Abstracts tagged "Bioinformatics"

Abstract Number: 1951 • ACR Convergence 2025
Quantitative HRCT Analysis in Sjögren’s Disease-associated ILD: CALIPER-Derived Imaging Biomarkers for Prognostic Assessment
Gaetano La Rocca¹, Francesco Ferro², Vincenzo Uggenti³, Beatrice Dei⁴, Giovanni Fulvio⁴, Michele Moretti⁴, Marta Mosca⁵, Chiara Romei³ and Chiara Baldini⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Pisa, Italy, ²Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, ³University of Pisa, ²nd Radiology Unit, Pisa, Italy, ⁴Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ⁵University of Pisa, Pisa, Pisa, Italy
Background/Purpose: Interstitial Lung Disease (ILD) is a frequent manifestation of Sjögren’s Disease (SjD), associated with significant morbidity and mortality. However, data on the prevalence of…
Abstract Number: 1004 • ACR Convergence 2025
Single-Cell Analysis Reveals Tissue Resident Memory T Cells Heterogeneity in the Joint
Yang Yang¹, Yusuke Miyashita², Madison Mangin³, Kellen Winden¹, Peter Nigrovic² and Margaret Chang¹, ¹Boston Children's Hospital, Boston, MA, ²Boston Children's Hospital, Brookline, MA, ³Boston Children's Hospital, St Simons Island, GA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint-specific memory, the phenomenon in which arthritis repeatedly flares in the same joints. We…
Abstract Number: 0230 • ACR Convergence 2025
An Epic journey – Therapeutic Drug Monitoring at an Academic Center
Puja Khanna¹ and Michael Rice², ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Gastroenterology, University of Michigan, Ann Arbor, MI
Background/Purpose: Non-oncologic use of immunomodulatory agents is increasing. These drugs have a narrow, patient-specific therapeutic index, making therapeutic drug monitoring essential for safe prescribing. However,…
Abstract Number: 1908 • ACR Convergence 2025
Clinical and Imaging Features of Haemochromatosis Arthropathy – a Systematic Literature Review and Meta- Analysis
Svenja Engelhardt¹, Sabine Buroh², Guido Schwarzer³, Andreas Kerschbaumer⁴, Axel Braner⁵, Mathilde Herber⁶, Pedro Machado⁷, Patrick Kiely⁸ and Stephanie Finzel⁹, ¹University of Freiburg, Freiburg im Breisgau, Germany, ²Library of the Medical Center - University of Freiburg, Faculty of Medicine, Library of the Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Freiburg, Germany, ³University of Freiburg, Freiburg, Germany, Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany, Freiburg, Germany, Freiburg, Germany, ⁴Stanford University / Medical University of Vienna, Stanford, CA, ⁵MVZ Aschaffenburg, Aschaffenburg, Germany, Frankfurt, Germany, ⁶Strasbourg Centre University, Strasbourg, France, Department of Internal Medicine, Strasbourg, France, Strasbourg, France, ⁷Department of Rheumatology, University College London, and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, ⁸St George's University Hospitals NHS Foundation Trust, London, United Kingdom, ⁹Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Background/Purpose: Haemochromatosis arthropathy (HA) has been little researched to date. Arthropathy frequently is amongst thefirst clinical manifestations of haemochromatosis, but might be overlooked or misdiagnosed…
Abstract Number: 1000 • ACR Convergence 2025
A Deep-Learning Based Approach Uncovers Novel Mediators of Micro-RNA Restraint of Type-2 Immunity
Shaan Sekhon¹, Robin Kageyama², Neil Sprenkle³, Hannah Happ², Eric Wigton², Heather Pua³ and Mark Ansel², ¹University of California, San Francisco, Berkeley, ²University of California, San Francisco, San Francisco, ³Vanderbilt University, Nashville
Background/Purpose: MicroRNAs, such as miR-24 and miR-27, co-expressed within the Mirc11 and Mirc22 clusters, orchestrate a regulatory network critical to Th2 cell differentiation and cytokine…
Abstract Number: 0177 • ACR Convergence 2025
