ACR Meeting Abstracts

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Abstracts tagged "Biologic agents"

  • Abstract Number: 1534 • 2017 ACR/ARHP Annual Meeting

    Comparison of Long Term Anti-Tnf Survival in Patients with Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis; Data from Turkbio Registry

    Gercek Can1, Ediz Dalkılıc2, Yavuz Pehlivan2, Soner Senel3, Servet Akar4, Dilek Solmaz5, Suleyman Serdar Koca6, Nevsun İnanc7, Pamir Atagunduz7, Ayten Yazıcı8, Ayse Cefle8, Berna Goker9, Berrin Zengin1, Sadettin Uslu10, Nurullah Akkoc11 and Fatos Onen1, 1Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, 2Rheumatology, Uludag University Faculty of Medicine Rheumatology, bursa, Turkey, 3Rheumatology, Erciyes University Faculty of Medicine Rheumatology, kayseri, Turkey, 4Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, Izmir, Turkey, 5Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, izmir, Turkey, 6Rheumatology, Fırat University Faculty of Medicine, elazıg, Turkey, 7Rheumatology, Marmara University Faculty of Medicine Rheumatology, istanbul, Turkey, 8Rheumatology, Kocaeli University Faculty of Medicine Rheumatology, kocaeli, Turkey, 9Rheumatology, Gazi Universty of Fakulty of Medicine, ankara, Turkey, 10Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 11Rheumatology, Private Practice, Rheumatology, İzmir, Turkey

    Background/Purpose: Limited data are available on anti-TNF survival in non-radiographic axial spondyloarthritis (nr-axSpA) patients and their long-term survival in ankylosing spondylitis (AS). The aim of…
  • Abstract Number: 2382 • 2017 ACR/ARHP Annual Meeting

    Reliability of the Biochemical Bone Markers CTX and P1NP during a TNF-Inhibitor Treatment Cycle in Patients with Rheumatoid Arthritis

    Kim Holmsted1, Niklas Rye Jørgensen2 and Ole Rintek Madsen1, 1Center for Rheumatology and Spine Diseases & The DANBIO Registry, Copenhagen University Hospital Rigshospitalet Gentofte Glostrup, Copenhagen, Denmark, 2Dept. of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of developing osteoporosis. Dual Energy X-ray Absorptiometry (DXA) with assessment of BMD is used for…
  • Abstract Number: 426 • 2017 ACR/ARHP Annual Meeting

    Serum Levels of the Anti-TNF Biologics Correlate with Clinical Efficacy in Patients with Inflammatory Arthritis

    Chi Chiu Mok1, Lai Shan Fong1, Ling Yin Ho2 and Chi Hung To3, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, 3Medicine, Pok Oi Hospital, Hong Kong, Hong Kong

    Background/Purpose: To study the correlation between levels of the anti-TNF biologics and clinical efficacy in patients with inflammatory arthritis Methods: Adult patients who fulfilled the…
  • Abstract Number: 1058 • 2017 ACR/ARHP Annual Meeting

    Variation in DMARD Therapy Following Methotrexate Failure for Newly-Identified Rheumatoid Arthritis in a National Veterans Health Administration Cohort

    John McDougall Jr.1,2, Cynthia Brandt3,4, Melissa Skanderson3, Joseph Goulet3 and Liana Fraenkel5, 1National Clinican Scholars Program, Yale School of Medicine, New Haven, CT, 2Dep't. of Rheumatology, Yale School of Medicine, New Haven, CT, 3Veterans Affairs Connecticut Healthcare System, West Haven, CT, 4Emergency Medicine, Yale School of Medicine, New Haven, CT, 5Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT

    Background/Purpose: Absent contraindications to conventional DMARD (cDMARD) use, the Veterans Administration (VA) requires a 3-month trial of 2 cDMARDs prior to the use of biologic…
  • Abstract Number: 1539 • 2017 ACR/ARHP Annual Meeting

    High Retention Rate and Sustained Responses with Secukinumab 150mg in Patients with Active Ankylosing Spondylitis: 3-Year Results from a Phase 3 Study

    Alan J. Kivitz1, Helena Marzo-Ortega2, Clarence Legerton3, Joachim Sieper4, Ricardo Blanco5, Martin Cohen6, Evie Maria Delicha7, Susanne Rohrer7 and Hanno Richards7, 1Altoona Center for Clinical Research, Duncansville, PA, 2NIHR LBRC, LTHT and LIRMM, UoL, Leeds, United Kingdom, 3Low Country Rheumatology, Articularis Healthcare, Charleston, SC, 4University Clinic Benjamin Franklin, Berlin, Germany, 5Hospital Universitario Marqués de Valdecilla, Santander, Spain, 6McGill University, Montreal, QC, Canada, 7Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Secukinumab provided sustained improvement in the signs and symptoms of ankylosing spondylitis (AS) over 2 years in the MEASURE 2 study (NCT01649375).1,2 Here we…
  • Abstract Number: 2386 • 2017 ACR/ARHP Annual Meeting

    The Risk Factors of Newly Developing/Worsening Pulmonary Abnormalities in Rheumatoid Arthritis

    Ayae Tanaka1, Kazuhiro Kurasawa1, Yuta Takamura1, Tomoyuki Miyao1, Ryutaro Yamazaki2, Satoko Arai1, Takayoshi Owada1, Reika Maezawa1 and Masafumi Arima1, 1Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, 2Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects various organs including the lung. The pulmonary involvement is critical for prognosis of the…
  • Abstract Number: 471 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients Resistant to Biologic Therapy, Are They Different?

