Abstracts tagged "Biologic agents"

Abstract Number: 1315 • 2016 ACR/ARHP Annual Meeting
Methotrexate and TNF-Blockers for Post Chikungunya Chronic Arthritis : The Martinican Experience
Marie Blettery¹, Lauren Brunier-Agot², JULIA MARY³, Katlyne Polomat⁴, Florence MOINET⁴, Christophe Deligny⁵, Serge ARFI⁶, Georges JEAN BAPTISTE⁷ and Michel De Bandt⁸, ¹rheumatology, CHU Fort de France, Fort de France, Martinique, ²Internal medicine and rheumatology, Zobda Quitman Hospital, Fort de France, Martinique, ³RHEUMATOLOGY, CHU Fort de France, 97261, Martinique, ⁴Rheumatology and Internal Medicine, Zobda Quitman Hospital, Fort de France, Martinique, ⁵Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique, ⁶University Hospital, CHU Fort de France, Fort de France, Martinique, ⁷RHEUMATOLOGY, CHU MARTINIQUE, FWI, Fort-de-France, Martinique, ⁸Rheumatology department, CHU Fort de France, Fort de France, France
Background/Purpose: To describe treatments in patients with chronic post-chikungunya polyarthritis seen during the Caribbean outbreak (December 2013 - January 2015). Methods: Patients were examined by…
Abstract Number: 1956 • 2016 ACR/ARHP Annual Meeting
High Dose Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Tumor Necrosis Factor Inhibitor Use Results in Less Radiographic Progression in Ankylosing Spondylitis – a Longitudinal Analysis
Lianne S. Gensler¹, John D. Reveille², MinJae Lee³, Thomas Learch⁴, Matthew Brown⁵, Mohammad H. Rahbar³, Michael Weisman⁶ and Michael Ward⁷, ¹Medicine/Rheumatology, UCSF, San Francisco, CA, ²Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴Radiology, Cedars Sinai Medical Center, Los Angeles, CA, ⁵Queensland University of Technology, Brisbane, Australia, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷NIH/NIAMS, Bethesda, MD
Background/Purpose: Over the last decade, the disease modifying effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Tumor Necrosis Factor inhibitors (TNFi) have resulted in conflicting studies. …
Abstract Number: 2546 • 2016 ACR/ARHP Annual Meeting
Utilization of Biologic Therapy in Patients with Rheumatoid Arthritis and Cancer
Natalia V. Zamora¹, Harish Siddhanamatha², Andrea Barbo³, Jean Tayar⁴, Heather Lin⁵ and Maria Suarez-Almazor⁶, ¹Section of Rheumatology and Clinical Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁴Department of Gentic Internal Medicine-AT & EC, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁶Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Biologic therapy for rheumatoid arthritis (RA) downregulates the immune response. Tumoral immunity is an important host mechanism against cancer progression, and for this reason,…
Abstract Number: 2950 • 2016 ACR/ARHP Annual Meeting
Cogan Syndrome: Treatment and Outcome from French Nationwide Retrospective Study and Literature Review of 62 Patients
CHARLOTTE DURTETTE¹, Mathieu Resche Regon², eric hachulla³, anne Graslands⁴, Thomas Papo^5,6, Jacques Pouchot⁷, jean Emmanuel kahn⁸, Thierry Zenone⁹, cedric landron¹⁰, benoit de Wazieres¹¹, Robin Dhote¹², Christophe Deligny¹³, Guillaume Gondran¹⁴, Edouard Pertuiset¹⁵, thomas quemeneur¹⁶, Bertrand Lioger¹⁷, Pascal Sève¹⁸, Christian Lavigne¹⁹, thomas le Galllou²⁰, Mohamed Hamidou²¹, claire delaunay²², Olivier Fain²³ and Arsene Mekinian²⁴, ¹SAINT ANTOINE HOSPITAL, PARIS, France, ²biostatistics Saint Louis Hospital, paris, France, ³chru lille hospital, lille, France, ⁴Service de Médecine interne, Hôpital Louis-Mourier, colombes, France, ⁵Department of Internal Medicine, AP-HP Bichat Hospital, Paris, France, ⁶Internal Medicine, Hôpital Bichat, Université Paris-Diderot, Paris, France, ⁷Paris University, Internal medicine, Paris, France, ⁸foch hospital, foch, France, ⁹Internal Medicine, Valence Hospital, Valence, France, ¹⁰service de médecine interne, CH Poitiers, CHU Poitiers, poitiers, France, ¹¹CHU de Nîmes, nimes, France, ¹²Internal Medicine, Hospital Avicenne, Bobigny, France, ¹³Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique, ¹⁴Internal Medicine Department, Limoges, France, ¹⁵CH René Dubos, Pontoise, France, ¹⁶valenciennes hospital, valenciennes, France, ¹⁷INTERNAL MEDICINE, tours, France, ¹⁸Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ¹⁹CHU Angers, department of Internal Medicine, Angers, France, ²⁰rennes CHU hospital, rennes, France, ²¹Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, ²²Centre hospitalier niort, niort, France, ²³Service de médecine interne. Hôpital Saint-Antoine., Paris, France, ²⁴DHU2iB, Internal Medicine Saint Antoine Hospital, PARIS, France
