriatic Arthritis: A Network Meta-Analysis of Randomised Controlled Trials

    Dongze Wu, Jiang Yue and Lai-Shan Tam, Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose:  According to EULAR recommendations, in patients with peripheral arthritis and an inadequate response to at least one conventional synthetic DMARD, biologic DMARDs targeting IL-12/23,…
  • Abstract Number: 1525 • 2017 ACR/ARHP Annual Meeting

    Characteristics and Treatment Patterns Among Patients with Psoriatic Arthritis Initiating Subcutaneously Administered Biologics: Descriptive Analyses from a US Claims Database

    Kurt R. Oelke1, Rahul Garg2, Peter Hur3, Olivier Chambenoit3, Amar Q. Majjhoo4, Stephani Gray5, Kate Higgins5 and Jacqueline B. Palmer3, 1Rheumatic Disease Center, Glendale, WI, 2PRO Unlimited, Inc, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Shores Rheumatology, St. Clair Shores, MI, 5Truven Health Analytics, Cambridge, MA

    Background/Purpose: To better understand the real-world efficacy of biologics for the treatment of psoriatic arthritis (PsA), there is a need to evaluate the persistence and…
  • Abstract Number: 2266 • 2017 ACR/ARHP Annual Meeting

    Patient Knowledge, Attitudes, and Beliefs Regarding Biologic Therapies in Ankylosing Spondylitis (AS): Insights from a Large-Scale Analysis of Social Media Platforms

    Deeba Minhas1, Benjamin Noah2, Eldin Dzubur2, Christopher Almario3, Mariko Ishimori1, Corey Arnold4, Amber Howard2, Carine Khalil2, Alma Jusufagic2, Michelle Chen2, Jina Park5, Michael Weisman1 and Brennan Spiegel3, 1Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, 2Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, 3Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Cedars-Sinai Medical Center Division of Digestive and Liver Diseases, Los Angeles, CA, 4Medical Imaging Informatics, Department of Radiology, University of California Los Angeles, Los Angeles, CA, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: While there are multiple biologic options for ankylosing spondylitis (AS), few attempts have been made to examine patients’ knowledge and understanding of these therapies…
  • Abstract Number: 324 • 2017 ACR/ARHP Annual Meeting

    The Predictors of the Efficacy of Denosumab, a Monoclonal Antibody to RANK Ligand, on Osteoporosis in Rheumatoid Arthritis Patients from Japanese Multicenter Study

    Kyosuke Hattori1, Yuji Hirano1, Yasuhide Kanayama2, Nobunori Takahashi3, Naoki Ishiguro3 and Toshihisa Kojima3, 1Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan, 2Orthopaedic Surgery and Rheumatology, Toyota Kosei Hospital, Toyota, Japan, 3Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Background/Purpose: Although early intensive treatment has improved medication of rheumatoid arthritis (RA), treatment for osteoporosis (OP) in RA patient will be more important. Here, we…
  • Abstract Number: 1007 • 2017 ACR/ARHP Annual Meeting

    Smoking Signicantly Reduces Effectiveness and Long-Term Survival of Biologic Treatment in Patients with Rheumatoid Arthritis

    Roger Rolon Campuzano1, Andrea Lujan Coronel Ale1, Osvaldo Luis Cerda1, Fernando Dal Pra1, Emilce E Schneeberger1, María de los Angeles Correa2, Marcos Rosemffet1, Emilio Buschiazzo3, Rodrigo Garcia Salinas4, Silvia Papasidero5, Belén Barrios5, Hernán Maldonado Ficco6 and Gustavo Citera7, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 2Section Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 3Section of Rheumatology, Hospital Señor del Milagro, Salta, Argentina, Salta, Argentina, 4Section of Rheumatology, Hospital Italiano de La Plata, Buenos Aires, Argentina, La Plata, Argentina, 5Section of Rheumatology, Hospital General de Agudos “Dr. E. Tornú”, Buenos Aires, Argentina, Buenos Aires, Argentina, 6section of Rheumatology, Clinica Regional del Sud, Córdoba, Argentina, Córdoba, Argentina, 7Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina

    Background/Purpose: The introduction of biological agents has been an important advance in the treatment of RA. However, they are not exempt from adverse events and…
  • Abstract Number: 1530 • 2017 ACR/ARHP Annual Meeting

    Improvements in Sleep Problems and Pain in Patients with Active Ankylosing Spondylitis Treated with Intravenous Golimumab: 28-Week Results of the Phase III Trial

    Atul A. Deodhar1, John D. Reveille2, Eric K. H. Chan3, Steven Peterson4, Nan Li4, Elizabeth C. Hsia5, Lilianne Kim4, Kim Hung Lo4, Diane D. Harrison4 and Chenglong Han6, 1Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 2University of Texas McGovern Medical School, Houston, TX, 3Janssen Global Services, LLC, Raritan, NJ, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, 6Janssen Global Services, LLC, Malvern, PA

    Background/Purpose: To investigate the effect of intravenously administered (IV) golimumab (GLM, 2 mg/kg), an anti-TNFα monoclonal antibody, on sleep problems, total back pain (TBP), and…
  • Abstract Number: 2285 • 2017 ACR/ARHP Annual Meeting