    Adeeba Al-Herz1, Aqeel Ghanem2, Khulood Saleh3, Adel Al-Awadhi4, Waleed Al-Kandari3, Eman Hasan5, Mohammad Hussain5, Ibrahim Nahar2, Fatemah Abutiban6, Ahmad Alenizi6, Yaser Ali2, Ali Aldei1, Hebah Alhajeri2, Sawsan Hayat2, Ahmad Khadrawy3, Ammad Fazal3, Khaled Mokaddem1, Agaz Zaman2, Ghada Mazloum2, Youssef Bartella1, Sally Hamed1, Ramia Alsouk6 and Ahmed Al-Saber7, 1Rheumatology, Al-Amiri Hospital, Kuwait city, Kuwait, 2Rheumatology, Mubarak Al-Kabeer Hospital, Hawally, Kuwait, 3Rheumatology, Farwania Hospital, Farwania, Kuwait, 4Faculty of Medicine, Kuwait, Kuwait, 5Al-Amiri Hospital, Kuwait city, Kuwait, 6Rheumatology, Jahra Hospital, Jahra, Kuwait, 7Department of Mathematics, Kuwait Technical College, Kuwait city, Kuwait

    Background/Purpose: Patients with rheumatoid arthritis (RA) may fail to respond to biologic therapy. We study patients who are resistant to different classes of biologic agents…
  • Abstract Number: 1158 • 2017 ACR/ARHP Annual Meeting

    Treatment of Non-Infectious Uveitis: A Comparative Long-Term Study between Biologic Therapy with Adalimumab and Two Conventional Disease-Modifying Antirheumatic Drugs

    Esteban Rubio Romero1, Roberto Aguilar Galán2, Raúl Menor Almagro1, Alejandro Muñoz1 and Juan Povedano1, 1Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 2Ophthalmology, Hospital Universitario Virgen del Rocío, Sevilla, Spain

    Background/Purpose: Uveitis are inflammatory processes of the vascular layer of the eye, the uvea, which is divided into iris (anterior uvea), ciliary body (intermediate) and…
  • Abstract Number: 1541 • 2017 ACR/ARHP Annual Meeting

    First Line Biological Treatment in Ankylosing Spondylitis, Prescription Rates, Baseline Demographics and Disease Activity. a Collaboration between Biological Registers in the Five Nordic Counties

    Bente Glintborg1, Ulf Lindström2, Kalle Aaltonen3, Eirik K Kristianslund4, Björn Gudbjornsson5, Katerina Chatzidionysiou2, Johan Askling6, Dan Nordström7, Merete Lund Hetland8, Daniela Di Giuseppe9, Lene Dreyer10, Tanja Schjødt Jørgensen11, Lars Erik Kristensen10, Kari Eklund3, Gerdur Grondal12, Sofia Ernestam2, Jaana Joensuu3, Tore K Kvien13, Elisabeth Lie13, Karen M Fagerli13, Arni Jon Geirsson12, Helgi Jonsson12 and Lennart TH Jacobsson14, 1The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 2On behalf of the SRQ/ARTIS registry, Stockholm, Sweden, 3On behalf of the ROB-FIN registry, Helsinki, Finland, 4Dept. of Rheumatology, On behalf of the NOR-DMARD registry, Oslo, Norway, 5ICEBIO, Reykjavik, Iceland, Reykjavik, Iceland, 6Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 7ROB-FIN, Helsinki, Finland, Helsinki, Finland, 8The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark, 9Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 10On behalf of the DANBIO registry, Copenhagen, Denmark, 11On behalf of the DANBIO registry, Copenhagen F, Denmark, 12On behalf of the ICEBIO registry, Reykjavik, Iceland, 13On behalf of the NOR-DMARD registry, Oslo, Norway, 14Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Large-scale observational cohorts identified in national biological registries may be used to study effectiveness of biological disease modifying drugs (bDMARDs) in ankylosing spondylitis (AS).…
  • Abstract Number: 2409 • 2017 ACR/ARHP Annual Meeting

    Older Age and Male Gender Are Independent Predictors of Quantiferon Positivity Among Adult Rheumatic Patients in a Tertiary Care Center from a BCG Vaccinated Country: Hur-BIO Single Center Real Life Results

    Emrah Seyhoglu1, Oguz Abdullah Uyaroglu1, Abdulsamet Erden2, Levent Kilic2, Berkan Armagan2, Alper Sari2, Omer Karadag2, Sule Apras Bilgen2, Ali Akdogan2, Ihsan Ertenli2, Umut Kalyoncu2 and Sedat Kiraz2, 1Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: TNF-α inhibitors increase the risk of emergence of active tuberculosis (TB). Screening rheumatic patients for latent TB is a necessity before initiation of biological…
  • Abstract Number: 475 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patient Characteristics Also Predict Response to Therapy with Biologic Agents: Results from the Corrona Certain Study