Artificial intelligence in adult and paediatric rheumatology practice and research: pilot results from an international survey
Ana Isabel Rebollo-Gimenez¹, Saverio La bella², Krystel Aouad³, Latika Gupta⁴, Davide Cangelosi⁵, Thomas Högle⁶, Johannes Knitza⁷, Nicolino Ruperto⁸, Vincenzo Venerito⁹, Abdellah El Maghraoui¹⁰, Alessandra Alongi¹¹, Wilson bautista molano¹², Deniz Bayraktar¹³, Thomas Davergne¹⁴, Dzifa Dey¹⁵, Ihsane Hmamouchi¹⁶, Alison Hoens¹⁷, Linda Li¹⁷, Angela Migowa¹⁸, Erin Treemarcki¹⁹, Nelly Ziade²⁰, Tue Kragstrup²¹ and Diego Benavent²², ¹Department of Rheumatology, Gregorio Marañon University Hospital, Gregorio Marañon Health Research Institute, Madrid, Spain, ²UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy, ³Department of Rheumatology, Saint George Hospital University Medical Center, Beirut, Lebanon, ⁴School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom, ⁵Unità di Bioinformatica Clinica, Direzione Scientifica, IRCCS Istituto Giannina Gaslini, Genoa, Italy, ⁶Department of Rheumatology, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland, ⁷Institute for Digital Medicine, University Hospital Gießen-Marburg, Philipps University, Marburg, Germany, ⁸Université Milano Bicocca and Fondazione IRCSS S. Gerardo dei Tintori, Monza, Monza and Brianza, Italy, ⁹Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, ¹⁰Department of Rheumatology, Military Hospital Mohammed V, Rabat, Morocco, ¹¹Università Milano Bicocca, Milano, MILAN, Italy, ¹²University Hospital Fundacion Santa Fe de Bogota, Bogota, Colombia, ¹³Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Izmir Katip Celebi University. Arthritis Research Canada, Vancouver, British Columbia., Izmir, Turkey, ¹⁴Department of rehabilitation.Team METHODS, CRESS UMR ¹¹⁵³ – University of Paris Cité, Paris, France, ¹⁵Rheumatology Unit Department of Medicine and Therapeutics, Korle bu Teaching Hospital, University of Ghana Medical School, Accra, Ghana, ¹⁶Health Sciences Research Center (CReSS).Faculty of Medicine, International University of Rabat, Rabat, Morocco, ¹⁷Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ¹⁸Aga Khan University Medical College East Africa, Nairobi, Kenya, ¹⁹Department of Pediatrics, Division of Pediatric Rheumatology, University of Utah, Salt Lake City, UT, ²⁰Department of Rheumatology, Saint-Joseph University and Hotel-Dieu de France, Beirut, Lebanon, ²¹Department of Biomedicine, Aarhus University & Rheumatology Sector, Medical Diagnostic Center, Silkeborg Regional Hospital, Silkeborg, Aarhus C, Denmark, ²²Hospital Universitari de Bellvitge, Madrid, Spain
Background/Purpose: Artificial intelligence (AI) is transforming rheumatology care, with innovative tools now empowering physicians and health professionals (HPRs). Our survey examines how adult and pediatric…
Abstract Number: 1872 • ACR Convergence 2025
High-throughput Screening Uncovers Distinct Molecular Signatures Linked with HRCT Patterns in SARD-ILD
Philip Stauffer¹, Vyacheslav Palchevskiy², Laura Much³, Phuong Diep⁴, Magdalena Abel⁴, Natasha Moe⁴, Thomas Gaisl⁵, Carolin Steinack⁵, Shahrzad Lari², Elena Pachera⁶, Øyvind Molberg⁷, Oliver Distler⁸, S. Samuel Weigt², John A. Belperio² and Anna-Maria Hoffmann-Vold⁴, ¹University of Zurich Hospital, Schlieren, Switzerland, ²UCLA, Los Angeles, ³Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁴Oslo University Hospital, Oslo, Norway, ⁵USZ, Zürich, Switzerland, ⁶University Hospital Zurich, Zurich, Switzerland, ⁷Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ⁸Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: High-Resolution Computed Tomography (HRCT) is crucial for diagnosing and managing interstitial lung disease associated with systemic autoimmune rheumatic diseases (SARD-ILD), as it reveals characteristic…
Abstract Number: 0964 • ACR Convergence 2025
A Single-Cell Atlas Reveals Dermal Endothelial Heterogeneity and Disease-Specific Pathways in Autoimmune Disorders
