Abstracts tagged "Bioinformatics"

Abstract Number: 807 • 2016 ACR/ARHP Annual Meeting
A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis, Pulmonary Fibrosis and Pulmonary Arterial Hypertension
Jaclyn N. Taroni¹, Casey S. Greene², Tammara A. Wood³, Romy B. Christmann⁴, Harrison W. Farber⁵, Robert A. Lafyatis⁶, Christopher Denton⁷, Monique Hinchcliff⁸, Patricia A. Pioli⁹, Michael L. Whitfield¹⁰ and J. Matthew Mahoney¹¹, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Division of Rheumatology, Boston University Medical School, Boston, MA, ⁵Pulmonary Center, Boston University Medical Center, Boston, MA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁰Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹¹Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT
Background/Purpose: Systemic sclerosis (SSc) is characterized by multi-organ involvement and clinical heterogeneity. “Big data” approaches have yielded powerful tools to infer tissue-specific pathobiology. Large amounts of…
Abstract Number: 1201 • 2016 ACR/ARHP Annual Meeting
Deconvolution of Immune Cell Proportions from Whole Blood RNA Using Next-Generation Sequencing
Omar Jabado¹, Sarah Hu², Julie Carman³, Suzanne Suchard³, Deborah Lee⁴, Zhenhao Qi⁵, Stefan Kirov⁶, Ryan Golhar⁷, Aiqing He⁷, Cate Speake⁸, Peter S. Linsley⁸, Steven G. Nadler⁹ and Somnath Bandyopadhyay², ¹3551 Lawrenceville Princeton, Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Princeton, NJ, ³Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ⁴Discovery Immunoscience, Bristol-Myers Squibb, Princeton, NJ, ⁵Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, ⁶Genetically Defined Diseased & Genomics, Bristol-Myers Squibb, Princeton, NJ, ⁷Genetically Defined Diseases & Genomics, Bristol-Myers Squibb, Princeton, NJ, ⁸Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁹Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Measurements of immune cell proportions from whole blood can be used to detect pharmacodynamic effects, as a marker for prognosis and to aid in…
Abstract Number: 1207 • 2016 ACR/ARHP Annual Meeting
Design of a Multiplex Serum Proteome Assay to Monitor Biologic Drug Response in Rheumatoid Arthritis Patients
Niamh Callan¹, Aisha Butt¹, Stephen R. Pennington², Cathy McGeough³, Philip Gardiner⁴, Gary Wright⁵, Tony Bjourson³ and David S. Gibson⁶, ¹Proteome Research Centre, Conway Institute, University College Dublin, Dublin, Ireland, ²Proteome Research Centre, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, ³Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom, ⁴Rheumatology, Altnagelvin Hospital, Londonderry, United Kingdom, ⁵Rheumatology, Musgrave Park Hospital, BELFAST, United Kingdom, ⁶Inflammatory Disease Research Group, Northern ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Background/Purpose: Biologic drugs have revolutionised the treatment of Rheumatoid Arthritis (RA), however these therapies are expensive and exhibit a high non–response rate (30%). Currently there…
Abstract Number: 1208 • 2016 ACR/ARHP Annual Meeting
High-Throughput Screening Discovers Multiple Novel Autoantibodies in Rheumatoid Arthritis, Systemic Lupus, Systemic Sclerosis and Sjogrens Syndrome
Peter Schulz-Knappe¹, Hans-Dieter Zucht¹, Petra Budde¹, Heike Göhler¹, Daniel Wirtz¹, Johannes Schulte-Pelkum¹, Stefan Vordenbäumen², Torsten Witte³ and Prof. Dr. Matthias Schneider⁴, ¹Protagen AG, Dortmund, Germany, ²Rheumatology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, ³Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ⁴Department of Rheumatology & Hiller Research Unit, Heinrich-Heine University, Düsseldorf, Germany
Background/Purpose: Diagnostic biomarkers are decision-making tools in clinical lab routine and are of growing importance for clinical management of patients. In autoimmune diseases, one important…
Abstract Number: 1211 • 2016 ACR/ARHP Annual Meeting
Allele-Dependent Binding of a Viral Protein to Autoimmune Disease-Associated Genetic Variants
Matthew T. Weirauch¹, Daniel Miller¹, Leah C. Kottyan², Ignacio Ibarra³, Sayeed Syed⁴, Xiaoting Chen¹, Erin Zoller¹, Arthur Lynch¹, Connor Schroeder¹, Josh Lee¹, Albert Magnussen¹, Ally Yang⁵, Timothy R. Hughes⁵, Joo-Seop Park¹, Charles Vinson⁴ and John B. Harley^6,7, ¹Cincinnati Childrens Hospital, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology, Cincinnati Childrens Hospital, Cincinnati, OH, ³EMBL, Heidelberg, Germany, ⁴NCI, Bethesda, MD, ⁵University of Toronto, Toronto, ON, Canada, ⁶US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH
Methods: We tested the hypothesis that some autoimmune variants might act by altering the binding of the EBV-encoded transcription factor ZTA, consequently resulting in downstream…
Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting
Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes
Celine C. Berthier¹, Jasmine Stannard², Emily Myers³, William Swindell⁴, Lori Lowe⁴, Tamra J. Reed⁵, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁶, ¹Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ²Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies. Phenotypic presentation and risk of systemic lupus manifestations differs by…
Abstract Number: 1254 • 2015 ACR/ARHP Annual Meeting
Deciphering the Immunome of Clinically Effective Immune Tolerization in Rheumatoid Arthritis
Jing Yao Leong^1,2, Raymond Ong Jr.³, Juntao Li⁴, Theodorus van den Broek⁵, Roberto Spreafico⁴, Maura Rossetti¹ and Salvatore Albani^1,2, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: We have previously described (Nature Medicine, PNAS, A&R, Nature Rheum, Lancet) how oral treatment with the pro-inflammatory, heat shock protein-derived dnaJP1 peptide induces detectable…
Abstract Number: 1929 • 2014 ACR/ARHP Annual Meeting
Echocardiographic Phenomics for Novel Classification of Cardiac Involvement in Systemic Sclerosis
Monique Hinchcliff¹, Vistasp Daruwalla², Lauren Beussink-Nelson³, Sofia Podlusky⁴, Mary A. Carns⁴, John Varga⁵ and Sanjiv J. Shah⁶, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Internal Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Traditional studies of systemic sclerosis (SSc) cardiac involvement have examined one or a few echocardiographic (echo) variables; however, cardiac involvement in SSc can be…
Abstract Number: 1669 • 2014 ACR/ARHP Annual Meeting
Validation of a Machine Learning Lupus Nephritis Decision Support Tool to Predict Complete Response to Therapy
Bethany Wolf¹, John Christian Spainhour¹, John Arthur², Michael Janech², Michelle Petri³, Adnan Kiani⁴ and Jim Oates^5,6, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴1830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁶Medical Service, Ralph H. Johnson VAMC, Charleston, SC
Background/Purpose .The American College of Rheumatology treatment guidelines for lupus nephritis (LN) recommend that induction therapy be changed when response to therapy has not occurred…
Abstract Number: 750 • 2014 ACR/ARHP Annual Meeting
Molecular Characterization of Systemic Sclerosis Esophageal Pathology Identifies Inflammatory and Proliferative Signatures with Few Fibrotic Markers
Jaclyn Taroni¹, Viktor Martyanov², Chiang-Ching Huang³, J. Matthew Mahoney⁴, Ikuo Hirano⁵, Tammara A. Wood², Brandon Shetuni⁶, Guang-Yu Yang⁶, Darren Brenner⁵, Barbara Jung⁷, Swati Bhattacharyya⁸, Orit Almagor⁹, Jungwha Lee¹⁰, Arlene Sirajuddin¹¹, Rowland W. Chang¹², John Varga¹³, Michael Whitfield¹⁴ and Monique Hinchcliff¹⁵, ¹Genetics, Giesel School of Medicine at Dartmouth, Hanover, NH, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁴Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT, ⁵Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Department of Medicine, Division of Gastroenterology, University of Illinois at Chicago, Chicago, IL, ⁸Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Northwestern University, Chicago, IL, ¹⁰Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹¹Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. Esophageal muscle atrophy without concomitant fibrosis is…
Abstract Number: 80 • 2014 ACR/ARHP Annual Meeting
Cellular Responses of IL6 Inhibition (Tocilizumab) in Rheumatoid Arthritis Using High-Accuracy Tandem Mass Spectrometry
Michael Kruse Meyer¹, Marlene Andersen², Grethe N. Andersen¹ and Allan Stensballe³, ¹Clinic of Rheumatology, Hospital of Vendsyssel/Aalborg University, Hjørring, Denmark, ²Department of Rheumatology, Aalborg University, Hjørring, Denmark, ³Health Science and Technology, Aalborg University, Aalborg, Denmark
Background/Purpose: In this study we are analyzing leukocyte subtype responses from patients with rheumatoid arthritis (RA) to IL6 inhibition. A large contribution to RA immunopathogenesis…

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