    Dimitrios A. Pappas1, James Murray2, Carol J. Etzel1, David R Nelson2, Bernice Gershenson3, Katherine C. Saunders1, Sabrina Rebello1 and Joel Kremer4, 1Corrona, LLC, Southborough, MA, 2Eli Lilly and Company, Indianapolis, IN, 3University of Massachusetts Medical School, Worcester, MA, 4Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Response to biologic agents approved for RA may be associated with patient reported factors that are not related to disease and usually not included…
  • Abstract Number: 1425 • 2017 ACR/ARHP Annual Meeting

    Treatment Patterns in Patients with Rheumatoid Arthritis Newly Initiated on Biologic and Non-Biologic Therapy Enrolled in a North American Clinical Registry

    Philip J Mease1, Neil Accortt2, Mei Liu3, Sabrina Rebello3, Mahdi Gharaibeh2 and David Collier2, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Amgen Inc., Thousand Oaks, CA, 3Corrona, LLC, Southborough, MA

    Background/Purpose: Many treatment options are currently available to patients with rheumatoid arthritis (RA), including tumor necrosis factor inhibitors (TNFi’s). While combination therapy of TNFi’s or…
  • Abstract Number: 1542 • 2017 ACR/ARHP Annual Meeting

    Inequity in Biologic DMARD Prescription for Spa across the Globe:  Results from the Multi-Centre, Cross-Sectional, ASAS Comospa Study

    Elena Nikiphorou1, Désirée van der Heijde2, Sam Norton3, Robert B.M. Landewé4, Anna Moltó5, Maxime Dougados6, Filip van Den Bosch7 and Sofia Ramiro8, 1LUMC, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Academic Rheumatology, King´s College London, London, United Kingdom, 4Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, 5Paris Descartes University, Paris, France, 6Paris-Descartes University,, Paris, France, 7Rheumatology, Ghent University Hospital, Gent, Belgium, 8Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands

    Background/Purpose: The value of biologic DMARDs (bDMARDs) in SpA is well recognized but global access to these treatments can be limited due to high cost…
  • Abstract Number: 2444 • 2017 ACR/ARHP Annual Meeting

    Effectiveness and Safety of CT-P13 in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis and Plaque Psoriasis: Observational Study in Republic of Korea

    Dong-Wook Kim1, Tae-Hwan Kim2, Seong Ryul Kwon3, Eun Young Lee4, Chang-Nam Son5, Yun Sung Kim6, Soung Hun Kim7, Yong-Beom Park8, Jin-Wuk Hur9, Hye-Soon Lee10, Sang Joon Lee11 and Jee Hye Suh12, 1Inje University Busan Paik Hospital, Busan, Korea, Republic of (South), 2Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 3Inha University Hospital, Incheon, Korea, Republic of (South), 4Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Keimyung University Dongsan Medial Center, Daegu, Korea, Republic of (South), 6Chosun University Hospital, Gwangju, Korea, Republic of (South), 7Gwangmyeong Saeum Hospital, Gyeonggi-do, Korea, Republic of (South), 8Yonsei University Severance Hospital, Seoul, Korea, Republic of (South), 9Eulji University Seoul Hospital, Seoul, Korea, Republic of (South), 10Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), 11CELLTRION, Inc., Incheon, Korea, Republic of (South), 12CELLTRION.Inc, Incheon, Korea, Republic of (South)

    Background/Purpose: CT-P13 is approved as a biosimilar of innovator infliximab for marketing in 81 countries. After approval, observational study has been conducted in Republic of…
  • Abstract Number: 521 • 2017 ACR/ARHP Annual Meeting

    Update on the Clinical Phase 1 and Phase 2 Trials Investigating the Fully Human Immunocytokine Dekavil (F8IL10) in Patients with Rheumatoid Arthritis

    Mauro Galeazzi1, Gian Domenico Sebastiani2, Jürgen Wollenhaupt3, Jean Dudler4, Christof Specker5, Reinhard Voll6, Pascal Zufferey7, Piercarlo Sarzi Puttini8, Ombretta Viapiana9 and Franziska Bootz10, 1Rheumatology, University Hospital of Siena, Siena, Italy, 2Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, 3Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 4Rheumatology, Cantonal Hospital Fribourg, Fribourg, Switzerland, 5Rheumatology, St. Josef Krankenhaus, Universitätsklinikum Essen, Esssen, Germany, 6Clinic for Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Freiburg, Germany, 7Department of Rheumatology, University Hospital Lausanne, Lausanne, Switzerland, 8Rheumatology, Luigi Sacco Hospital, Milan, Italy, 9University Hospital Verona, Verona, Italy, 10Clinical Department, Philochem AG (Philogen Group), Otelfingen, Switzerland

    Background/Purpose: The antibody-based targeted pharmacodelivery of cytokines by means of immunocytokines has the potential to enhance therapeutic activity at the site of disease while sparing…
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