Haoyu Pan¹, Jinyi Qian¹, Shuyi Yu¹, Zhixia Yang¹, Jason S. Knight², Eliza Tsou³ and Hui Shi⁴, ¹Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, Shanghai, China (People's Republic), ²University of Michigan, Ann Arbor, MI, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan; Ann Arbor, Michigan, USA., Ann Arbor, MI, ⁴Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai, China (People's Republic)
Background/Purpose: Autoimmune conditions with skin involvement, including scleroderma (SSc), antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and psoriasis (PSO), involve intricate interactions between immune cells…
Abstract Number: 0145 • ACR Convergence 2025
Population Assessment of Cancer Incidence among Patients with Idiopathic Inflammatory Myopathies in North Carolina
Astia Allenzara¹, Ben Albright², Xi Zhou², Amanda Nelson³, Laura Green⁴, Katherine Reeder-Hayes⁴, Jennifer Lund⁴, Caroline Thompson⁴ and Chris Baggett⁴, ¹UNC, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina, Chapel Hill
Background/Purpose: Cancer is highly prevalent and a leading cause of death for patients with Idiopathic Inflammatory Myopathies (IIM). Evaluating cancer type and stage at diagnosis…
Abstract Number: 1867 • ACR Convergence 2025
Deciphering the Molecular Landscape of the Small Intestine in Early and Late SSc Using High-Definition Spatial Transcriptomics
Laura Much¹, Elena Pachera², Havard Fretheim³, Knut EA Lundin⁴, Lumeng Li⁵, Astrid Hofman⁶, Pietro Bearzi⁵, Philip Stauffer¹, Michael Scharl⁷, Oyvind Molberg⁸, Oliver Distler⁹ and Anna-Maria Hoffmann-Vold³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ²University Hospital Zurich, Zurich, Switzerland, ³Oslo University Hospital, Oslo, Norway, ⁴Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zürich, Switzerland, ⁶Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, ⁷Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁸Oslo University Hospital, Oslo, Nepal, ⁹Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: SSc frequently results in serious gastrointestinal (GI) complications that contribute to increased morbidity and mortality. Understanding the molecular changes across different disease stages is…
Abstract Number: 0957 • ACR Convergence 2025
Multi-Omic Profiling Reveals a Monocyte-Vascular Signature Associated with the Regression of Skin Fibrosis in SSc
Astrid Hofman¹, Pietro Bearzi², Elena Pachera³, Cosimo Bruni⁴, Lumeng Li², Laura Much⁵, Kristina Bürki¹, Mike Becker⁶, Anna-Maria Hoffmann-Vold⁷ and Oliver Distler⁸, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zürich, Switzerland, ³University Hospital Zurich, Zurich, Switzerland, ⁴University of Zurich, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁶Dept. of Rheumatology, University Hospital Zurich, Zürich, Switzerland, ⁷Oslo University Hospital, Oslo, Norway, ⁸Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Regression of skin fibrosis is a feature of the natural history of dcSSc. The molecular mechanisms underlying this resolution remain unclear. This study aims…
Abstract Number: 0127 • ACR Convergence 2025
Single-cell Profiling of Dermal Endothelial Cells Reveals Potential Cell-Cell Interactions in Patients with APS and a History of Cardiac Valve Disease
Wenying Liang¹, Qinmengge Li², Jacqueline Madison¹, Ran Jing¹, Emily Chong¹, Yiran Shen¹, Rachael Bogle³, Srilakshmi Yalavarthi¹, Cyrus Sarosh⁴, Ajay Tambralli¹, Yu (Ray) Zuo¹, Johann Gudjonsson¹, Hui Shi⁵, Pei-Suen Tsou¹, Alex Tsoi³ and Jason S. Knight¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Ypsilanti, MI, ³University of Michigan, Holland, OH, ⁴University of Michigan, Temperance, MI, ⁵Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai, China (People's Republic)
Background/Purpose: Some of the rarer manifestations of antiphospholipid syndrome (APS), such as cardiac valve disease, remain poorly understood at the molecular level. A previous study…
