Abstracts tagged "Bioinformatics"

Abstract Number: 1356 • 2016 ACR/ARHP Annual Meeting
Correlation of Erythrocyte Sedimentation Rate with Glycohemoglobin Values and Other Patient Factors
Brian LaMoreaux, Dept of Internal Medicine, Division of Rheumatology, The Ohio State University, Columbus, OH
Background/Purpose: The erythrocyte sedimentation rate (ESR) is a laboratory test commonly used in clinical practice as an assessment of systemic inflammation. The glycohemoglobin (A1c) measures…
Abstract Number: 2832 • 2016 ACR/ARHP Annual Meeting
Novel Gene Variants Associated with Cardiovascular Disease in Systemic Lupus Erythematosus
Dag Leonard¹, Andrei Alexsson¹, Johanna Dahlqvist², Kimberly Taylor³, Johanna K Sandling⁴, Christine Bengtsson⁵, Elisabet Svenungsson⁶, Christopher Sjöwall⁷, Andreas Jönsen⁸, Iva Gunnarsson⁶, Anders A. Bengtsson⁸, Solbritt Rantapaa-Dahlqvist⁵, Maija-Leena Eloranta¹, Ann-Christine Syvänen⁴, Lindsey A. Criswell⁹ and Lars Rönnblom¹, ¹Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ²Uppsala University, Department of Medical Biochemistry and Microbiology Science for Life Laboratory, Uppsala, Sweden, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Uppsala University, Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala, Sweden, ⁵Umeå University, Department of Public Health and Clinical Medicine/ Rheumatology, Umeå, Sweden, ⁶Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, ⁷Linköping University, Department of Clinical and Experimental Medicine Rheumatology/AIR, Linköping, Sweden, ⁸Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose: Methods: An association between a locus located on chromosome 14 and stroke/TIA was shown in both the Swedish (OR 1.8, p=0.0002) and the US…
Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Bethany Wolf¹, Paula S. Ramos², Paul Nietert³, J. Madison Hyer¹, Viswanathan Ramakrishnan¹, Gary S. Gilkeson⁴, Gerard Hardiman² and Diane L. Kamen⁵, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…
Abstract Number: 799 • 2016 ACR/ARHP Annual Meeting
Biomarker Identification & Molecular Sub-Classification in Systemic Sclerosis for Precision Medicine Using RNA-Seq
Elisha D.O. Roberson^1,2, Li Cao¹, David J. Morales-Heil¹, Benjamin Korman³ and John Varga⁴, ¹Department of Medicine, Washington University, St. Louis, MO, ²Department of Genetics, Washington University, St. Louis, MO, ³Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Systemic sclerosis (SSc) is a complex and highly heterogeneous disease with multi-organ involvement. Accurate tools for disease sub-classification are lacking. In most patients, skin…
Abstract Number: 807 • 2016 ACR/ARHP Annual Meeting
A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis, Pulmonary Fibrosis and Pulmonary Arterial Hypertension
Jaclyn N. Taroni¹, Casey S. Greene², Tammara A. Wood³, Romy B. Christmann⁴, Harrison W. Farber⁵, Robert A. Lafyatis⁶, Christopher Denton⁷, Monique Hinchcliff⁸, Patricia A. Pioli⁹, Michael L. Whitfield¹⁰ and J. Matthew Mahoney¹¹, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Division of Rheumatology, Boston University Medical School, Boston, MA, ⁵Pulmonary Center, Boston University Medical Center, Boston, MA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁰Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹¹Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT
Background/Purpose: Systemic sclerosis (SSc) is characterized by multi-organ involvement and clinical heterogeneity. “Big data” approaches have yielded powerful tools to infer tissue-specific pathobiology. Large amounts of…
Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting
Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes
Celine C. Berthier¹, Jasmine Stannard², Emily Myers³, William Swindell⁴, Lori Lowe⁴, Tamra J. Reed⁵, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁶, ¹Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ²Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies. Phenotypic presentation and risk of systemic lupus manifestations differs by…
Abstract Number: 1254 • 2015 ACR/ARHP Annual Meeting
Deciphering the Immunome of Clinically Effective Immune Tolerization in Rheumatoid Arthritis
Jing Yao Leong^1,2, Raymond Ong Jr.³, Juntao Li⁴, Theodorus van den Broek⁵, Roberto Spreafico⁴, Maura Rossetti¹ and Salvatore Albani^1,2, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: We have previously described (Nature Medicine, PNAS, A&R, Nature Rheum, Lancet) how oral treatment with the pro-inflammatory, heat shock protein-derived dnaJP1 peptide induces detectable…
Abstract Number: 1929 • 2014 ACR/ARHP Annual Meeting
Echocardiographic Phenomics for Novel Classification of Cardiac Involvement in Systemic Sclerosis
Monique Hinchcliff¹, Vistasp Daruwalla², Lauren Beussink-Nelson³, Sofia Podlusky⁴, Mary A. Carns⁴, John Varga⁵ and Sanjiv J. Shah⁶, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Internal Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Traditional studies of systemic sclerosis (SSc) cardiac involvement have examined one or a few echocardiographic (echo) variables; however, cardiac involvement in SSc can be…
Abstract Number: 1669 • 2014 ACR/ARHP Annual Meeting
Validation of a Machine Learning Lupus Nephritis Decision Support Tool to Predict Complete Response to Therapy
Bethany Wolf¹, John Christian Spainhour¹, John Arthur², Michael Janech², Michelle Petri³, Adnan Kiani⁴ and Jim Oates^5,6, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴1830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁶Medical Service, Ralph H. Johnson VAMC, Charleston, SC
Background/Purpose .The American College of Rheumatology treatment guidelines for lupus nephritis (LN) recommend that induction therapy be changed when response to therapy has not occurred…
Abstract Number: 750 • 2014 ACR/ARHP Annual Meeting
Molecular Characterization of Systemic Sclerosis Esophageal Pathology Identifies Inflammatory and Proliferative Signatures with Few Fibrotic Markers
Jaclyn Taroni¹, Viktor Martyanov², Chiang-Ching Huang³, J. Matthew Mahoney⁴, Ikuo Hirano⁵, Tammara A. Wood², Brandon Shetuni⁶, Guang-Yu Yang⁶, Darren Brenner⁵, Barbara Jung⁷, Swati Bhattacharyya⁸, Orit Almagor⁹, Jungwha Lee¹⁰, Arlene Sirajuddin¹¹, Rowland W. Chang¹², John Varga¹³, Michael Whitfield¹⁴ and Monique Hinchcliff¹⁵, ¹Genetics, Giesel School of Medicine at Dartmouth, Hanover, NH, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁴Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT, ⁵Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Department of Medicine, Division of Gastroenterology, University of Illinois at Chicago, Chicago, IL, ⁸Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Northwestern University, Chicago, IL, ¹⁰Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. Esophageal muscle atrophy without concomitant fibrosis is…
Abstract Number: 80 • 2014 ACR/ARHP Annual Meeting
Cellular Responses of IL6 Inhibition (Tocilizumab) in Rheumatoid Arthritis Using High-Accuracy Tandem Mass Spectrometry
Michael Kruse Meyer¹, Marlene Andersen², Grethe N. Andersen¹ and Allan Stensballe³, ¹Clinic of Rheumatology, Hospital of Vendsyssel/Aalborg University, Hjørring, Denmark, ²Department of Rheumatology, Aalborg University, Hjørring, Denmark, ³Health Science and Technology, Aalborg University, Aalborg, Denmark
Background/Purpose: In this study we are analyzing leukocyte subtype responses from patients with rheumatoid arthritis (RA) to IL6 inhibition. A large contribution to RA immunopathogenesis…

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