    Treatment of Adult Juvenile Idiopathic Arthritis Patients with Biologic Agents. Data from the National Registry

    Katerina Jarosova1, Lenka Szczukova2, Zlatuse Kristkov3 and Jiri Vencovsky4, 1Institute of Rheumatology, Prague, Czech Republic, 2Institute of Biostatistics and Analyses. Faculty of Medicine, Masaryk University, Brno, Czech Republic, 3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 4Institute of Rheumatology, Prague 2, Czech Republic

    Background/Purpose: To analyze the efficacy and safety of biologic agents in adult patients with juvenile idiopathic arthritis (JIA). Methods: ATTRA is a Czech national registry…
  • Abstract Number: 379 • 2017 ACR/ARHP Annual Meeting

    H Syndrome: Five New Cases from the United States with Novel Features and Responses to Therapy

    Jessica Bloom1, Clara Lin2, Lisa F. Imundo3, Stephen Guthery4, Shelly Stepenaskie5, Csaba Galambos6, Amy Lowichik7 and John F. Bohnsack8, 1Pediatrics, Children's Hospital Colorado, Aurora, CO, 2Pediatric Rheumatology, Children's Hospital Colorado, Aurora, CO, 3Pediatrics, Columbia University Medical Center, New York, NY, 4Department of Pediatrics,, University of Utah, Salt Lake City, UT, 5Pathology and Dermatology, University of New Mexico, Albuquerque, NM, 6Pathology, Children's Hospital Colorado, Aurora, CO, 7Pathology, University of Utah, Salt Lake City, UT, 8Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: H Syndrome is an autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, and induration with numerous systemic manifestations. The syndrome is caused by mutations…
  • Abstract Number: 1046 • 2017 ACR/ARHP Annual Meeting

    Biological and Targeted Synthetic Dmards’ Prior Authorization Time Is Significantly Reduced with Pharmacy Presence in the Rheumatology Clinic

    Wendy Ramey1, Kristine M. Lohr2, Matt Zeltner1, Haley Herrell Postonl1, Andrew Johannemann1, Aric D. Schadler1 and Aleksander Lenert3, 1University of Kentucky, Lexington, KY, 2Rheumatology, University of Kentucky, Lexington, KY, 3Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY

    Background/Purpose: Treatment with biological DMARDs (bDMARD) and targeted synthetic DMARDs (tsDMARD) has led to improved outcomes for chronic rheumatic diseases. Current treat-to-target (T2T) strategy relies…
  • Abstract Number: 1532 • 2017 ACR/ARHP Annual Meeting

    Safety and Efficacy of Intravenous Golimumab in Adult Patients with Active Ankylosing Spondylitis: Results through 1 Year

    John D. Reveille1, Atul A. Deodhar2, Diane D. Harrison3, Lilianne Kim3, Kim Hung Lo3 and Elizabeth C. Hsia4, 1University of Texas McGovern Medical School, Houston, TX, 2Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 3Janssen Research & Development, LLC, Spring House, PA, 4Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA

    Background/Purpose: Subcutaneous (SC) golimumab (GLM) is currently approved for adult patients (pts) with RA, PsA, and AS. The GO-ALIVE study was designed to evaluate the…
  • Abstract Number: 2333 • 2017 ACR/ARHP Annual Meeting

    Adjudication of Infections from the Pharmacovigilance in Juvenile Idiopathic Arthritis Patients (PHARMACHILD) Treated with Biologic Agents and/or Methotrexate with a Focus on Opportunistic Infections

    Joost Swart1, Gabriella Giancane1,2, Elio Castagnola1, Andreas Groll1, Gerd Horneff1, Hans-Iko Huppertz1, Daniel J Lovell3, Tom Wolfs1, Michaël Hofer1, Ekaterina Alexeeva1, Violeta Vladislava Panaviene1, Susan Nielsen1, Jordi Anton1, Florence Uettwiller1, Valda Stanevicha1, Maria Trachana1, Fabrizio De Benedetti1, Constantin Ailioaie1, Elena Tsitsami1, Sylvia S.M. Kamphuis1, Troels Herlin1, Pavla Dolezalová1, Gordana Susic1, Berit Flato1, Flavio Sztajnbok1, Elena Fueri4, Francesca Bovis5, Francesca Bagnasco1, Angela Pistorio1, Alberto Martini6, Nico Wulffraat7 and Nicolino Ruperto6, 1Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, 2Pediatria II, Reumatologia - PRINTO, Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genova, Italy, 3Rheumatology, PRCSG - Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 4Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genova, Italy, 5Università degli Studi di Genova, Genoa, Italy, 6Istituto Giannina Gaslini, Genoa, Italy, 7Pediatric rheumatology, Wilhelmina Children's Hospital/ UMC Utrecht, Utrecht, Netherlands

    Background/Purpose: Pharmachild is a pharmacovigilance registry on children with JIA treated mainly with biologics ± methotrexate (MTX). Little evidence exists in literature about the role…
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