Background/Purpose: Methods: Sixty two patients were included with median age 37 [2-76] and 31/62 (50%) women. At the diagnosis, 61 (98%) had audiovestibular involvement,…
Abstract Number: 1319 • 2016 ACR/ARHP Annual Meeting
Chikungunya Fever in Patients on Biological and on Conventional Dmards Therapy – Results from the Brazilian Register Biobadabrasil
Aline Ranzolin¹, Angela Duarte², Claudia Marques³, Laurindo Rocha Jr⁴, Samia Araujo de Souza Studart⁵, José Caetano Macieira⁶, Monica Valeria Siqueira S de Vechi⁶, Lina Oliveira de Carvalho⁶, Ines Guimarães da Silveira⁷, Ieda Maria Magalhães Laurindo⁸ and BiobadaBrasil, ¹Rheumatology, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil, ²Internal Medicine, Hospital das Clínicas - UFPE, Recife, Brazil, ³Hospital das Clínicas, Universidade Federal de Pernambuco, Recife - PE, Brazil, ⁴Rheumatology, Instituto de Medicina Integral Professor Fernando Figueira - IMIP, Recife, Brazil, ⁵Reumatologia, Hospital Geral de Fortaleza, Fortaleza, Brazil, ⁶Reumatologia, Hospital Federal de Sergipe, Aracaju, Brazil, ⁷Reumatologia, Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil, ⁸Internal Medicine - Rheumatology, Faculdade de Medicina da Universidade Nove de Julho, São Paulo, Brazil
Background/Purpose: Chikungunya fever (CHIKF) is a systemic arboviral disease manifesting with fever, acute arthritis and rash. The acute symptoms can last for days but…
Abstract Number: 1993 • 2016 ACR/ARHP Annual Meeting
The Risk of Stroke in Patients with Rheumatoid Arthritis and the Association with Competing Adverse Events
Yvette Meißner¹, Adrian Richter², Joern Kekow³, Hans Peter Tony⁴, Elke Wilden⁵, Angela Zink^6,7, Joachim Listing² and Anja Strangfeld⁷, ¹Programme Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, ²German Rheumatism Research Center, Berlin, Germany, ³University of Magdeburg, Clinic of Rheumatology, Magdeburg, Germany, ⁴Rheumatology / Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, ⁵Rheumatologist, Köln, Germany, ⁶Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁷Epidemiology, German Rheumatism Research Center, Berlin, Germany
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for infections, hospitalizations and cardiovascular (CV) events. The association of serious adverse events (SAE) with…
Abstract Number: 2587 • 2016 ACR/ARHP Annual Meeting
The Serum Level of Reactive Oxygen Metabolities (ROM) at 12 Weeks during Treatment with Biologic Agents for Rheumatoid Arthritis Is a Predictor for the 52-Week Remission
Arata Nakajima¹, Keiichiro Yamamoto² and Koichi Nakagawa³, ¹Orthopaedics, Toho University Sakura Medical Center, Sakura, Japan, ²Orthopedics, Toho University Sakura Medical Center, Sakura, Japan, ³Toho University Sakura Medical Center, Sakura, Japan
Background/Purpose: Oxidative stress induced by reactive oxygen species is thought to be an important mechanism that underlies joint destruction and synovial proliferation. We have shown…
Abstract Number: 2955 • 2016 ACR/ARHP Annual Meeting
Biologic Therapy in Severe Peripheral Ulcerative Keratitis (PUK). Multicenter Study of 27 Patients
Lucia C. Domínguez-Casas¹, Vanesa Calvo-Río¹, Olga Maiz², Ana Blanco³, Emma Beltran⁴, L. Martinez-Costa⁵, Maria Concepcion Alvarez de Buergo⁶, Esteban Rubio-Romero⁷, David Diaz-Valle⁸, R. López-González⁹, Angel M. Garcia-Aparicio¹⁰, Antonio Juan Mas¹¹, Natalia Palmou-Fontana¹, Miguel Angel Gonzalez-Gay¹ and Ricardo Blanco¹², ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Hospital Universitario Donostia, Donostia, Spain, ³Hospital Universitario Donostia, San Sebastian, Spain, ⁴Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, ⁵Hospital Dr. Peset., Valencia, Spain, ⁶Hosp. Rio Carrion, Palencia, Spain, ⁷Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁸Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain, ⁹Rheumatology, Complejo Hospitalario de Zamora, Zamora, Spain, ¹⁰Rheumatology, Hospital Virgen de la Salud, Toledo, Spain, ¹¹Rheumatology, Hospital Son Llàtzer., Palma de Mallorca., Spain, ¹²Rheumatology Department. Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Peripheral Ulcerative Keratitis (PUK) is a severe inflammation of the outer portions of the cornea that may be associated with systemic conditions. The…