Abstract Number: 1866 • ACR Convergence 2025
Elucidating gastric pathology in systemic sclerosis using single-cell RNA sequencing
kristina clark¹, Moustafa Attar², Matthias Friedrich³, Charles Murray⁴, Alexander Clarke² and Christopher Denton⁵, ¹Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ²Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ³Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom, ⁴Royal Free Hospital NHS Trust, London, United Kingdom, ⁵University College London, UK, London, United Kingdom
Background/Purpose: Gastrointestinal (GI) involvement in systemic sclerosis (SSc) affects over 90% of patients and represents a large clinical burden and unmet need. Unlike the skin…
Abstract Number: 0901 • ACR Convergence 2025
Data-Driven Metabolomics Identifies Diagnostic Signatures and Patient Subgroups in Systemic Autoimmune Disorders
Chary López pedrera¹, Antonio Perez-Campoamor², Gema Dolores García-Delgado³, Beatriz Vellón-García⁴, Adrián Llamas Urbano⁵, Laura Romero Zurita⁶, Pedro Ortiz Buitrago⁷, Christian Merlo⁸, Maria del carmen abalos-aguilera⁸, Nuria Barbarroja⁹, Verónica Bolón-Canedo¹⁰, MARIA ANGELES AGUIRRE ZAMORANO¹¹, Rafaela Ortega-Castro¹², Jerusalén Calvo¹³, Lourdes Ladehesa¹⁴, Marta Alarcon-Riquelme¹⁵, Alejandro Escudero-contreras⁸ and Carlos Pérez Sánchez¹⁶, ¹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, ²STARTQUAKE S.L., Gijón, Spain/Research Center on Information and Communication Technologies (CITIC), University of A Coruña, A Coruña, Spain, Gijón, Spain, ³Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain/Department of Cell Biology, Physiology and Immunology, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Cordoba, Spain, ⁴Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain/Department of Cell Biology, Physiology and Immunology, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain, Cordoba, Spain, ⁵Cobiomic Bioscience SL. EBT University of Cordoba/IMIBIC, Cordoba, Spain., Cordoba, Spain, ⁶Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba/ Reina Sofia University Hospital, Rheumatology service/Department of Medical and Surgical Sciences, Cordoba, Spain, Córdoba, Spain, ⁷Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Cordoba, Andalucia, Spain, ⁸Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain, Cordoba, Spain, ⁹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, ¹⁰Research Center on Information and Communication Technologies (CITIC), University of A Coruña, A Coruña, Spain, A coruña, Spain, ¹¹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, ¹²Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, ¹³IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, ¹⁴IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Cordoba, Spain, ¹⁵Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ¹⁶Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain
Background/Purpose: This study aims to characterize the metabolomic fingerprint of several systemic autoimmune diseases (SADs) and apply machine learning (ML) techniques to identify disease-specific biomarkers…
Abstract Number: 0124 • ACR Convergence 2025
Single-cell atlas reveals the central-and-peripheral immune remodeling mechanism and clinical benefits of talitacicept therapy in patients with primary antiphospholipid syndrome
Haoyu Pan¹, Shiyan Gu¹, Xiaohan Wei², Yuying Fan¹, Jinyi Qian¹, Shuyi Yu¹ and Hui Shi³, ¹Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, Shanghai, China (People's Republic), ²Shanghai JiaoTong University, Shanghai, China (People's Republic), ³Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai, China (People's Republic)
Background/Purpose: To elucidate the molecular and cellular mechanisms underlying Talitacicept therapy in primary antiphospholipid syndrome (PAPS) patients using integrated single-cell RNA and TCR/BCR profiling of…

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