Abstract Number: 1338 • 2016 ACR/ARHP Annual Meeting
Use of Subcutaneous Golimumab in Autoimmune Inner Ear Disease
Deeba Minhas¹, Michele Gandolfi², Jennifer Derebery³, Eric Wilkinson³ and Mariko Ishimori¹, ¹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Otology, House Clinic, Los Angeles, CA, ³House Clinic, Los Angeles, CA
Background/Purpose: Autoimmune Inner Ear Disease (AIED) is characterized by rapidly progressive sensorineural hearing loss accompanied by tinnitus, with or without vertigo, which may progress to…
Abstract Number: 1999 • 2016 ACR/ARHP Annual Meeting
Claims-Based Analysis of Cost-Effectiveness Among Patients with Rheumatoid Arthritis Who Switched from a Tumor Necrosis Factor Inhibitor to Another Targeted Disease-Modifying Antirheumatic Drug
Machaon Bonafede¹, Wenhui Wei², Chieh-I Chen³, Donna McMorrow¹, Stefano Fiore⁴, Jonathan Fay³, Toshio Kimura³ and Jeffrey R. Curtis⁵, ¹Truven Health Analytics, Cambridge, MA, ²Sanofi US, Inc., Bridgewater, NJ, ³Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁴Sanofi Genzyme, Bridgwater, NJ, ⁵Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Patients with rheumatoid arthritis (RA) who have an inadequate response to a tumor necrosis factor inhibitor (TNFi) can switch to another targeted disease-modifying antirheumatic…
Abstract Number: 2611 • 2016 ACR/ARHP Annual Meeting
Cardiovascular Safety of Tocilizumab Versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis
Seoyoung C. Kim¹, Daniel H. Solomon¹, James R. Rogers¹, Sara Gale², Micki Klearman², Khaled Sarsour² and Sebastian Schneeweiss¹, ¹Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ²Genentech, South San Francisco, CA
Background/Purpose: Patients with rheumatoid arthritis (RA) are at elevated risk for cardiovascular (CV) disease. Patients using tocilizumab (TCZ) may experience increased serum lipid levels. It…
Abstract Number: 2982 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Inhibitors and the Risk of Malignancy in the Treatment of Juvenile Idiopathic Arthritis
Timothy Beukelman¹, Fenglong Xie², Lang Chen², Daniel Horton³, James D. Lewis⁴, Ronac Mamtani⁴, Melissa Mannion⁵, Kenneth G. Saag⁶, Jie Zhang⁷ and Jeffrey R. Curtis⁶, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Epidemilogy, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The possible association between tumor necrosis factor inhibitors (TNFi) in the treatment of juvenile idiopathic arthritis (JIA) and an increased risk of malignancy remains…
Abstract Number: 10 • 2016 ACR/ARHP Annual Meeting
The Utility of Screening for Infectious Diseases in Recipients of Anti-TNF-α Therapy
Kristal Choi¹, Lester Mertz², Russell Heigh³, James Yiannias⁴ and Janis Blair⁵, ¹Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ, ²Rheumatology, Mayo Clinic Arizona, Scottsdale, AZ, ³Gastroenterology, Mayo Clinic Arizona, Scottsdale, AZ, ⁴Dermatology, Mayo Clinic Arizona, Scottsdale, AZ, ⁵Infectious Diseases, Mayo Clinic Arizona, Scottsdale, AZ
The Utility of Screening for Infectious Diseases in Recipients of Anti-TNF-α Therapy Choi, Kristal, Mertz, Lester, Heigh, Russell, Yiannias, James, Blair, Janis Background/Purpose: Tumor…
Abstract Number: 1358 • 2016 ACR/ARHP Annual Meeting
Response of Hidradenitis Suppurativa to Biologic Therapy
Shaunak Mulani¹, Sean McNish², Sarah Harris¹ and Victoria K. Shanmugam², ¹The George Washington University, Washington, DC, ²Division of Rheumatology, The George Washington University, Washington, DC
Response of Hidradenitis Suppurativa to Biologic Therapy Background/Purpose: Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory disease of apocrine sweat glands, characterized by recurrent abscessing…
Abstract Number: 2001 • 2016 ACR/ARHP Annual Meeting
Perioperative Use of Synthetic Disease-Modifying Anti-Rheumatic Drugs or Tumor Necrosis Factor α Inhibitors Does Not Associate with Increased Rates of Post-Operative Infections
Hsin-Hsuan Juo^1,2, Anders Peck^3,4, Nancy Gove⁵ and Bernard Ng^1,2, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ³Medicine / Rheumatology, University of Washington, Seattle, WA, ⁴The Seattle Arthritis Clinic, Seattle, WA, ⁵Biostatistics, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: The aim of the study is to assess whether the risk of post-operative infectious complications in rheumatoid arthritis (RA) patients undergoing surgical procedures is…

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